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Vitamin K deficiency

MedGen UID:
22672
•Concept ID:
C0042880
•
Disease or Syndrome
Synonyms: Deficiencies, Vitamin K; Deficiency, Vitamin K; Vitamin K Deficiencies; Vitamin K Deficiency
SNOMED CT: Deficiency of vitamin K (52675005); Vitamin K deficiency (52675005)

Definition

Deficiency of vitamin K. It may lead to bleeding, manifested with ecchymoses, petechiae, and hematomas. In infants it may cause hemorrhagic disease of newborn with intracranial and retroperitoneal bleeding. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVitamin K deficiency

Professional guidelines

PubMed

Belgian Consensus Recommendations to Prevent Vitamin K Deficiency Bleeding in the Term and Preterm Infant.
Fiesack S, Smits A, Rayyan M, Allegaert K, Alliet P, Arts W, Bael A, Cornette L, De Guchtenaere A, De Mulder N, George I, Henrion E, Keiren K, Kreins N, Raes M, Philippet P, Van Overmeire B, Van Winckel M, Vlieghe V, Vandenplas Y, On Behalf Of The Groups
Nutrients 2021 Nov 16;13(11) doi: 10.3390/nu13114109. PMID: 34836364Free PMC Article
A guide to acquired vitamin K coagulophathy diagnosis and treatment: the Russian perspective.
Wojciechowski VV, Calina D, Tsarouhas K, Pivnik AV, Sergievich AA, Kodintsev VV, Filatova EA, Ozcagli E, Docea AO, Arsene AL, Gofita E, Tsitsimpikou C, Tsatsakis AM, Golokhvast KS
Daru 2017 Apr 17;25(1):10. doi: 10.1186/s40199-017-0175-z. PMID: 28416008Free PMC Article
Prevention of Vitamin K Deficiency Bleeding in Newborn Infants: A Position Paper by the ESPGHAN Committee on Nutrition.
Mihatsch WA, Braegger C, Bronsky J, Campoy C, Domellöf M, Fewtrell M, Mis NF, Hojsak I, Hulst J, Indrio F, Lapillonne A, Mlgaard C, Embleton N, van Goudoever J; ESPGHAN Committee on Nutrition
J Pediatr Gastroenterol Nutr 2016 Jul;63(1):123-9. doi: 10.1097/MPG.0000000000001232. PMID: 27050049

Recent clinical studies

Etiology

Vitamin K Nutrition and Bone Health.
Tsugawa N, Shiraki M
Nutrients 2020 Jun 27;12(7) doi: 10.3390/nu12071909. PMID: 32605143Free PMC Article
Calciphylaxis: Diagnosis, Pathogenesis, and Treatment.
Chang JJ
Adv Skin Wound Care 2019 May;32(5):205-215. doi: 10.1097/01.ASW.0000554443.14002.13. PMID: 31008757
Vitamin K and cancer.
Dahlberg S, Ede J, Schött U
Scand J Clin Lab Invest 2017 Dec;77(8):555-567. Epub 2017 Sep 21 doi: 10.1080/00365513.2017.1379090. PMID: 28933567
Vitamin K prophylaxis for prevention of vitamin K deficiency bleeding: a systematic review.
Sankar MJ, Chandrasekaran A, Kumar P, Thukral A, Agarwal R, Paul VK
J Perinatol 2016 May;36 Suppl 1(Suppl 1):S29-35. doi: 10.1038/jp.2016.30. PMID: 27109090Free PMC Article
Coagulation disorders in liver disease.
Amitrano L, Guardascione MA, Brancaccio V, Balzano A
Semin Liver Dis 2002 Feb;22(1):83-96. doi: 10.1055/s-2002-23205. PMID: 11928081

Diagnosis

Vitamin K Nutrition and Bone Health.
Tsugawa N, Shiraki M
Nutrients 2020 Jun 27;12(7) doi: 10.3390/nu12071909. PMID: 32605143Free PMC Article
Calciphylaxis: Diagnosis, Pathogenesis, and Treatment.
Chang JJ
Adv Skin Wound Care 2019 May;32(5):205-215. doi: 10.1097/01.ASW.0000554443.14002.13. PMID: 31008757
Calciphylaxis.
Nigwekar SU
Curr Opin Nephrol Hypertens 2017 Jul;26(4):276-281. doi: 10.1097/MNH.0000000000000328. PMID: 28375870Free PMC Article
Vitamins.
Lauer B, Spector N
Pediatr Rev 2012 Aug;33(8):339-51; quiz 351-2. doi: 10.1542/pir.33-8-339. PMID: 22855926
Coagulation disorders in liver disease.
Amitrano L, Guardascione MA, Brancaccio V, Balzano A
Semin Liver Dis 2002 Feb;22(1):83-96. doi: 10.1055/s-2002-23205. PMID: 11928081

Therapy

Vitamin K prophylaxis in newborns.
Jullien S
BMC Pediatr 2021 Sep 8;21(Suppl 1):350. doi: 10.1186/s12887-021-02701-4. PMID: 34496783Free PMC Article
Vitamin K and vascular calcification.
Lees JS, Mark PB, Witham MD
Curr Opin Nephrol Hypertens 2021 Jul 1;30(4):430-436. doi: 10.1097/MNH.0000000000000712. PMID: 33871429
Vitamin K Deficiency Bleeding in Infancy.
Araki S, Shirahata A
Nutrients 2020 Mar 16;12(3) doi: 10.3390/nu12030780. PMID: 32187975Free PMC Article
Multicenter Randomized Controlled Trial of Vitamin K Antagonist Replacement by Rivaroxaban with or without Vitamin K2 in Hemodialysis Patients with Atrial Fibrillation: the Valkyrie Study.
De Vriese AS, Caluwé R, Pyfferoen L, De Bacquer D, De Boeck K, Delanote J, De Surgeloose D, Van Hoenacker P, Van Vlem B, Verbeke F
J Am Soc Nephrol 2020 Jan;31(1):186-196. Epub 2019 Nov 8 doi: 10.1681/ASN.2019060579. PMID: 31704740Free PMC Article
Vitamin K prophylaxis for prevention of vitamin K deficiency bleeding: a systematic review.
Sankar MJ, Chandrasekaran A, Kumar P, Thukral A, Agarwal R, Paul VK
J Perinatol 2016 May;36 Suppl 1(Suppl 1):S29-35. doi: 10.1038/jp.2016.30. PMID: 27109090Free PMC Article

Prognosis

Vitamin K and the Newborn Infant.
Hand I, Noble L, Abrams SA
Pediatrics 2022 Mar 1;149(3) doi: 10.1542/peds.2021-056036. PMID: 35190810
PIVKA-II serves as a potential biomarker that complements AFP for the diagnosis of hepatocellular carcinoma.
Feng H, Li B, Li Z, Wei Q, Ren L
BMC Cancer 2021 Apr 13;21(1):401. doi: 10.1186/s12885-021-08138-3. PMID: 33849479Free PMC Article
Vascular pathologies in chronic kidney disease: pathophysiological mechanisms and novel therapeutic approaches.
Düsing P, Zietzer A, Goody PR, Hosen MR, Kurts C, Nickenig G, Jansen F
J Mol Med (Berl) 2021 Mar;99(3):335-348. Epub 2021 Jan 22 doi: 10.1007/s00109-021-02037-7. PMID: 33481059Free PMC Article
Calciphylaxis.
Nigwekar SU
Curr Opin Nephrol Hypertens 2017 Jul;26(4):276-281. doi: 10.1097/MNH.0000000000000328. PMID: 28375870Free PMC Article
Vitamin K prophylaxis for prevention of vitamin K deficiency bleeding: a systematic review.
Sankar MJ, Chandrasekaran A, Kumar P, Thukral A, Agarwal R, Paul VK
J Perinatol 2016 May;36 Suppl 1(Suppl 1):S29-35. doi: 10.1038/jp.2016.30. PMID: 27109090Free PMC Article

Clinical prediction guides

Vitamin K and cardiovascular complications in chronic kidney disease patients.
Kaesler N, Schurgers LJ, Floege J
Kidney Int 2021 Nov;100(5):1023-1036. Epub 2021 Jul 24 doi: 10.1016/j.kint.2021.06.037. PMID: 34310988
Laboratory assessment of vitamin K status.
Card DJ, Gorska R, Harrington DJ
J Clin Pathol 2020 Feb;73(2):70-75. Epub 2019 Dec 20 doi: 10.1136/jclinpath-2019-205997. PMID: 31862867
Multicenter Randomized Controlled Trial of Vitamin K Antagonist Replacement by Rivaroxaban with or without Vitamin K2 in Hemodialysis Patients with Atrial Fibrillation: the Valkyrie Study.
De Vriese AS, Caluwé R, Pyfferoen L, De Bacquer D, De Boeck K, Delanote J, De Surgeloose D, Van Hoenacker P, Van Vlem B, Verbeke F
J Am Soc Nephrol 2020 Jan;31(1):186-196. Epub 2019 Nov 8 doi: 10.1681/ASN.2019060579. PMID: 31704740Free PMC Article
Vitamin K prophylaxis for prevention of vitamin K deficiency bleeding: a systematic review.
Sankar MJ, Chandrasekaran A, Kumar P, Thukral A, Agarwal R, Paul VK
J Perinatol 2016 May;36 Suppl 1(Suppl 1):S29-35. doi: 10.1038/jp.2016.30. PMID: 27109090Free PMC Article
Vitamin K and musculoskeletal health in postmenopausal women.
Hamidi MS, Cheung AM
Mol Nutr Food Res 2014 Aug;58(8):1647-57. Epub 2014 Jun 23 doi: 10.1002/mnfr.201300950. PMID: 24956598

Recent systematic reviews

Hyperemesis gravidarum and vitamin K deficiency: a systematic review.
Nijsten K, van der Minnen L, Wiegers HMG, Koot MH, Middeldorp S, Roseboom TJ, Grooten IJ, Painter RC
Br J Nutr 2022 Jul 14;128(1):30-42. Epub 2021 Jul 30 doi: 10.1017/S0007114521002865. PMID: 34325760Free PMC Article
Vitamin K for reversal of excessive vitamin K antagonist anticoagulation: a systematic review and meta-analysis.
Khatib R, Ludwikowska M, Witt DM, Ansell J, Clark NP, Holbrook A, Wiercioch W, Schünemann H, Nieuwlaat R
Blood Adv 2019 Mar 12;3(5):789-796. doi: 10.1182/bloodadvances.2018025163. PMID: 30850385Free PMC Article
Prophylactic vitamin K for the prevention of vitamin K deficiency bleeding in preterm neonates.
Ardell S, Offringa M, Ovelman C, Soll R
Cochrane Database Syst Rev 2018 Feb 5;2(2):CD008342. doi: 10.1002/14651858.CD008342.pub2. PMID: 29401369Free PMC Article
Vitamin K supplementation for cystic fibrosis.
Jagannath VA, Thaker V, Chang AB, Price AI
Cochrane Database Syst Rev 2017 Aug 22;8(8):CD008482. doi: 10.1002/14651858.CD008482.pub5. PMID: 28829533Free PMC Article
Vitamin K prophylaxis for prevention of vitamin K deficiency bleeding: a systematic review.
Sankar MJ, Chandrasekaran A, Kumar P, Thukral A, Agarwal R, Paul VK
J Perinatol 2016 May;36 Suppl 1(Suppl 1):S29-35. doi: 10.1038/jp.2016.30. PMID: 27109090Free PMC Article

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