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Breast Ductal Carcinoma In Situ, High Grade

MedGen UID:
232282
Concept ID:
C1334002
Neoplastic Process
Synonyms: DCIS Grade 3; Ductal Intraepithelial Neoplasia, Grade 3; High Grade Ductal Breast Carcinoma In Situ; High-Grade DCIS of Breast; High-Grade DCIS of the Breast; High-Grade Ductal Carcinoma In Situ of Breast

Definition

Breast ductal carcinoma in situ characterized by the presence of neoplastic cells with severe dysplasia and the formation of micropapillary, cribriform, or solid patterns. The nuclei show marked pleomorphism and have prominent nucleoli. Mitotic activity is usually present. There is comedo-type of necrosis present in the ducts. The necrotic debris is surrounded by pleomorphic malignant cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBreast Ductal Carcinoma In Situ, High Grade

Professional guidelines

PubMed

Knowlton CA, Jimenez RB, Moran MS
Semin Radiat Oncol 2022 Jul;32(3):189-197. doi: 10.1016/j.semradonc.2022.01.005. PMID: 35688517
Benson JR, Jatoi I, Toi M
Lancet Oncol 2016 Oct;17(10):e442-e451. doi: 10.1016/S1470-2045(16)30367-9. PMID: 27733270
Prescrire Int 2013 Dec;22(144):298-303. PMID: 24600734

Recent clinical studies

Etiology

Schandiz H, Park D, Kaiser YL, Lyngra M, Talleraas IS, Geisler J, Sauer T
Breast Cancer Res Treat 2023 Sep;201(2):329-338. Epub 2023 Jul 15 doi: 10.1007/s10549-023-07016-9. PMID: 37453021Free PMC Article
Hutten SJ, de Bruijn R, Lutz C, Badoux M, Eijkman T, Chao X, Ciwinska M, Sheinman M, Messal H, Herencia-Ropero A, Kristel P, Mulder L, van der Waal R, Sanders J, Almekinders MM, Llop-Guevara A, Davies HR, van Haren MJ, Martin NI, Behbod F, Nik-Zainal S, Serra V, van Rheenen J, Lips EH, Wessels LFA; Grand Challenge PRECISION Consortium, Wesseling J, Scheele CLGJ, Jonkers J
Cancer Cell 2023 May 8;41(5):986-1002.e9. Epub 2023 Apr 27 doi: 10.1016/j.ccell.2023.04.002. PMID: 37116492Free PMC Article
Kelly C, Fitzpatrick P, Quinn C, Flanagan F, Connors A, Larke A, Mooney T, Kennedy M, Sheehan M, Bennett MW, Brodie C, O'Doherty A
J Med Screen 2022 Sep;29(3):172-177. Epub 2022 Mar 28 doi: 10.1177/09691413221090739. PMID: 35341364
Cserni G, Sejben A
Pathol Oncol Res 2020 Apr;26(2):665-671. Epub 2019 Nov 27 doi: 10.1007/s12253-019-00760-8. PMID: 31776839Free PMC Article
Sanati S
Am J Pathol 2019 May;189(5):946-955. Epub 2018 Oct 29 doi: 10.1016/j.ajpath.2018.07.031. PMID: 30385094

Diagnosis

Schandiz H, Park D, Kaiser YL, Lyngra M, Talleraas IS, Geisler J, Sauer T
Breast Cancer Res Treat 2023 Sep;201(2):329-338. Epub 2023 Jul 15 doi: 10.1007/s10549-023-07016-9. PMID: 37453021Free PMC Article
Ben Khadra S, Hacking SM, Carpentier B, Singh K, Wang L, Yakirevich E, Wang Y
Pathol Res Pract 2022 Sep;237:154035. Epub 2022 Jul 21 doi: 10.1016/j.prp.2022.154035. PMID: 35878531
Kelly C, Fitzpatrick P, Quinn C, Flanagan F, Connors A, Larke A, Mooney T, Kennedy M, Sheehan M, Bennett MW, Brodie C, O'Doherty A
J Med Screen 2022 Sep;29(3):172-177. Epub 2022 Mar 28 doi: 10.1177/09691413221090739. PMID: 35341364
Benson JR, Jatoi I, Toi M
Lancet Oncol 2016 Oct;17(10):e442-e451. doi: 10.1016/S1470-2045(16)30367-9. PMID: 27733270
Dereere E, Papadimitriou K, Tjalma W, Altintas S
Minerva Chir 2015 Aug;70(4):231-9. Epub 2015 Apr 28 PMID: 25916193

Therapy

Hong M, Fan S, Yu Z, Gao C, Fang Z, Du L, Wang S, Chen X, Xu M, Zhou C
J Magn Reson Imaging 2023 Aug;58(2):454-463. Epub 2022 Nov 28 doi: 10.1002/jmri.28539. PMID: 36440711
Offersen BV, Alsner J, Nielsen HM, Jakobsen EH, Nielsen MH, Krause M, Stenbygaard L, Mjaaland I, Schreiber A, Kasti UM, Overgaard J; Danish Breast Cancer Group Radiation Therapy Committee
J Clin Oncol 2020 Nov 1;38(31):3615-3625. Epub 2020 Sep 10 doi: 10.1200/JCO.20.01363. PMID: 32910709
Cutuli B, Lemanski C, De Lafontan B, Chauvet MP, De Lara CT, Mege A, Fric D, Richard-Molard M, Mazouni C, Cuvier C, Carre A, Kirova Y
Clin Breast Cancer 2020 Apr;20(2):e164-e172. Epub 2019 Aug 22 doi: 10.1016/j.clbc.2019.08.002. PMID: 31780381
Cserni G, Sejben A
Pathol Oncol Res 2020 Apr;26(2):665-671. Epub 2019 Nov 27 doi: 10.1007/s12253-019-00760-8. PMID: 31776839Free PMC Article
Dereere E, Papadimitriou K, Tjalma W, Altintas S
Minerva Chir 2015 Aug;70(4):231-9. Epub 2015 Apr 28 PMID: 25916193

Prognosis

Schandiz H, Park D, Kaiser YL, Lyngra M, Talleraas IS, Geisler J, Sauer T
Breast Cancer Res Treat 2023 Sep;201(2):329-338. Epub 2023 Jul 15 doi: 10.1007/s10549-023-07016-9. PMID: 37453021Free PMC Article
Hutten SJ, de Bruijn R, Lutz C, Badoux M, Eijkman T, Chao X, Ciwinska M, Sheinman M, Messal H, Herencia-Ropero A, Kristel P, Mulder L, van der Waal R, Sanders J, Almekinders MM, Llop-Guevara A, Davies HR, van Haren MJ, Martin NI, Behbod F, Nik-Zainal S, Serra V, van Rheenen J, Lips EH, Wessels LFA; Grand Challenge PRECISION Consortium, Wesseling J, Scheele CLGJ, Jonkers J
Cancer Cell 2023 May 8;41(5):986-1002.e9. Epub 2023 Apr 27 doi: 10.1016/j.ccell.2023.04.002. PMID: 37116492Free PMC Article
Knowlton CA, Jimenez RB, Moran MS
Semin Radiat Oncol 2022 Jul;32(3):189-197. doi: 10.1016/j.semradonc.2022.01.005. PMID: 35688517
Sanati S
Am J Pathol 2019 May;189(5):946-955. Epub 2018 Oct 29 doi: 10.1016/j.ajpath.2018.07.031. PMID: 30385094
Benson JR, Jatoi I, Toi M
Lancet Oncol 2016 Oct;17(10):e442-e451. doi: 10.1016/S1470-2045(16)30367-9. PMID: 27733270

Clinical prediction guides

Schandiz H, Park D, Kaiser YL, Lyngra M, Talleraas IS, Geisler J, Sauer T
Breast Cancer Res Treat 2023 Sep;201(2):329-338. Epub 2023 Jul 15 doi: 10.1007/s10549-023-07016-9. PMID: 37453021Free PMC Article
Hutten SJ, de Bruijn R, Lutz C, Badoux M, Eijkman T, Chao X, Ciwinska M, Sheinman M, Messal H, Herencia-Ropero A, Kristel P, Mulder L, van der Waal R, Sanders J, Almekinders MM, Llop-Guevara A, Davies HR, van Haren MJ, Martin NI, Behbod F, Nik-Zainal S, Serra V, van Rheenen J, Lips EH, Wessels LFA; Grand Challenge PRECISION Consortium, Wesseling J, Scheele CLGJ, Jonkers J
Cancer Cell 2023 May 8;41(5):986-1002.e9. Epub 2023 Apr 27 doi: 10.1016/j.ccell.2023.04.002. PMID: 37116492Free PMC Article
Knowlton CA, Jimenez RB, Moran MS
Semin Radiat Oncol 2022 Jul;32(3):189-197. doi: 10.1016/j.semradonc.2022.01.005. PMID: 35688517
Kelly C, Fitzpatrick P, Quinn C, Flanagan F, Connors A, Larke A, Mooney T, Kennedy M, Sheehan M, Bennett MW, Brodie C, O'Doherty A
J Med Screen 2022 Sep;29(3):172-177. Epub 2022 Mar 28 doi: 10.1177/09691413221090739. PMID: 35341364
Benson JR, Jatoi I, Toi M
Lancet Oncol 2016 Oct;17(10):e442-e451. doi: 10.1016/S1470-2045(16)30367-9. PMID: 27733270

Recent systematic reviews

Poelhekken K, Lin Y, Greuter MJW, van der Vegt B, Dorrius M, de Bock GH
Breast 2023 Oct;71:74-81. Epub 2023 Jul 27 doi: 10.1016/j.breast.2023.07.012. PMID: 37541171Free PMC Article
Atakpa EC, Thorat MA, Cuzick J, Brentnall AR
Cochrane Database Syst Rev 2021 Oct 26;10(10):CD013091. doi: 10.1002/14651858.CD013091.pub2. PMID: 34697802Free PMC Article
Hickey BE, Lehman M
Cochrane Database Syst Rev 2021 Aug 30;8(8):CD007077. doi: 10.1002/14651858.CD007077.pub4. PMID: 34459500Free PMC Article
Stebbing J, Delaney G, Thompson A
BMJ Clin Evid 2011 Feb 8;2011 PMID: 21718560Free PMC Article
Goodwin A, Parker S, Ghersi D, Wilcken N
Breast 2009 Jun;18(3):143-9. Epub 2009 May 17 doi: 10.1016/j.breast.2009.04.003. PMID: 19447038

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