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Spontaneously Regressed Retinoblastoma

MedGen UID:
226855
•Concept ID:
C1266186
•
Neoplastic Process
Synonym: Retinoblastoma, spontaneously regressed
SNOMED CT: Retinoblastoma, spontaneously regressed (128794002)

Definition

An archaic term that refers to benign, non-progressive retinal lesions in patients with mutation of the RB1 gene. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSpontaneously Regressed Retinoblastoma

Professional guidelines

PubMed

The impact of epithelial biomarkers, local immune response and human papillomavirus genotype in the regression of cervical intraepithelial neoplasia grades 2-3.
Ovestad IT, Gudlaugsson E, Skaland I, Malpica A, Munk AC, Janssen EA, Baak JP
J Clin Pathol 2011 Apr;64(4):303-7. doi: 10.1136/jcp.2010.083626. PMID: 21421698
Retinoblastoma in Turkey--treatment and prognosis.
Günalp I, Gündüz K, Arslan Y
Jpn J Ophthalmol 1996;40(1):95-102. PMID: 8739506

Recent clinical studies

Etiology

Progressive resorption of a presumed spontaneously regressed retinoblastoma over 20 years.
Lam A, Shields CL, Manquez ME, Shields JA
Retina 2005 Feb-Mar;25(2):230-1. doi: 10.1097/00006982-200502000-00025. PMID: 15689823
Histopathologic verification of Verhoeff's 1918 irradiation cure of retinoblastoma.
Marcus DM, Craft JL, Albert DM
Ophthalmology 1990 Feb;97(2):221-4. doi: 10.1016/s0161-6420(90)32602-7. PMID: 2326011
Malignant transformation of spontaneously regressed retinoblastoma, retinoma/retinocytoma variant.
Eagle RC Jr, Shields JA, Donoso L, Milner RS
Ophthalmology 1989 Sep;96(9):1389-95. doi: 10.1016/s0161-6420(89)32714-x. PMID: 2780006

Diagnosis

Malignant transformation of spontaneously regressed retinoblastoma, retinoma/retinocytoma variant.
Eagle RC Jr, Shields JA, Donoso L, Milner RS
Ophthalmology 1989 Sep;96(9):1389-95. doi: 10.1016/s0161-6420(89)32714-x. PMID: 2780006
Spontaneous regression of bilateral retinoblastoma.
Sanborn GE, Augsburger JJ, Shields JA
Br J Ophthalmol 1982 Nov;66(11):685-90. doi: 10.1136/bjo.66.11.685. PMID: 7126513Free PMC Article
Presumed spontaneously regressed retinoblastoma.
Benson WE, Cameron JD, Furgiuele FP, Felberg NT, Yanoff M
Ann Ophthalmol 1978 Jul;10(7):897-9. PMID: 677667

Prognosis

Progressive resorption of a presumed spontaneously regressed retinoblastoma over 20 years.
Lam A, Shields CL, Manquez ME, Shields JA
Retina 2005 Feb-Mar;25(2):230-1. doi: 10.1097/00006982-200502000-00025. PMID: 15689823
Histopathologic verification of Verhoeff's 1918 irradiation cure of retinoblastoma.
Marcus DM, Craft JL, Albert DM
Ophthalmology 1990 Feb;97(2):221-4. doi: 10.1016/s0161-6420(90)32602-7. PMID: 2326011
Malignant transformation of spontaneously regressed retinoblastoma, retinoma/retinocytoma variant.
Eagle RC Jr, Shields JA, Donoso L, Milner RS
Ophthalmology 1989 Sep;96(9):1389-95. doi: 10.1016/s0161-6420(89)32714-x. PMID: 2780006

Clinical prediction guides

Immunohistochemical observation of anterior subcapsular cataract in eye with spontaneously regressed retinoblastoma.
Shirai K, Okada Y, Saika S
J Cataract Refract Surg 2010 Mar;36(3):503-7. doi: 10.1016/j.jcrs.2009.08.042. PMID: 20202553
Malignant transformation of spontaneously regressed retinoblastoma, retinoma/retinocytoma variant.
Eagle RC Jr, Shields JA, Donoso L, Milner RS
Ophthalmology 1989 Sep;96(9):1389-95. doi: 10.1016/s0161-6420(89)32714-x. PMID: 2780006

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