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Ampulla of Vater Undifferentiated Carcinoma

MedGen UID:: 231059
•Concept ID:: C1332254
•: Neoplastic Process

Definition

An aggressive carcinoma arising from the ampulla of Vater. Morphologically, it is characterized by the presence of malignant epithelial cells without evidence of glandular or squamous differentiation. Signs and symptoms include jaundice, abdominal pain, anorexia, nausea, vomiting, and weight loss. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVAmpulla of Vater Undifferentiated Carcinoma

Disorder of digestive system
- Abnormality of the digestive system
  - Digestive system neoplasm
    - Neoplasm of the gastrointestinal tract
      - Ampulla of Vater carcinoma
        Ampulla of Vater Undifferentiated Carcinoma
        Ampulla of Vater Undifferentiated Carcinoma with Osteoclast-Like Giant Cells

Professional guidelines

PubMed

The Diagnosis and Treatment of Ampullary Carcinoma.

Walter D, Schnitzbauer AA, Schulze F, Trojan J
Dtsch Arztebl Int 2023 Oct 27;120(43):729-735. doi: 10.3238/arztebl.m2023.0195. PMID: 37656482 Free PMC Article

Ampullary Adenocarcinoma, Version 1.2023, NCCN Clinical Practice Guidelines in Oncology.

Chiorean EG, Chiaro MD, Tempero MA, Malafa MP, Benson AB, Cardin DB, Christensen JA, Chung V, Czito B, Dillhoff M, Donahue TR, Dotan E, Fountzilas C, Glazer ES, Hardacre J, Hawkins WG, Klute K, Ko AH, Kunstman JW, LoConte N, Lowy AM, Masood A, Moravek C, Nakakura EK, Narang AK, Nardo L, Obando J, Polanco PM, Reddy S, Reyngold M, Scaife C, Shen J, Truty MJ, Vollmer C, Wolff RA, Wolpin BM, Rn BM, Lubin S, Darlow SD
J Natl Compr Canc Netw 2023 Jul;21(7):753-782. doi: 10.6004/jnccn.2023.0034. PMID: 37433437

Controversies in the diagnosis and treatment of periampullary tumours.

Skórzewska M, Kurzawa P, Ciszewski T, Pelc Z, Polkowski WP
Surg Oncol 2022 Sep;44:101853. Epub 2022 Sep 14 doi: 10.1016/j.suronc.2022.101853. PMID: 36152420

See all (84)

Recent clinical studies

Etiology

Management of Primary Hepatopancreatobiliary and Ampulla Large Cell Neuroendocrine Carcinoma.

Zhu J, Xiao W, Li Y
J Laparoendosc Adv Surg Tech A 2022 Jun;32(6):639-645. Epub 2021 Oct 11 doi: 10.1089/lap.2021.0482. PMID: 34637632

Adjuvant Chemotherapy for Resected Ampulla of Vater Carcinoma: Retrospective Analysis of 646 Patients.

Kim JH, Jeong JH, Ryoo BY, Kim KP, Chang HM, Oh D, Song TJ, Lee SS, Seo DW, Lee SK, Kim MH, Park Y, Kwon JW, Hwang DW, Lee JH, Lee W, Kim SC, Yoo C, Song KB
Cancer Res Treat 2021 Apr;53(2):424-435. Epub 2020 Nov 9 doi: 10.4143/crt.2020.953. PMID: 33171024 Free PMC Article

Approaches to Biopsy and Resection Specimens from the Ampulla.

Xue Y, Reid MD
Surg Pathol Clin 2020 Sep;13(3):453-467. Epub 2020 Jul 15 doi: 10.1016/j.path.2020.05.005. PMID: 32773194

Laparoscopic pancreatoduodenectoy.

Guerrero-Martínez GA, Estrada-Gómez R, Basilio-Roque A, Viveros-Luna R, Lorenzo-Yacamix C, Dávila-Esparza PA
Cir Cir 2020;88(3):263-268. doi: 10.24875/CIRU.19000093. PMID: 32539015

Ampullary cancer: an overview.

Ahn DH, Bekaii-Saab T
Am Soc Clin Oncol Educ Book 2014:112-5. doi: 10.14694/EdBook_AM.2014.34.112. PMID: 24857067 Free PMC Article

See all (957)

Diagnosis

The Diagnosis and Treatment of Ampullary Carcinoma.

Walter D, Schnitzbauer AA, Schulze F, Trojan J
Dtsch Arztebl Int 2023 Oct 27;120(43):729-735. doi: 10.3238/arztebl.m2023.0195. PMID: 37656482 Free PMC Article

Ampullary Adenocarcinoma, Version 1.2023, NCCN Clinical Practice Guidelines in Oncology.

Controversies in the diagnosis and treatment of periampullary tumours.

Skórzewska M, Kurzawa P, Ciszewski T, Pelc Z, Polkowski WP
Surg Oncol 2022 Sep;44:101853. Epub 2022 Sep 14 doi: 10.1016/j.suronc.2022.101853. PMID: 36152420

Management of Primary Hepatopancreatobiliary and Ampulla Large Cell Neuroendocrine Carcinoma.

Zhu J, Xiao W, Li Y
J Laparoendosc Adv Surg Tech A 2022 Jun;32(6):639-645. Epub 2021 Oct 11 doi: 10.1089/lap.2021.0482. PMID: 34637632

Treatment Approach to Adenocarcinoma of the Ampulla of Vater.

Patel M, Uboha NV
Curr Treat Options Oncol 2021 Sep 29;22(11):103. doi: 10.1007/s11864-021-00894-5. PMID: 34586537

See all (922)

Therapy

Menopausal hormone therapy and risk of biliary tract cancers.

Jackson SS, Pfeiffer RM, Gabbi C, Anderson L, Gadalla SM, Koshiol J
Hepatology 2022 Feb;75(2):309-321. doi: 10.1002/hep.32198. PMID: 34766362 Free PMC Article

Treatment Approach to Adenocarcinoma of the Ampulla of Vater.

Patel M, Uboha NV
Curr Treat Options Oncol 2021 Sep 29;22(11):103. doi: 10.1007/s11864-021-00894-5. PMID: 34586537

Insights and updates on endoscopic papillectomy.

Yamamoto K, Iwasaki E, Itoi T
Expert Rev Gastroenterol Hepatol 2020 Jun;14(6):435-444. Epub 2020 May 22 doi: 10.1080/17474124.2020.1766965. PMID: 32380873

Ampullary cancer: an overview.

Ahn DH, Bekaii-Saab T
Am Soc Clin Oncol Educ Book 2014:112-5. doi: 10.14694/EdBook_AM.2014.34.112. PMID: 24857067 Free PMC Article

Effect of adjuvant chemotherapy with fluorouracil plus folinic acid or gemcitabine vs observation on survival in patients with resected periampullary adenocarcinoma: the ESPAC-3 periampullary cancer randomized trial.

Neoptolemos JP, Moore MJ, Cox TF, Valle JW, Palmer DH, McDonald AC, Carter R, Tebbutt NC, Dervenis C, Smith D, Glimelius B, Charnley RM, Lacaine F, Scarfe AG, Middleton MR, Anthoney A, Ghaneh P, Halloran CM, Lerch MM, Oláh A, Rawcliffe CL, Verbeke CS, Campbell F, Büchler MW; European Study Group for Pancreatic Cancer
JAMA 2012 Jul 11;308(2):147-56. doi: 10.1001/jama.2012.7352. PMID: 22782416

See all (342)

Prognosis

The Diagnosis and Treatment of Ampullary Carcinoma.

Walter D, Schnitzbauer AA, Schulze F, Trojan J
Dtsch Arztebl Int 2023 Oct 27;120(43):729-735. doi: 10.3238/arztebl.m2023.0195. PMID: 37656482 Free PMC Article

Management of Primary Hepatopancreatobiliary and Ampulla Large Cell Neuroendocrine Carcinoma.

Zhu J, Xiao W, Li Y
J Laparoendosc Adv Surg Tech A 2022 Jun;32(6):639-645. Epub 2021 Oct 11 doi: 10.1089/lap.2021.0482. PMID: 34637632

Treatment Approach to Adenocarcinoma of the Ampulla of Vater.

Patel M, Uboha NV
Curr Treat Options Oncol 2021 Sep 29;22(11):103. doi: 10.1007/s11864-021-00894-5. PMID: 34586537

Ampullary cancer: an overview.

Ahn DH, Bekaii-Saab T
Am Soc Clin Oncol Educ Book 2014:112-5. doi: 10.14694/EdBook_AM.2014.34.112. PMID: 24857067 Free PMC Article

Periampullary carcinomas.

Filiz G, Yerci O, Adim SB, Gurel S, Dolar E, Memik F
Hepatogastroenterology 2007 Jun;54(76):1247-9. PMID: 17629080

See all (976)

Clinical prediction guides

Ampullary carcinoma of the duodenum: current clinical issues and genomic overview.

Okano K, Oshima M, Suto H, Ando Y, Asano E, Kamada H, Kobara H, Masaki T, Suzuki Y
Surg Today 2022 Feb;52(2):189-197. Epub 2021 Apr 2 doi: 10.1007/s00595-021-02270-0. PMID: 33797636

Clinical and phenotypical characteristics of submucosal invasive carcinoma in non-ampullary duodenal cancer.

Matsueda K, Kanzaki H, Takenaka R, Nakagawa M, Matsueda K, Iwamuro M, Kawano S, Kawahara Y, Toji T, Tanaka T, Yagi T, Fujiwara T, Okada H
PLoS One 2021;16(8):e0256797. Epub 2021 Aug 27 doi: 10.1371/journal.pone.0256797. PMID: 34449813 Free PMC Article

Approaches to Biopsy and Resection Specimens from the Ampulla.

Xue Y, Reid MD
Surg Pathol Clin 2020 Sep;13(3):453-467. Epub 2020 Jul 15 doi: 10.1016/j.path.2020.05.005. PMID: 32773194

Periampullary carcinomas.

Filiz G, Yerci O, Adim SB, Gurel S, Dolar E, Memik F
Hepatogastroenterology 2007 Jun;54(76):1247-9. PMID: 17629080

See all (509)

Recent systematic reviews

Impact of histopathological type on the prognosis of ampullary carcinoma: A systematic review and meta-analysis.

Shin DW, Kim S, Jung K, Jung JH, Kim B, Ahn J, Kim J, Hwang JH, Lee JC
Eur J Surg Oncol 2023 Feb;49(2):306-315. Epub 2022 Oct 9 doi: 10.1016/j.ejso.2022.10.001. PMID: 36272870

Somatostatinoma of the Ampulla of Vater: A Systematic Review.

Giannakodimos I, Giannakodimos A, Ziogou A, Frountzas M, Kritikos N, Vlachos K, Toutouzas KG, Schizas D
J Gastrointestin Liver Dis 2022 Dec 17;31(4):459-466. doi: 10.15403/jgld-4383. PMID: 36535044

Review of the investigation and surgical management of resectable ampullary adenocarcinoma.

Askew J, Connor S
HPB (Oxford) 2013 Nov;15(11):829-38. Epub 2013 Jan 10 doi: 10.1111/hpb.12038. PMID: 23458317 Free PMC Article

Association between alcohol consumption and cancers in the Chinese population--a systematic review and meta-analysis.

Li Y, Yang H, Cao J
PLoS One 2011 Apr 15;6(4):e18776. doi: 10.1371/journal.pone.0018776. PMID: 21526212 Free PMC Article

Diabetes mellitus and increased risk of biliary tract cancer: systematic review and meta-analysis.

Ren HB, Yu T, Liu C, Li YQ
Cancer Causes Control 2011 Jun;22(6):837-47. Epub 2011 Mar 19 doi: 10.1007/s10552-011-9754-3. PMID: 21424210

See all (32)

MedGen

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Ampulla of Vater Undifferentiated Carcinoma

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Practice guidelines

Related information

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