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Non-pitting edema

MedGen UID:
224749
•Concept ID:
C1265804
•
Finding
Synonym: Edema, nonpitting
SNOMED CT: Non-pitting edema (125308006); Non-pitting edema (420435001)
 
HPO: HP:6000507

Definition

Non-pitting edema occurs when excess fluid builds up in the body causing swelling that does not indent when pressure is applied. It usually occurs in the limbs, and often results from underlying medical conditions affecting lymphatic system function. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNon-pitting edema

Professional guidelines

PubMed

Primary lymphedema French National Diagnosis and Care Protocol (PNDS; Protocole National de Diagnostic et de Soins).
Vignes S, Albuisson J, Champion L, Constans J, Tauveron V, Malloizel J, Quéré I, Simon L, Arrault M, Trévidic P, Azria P, Maruani A; French National Referral Center for Primary Lymphedema
Orphanet J Rare Dis 2021 Jan 6;16(1):18. doi: 10.1186/s13023-020-01652-w. PMID: 33407666Free PMC Article
Evaluation and Management of Angioedema in the Emergency Department.
Long BJ, Koyfman A, Gottlieb M
West J Emerg Med 2019 Jul;20(4):587-600. Epub 2019 Jul 2 doi: 10.5811/westjem.2019.5.42650. PMID: 31316698Free PMC Article
Current treatment options for hereditary angioedema due to C1 inhibitor deficiency.
Wu MA, Zanichelli A, Mansi M, Cicardi M
Expert Opin Pharmacother 2016;17(1):27-40. Epub 2015 Oct 29 doi: 10.1517/14656566.2016.1104300. PMID: 26512744

Recent clinical studies

Etiology

Elephantiasis mimicry in recurrent lower limb skin infections in a diabetic patient: a case report.
Bramania P, Moshi E, Foi A, Shayo G
J Med Case Rep 2023 Dec 16;17(1):547. doi: 10.1186/s13256-023-04260-x. PMID: 38102695Free PMC Article
Primary lymphedema French National Diagnosis and Care Protocol (PNDS; Protocole National de Diagnostic et de Soins).
Vignes S, Albuisson J, Champion L, Constans J, Tauveron V, Malloizel J, Quéré I, Simon L, Arrault M, Trévidic P, Azria P, Maruani A; French National Referral Center for Primary Lymphedema
Orphanet J Rare Dis 2021 Jan 6;16(1):18. doi: 10.1186/s13023-020-01652-w. PMID: 33407666Free PMC Article
Evaluation and Management of Angioedema in the Emergency Department.
Long BJ, Koyfman A, Gottlieb M
West J Emerg Med 2019 Jul;20(4):587-600. Epub 2019 Jul 2 doi: 10.5811/westjem.2019.5.42650. PMID: 31316698Free PMC Article
Clinical Experience with Rituximab and Intravenous Immunoglobulin for Pretibial Myxedema: A Case Series.
Kotwal A, Turcu AF, Sonawane V, Bahn RS, Pittelkow MR, Bridges A, Stan MN
Thyroid 2019 May;29(5):692-699. Epub 2019 Apr 8 doi: 10.1089/thy.2018.0706. PMID: 30854936
Kawasaki Disease in the neonate: case report and literature review.
Altammar F, Lang B
Pediatr Rheumatol Online J 2018 Jul 3;16(1):43. doi: 10.1186/s12969-018-0263-8. PMID: 29970110Free PMC Article

Diagnosis

Post-COMIRNATY(®) Non-episodic Angioedema with Eosinophilia: An Elderly Case.
Sato Y, Murata K, Kasami S, Kato M
Intern Med 2022 Jun 15;61(12):1927-1928. Epub 2021 Nov 13 doi: 10.2169/internalmedicine.8599-21. PMID: 34776494Free PMC Article
Kawasaki Disease in the neonate: case report and literature review.
Altammar F, Lang B
Pediatr Rheumatol Online J 2018 Jul 3;16(1):43. doi: 10.1186/s12969-018-0263-8. PMID: 29970110Free PMC Article
Cutaneous Manifestations of Small-Vessel Leukocytoclastic Vasculitides in Childhood.
Lava SAG, Milani GP, Fossali EF, Simonetti GD, Agostoni C, Bianchetti MG
Clin Rev Allergy Immunol 2017 Dec;53(3):439-451. doi: 10.1007/s12016-017-8626-3. PMID: 28836099
Acute Hemorrhagic Edema of Infancy.
Serra E Moura Garcia C, Sokolova A, Torre ML, Amaro C
Eur Ann Allergy Clin Immunol 2016 Jan;48(1):22-6. PMID: 26808448
Non pitting edema, arthritis and ichthyosis; presenting manifestation of leprosy.
Moulick A, Jana A, Sarkar N, Guha P, Mahapatra C, Lallawmzuala K
Indian J Lepr 2013 Apr-Jun;85(2):83-6. PMID: 24236367

Therapy

Evaluation and Management of Angioedema in the Emergency Department.
Long BJ, Koyfman A, Gottlieb M
West J Emerg Med 2019 Jul;20(4):587-600. Epub 2019 Jul 2 doi: 10.5811/westjem.2019.5.42650. PMID: 31316698Free PMC Article
Clinical Experience with Rituximab and Intravenous Immunoglobulin for Pretibial Myxedema: A Case Series.
Kotwal A, Turcu AF, Sonawane V, Bahn RS, Pittelkow MR, Bridges A, Stan MN
Thyroid 2019 May;29(5):692-699. Epub 2019 Apr 8 doi: 10.1089/thy.2018.0706. PMID: 30854936
Kawasaki Disease in the neonate: case report and literature review.
Altammar F, Lang B
Pediatr Rheumatol Online J 2018 Jul 3;16(1):43. doi: 10.1186/s12969-018-0263-8. PMID: 29970110Free PMC Article
Current treatment options for hereditary angioedema due to C1 inhibitor deficiency.
Wu MA, Zanichelli A, Mansi M, Cicardi M
Expert Opin Pharmacother 2016;17(1):27-40. Epub 2015 Oct 29 doi: 10.1517/14656566.2016.1104300. PMID: 26512744
Angioneurotic edema of the upper airways and antihypertensive therapy.
Zanoletti E, Bertino G, Malvezzi L, Benazzo M, Mira E
Acta Otolaryngol 2003 Oct;123(8):960-4. doi: 10.1080/00016480310005129. PMID: 14606600

Prognosis

Case Report: Non-episodic Angioedema With Eosinophilia in a Young Lactating Woman.
Hirmatsu-Ito M, Nakamura N, Miyabe M, Matsubara T, Naruse K
Front Immunol 2021;12:627360. Epub 2021 Apr 26 doi: 10.3389/fimmu.2021.627360. PMID: 33981299Free PMC Article
Lethal manifestations of angioedema.
Gilbert JD, Byard RW
Forensic Sci Med Pathol 2019 Sep;15(3):494-497. Epub 2018 Nov 3 doi: 10.1007/s12024-018-0045-0. PMID: 30390279
Long-term follow-up and epidemiological trends in patients with pretibial myxedema: an 11-year study from a tertiary care center in northern India.
Sendhil Kumaran M, Dutta P, Sakia U, Dogra S
Int J Dermatol 2015 Aug;54(8):e280-6. Epub 2015 May 27 doi: 10.1111/ijd.12658. PMID: 26019115
Cutaneous angiosarcoma clinically presenting as progressive solid facial edema in a 43-year-old male.
Choi WT, Stetsenko GY, Zhang J, Olerud JE, Argenyi ZB, George E
Dermatol Online J 2013 Nov 15;19(11):20409. PMID: 24314784
Lymphatic tissue transplant in lymphedema--a minimally invasive, outpatient, surgical method: a 10-year follow-up pilot study.
Belcaro G, Errichi BM, Cesarone MR, Ippolito E, Dugall M, Ledda A, Ricci A
Angiology 2008 Feb-Mar;59(1):77-83. doi: 10.1177/0003319707308564. PMID: 18319226

Clinical prediction guides

Primary lymphedema French National Diagnosis and Care Protocol (PNDS; Protocole National de Diagnostic et de Soins).
Vignes S, Albuisson J, Champion L, Constans J, Tauveron V, Malloizel J, Quéré I, Simon L, Arrault M, Trévidic P, Azria P, Maruani A; French National Referral Center for Primary Lymphedema
Orphanet J Rare Dis 2021 Jan 6;16(1):18. doi: 10.1186/s13023-020-01652-w. PMID: 33407666Free PMC Article
Observing pretibial myxedema in patients with Graves' disease using digital infrared thermal imaging and high-resolution ultrasonography: for better records, early detection, and further investigation.
Shih SR, Lin MS, Li HY, Yang HY, Hsiao YL, Chang MT, Chen CM, Chang TC
Eur J Endocrinol 2011 Apr;164(4):605-11. Epub 2011 Jan 25 doi: 10.1530/EJE-10-1095. PMID: 21266550
A case of type 2 diabetes mellitus developing hypothyroidism discovered as a result of a discrepancy between glycated hemoglobin and glycated albumin values.
Moriyama K, Kanamoto N, Hataya Y, Nanbu T, Hosoda K, Arai H, Nakao K
Diabetes Res Clin Pract 2006 Mar;71(3):227-32. Epub 2005 Aug 19 doi: 10.1016/j.diabres.2005.06.013. PMID: 16112242
Healing of chronic arterial and venous leg ulcers through systemic effects of electromagnetic fields [corrected].
Cañedo-Dorantes L, García-Cantú R, Barrera R, Méndez-Ramírez I, Navarro VH, Serrano G
Arch Med Res 2002 May-Jun;33(3):281-9. doi: 10.1016/s0188-4409(02)00357-0. PMID: 12031635

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