Thymic basaloid carcinoma

MedGen UID:: 231420
•Concept ID:: C1332464
•: Neoplastic Process

Synonyms:	Basaloid Carcinoma of the Thymus; basaloid carcinoma of the Thymus; Basaloid Carcinoma of Thymus; basaloid carcinoma of Thymus; Thymic Basaloid Carcinoma; thymic basaloid carcinoma; Thymus Basaloid Carcinoma; Thymus basaloid carcinoma; thymus basaloid squamous cell carcinoma

Monarch Initiative:	MONDO:0004092

Definition

A rare primary thymic carcinoma, characterized by the presence of tumor cell lobules with peripheral palisading, and a basophilic staining pattern. More than half of reported cases were associated with the presence of a multilocular thymic cyst. Metastases to lung and liver have been reported in approximately 30% of cases. [from NCI]

Recent clinical studies

Etiology

Thymic carcinoma presenting as atypical chest pain.

Siddiqui S, Connelly T, Keita L, Blazkova S, Veerasingam D
BMJ Case Rep 2015 Nov 25;2015 doi: 10.1136/bcr-2015-211374. PMID: 26607199 Free PMC Article

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Diagnosis

A basaloid carcinoma with multilocular thymic cyst mimicking a mediastinal teratoma.

Su C, Zhu X, Wang Q, Zhang J
J Cardiothorac Surg 2024 Apr 10;19(1):198. doi: 10.1186/s13019-024-02712-z. PMID: 38600577 Free PMC Article

Two-year disease remission of an unresectable basaloid thymic carcinoma with second line chemotherapy drugs: report of a case.

Buero A, Quadrelli S, Pankl LG, Vigovich F
Pan Afr Med J 2019;33:53. Epub 2019 May 24 doi: 10.11604/pamj.2019.33.53.12401. PMID: 31448016 Free PMC Article

Thymic basaloid carcinoma with aggressive invasion of the lung and pericardium: report of a case.

Suemitsu R, Takeo S, Momosaki S, Furuya K
Surg Today 2011 Jul;41(7):986-8. Epub 2011 Jul 12 doi: 10.1007/s00595-010-4374-1. PMID: 21748617

Thymic basaloid carcinoma: a clinicopathologic study of 12 cases, with a general discussion of basaloid carcinoma and its relationship with adenoid cystic carcinoma.

Brown JG, Familiari U, Papotti M, Rosai J
Am J Surg Pathol 2009 Aug;33(8):1113-24. doi: 10.1097/PAS.0b013e3181a2443b. PMID: 19461509

Fine-needle aspiration cytology of thymic basaloid carcinoma: case studies and review of the literature.

Posligua L, Ylagan L
Diagn Cytopathol 2006 May;34(5):358-66. doi: 10.1002/dc.20433. PMID: 16604555

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Therapy

Thymic basaloid carcinoma: a rare clinical entity.

Manthri S, Rehman HH, Costello PN, Chakraborty K
BMJ Case Rep 2019 Nov 28;12(11) doi: 10.1136/bcr-2019-231980. PMID: 31780620 Free PMC Article

Advanced thymic cancer treated with carboplatin and paclitaxel in a patient undergoing hemodialysis.

Miura S, Kagamu H, Sakai T, Nozaki K, Asakawa K, Moro H, Okajima M, Watanabe S, Yamamoto S, Iino N, Goto S, Kazama JJ, Yoshizawa H, Narita I
Intern Med 2015;54(1):55-8. Epub 2015 Jan 1 doi: 10.2169/internalmedicine.54.3484. PMID: 25742894

S-1 plus cisplatin chemotherapy with concurrent radiation for thymic basaloid carcinoma.

Tagawa T, Ohta M, Kuwata T, Awaya H, Ishida T
J Thorac Oncol 2010 Apr;5(4):572-3. doi: 10.1097/JTO.0b013e3181d0a4a7. PMID: 20357624

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Prognosis

Thymic carcinoma presenting as atypical chest pain.

Siddiqui S, Connelly T, Keita L, Blazkova S, Veerasingam D
BMJ Case Rep 2015 Nov 25;2015 doi: 10.1136/bcr-2015-211374. PMID: 26607199 Free PMC Article

Thymic basaloid carcinoma with pleural dissemination that developed after a curative resection: report of a case.

Sakakura N, Tateyama H, Usami N, Yokoi K
Surg Today 2010 Nov;40(11):1073-8. Epub 2010 Nov 3 doi: 10.1007/s00595-009-4203-6. PMID: 21046508

Thymic basaloid carcinoma with hepatic metastasis.

Matsuo T, Hayashida R, Kobayashi K, Tanaka Y, Ohtsuka S
Ann Thorac Surg 2002 Aug;74(2):579-82. doi: 10.1016/s0003-4975(02)03555-5. PMID: 12173853

Thymic basaloid carcinoma: a case report and review of the literature.

Iezzoni JC, Nass LB
Mod Pathol 1996 Jan;9(1):21-5. PMID: 8821951

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