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mitochondrial hepatopathy

MedGen UID:
230966
Concept ID:
C1328348
Disease or Syndrome
Synonym: Mitochondrial Hepatopathy

Definition

A liver disorder caused by primary or secondary defects in the function of the mitochondria in the hepatocytes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • mitochondrial hepatopathy

Professional guidelines

PubMed

Chen HL, Wu SH, Hsu SH, Liou BY, Chen HL, Chang MH
J Biomed Sci 2018 Oct 26;25(1):75. doi: 10.1186/s12929-018-0475-8. PMID: 30367658Free PMC Article

Recent clinical studies

Etiology

Squires JE, Miethke AG, Valencia CA, Hawthorne K, Henn L, Van Hove JLK, Squires RH, Bove K, Horslen S, Kohli R, Molleston JP, Romero R, Alonso EM, Bezerra JA, Guthery SL, Hsu E, Karpen SJ, Loomes KM, Ng VL, Rosenthal P, Mysore K, Wang KS, Friederich MW, Magee JC, Sokol RJ; Childhood Liver Disease Research Network (ChiLDReN)
Hepatol Commun 2023 Jun 1;7(6) Epub 2023 May 15 doi: 10.1097/HC9.0000000000000139. PMID: 37184518Free PMC Article
Hegarty R, Gibson P, Sambrotta M, Strautnieks S, Foskett P, Ellard S, Baptista J, Lillis S, Bansal S, Vara R, Dhawan A, Grammatikopoulos T, Thompson RJ
J Pediatr 2021 Sep;236:124-130. Epub 2021 May 21 doi: 10.1016/j.jpeds.2021.05.041. PMID: 34023347
Lone KS, AlSaleem B, Asery A, Bashir MS, Al-Hussaini A
J Pediatr Gastroenterol Nutr 2020 Feb;70(2):e26-e32. doi: 10.1097/MPG.0000000000002554. PMID: 31978013
Cloots K, Verbeek J, Orlent H, Meersseman W, Cassiman D
Eur J Gastroenterol Hepatol 2013 Aug;25(8):892-8. doi: 10.1097/MEG.0b013e32835ee629. PMID: 23426270
Mancuso M, Filosto M, Tsujino S, Lamperti C, Shanske S, Coquet M, Desnuelle C, DiMauro S
Arch Neurol 2003 Oct;60(10):1445-7. doi: 10.1001/archneur.60.10.1445. PMID: 14568816

Diagnosis

Squires JE, Miethke AG, Valencia CA, Hawthorne K, Henn L, Van Hove JLK, Squires RH, Bove K, Horslen S, Kohli R, Molleston JP, Romero R, Alonso EM, Bezerra JA, Guthery SL, Hsu E, Karpen SJ, Loomes KM, Ng VL, Rosenthal P, Mysore K, Wang KS, Friederich MW, Magee JC, Sokol RJ; Childhood Liver Disease Research Network (ChiLDReN)
Hepatol Commun 2023 Jun 1;7(6) Epub 2023 May 15 doi: 10.1097/HC9.0000000000000139. PMID: 37184518Free PMC Article
Ayers M, Horslen SP, Gómez AM, Squires JE
Clin Liver Dis 2022 Aug;26(3):421-438. Epub 2022 Jun 25 doi: 10.1016/j.cld.2022.03.006. PMID: 35868683
Chen HL, Wu SH, Hsu SH, Liou BY, Chen HL, Chang MH
J Biomed Sci 2018 Oct 26;25(1):75. doi: 10.1186/s12929-018-0475-8. PMID: 30367658Free PMC Article
Cloots K, Verbeek J, Orlent H, Meersseman W, Cassiman D
Eur J Gastroenterol Hepatol 2013 Aug;25(8):892-8. doi: 10.1097/MEG.0b013e32835ee629. PMID: 23426270
Fellman V, Kotarsky H
Semin Fetal Neonatal Med 2011 Aug;16(4):222-8. Epub 2011 Jun 15 doi: 10.1016/j.siny.2011.05.002. PMID: 21680270

Therapy

Squires JE, Miethke AG, Valencia CA, Hawthorne K, Henn L, Van Hove JLK, Squires RH, Bove K, Horslen S, Kohli R, Molleston JP, Romero R, Alonso EM, Bezerra JA, Guthery SL, Hsu E, Karpen SJ, Loomes KM, Ng VL, Rosenthal P, Mysore K, Wang KS, Friederich MW, Magee JC, Sokol RJ; Childhood Liver Disease Research Network (ChiLDReN)
Hepatol Commun 2023 Jun 1;7(6) Epub 2023 May 15 doi: 10.1097/HC9.0000000000000139. PMID: 37184518Free PMC Article

Prognosis

Samanta A, Srivastava A, Mandal K, Sarma MS, Poddar U
Indian J Gastroenterol 2023 Aug;42(4):569-574. Epub 2023 Feb 8 doi: 10.1007/s12664-022-01281-0. PMID: 36753038
Lone KS, AlSaleem B, Asery A, Bashir MS, Al-Hussaini A
J Pediatr Gastroenterol Nutr 2020 Feb;70(2):e26-e32. doi: 10.1097/MPG.0000000000002554. PMID: 31978013
Cloots K, Verbeek J, Orlent H, Meersseman W, Cassiman D
Eur J Gastroenterol Hepatol 2013 Aug;25(8):892-8. doi: 10.1097/MEG.0b013e32835ee629. PMID: 23426270

Clinical prediction guides

Samanta A, Srivastava A, Mandal K, Sarma MS, Poddar U
Indian J Gastroenterol 2023 Aug;42(4):569-574. Epub 2023 Feb 8 doi: 10.1007/s12664-022-01281-0. PMID: 36753038
Shimizu S, Sakamoto S, Fukuda A, Yanagi Y, Uchida H, Mimori K, Nakao T, Sun C, Horikawa R, Kasahara M
Pediatr Transplant 2022 Mar;26(2):e14174. Epub 2021 Oct 23 doi: 10.1111/petr.14174. PMID: 34687480
Lone KS, AlSaleem B, Asery A, Bashir MS, Al-Hussaini A
J Pediatr Gastroenterol Nutr 2020 Feb;70(2):e26-e32. doi: 10.1097/MPG.0000000000002554. PMID: 31978013
Cloots K, Verbeek J, Orlent H, Meersseman W, Cassiman D
Eur J Gastroenterol Hepatol 2013 Aug;25(8):892-8. doi: 10.1097/MEG.0b013e32835ee629. PMID: 23426270

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