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Lipohypertrophy

MedGen UID:
226799
•Concept ID:
C1262113
•
Disease or Syndrome

Definition

Hypertrophy of the subcutaneous adipose tissue at the site of multiple subcutaneous injections of insulin. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLipohypertrophy

Professional guidelines

PubMed

Errors in insulin treatment management and risk of lipohypertrophy.
Pozzuoli GM, Laudato M, Barone M, Crisci F, Pozzuoli B
Acta Diabetol 2018 Jan;55(1):67-73. Epub 2017 Nov 2 doi: 10.1007/s00592-017-1066-y. PMID: 29098390
Practical Review of Recognition and Management of Obesity and Lipohypertrophy in Human Immunodeficiency Virus Infection.
Lake JE, Stanley TL, Apovian CM, Bhasin S, Brown TT, Capeau J, Currier JS, Dube MP, Falutz J, Grinspoon SK, Guaraldi G, Martinez E, McComsey GA, Sattler FR, Erlandson KM
Clin Infect Dis 2017 May 15;64(10):1422-1429. doi: 10.1093/cid/cix178. PMID: 28329372Free PMC Article
Pathogenesis and treatment of HIV lipohypertrophy.
Leung VL, Glesby MJ
Curr Opin Infect Dis 2011 Feb;24(1):43-9. doi: 10.1097/QCO.0b013e3283420eef. PMID: 21124215Free PMC Article

Recent clinical studies

Etiology

Lipohypertrophy and Insulin: An Old Dog That Needs New Tricks.
Huang J, Yeung AM, Kerr D, Gentile S, Heinemann L, Al-Sofiani ME, Joseph JI, Seley JJ, Klonoff DC
Endocr Pract 2023 Aug;29(8):670-677. Epub 2023 Apr 23 doi: 10.1016/j.eprac.2023.04.006. PMID: 37098370
HIV and antiretroviral therapy-related fat alterations.
Koethe JR, Lagathu C, Lake JE, Domingo P, Calmy A, Falutz J, Brown TT, Capeau J
Nat Rev Dis Primers 2020 Jun 18;6(1):48. doi: 10.1038/s41572-020-0181-1. PMID: 32555389
Practical Review of Recognition and Management of Obesity and Lipohypertrophy in Human Immunodeficiency Virus Infection.
Lake JE, Stanley TL, Apovian CM, Bhasin S, Brown TT, Capeau J, Currier JS, Dube MP, Falutz J, Grinspoon SK, Guaraldi G, Martinez E, McComsey GA, Sattler FR, Erlandson KM
Clin Infect Dis 2017 May 15;64(10):1422-1429. doi: 10.1093/cid/cix178. PMID: 28329372Free PMC Article
New Insulin Delivery Recommendations.
Frid AH, Kreugel G, Grassi G, Halimi S, Hicks D, Hirsch LJ, Smith MJ, Wellhoener R, Bode BW, Hirsch IB, Kalra S, Ji L, Strauss KW
Mayo Clin Proc 2016 Sep;91(9):1231-55. doi: 10.1016/j.mayocp.2016.06.010. PMID: 27594187
Prevention of lipohypertrophy.
Kalra S, Kumar A, Gupta Y
J Pak Med Assoc 2016 Jul;66(7):910-1. PMID: 27427150

Diagnosis

Lipohypertrophy and Insulin: An Old Dog That Needs New Tricks.
Huang J, Yeung AM, Kerr D, Gentile S, Heinemann L, Al-Sofiani ME, Joseph JI, Seley JJ, Klonoff DC
Endocr Pract 2023 Aug;29(8):670-677. Epub 2023 Apr 23 doi: 10.1016/j.eprac.2023.04.006. PMID: 37098370
Cutaneous Manifestations of Diabetes Mellitus: A Review.
Lima AL, Illing T, Schliemann S, Elsner P
Am J Clin Dermatol 2017 Aug;18(4):541-553. doi: 10.1007/s40257-017-0275-z. PMID: 28374407
Prevention of lipohypertrophy.
Kalra S, Kumar A, Gupta Y
J Pak Med Assoc 2016 Jul;66(7):910-1. PMID: 27427150
Lipohypertrophy.
Kalra S, Jawad F
J Pak Med Assoc 2016 Jun;66(6):779-80. PMID: 27339591
Diabetes mellitus.
Ahmed I, Goldstein B
Clin Dermatol 2006 Jul-Aug;24(4):237-46. doi: 10.1016/j.clindermatol.2006.04.009. PMID: 16828404

Therapy

Lipohypertrophy and Insulin: An Update From the Diabetes Technology Society.
Tian T, Aaron RE, Huang J, Yeung AM, Svensson J, Gentile S, Forbes A, Heinemann L, Seley JJ, Kerr D, Klonoff DC
J Diabetes Sci Technol 2023 Nov;17(6):1711-1721. Epub 2023 Aug 9 doi: 10.1177/19322968231187661. PMID: 37555266Free PMC Article
Cutaneous Manifestations of Diabetes Mellitus: A Review.
Lima AL, Illing T, Schliemann S, Elsner P
Am J Clin Dermatol 2017 Aug;18(4):541-553. doi: 10.1007/s40257-017-0275-z. PMID: 28374407
New Insulin Delivery Recommendations.
Frid AH, Kreugel G, Grassi G, Halimi S, Hicks D, Hirsch LJ, Smith MJ, Wellhoener R, Bode BW, Hirsch IB, Kalra S, Ji L, Strauss KW
Mayo Clin Proc 2016 Sep;91(9):1231-55. doi: 10.1016/j.mayocp.2016.06.010. PMID: 27594187
Prevention of lipohypertrophy.
Kalra S, Kumar A, Gupta Y
J Pak Med Assoc 2016 Jul;66(7):910-1. PMID: 27427150
Lipohypertrophy.
Kalra S, Jawad F
J Pak Med Assoc 2016 Jun;66(6):779-80. PMID: 27339591

Prognosis

Lipohypertrophy and Insulin: An Old Dog That Needs New Tricks.
Huang J, Yeung AM, Kerr D, Gentile S, Heinemann L, Al-Sofiani ME, Joseph JI, Seley JJ, Klonoff DC
Endocr Pract 2023 Aug;29(8):670-677. Epub 2023 Apr 23 doi: 10.1016/j.eprac.2023.04.006. PMID: 37098370
Endocrinological aspects of HIV infection.
Mirza FS, Luthra P, Chirch L
J Endocrinol Invest 2018 Aug;41(8):881-899. Epub 2018 Jan 8 doi: 10.1007/s40618-017-0812-x. PMID: 29313284
HIV/AIDS and lipodystrophy: implications for clinical management in resource-limited settings.
Finkelstein JL, Gala P, Rochford R, Glesby MJ, Mehta S
J Int AIDS Soc 2015;18(1):19033. Epub 2015 Jan 15 doi: 10.7448/IAS.18.1.19033. PMID: 25598476Free PMC Article
Side effects of HIV therapy.
Esser S, Helbig D, Hillen U, Dissemond J, Grabbe S
J Dtsch Dermatol Ges 2007 Sep;5(9):745-54. doi: 10.1111/j.1610-0387.2007.06322.x. PMID: 17760894
Diabetes mellitus.
Ahmed I, Goldstein B
Clin Dermatol 2006 Jul-Aug;24(4):237-46. doi: 10.1016/j.clindermatol.2006.04.009. PMID: 16828404

Clinical prediction guides

Adipose Tissue Dysfunction and Energy Balance Paradigms in People Living With HIV.
Ramirez Bustamante CE, Agarwal N, Cox AR, Hartig SM, Lake JE, Balasubramanyam A
Endocr Rev 2024 Mar 4;45(2):190-209. doi: 10.1210/endrev/bnad028. PMID: 37556371Free PMC Article
Subclinical lipohypertrophy--Easily ignored complications of insulin therapy.
Luo D, Shi Y, Zhu M, Wang H, Yan D, Yu J, Ji J, Liu X, Fan B, Xu Y, Zhang M, He W, Xu J, Yang T
J Diabetes Complications 2021 Mar;35(3):107806. Epub 2020 Nov 26 doi: 10.1016/j.jdiacomp.2020.107806. PMID: 33280982
Nanotechnology in Insulin Delivery for Management of Diabetes.
Bahman F, Greish K, Taurin S
Pharm Nanotechnol 2019;7(2):113-128. doi: 10.2174/2211738507666190321110721. PMID: 30907328
Ultrasound detection of insulin-induced lipohypertrophy in Type 1 and Type 2 diabetes.
Kapeluto JE, Paty BW, Chang SD, Meneilly GS
Diabet Med 2018 Oct;35(10):1383-1390. Epub 2018 Jul 16 doi: 10.1111/dme.13764. PMID: 29908078
Pathogenesis and treatment of HIV lipohypertrophy.
Leung VL, Glesby MJ
Curr Opin Infect Dis 2011 Feb;24(1):43-9. doi: 10.1097/QCO.0b013e3283420eef. PMID: 21124215Free PMC Article

Recent systematic reviews

Relationship Between Lipohypertrophy, Glycemic Control, and Insulin Dosing: A Systematic Meta-Analysis.
Mader JK, Fornengo R, Hassoun A, Heinemann L, Kulzer B, Monica M, Nguyen T, Sieber J, Renard E, Reznik Y, Ryś P, Stożek-Tutro A, Wilmot EG
Diabetes Technol Ther 2024 May;26(5):351-362. Epub 2024 Feb 12 doi: 10.1089/dia.2023.0491. PMID: 38215209Free PMC Article
Efficacy of education on injection technique for patients diagnosed with diabetes with lipohypertrophy: systematic review and meta-analysis.
Ichikawa M, Akiyama T, Tsujimoto Y, Anan K, Yamakawa T, Terauchi Y
BMJ Open 2022 Mar 7;12(3):e055529. doi: 10.1136/bmjopen-2021-055529. PMID: 35256444Free PMC Article
Alternative Cosmetic and Medical Applications of Injectable Deoxycholic Acid: A Systematic Review.
Liu C, Li MK, Alster TS
Dermatol Surg 2021 Nov 1;47(11):1466-1472. doi: 10.1097/DSS.0000000000003159. PMID: 34537786
Safety of the reuse of needles for subcutaneous insulin injection: A systematic review and meta-analysis.
Zabaleta-Del-Olmo E, Vlacho B, Jodar-Fernández L, Urpí-Fernández AM, Lumillo-Gutiérrez I, Agudo-Ugena J, Morros-Pedrós R, Violán C
Int J Nurs Stud 2016 Aug;60:121-32. Epub 2016 Apr 27 doi: 10.1016/j.ijnurstu.2016.04.010. PMID: 27297374

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