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Appendix leiomyoma

MedGen UID:
231077
•Concept ID:
C1332327
•
Neoplastic Process
Synonyms: Appendiceal Leiomyoma; appendiceal leiomyoma; Appendix Leiomyoma; appendix leiomyoma; Leiomyoma of appendix; Leiomyoma of Appendix; leiomyoma of appendix; Leiomyoma of the Appendix; leiomyoma of the appendix; leiomyoma of vermiform appendix; vermiform appendix leiomyoma
SNOMED CT: Leiomyoma of appendix (1196825006)
 
Monarch Initiative: MONDO:0003300

Definition

A well-circumscribed benign smooth muscle neoplasm arising from the appendix. It is characterized by the presence of spindle cells with cigar-shaped nuclei, interlacing fascicles, and a whorled pattern. [from NCI]

Professional guidelines

PubMed

Guideline No. 446: Hysteroscopic Surgery in Fertility Therapy.
Motan T, Cockwell H, Elliott J, Antaki R
J Obstet Gynaecol Can 2024 Feb;46(2):102400. Epub 2024 Feb 5 doi: 10.1016/j.jogc.2024.102400. PMID: 38320665
Guideline No. 435: Minimally Invasive Surgery in Fertility Therapy.
Motan T, Antaki R, Han J, Elliott J, Cockwell H
J Obstet Gynaecol Can 2023 Apr;45(4):273-282.e2. doi: 10.1016/j.jogc.2023.03.004. PMID: 37149339
Laparoscopic treatment of chronic pelvic pain in 100 adult women.
Carter JE
J Am Assoc Gynecol Laparosc 1995 May;2(3):255-62. doi: 10.1016/s1074-3804(05)80105-7. PMID: 9050567

Recent clinical studies

Etiology

Imaging of pediatric gastrointestinal tumors: A tertiary center experience over 19 years.
Kraus MS, Selvam S, Siddiqui I, Reyes JA, Chavhan GB
Eur J Radiol 2024 Jun;175:111461. Epub 2024 Apr 10 doi: 10.1016/j.ejrad.2024.111461. PMID: 38615503
Guideline No. 446: Hysteroscopic Surgery in Fertility Therapy.
Motan T, Cockwell H, Elliott J, Antaki R
J Obstet Gynaecol Can 2024 Feb;46(2):102400. Epub 2024 Feb 5 doi: 10.1016/j.jogc.2024.102400. PMID: 38320665
Guideline No. 435: Minimally Invasive Surgery in Fertility Therapy.
Motan T, Antaki R, Han J, Elliott J, Cockwell H
J Obstet Gynaecol Can 2023 Apr;45(4):273-282.e2. doi: 10.1016/j.jogc.2023.03.004. PMID: 37149339
A multi-centre, randomized, non-inferiority trial to compare ulipristal with standard surgical treatment in women with symptomatic uterine fibroids: Protocol of the MYOMEX-2 trial.
Middelkoop MA, Huirne JAF, van der Weide MCJ, Bosmans JE, Hehenkamp WJK; MYOMEX-2 TRIAL GROUP
Eur J Obstet Gynecol Reprod Biol 2021 Jan;256:63-69. Epub 2020 Oct 28 doi: 10.1016/j.ejogrb.2020.10.058. PMID: 33171419
Tumors of the appendix.
Schmutzer KJ, Bayar M, Zaki AE, Regan JF, Poletti JB
Dis Colon Rectum 1975 May-Jun;18(4):324-31. doi: 10.1007/BF02587395. PMID: 1126268

Diagnosis

Guideline No. 446: Hysteroscopic Surgery in Fertility Therapy.
Motan T, Cockwell H, Elliott J, Antaki R
J Obstet Gynaecol Can 2024 Feb;46(2):102400. Epub 2024 Feb 5 doi: 10.1016/j.jogc.2024.102400. PMID: 38320665
Concurrent appendiceal and umbilical endometriosis: a case report and review of the literature.
Paramythiotis D, Stavrou G, Panidis S, Panagiotou D, Chatzopoulos K, Papadopoulos VN, Michalopoulos A
J Med Case Rep 2014 Jul 22;8:258. doi: 10.1186/1752-1947-8-258. PMID: 25052818Free PMC Article
Nonovarian cystic lesions of the pelvis.
Moyle PL, Kataoka MY, Nakai A, Takahata A, Reinhold C, Sala E
Radiographics 2010 Jul-Aug;30(4):921-38. doi: 10.1148/rg.304095706. PMID: 20631360
Tumors of the appendix and colon.
Hatch KF, Blanchard DK, Hatch GF 3rd, Wertheimer-Hatch L, Davis GB, Foster RS Jr, Skandalakis JE
World J Surg 2000 Apr;24(4):430-6. doi: 10.1007/s002689910068. PMID: 10706915
Leiomyoma of the appendix.
Powell JL, Fuerst JF, Tapia RA
South Med J 1980 Sep;73(9):1298-9. doi: 10.1097/00007611-198009000-00057. PMID: 7414395

Therapy

Guideline No. 446: Hysteroscopic Surgery in Fertility Therapy.
Motan T, Cockwell H, Elliott J, Antaki R
J Obstet Gynaecol Can 2024 Feb;46(2):102400. Epub 2024 Feb 5 doi: 10.1016/j.jogc.2024.102400. PMID: 38320665
A multi-centre, randomized, non-inferiority trial to compare ulipristal with standard surgical treatment in women with symptomatic uterine fibroids: Protocol of the MYOMEX-2 trial.
Middelkoop MA, Huirne JAF, van der Weide MCJ, Bosmans JE, Hehenkamp WJK; MYOMEX-2 TRIAL GROUP
Eur J Obstet Gynecol Reprod Biol 2021 Jan;256:63-69. Epub 2020 Oct 28 doi: 10.1016/j.ejogrb.2020.10.058. PMID: 33171419
A unique presentation of superinfected pseudomyxoma peritonei secondary to a low-grade appendiceal mucinous neoplasm.
Sullivan BJ, Bolton N, Sarpel U, Magge D
World J Surg Oncol 2019 Feb 18;17(1):34. doi: 10.1186/s12957-019-1578-8. PMID: 30777068Free PMC Article

Prognosis

An appendiceal leiomyoma in a child with acquired immunodeficiency syndrome.
Sambol E, Patterson D, Rivera R, Borys D, Greco MA, Kaul A, Nadler EP
Pediatr Surg Int 2006 Oct;22(10):865-8. Epub 2006 Aug 30 doi: 10.1007/s00383-006-1773-x. PMID: 16944181
Gastrointestinal stromal tumors: update.
Xie XY, Carter N, Darwin PE, Drachenberg CB
Arkh Patol 2004 Mar-Apr;66(2):36-40. PMID: 15154382
Tumors of the appendix and colon.
Hatch KF, Blanchard DK, Hatch GF 3rd, Wertheimer-Hatch L, Davis GB, Foster RS Jr, Skandalakis JE
World J Surg 2000 Apr;24(4):430-6. doi: 10.1007/s002689910068. PMID: 10706915
Laparoscopic treatment of chronic pelvic pain in 100 adult women.
Carter JE
J Am Assoc Gynecol Laparosc 1995 May;2(3):255-62. doi: 10.1016/s1074-3804(05)80105-7. PMID: 9050567
Mucinous carcinoid and endometriosis in an inside-out appendix.
Rodriguez MA, Wasdahl WA
Am J Gastroenterol 1978 Feb;69(2):199-202. PMID: 665643

Clinical prediction guides

A multi-centre, randomized, non-inferiority trial to compare ulipristal with standard surgical treatment in women with symptomatic uterine fibroids: Protocol of the MYOMEX-2 trial.
Middelkoop MA, Huirne JAF, van der Weide MCJ, Bosmans JE, Hehenkamp WJK; MYOMEX-2 TRIAL GROUP
Eur J Obstet Gynecol Reprod Biol 2021 Jan;256:63-69. Epub 2020 Oct 28 doi: 10.1016/j.ejogrb.2020.10.058. PMID: 33171419
Neurogenous hyperplasia in the oesophagus.
Kara T, Gurses I, Serinsoz E, Bozdogan Arpaci R, Ucbilek E, Polat A
Malays J Pathol 2013 Jun;35(1):99-102. PMID: 23817402
Novel immunohistochemical localization of 28,000 molecular-weight (Mr) calcium binding protein (calbindin-D28k) in enterochromaffin cells of the human appendix and neuroendocrine tumors (carcinoids and small-cell carcinomas) of the midgut and foregut.
Katsetos CD, Jami MM, Krishna L, Jackson R, Patchefsky AS, Cooper HS
Arch Pathol Lab Med 1994 Jun;118(6):633-9. PMID: 8204010
Tumors of the appendix.
Schmutzer KJ, Bayar M, Zaki AE, Regan JF, Poletti JB
Dis Colon Rectum 1975 May-Jun;18(4):324-31. doi: 10.1007/BF02587395. PMID: 1126268

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