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Uveoparotid fever

MedGen UID:
22600
•Concept ID:
C0042171
•
Disease or Syndrome
Synonyms: Fever, Uveoparotid; Fevers, Uveoparotid; Heerfordt Syndrome; Syndrome, Heerfordt; Uveoparotid Fever; Uveoparotid Fevers; Uveoparotitides; Uveoparotitis
SNOMED CT: Heerfordt syndrome (4416007); Heerfordt-Waldenström syndrome (4416007); Heerfordt-Waldenstrom syndrome (4416007); Heerfordt's syndrome (4416007); Uveoparotid fever (4416007)
 
Monarch Initiative: MONDO:0007011

Definition

A manifestation of sarcoidosis marked by chronic inflammation of the parotid gland and the uvea. [from MONDO]

Professional guidelines

PubMed

Neurosarcoidosis: a clinical approach to diagnosis and management.
Ibitoye RT, Wilkins A, Scolding NJ
J Neurol 2017 May;264(5):1023-1028. Epub 2016 Nov 22 doi: 10.1007/s00415-016-8336-4. PMID: 27878437Free PMC Article

Recent clinical studies

Etiology

Ocular sarcoidosis: clinical experience and recent pathogenetic and therapeutic advancements.
Dammacco R, Biswas J, Kivelä TT, Zito FA, Leone P, Mavilio A, Sisto D, Alessio G, Dammacco F
Int Ophthalmol 2020 Dec;40(12):3453-3467. Epub 2020 Aug 1 doi: 10.1007/s10792-020-01531-0. PMID: 32740881Free PMC Article
Rare manifestations of sarcoidosis in modern era of new diagnostic tools.
Sharma SK, Soneja M, Sharma A, Sharma MC, Hari S
Indian J Med Res 2012 May;135(5):621-9. PMID: 22771590Free PMC Article
HLA-DRB1* alleles and symptoms associated with Heerfordt's syndrome in sarcoidosis.
Darlington P, Tallstedt L, Padyukov L, Kockum I, Cederlund K, Eklund A, Grunewald J
Eur Respir J 2011 Nov;38(5):1151-7. Epub 2011 May 12 doi: 10.1183/09031936.00025011. PMID: 21565911
Diagnosis of Heerfordt's syndrome by state-of-the-art ultrasound in combination with parotid biopsy: a case report.
Fischer T, Filimonow S, Petersein J, Zimmer C, Beyersdorff D, Guski H
Eur Radiol 2002 Jan;12(1):134-7. Epub 2001 Apr 6 doi: 10.1007/s003300100879. PMID: 11868089
Parotid gland sarcoidosis.
James DG, Sharma OP
Sarcoidosis Vasc Diffuse Lung Dis 2000 Mar;17(1):27-32. PMID: 10746259

Diagnosis

Ocular sarcoidosis: clinical experience and recent pathogenetic and therapeutic advancements.
Dammacco R, Biswas J, Kivelä TT, Zito FA, Leone P, Mavilio A, Sisto D, Alessio G, Dammacco F
Int Ophthalmol 2020 Dec;40(12):3453-3467. Epub 2020 Aug 1 doi: 10.1007/s10792-020-01531-0. PMID: 32740881Free PMC Article
Neurosarcoidosis: a clinical approach to diagnosis and management.
Ibitoye RT, Wilkins A, Scolding NJ
J Neurol 2017 May;264(5):1023-1028. Epub 2016 Nov 22 doi: 10.1007/s00415-016-8336-4. PMID: 27878437Free PMC Article
Parotid gland sarcoidosis.
James DG, Sharma OP
Sarcoidosis Vasc Diffuse Lung Dis 2000 Mar;17(1):27-32. PMID: 10746259
Differential diagnosis of facial nerve palsy.
James DG
Sarcoidosis Vasc Diffuse Lung Dis 1997 Sep;14(2):115-20. PMID: 9306501
Sarcoidosis--the beginning: historical highlights of personalities and their accomplishments during the early years.
Young RC Jr, Rachal RE, Cowan CL Jr
J Natl Med Assoc 1984 Sep;76(9):887-96. PMID: 6387158Free PMC Article

Therapy

Heerfordt's Syndrome Associated with a High Fever and Elevation of TNF-α.
Makimoto G, Miyahara N, Yoshikawa M, Taniguchi A, Kanehiro A, Tanimoto M, Kiura K
Acta Med Okayama 2016 Aug;70(4):273-7. doi: 10.18926/AMO/54503. PMID: 27549672
Progressive multifocal leukoencephalopathy developed in incomplete Heerfordt syndrome, a rare manifestation of sarcoidosis, without steroid therapy responding to cidofovir.
Yagi T, Hattori H, Ohira M, Nakamichi K, Takayama-Ito M, Saijo M, Shimizu T, Ito D, Takahashi K, Suzuki N
Clin Neurol Neurosurg 2010 Feb;112(2):153-6. Epub 2009 Nov 4 doi: 10.1016/j.clineuro.2009.10.005. PMID: 19892460
Bilateral parotitis and facial nerve palsy.
King CS, Zapor M
Cleve Clin J Med 2007 Jul;74(7):512-3. doi: 10.3949/ccjm.74.7.512. PMID: 17682628
Heerfordt syndrome with internal ophthalmoplegia.
Blair MP, Rizen M
Arch Ophthalmol 2005 Jul;123(7):1017. doi: 10.1001/archopht.123.7.1017. PMID: 16009851
Ocular sarcoidosis.
James DG, Neville E, Langley DA
Trans Ophthalmol Soc U K (1962) 1976 Apr;96(1):133-9. PMID: 1070842

Prognosis

Ocular sarcoidosis: clinical experience and recent pathogenetic and therapeutic advancements.
Dammacco R, Biswas J, Kivelä TT, Zito FA, Leone P, Mavilio A, Sisto D, Alessio G, Dammacco F
Int Ophthalmol 2020 Dec;40(12):3453-3467. Epub 2020 Aug 1 doi: 10.1007/s10792-020-01531-0. PMID: 32740881Free PMC Article
Heerfordt syndrome initially presenting with subcutaneous mass lesions: usefulness of gallium-67 scans before and after treatment.
Sugawara Y, Sakayama K, Sada E, Kajihara M, Semba T, Higashino H, Mochizuki T
Clin Nucl Med 2005 Nov;30(11):732-3. doi: 10.1097/01.rlu.0000182264.76461.74. PMID: 16237297
Differential diagnosis of facial nerve palsy.
James DG
Sarcoidosis Vasc Diffuse Lung Dis 1997 Sep;14(2):115-20. PMID: 9306501

Clinical prediction guides

Parotid gland involvement in Heerfordt syndrome: a case report.
Broggi G, Reggio E, Giuliano L, Palmucci S, Caltabiano R, Lanzafame S
Pathologica 2017 Dec;109(4):418-420. PMID: 29449738
Rare manifestations of sarcoidosis in modern era of new diagnostic tools.
Sharma SK, Soneja M, Sharma A, Sharma MC, Hari S
Indian J Med Res 2012 May;135(5):621-9. PMID: 22771590Free PMC Article
Facial palsy in Heerfordt's syndrome: electrophysiological localization of the lesion.
Glocker FX, Seifert C, Lücking CH
Muscle Nerve 1999 Sep;22(9):1279-82. doi: 10.1002/(sici)1097-4598(199909)22:9<1279::aid-mus18>3.0.co;2-#. PMID: 10454727

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