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Apocrine adenosis of breast

MedGen UID:
231072
•Concept ID:
C1332314
•
Disease or Syndrome
Synonyms: Apocrine Adenosis of Breast; apocrine adenosis of breast; Apocrine Adenosis of the Breast; apocrine adenosis of the breast; Breast Apocrine Adenosis; breast apocrine adenosis
 
Monarch Initiative: MONDO:0003726

Definition

Breast adenosis characterized by the presence of extensive apocrine metaplasia. [from NCI]

Professional guidelines

PubMed

Surgical follow-up results for apocrine adenosis and atypical apocrine adenosis diagnosed on breast core biopsy.
Hou Y, Chaudhary S, Gao FF, Li Z
Ann Diagn Pathol 2016 Oct;24:4-6. Epub 2016 Jul 11 doi: 10.1016/j.anndiagpath.2016.07.001. PMID: 27649945
Atypical apocrine adenosis diagnosed on breast core biopsy: implications for management.
Calhoun BC, Booth CN
Hum Pathol 2014 Oct;45(10):2130-5. Epub 2014 Jun 27 doi: 10.1016/j.humpath.2014.06.010. PMID: 25106711
Cytologic differential diagnosis of papillary pattern in breast aspirates: correlation with histology.
Nayar R, De Frias DV, Bourtsos EP, Sutton V, Bedrossian C
Ann Diagn Pathol 2001 Feb;5(1):34-42. doi: 10.1053/adpa.2001.21477. PMID: 11172205

Recent clinical studies

Etiology

Ultrasound Features and Rate of Upgrade to Malignancy in Atypical Apocrine Lesions of the Breast.
Jung HK, Kim SJ, Kim W, Lim YJ, Lee Y, Hahn S, Lee HJ
J Ultrasound Med 2020 Aug;39(8):1517-1524. Epub 2020 Feb 10 doi: 10.1002/jum.15240. PMID: 32037565
Upgrade Rate and Imaging Features of Atypical Apocrine Lesions.
Chang Sen LQ, Berg WA, Carter GJ
Breast J 2017 Sep;23(5):569-578. Epub 2017 Mar 23 doi: 10.1111/tbj.12789. PMID: 28333404
Prevalence of Ectopic Breast Tissue and Tumor: A 20-Year Single Center Experience.
Famá F, Cicciú M, Sindoni A, Scarfó P, Pollicino A, Giacobbe G, Buccheri G, Taranto F, Palella J, Gioffré-Florio M
Clin Breast Cancer 2016 Aug;16(4):e107-12. Epub 2016 Mar 31 doi: 10.1016/j.clbc.2016.03.004. PMID: 27117240
Atypical apocrine adenosis of the breast: long-term follow-up in 37 patients.
Fuehrer N, Hartmann L, Degnim A, Allers T, Vierkant R, Frost M, Visscher D
Arch Pathol Lab Med 2012 Feb;136(2):179-82. doi: 10.5858/arpa.2011-0225-OA. PMID: 22288965Free PMC Article
Breast macrocysts.
Hughes LE, Bundred NJ
World J Surg 1989 Nov-Dec;13(6):711-4. doi: 10.1007/BF01658419. PMID: 2696224

Diagnosis

Apocrine lesions of the breast.
Quinn CM, D'Arcy C, Wells C
Virchows Arch 2022 Jan;480(1):177-189. Epub 2021 Sep 18 doi: 10.1007/s00428-021-03185-4. PMID: 34537861Free PMC Article
Sclerosing Polycystic Adenoma.
Bishop JA, Thompson LDR
Surg Pathol Clin 2021 Mar;14(1):17-24. doi: 10.1016/j.path.2020.09.004. PMID: 33526220
Microglandular adenosis of the breast: a deceptive and still mysterious benign lesion.
Foschini MP, Eusebi V
Hum Pathol 2018 Dec;82:1-9. Epub 2018 Jun 24 doi: 10.1016/j.humpath.2018.06.025. PMID: 29949742
Atypical Apocrine Adenosis: Diagnostic Challenges and Pitfalls.
Asirvatham JR, Falcone MM, Kleer CG
Arch Pathol Lab Med 2016 Oct;140(10):1045-51. doi: 10.5858/arpa.2016-0238-RA. PMID: 27684975
Mimickers of breast malignancy on breast sonography.
Cho SH, Park SH
J Ultrasound Med 2013 Nov;32(11):2029-36. doi: 10.7863/ultra.32.11.2029. PMID: 24154908

Therapy

Epstein-Barr virus and breast cancer: lack of evidence for an association in Iranian women.
Kadivar M, Monabati A, Joulaee A, Hosseini N
Pathol Oncol Res 2011 Sep;17(3):489-92. Epub 2011 Jan 6 doi: 10.1007/s12253-010-9325-z. PMID: 21207256
Differential diagnosis of oncocytic lesions of the breast and thyroid utilizing a semiquantitative approach.
Nasuti JF, Benedict C, Hurford M, Bibbo M
Acta Cytol 1999 Jul-Aug;43(4):544-51. doi: 10.1159/000331145. PMID: 10432873
Toward a physiological approach to breast cancer prevention.
Russo J, Russo IH
Cancer Epidemiol Biomarkers Prev 1994 Jun;3(4):353-64. PMID: 8061586
Uneven distribution and significant concentration of apocrine metaplasia in lower breast quadrants.
Benigni G, Squartini F
Tumori 1986 Apr 30;72(2):179-82. doi: 10.1177/030089168607200210. PMID: 3705191
Fibrocystic disease of the breast.
Greenblatt RB, Samaras C, Vasquez JM, Nezhat C
Clin Obstet Gynecol 1982 Jun;25(2):365-71. doi: 10.1097/00003081-198206000-00019. PMID: 7105513

Prognosis

Sclerosing Polycystic Adenoma.
Bishop JA, Thompson LDR
Surg Pathol Clin 2021 Mar;14(1):17-24. doi: 10.1016/j.path.2020.09.004. PMID: 33526220
Microglandular adenosis of the breast: a deceptive and still mysterious benign lesion.
Foschini MP, Eusebi V
Hum Pathol 2018 Dec;82:1-9. Epub 2018 Jun 24 doi: 10.1016/j.humpath.2018.06.025. PMID: 29949742
Surgical follow-up results for apocrine adenosis and atypical apocrine adenosis diagnosed on breast core biopsy.
Hou Y, Chaudhary S, Gao FF, Li Z
Ann Diagn Pathol 2016 Oct;24:4-6. Epub 2016 Jul 11 doi: 10.1016/j.anndiagpath.2016.07.001. PMID: 27649945
Atypical apocrine adenosis of the breast: long-term follow-up in 37 patients.
Fuehrer N, Hartmann L, Degnim A, Allers T, Vierkant R, Frost M, Visscher D
Arch Pathol Lab Med 2012 Feb;136(2):179-82. doi: 10.5858/arpa.2011-0225-OA. PMID: 22288965Free PMC Article
Is cystic disease related to breast cancer?
Haagensen DE Jr
Am J Surg Pathol 1991 Jul;15(7):687-94. doi: 10.1097/00000478-199107000-00010. PMID: 2058763

Clinical prediction guides

Alpha-methylacyl-CoA racemase (AMACR) protein is upregulated in early proliferative lesions of the breast irrespective of apocrine differentiation.
Gatalica Z, Stafford P, Vranic S
Hum Pathol 2022 Nov;129:40-46. Epub 2022 Aug 21 doi: 10.1016/j.humpath.2022.08.002. PMID: 35998819
The diagnostic utility of EZH2 H-score and Ki-67 index in non-invasive breast apocrine lesions.
Vougiouklakis T, Belovarac BJ, Lytle A, Chiriboga L, Ozerdem U
Pathol Res Pract 2020 Sep;216(9):153041. Epub 2020 Jun 2 doi: 10.1016/j.prp.2020.153041. PMID: 32825929
Microglandular adenosis of the breast: a deceptive and still mysterious benign lesion.
Foschini MP, Eusebi V
Hum Pathol 2018 Dec;82:1-9. Epub 2018 Jun 24 doi: 10.1016/j.humpath.2018.06.025. PMID: 29949742
Prevalence of Ectopic Breast Tissue and Tumor: A 20-Year Single Center Experience.
Famá F, Cicciú M, Sindoni A, Scarfó P, Pollicino A, Giacobbe G, Buccheri G, Taranto F, Palella J, Gioffré-Florio M
Clin Breast Cancer 2016 Aug;16(4):e107-12. Epub 2016 Mar 31 doi: 10.1016/j.clbc.2016.03.004. PMID: 27117240
Atypical apocrine metaplasia in sclerosing lesions of the breast: a study of 51 patients.
Carter DJ, Rosen PP
Mod Pathol 1991 Jan;4(1):1-5. PMID: 2020652

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