U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Childhood botryoid rhabdomyosarcoma

MedGen UID:
232054
•Concept ID:
C1332944
•
Neoplastic Process
Synonyms: botryoid rhabdomyosarcoma of childhood; Childhood Botryoid Rhabdomyosarcoma; childhood botryoid rhabdomyosarcoma; Childhood Botryoid-Type Embryonal Rhabdomyosarcoma; childhood botryoid-type embryonal rhabdomyosarcoma; Childhood Sarcoma Botryoides; childhood sarcoma Botryoides; paediatric botryoid rhabdomyosarcoma; pediatric botryoid rhabdomyosarcoma
 
Monarch Initiative: MONDO:0003992

Definition

A morphologic variant of embryonal rhabdomyosarcoma occurring in children. The tumor arises from organs with a mucosal epithelial surface. It is characterized by the formation of a cambium layer in the affected tissue and polypoid nodules within an abundant myxoid stroma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChildhood botryoid rhabdomyosarcoma

Professional guidelines

PubMed

Rhabdomyosarcoma: From Obscurity to Clarity in Diagnosis … But With Ongoing Challenges in Management: The Farber-Landing Lecture of 2020.
Parham DM, Giannikopoulos P
Pediatr Dev Pathol 2021 Mar-Apr;24(2):87-95. Epub 2021 Jan 13 doi: 10.1177/1093526620977720. PMID: 33439112
Management of stage I cervical sarcoma botryoides in childhood and adolescence.
Gruessner SE, Omwandho CO, Dreyer T, Blütters-Sawatzki R, Reiter A, Tinneberg HR, Bohle RM
Eur J Pediatr 2004 Aug;163(8):452-6. Epub 2004 Jun 2 doi: 10.1007/s00431-004-1469-y. PMID: 15173941

Recent clinical studies

Etiology

The prognostic significance of anaplasia in childhood rhabdomyosarcoma: A report from the Children's Oncology Group.
Shenoy A, Alvarez E, Chi YY, Li M, Shern JF, Khan J, Hiniker SM, Granberg CF, Hawkins DS, Parham DM, Teot LA, Rudzinski ER
Eur J Cancer 2021 Jan;143:127-133. Epub 2020 Dec 7 doi: 10.1016/j.ejca.2020.10.018. PMID: 33302115Free PMC Article
Clinical characteristics and the prognosis of childhood rhabdomyosarcoma in 60 patients treated at a single institute.
Company F, Pedram M, Rezaei N
Acta Med Iran 2011;49(4):219-24. PMID: 21713731
Pathologic classification of rhabdomyosarcomas and correlations with molecular studies.
Parham DM
Mod Pathol 2001 May;14(5):506-14. doi: 10.1038/modpathol.3880339. PMID: 11353062
Intergroup Rhabdomyosarcoma Study: update for pathologists.
Qualman SJ, Coffin CM, Newton WA, Hojo H, Triche TJ, Parham DM, Crist WM
Pediatr Dev Pathol 1998 Nov-Dec;1(6):550-61. doi: 10.1007/s100249900076. PMID: 9724344
Rhabdomyosarcoma of the uterus in a postmenopausal patient.
Podczaski E, Sees J, Kaminski P, Sorosky J, Larson JE, DeGeest K, Zaino RJ, Mortel R
Gynecol Oncol 1990 Jun;37(3):439-42. doi: 10.1016/0090-8258(90)90384-w. PMID: 2190875

Diagnosis

Rhabdomyosarcoma: From Obscurity to Clarity in Diagnosis … But With Ongoing Challenges in Management: The Farber-Landing Lecture of 2020.
Parham DM, Giannikopoulos P
Pediatr Dev Pathol 2021 Mar-Apr;24(2):87-95. Epub 2021 Jan 13 doi: 10.1177/1093526620977720. PMID: 33439112
Intergroup Rhabdomyosarcoma Study: update for pathologists.
Qualman SJ, Coffin CM, Newton WA, Hojo H, Triche TJ, Parham DM, Crist WM
Pediatr Dev Pathol 1998 Nov-Dec;1(6):550-61. doi: 10.1007/s100249900076. PMID: 9724344
New entities, concepts, and questions in childhood tumor pathology.
Harms D
Gen Diagn Pathol 1995 May;141(1):1-14. PMID: 8542501
The diagnosis and classification of childhood rhabdomyosarcoma.
Tsokos M
Semin Diagn Pathol 1994 Feb;11(1):26-38. PMID: 8202644
Botryoid rhabdomyosarcoma of the biliary tract.
Lack EE, Perez-Atayde AR, Schuster SR
Am J Surg Pathol 1981 Oct;5(7):643-52. doi: 10.1097/00000478-198110000-00006. PMID: 7337157

Therapy

Botryoid rhabdomyosarcoma of the biliary tract in children: a unique case report.
Zampieri N, Camoglio F, Corroppolo M, Cecchetto M, Ornis S, Ottolenghi A
Eur J Cancer Care (Engl) 2006 Dec;15(5):463-6. doi: 10.1111/j.1365-2354.2006.00683.x. PMID: 17177904
Management of stage I cervical sarcoma botryoides in childhood and adolescence.
Gruessner SE, Omwandho CO, Dreyer T, Blütters-Sawatzki R, Reiter A, Tinneberg HR, Bohle RM
Eur J Pediatr 2004 Aug;163(8):452-6. Epub 2004 Jun 2 doi: 10.1007/s00431-004-1469-y. PMID: 15173941
Survival after relapse in children and adolescents with rhabdomyosarcoma: A report from the Intergroup Rhabdomyosarcoma Study Group.
Pappo AS, Anderson JR, Crist WM, Wharam MD, Breitfeld PP, Hawkins D, Raney RB, Womer RB, Parham DM, Qualman SJ, Grier HE
J Clin Oncol 1999 Nov;17(11):3487-93. doi: 10.1200/JCO.1999.17.11.3487. PMID: 10550146
Prognosis in children with rhabdomyosarcoma: a report of the intergroup rhabdomyosarcoma studies I and II. Intergroup Rhabdomyosarcoma Committee.
Crist WM, Garnsey L, Beltangady MS, Gehan E, Ruymann F, Webber B, Hays DM, Wharam M, Maurer HM
J Clin Oncol 1990 Mar;8(3):443-52. doi: 10.1200/JCO.1990.8.3.443. PMID: 2407808
Histopathology of childhood sarcomas, Intergroup Rhabdomyosarcoma Studies I and II: clinicopathologic correlation.
Newton WA Jr, Soule EH, Hamoudi AB, Reiman HM, Shimada H, Beltangady M, Maurer H
J Clin Oncol 1988 Jan;6(1):67-75. doi: 10.1200/JCO.1988.6.1.67. PMID: 3275751

Prognosis

Clinical characteristics and the prognosis of childhood rhabdomyosarcoma in 60 patients treated at a single institute.
Company F, Pedram M, Rezaei N
Acta Med Iran 2011;49(4):219-24. PMID: 21713731
Pathologic classification of rhabdomyosarcomas and correlations with molecular studies.
Parham DM
Mod Pathol 2001 May;14(5):506-14. doi: 10.1038/modpathol.3880339. PMID: 11353062
Intergroup Rhabdomyosarcoma Study: update for pathologists.
Qualman SJ, Coffin CM, Newton WA, Hojo H, Triche TJ, Parham DM, Crist WM
Pediatr Dev Pathol 1998 Nov-Dec;1(6):550-61. doi: 10.1007/s100249900076. PMID: 9724344
New entities, concepts, and questions in childhood tumor pathology.
Harms D
Gen Diagn Pathol 1995 May;141(1):1-14. PMID: 8542501
The diagnosis and classification of childhood rhabdomyosarcoma.
Tsokos M
Semin Diagn Pathol 1994 Feb;11(1):26-38. PMID: 8202644

Clinical prediction guides

Rhabdomyosarcoma: From Obscurity to Clarity in Diagnosis … But With Ongoing Challenges in Management: The Farber-Landing Lecture of 2020.
Parham DM, Giannikopoulos P
Pediatr Dev Pathol 2021 Mar-Apr;24(2):87-95. Epub 2021 Jan 13 doi: 10.1177/1093526620977720. PMID: 33439112
Management of stage I cervical sarcoma botryoides in childhood and adolescence.
Gruessner SE, Omwandho CO, Dreyer T, Blütters-Sawatzki R, Reiter A, Tinneberg HR, Bohle RM
Eur J Pediatr 2004 Aug;163(8):452-6. Epub 2004 Jun 2 doi: 10.1007/s00431-004-1469-y. PMID: 15173941
Clinical relevance of DNA ploidy and proliferative activity in childhood rhabdomyosarcoma: a retrospective analysis of patients enrolled onto the Italian Cooperative Rhabdomyosarcoma Study RMS88.
De Zen L, Sommaggio A, d'Amore ES, Masiero L, di Montezemolo LC, Linari A, Madon E, Dominici C, Bosco S, Bisogno G, Carli M, Ninfo V, Basso G
J Clin Oncol 1997 Mar;15(3):1198-205. doi: 10.1200/JCO.1997.15.3.1198. PMID: 9060564
Histopathological classification of childhood rhabdomyosarcomas: relationship with clinical parameters and prognosis.
Wijnaendts LC, van der Linden JC, van Unnik AJ, Delemarre JF, Voute PA, Meijer CJ
Hum Pathol 1994 Sep;25(9):900-7. doi: 10.1016/0046-8177(94)90009-4. PMID: 8088765
Histopathology of childhood sarcomas, Intergroup Rhabdomyosarcoma Studies I and II: clinicopathologic correlation.
Newton WA Jr, Soule EH, Hamoudi AB, Reiman HM, Shimada H, Beltangady M, Maurer H
J Clin Oncol 1988 Jan;6(1):67-75. doi: 10.1200/JCO.1988.6.1.67. PMID: 3275751

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...