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Borderline Exocrine Pancreatic Neoplasm

MedGen UID:
231455
•Concept ID:
C1332593
•
Neoplastic Process
Synonyms: Borderline Exocrine Pancreatic Tumor; Borderline Neoplasm of Exocrine Pancreas; Borderline Neoplasm of the Exocrine Pancreas; Borderline Tumor of Exocrine Pancreas; Borderline Tumor of the Exocrine Pancreas; Exocrine Pancreatic Neoplasm of Uncertain Malignant Potential; Exocrine Pancreatic Tumor of Uncertain Malignant Potential; Neoplasm of Uncertain Malignant Potential of Exocrine Pancreas; Neoplasm of Uncertain Malignant Potential of the Exocrine Pancreas; Tumor of Uncertain Malignant Potential of Exocrine Pancreas; Tumor of Uncertain Malignant Potential of the Exocrine Pancreas

Definition

A group of epithelial neoplasms that arise from the exocrine pancreatic tissue and have the potential to evolve into invasive malignant neoplasms. This group includes the pancreatic intraepithelial neoplasias, non-invasive pancreatic mucinous-cystic neoplasms, pancreatic intraductal papillary-mucinous neoplasms, and pancreatic intraductal tubulopapillary neoplasms. [from NCI]

Professional guidelines

PubMed

Immunonutrition and prehabilitation in pancreatic cancer surgery: A new concept in the era of ERAS® and neoadjuvant treatment.
De Luca R, Gianotti L, Pedrazzoli P, Brunetti O, Rizzo A, Sandini M, Paiella S, Pecorelli N, Pugliese L, Pietrabissa A, Zerbi A, Salvia R, Boggi U, Casirati A, Falconi M, Caccialanza R
Eur J Surg Oncol 2023 Mar;49(3):542-549. Epub 2022 Dec 22 doi: 10.1016/j.ejso.2022.12.006. PMID: 36577556
Expert opinion on management of pancreatic exocrine insufficiency in pancreatic cancer.
Roeyen G, Berrevoet F, Borbath I, Geboes K, Peeters M, Topal B, Van Cutsem E, Van Laethem JL
ESMO Open 2022 Feb;7(1):100386. Epub 2022 Feb 3 doi: 10.1016/j.esmoop.2022.100386. PMID: 35124465Free PMC Article
Ductal pancreatic adenocarcinoma.
Seufferlein T, Porzner M, Heinemann V, Tannapfel A, Stuschke M, Uhl W
Dtsch Arztebl Int 2014 May 30;111(22):396-402. doi: 10.3238/arztebl.2014.0396. PMID: 24980565Free PMC Article

Recent clinical studies

Etiology

Prescription patterns of pancreatic enzyme replacement therapy for patients with pancreatic cancer in the United States.
Jain T, Sharma P, Giri B, Iyer S, Sethi V, Bava EP, Vaish U, Sahay P, Datta J, Reddy S, Bart Rose J, Khan A, Merchant N, Chari ST, Dudeja V
HPB (Oxford) 2022 Oct;24(10):1729-1737. Epub 2022 May 23 doi: 10.1016/j.hpb.2022.05.003. PMID: 35717430
Neoadjuvant Chemotherapy Switch in Borderline Resectable/Locally Advanced Pancreatic Cancer.
Alva-Ruiz R, Yohanathan L, Yonkus JA, Abdelrahman AM, Gregory LA, Halfdanarson TR, Mahipal A, McWilliams RR, Ma WW, Hallemeier CL, Graham RP, Grotz TE, Smoot RL, Cleary SP, Nagorney DM, Kendrick ML, Truty MJ
Ann Surg Oncol 2022 Mar;29(3):1579-1591. Epub 2021 Nov 1 doi: 10.1245/s10434-021-10991-2. PMID: 34724125Free PMC Article
Is Central Pancreatectomy Truly Recommendable? A 9-Year Single-Center Experience.
Lv A, Qian HG, Qiu H, Wu JH, Hao CY
Dig Surg 2018;35(6):532-538. Epub 2017 Dec 22 doi: 10.1159/000485806. PMID: 29275422
Expanding the indications of pancreas transplantation alone.
Mehrabi A, Golriz M, Adili-Aghdam F, Hafezi M, Ashrafi M, Morath C, Zeier M, Hackert T, Schemmer P
Pancreas 2014 Nov;43(8):1190-3. doi: 10.1097/MPA.0000000000000181. PMID: 25333402
Enucleation of pancreatic neoplasms.
Crippa S, Bassi C, Salvia R, Falconi M, Butturini G, Pederzoli P
Br J Surg 2007 Oct;94(10):1254-9. doi: 10.1002/bjs.5833. PMID: 17583892

Diagnosis

An osteoclast-like giant cell tumor embedded in the mural nodule of a pancreatic mucinous cystic neoplasm: A case report and literature review.
Fan X, Wang W, Li C, Tang T, Han Y, An K
Medicine (Baltimore) 2019 Apr;98(16):e15246. doi: 10.1097/MD.0000000000015246. PMID: 31008959Free PMC Article
Pancreatic adenocarcinoma, version 2.2014: featured updates to the NCCN guidelines.
Tempero MA, Malafa MP, Behrman SW, Benson AB 3rd, Casper ES, Chiorean EG, Chung V, Cohen SJ, Czito B, Engebretson A, Feng M, Hawkins WG, Herman J, Hoffman JP, Ko A, Komanduri S, Koong A, Lowy AM, Ma WW, Merchant NB, Mulvihill SJ, Muscarella P 2nd, Nakakura EK, Obando J, Pitman MB, Reddy S, Sasson AR, Thayer SP, Weekes CD, Wolff RA, Wolpin BM, Burns JL, Freedman-Cass DA
J Natl Compr Canc Netw 2014 Aug;12(8):1083-93. doi: 10.6004/jnccn.2014.0106. PMID: 25099441
Ductal pancreatic adenocarcinoma.
Seufferlein T, Porzner M, Heinemann V, Tannapfel A, Stuschke M, Uhl W
Dtsch Arztebl Int 2014 May 30;111(22):396-402. doi: 10.3238/arztebl.2014.0396. PMID: 24980565Free PMC Article
Laparoscopic enucleation of pancreatic neoplasm.
Dedieu A, Rault A, Collet D, Masson B, Sa Cunha A
Surg Endosc 2011 Feb;25(2):572-6. Epub 2010 Jul 10 doi: 10.1007/s00464-010-1223-7. PMID: 20623235
Enucleation of pancreatic neoplasms.
Crippa S, Bassi C, Salvia R, Falconi M, Butturini G, Pederzoli P
Br J Surg 2007 Oct;94(10):1254-9. doi: 10.1002/bjs.5833. PMID: 17583892

Therapy

Immunonutrition and prehabilitation in pancreatic cancer surgery: A new concept in the era of ERAS® and neoadjuvant treatment.
De Luca R, Gianotti L, Pedrazzoli P, Brunetti O, Rizzo A, Sandini M, Paiella S, Pecorelli N, Pugliese L, Pietrabissa A, Zerbi A, Salvia R, Boggi U, Casirati A, Falconi M, Caccialanza R
Eur J Surg Oncol 2023 Mar;49(3):542-549. Epub 2022 Dec 22 doi: 10.1016/j.ejso.2022.12.006. PMID: 36577556
Prescription patterns of pancreatic enzyme replacement therapy for patients with pancreatic cancer in the United States.
Jain T, Sharma P, Giri B, Iyer S, Sethi V, Bava EP, Vaish U, Sahay P, Datta J, Reddy S, Bart Rose J, Khan A, Merchant N, Chari ST, Dudeja V
HPB (Oxford) 2022 Oct;24(10):1729-1737. Epub 2022 May 23 doi: 10.1016/j.hpb.2022.05.003. PMID: 35717430
Expert opinion on management of pancreatic exocrine insufficiency in pancreatic cancer.
Roeyen G, Berrevoet F, Borbath I, Geboes K, Peeters M, Topal B, Van Cutsem E, Van Laethem JL
ESMO Open 2022 Feb;7(1):100386. Epub 2022 Feb 3 doi: 10.1016/j.esmoop.2022.100386. PMID: 35124465Free PMC Article
Expanding the indications of pancreas transplantation alone.
Mehrabi A, Golriz M, Adili-Aghdam F, Hafezi M, Ashrafi M, Morath C, Zeier M, Hackert T, Schemmer P
Pancreas 2014 Nov;43(8):1190-3. doi: 10.1097/MPA.0000000000000181. PMID: 25333402
Ductal pancreatic adenocarcinoma.
Seufferlein T, Porzner M, Heinemann V, Tannapfel A, Stuschke M, Uhl W
Dtsch Arztebl Int 2014 May 30;111(22):396-402. doi: 10.3238/arztebl.2014.0396. PMID: 24980565Free PMC Article

Prognosis

Immunonutrition and prehabilitation in pancreatic cancer surgery: A new concept in the era of ERAS® and neoadjuvant treatment.
De Luca R, Gianotti L, Pedrazzoli P, Brunetti O, Rizzo A, Sandini M, Paiella S, Pecorelli N, Pugliese L, Pietrabissa A, Zerbi A, Salvia R, Boggi U, Casirati A, Falconi M, Caccialanza R
Eur J Surg Oncol 2023 Mar;49(3):542-549. Epub 2022 Dec 22 doi: 10.1016/j.ejso.2022.12.006. PMID: 36577556
Neoadjuvant Chemotherapy Switch in Borderline Resectable/Locally Advanced Pancreatic Cancer.
Alva-Ruiz R, Yohanathan L, Yonkus JA, Abdelrahman AM, Gregory LA, Halfdanarson TR, Mahipal A, McWilliams RR, Ma WW, Hallemeier CL, Graham RP, Grotz TE, Smoot RL, Cleary SP, Nagorney DM, Kendrick ML, Truty MJ
Ann Surg Oncol 2022 Mar;29(3):1579-1591. Epub 2021 Nov 1 doi: 10.1245/s10434-021-10991-2. PMID: 34724125Free PMC Article
Is Central Pancreatectomy Truly Recommendable? A 9-Year Single-Center Experience.
Lv A, Qian HG, Qiu H, Wu JH, Hao CY
Dig Surg 2018;35(6):532-538. Epub 2017 Dec 22 doi: 10.1159/000485806. PMID: 29275422
Laparoscopic enucleation of pancreatic neoplasm.
Dedieu A, Rault A, Collet D, Masson B, Sa Cunha A
Surg Endosc 2011 Feb;25(2):572-6. Epub 2010 Jul 10 doi: 10.1007/s00464-010-1223-7. PMID: 20623235
Enucleation of pancreatic neoplasms.
Crippa S, Bassi C, Salvia R, Falconi M, Butturini G, Pederzoli P
Br J Surg 2007 Oct;94(10):1254-9. doi: 10.1002/bjs.5833. PMID: 17583892

Clinical prediction guides

Expert opinion on management of pancreatic exocrine insufficiency in pancreatic cancer.
Roeyen G, Berrevoet F, Borbath I, Geboes K, Peeters M, Topal B, Van Cutsem E, Van Laethem JL
ESMO Open 2022 Feb;7(1):100386. Epub 2022 Feb 3 doi: 10.1016/j.esmoop.2022.100386. PMID: 35124465Free PMC Article
Neoadjuvant Chemotherapy Switch in Borderline Resectable/Locally Advanced Pancreatic Cancer.
Alva-Ruiz R, Yohanathan L, Yonkus JA, Abdelrahman AM, Gregory LA, Halfdanarson TR, Mahipal A, McWilliams RR, Ma WW, Hallemeier CL, Graham RP, Grotz TE, Smoot RL, Cleary SP, Nagorney DM, Kendrick ML, Truty MJ
Ann Surg Oncol 2022 Mar;29(3):1579-1591. Epub 2021 Nov 1 doi: 10.1245/s10434-021-10991-2. PMID: 34724125Free PMC Article
Is Central Pancreatectomy Truly Recommendable? A 9-Year Single-Center Experience.
Lv A, Qian HG, Qiu H, Wu JH, Hao CY
Dig Surg 2018;35(6):532-538. Epub 2017 Dec 22 doi: 10.1159/000485806. PMID: 29275422
Investigation of Association Between Borderline Pancreatic Head Cancer and Glucose Uptake by Using Positron-Emission Tomographic Studies.
Zhang Y, Qin L, Zhang C
Med Sci Monit 2017 Oct 16;23:4947-4953. doi: 10.12659/msm.904746. PMID: 29036034Free PMC Article
Laparoscopic enucleation of pancreatic neoplasm.
Dedieu A, Rault A, Collet D, Masson B, Sa Cunha A
Surg Endosc 2011 Feb;25(2):572-6. Epub 2010 Jul 10 doi: 10.1007/s00464-010-1223-7. PMID: 20623235

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