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High Grade Cervical Intraepithelial Neoplasia

MedGen UID:
232286
Concept ID:
C1334011
Neoplastic Process

Definition

Squamous or glandular cervical intraepithelial neoplasia characterized by the presence of moderate or severe dysplastic changes. [from NCI]

Professional guidelines

PubMed

Bonde J, Bottari F, Iacobone AD, Cocuzza CE, Sandri MT, Bogliatto F, Khan KS, Ejegod DM, Gary DS, Andrews JC
J Low Genit Tract Dis 2021 Jan 1;25(1):27-37. doi: 10.1097/LGT.0000000000000573. PMID: 33105450Free PMC Article
Burness JV, Schroeder JM, Warren JB
Am Fam Physician 2020 Jul 1;102(1):39-48. PMID: 32603071
Arbyn M, Redman CWE, Verdoodt F, Kyrgiou M, Tzafetas M, Ghaem-Maghami S, Petry KU, Leeson S, Bergeron C, Nieminen P, Gondry J, Reich O, Moss EL
Lancet Oncol 2017 Dec;18(12):1665-1679. Epub 2017 Nov 7 doi: 10.1016/S1470-2045(17)30700-3. PMID: 29126708

Recent clinical studies

Etiology

Jentschke M, Kampers J, Becker J, Sibbertsen P, Hillemanns P
Vaccine 2020 Sep 22;38(41):6402-6409. Epub 2020 Aug 4 doi: 10.1016/j.vaccine.2020.07.055. PMID: 32762871
Szekerczés T, Galamb Á, Varga N, Benczik M, Kocsis A, Schlachter K, Kiss A, Ács N, Schaff Z, Jeney C, Lendvai G, Sobel G
Pathol Oncol Res 2020 Oct;26(4):2633-2640. Epub 2020 Jul 8 doi: 10.1007/s12253-020-00852-w. PMID: 32643116Free PMC Article
Burness JV, Schroeder JM, Warren JB
Am Fam Physician 2020 Jul 1;102(1):39-48. PMID: 32603071
Meijer CJ, Berkhof J, Castle PE, Hesselink AT, Franco EL, Ronco G, Arbyn M, Bosch FX, Cuzick J, Dillner J, Heideman DA, Snijders PJ
Int J Cancer 2009 Feb 1;124(3):516-20. doi: 10.1002/ijc.24010. PMID: 18973271Free PMC Article
Brink AA, Snijders PJ, Meijer CJ
Dis Markers 2007;23(4):273-81. doi: 10.1155/2007/147429. PMID: 17627062Free PMC Article

Diagnosis

van den Helder R, Steenbergen RDM, van Splunter AP, Mom CH, Tjiong MY, Martin I, Rosier-van Dunné FMF, van der Avoort IAM, Bleeker MCG, van Trommel NE
Clin Cancer Res 2022 May 13;28(10):2061-2068. doi: 10.1158/1078-0432.CCR-21-3710. PMID: 35266975
Burness JV, Schroeder JM, Warren JB
Am Fam Physician 2020 Jul 1;102(1):39-48. PMID: 32603071
Arbyn M, Redman CWE, Verdoodt F, Kyrgiou M, Tzafetas M, Ghaem-Maghami S, Petry KU, Leeson S, Bergeron C, Nieminen P, Gondry J, Reich O, Moss EL
Lancet Oncol 2017 Dec;18(12):1665-1679. Epub 2017 Nov 7 doi: 10.1016/S1470-2045(17)30700-3. PMID: 29126708
Koeneman MM, Kruitwagen RF, Nijman HW, Slangen BF, Van Gorp T, Kruse AJ
Expert Rev Mol Diagn 2015 Apr;15(4):527-46. Epub 2015 Feb 21 doi: 10.1586/14737159.2015.1012068. PMID: 25703310
Meijer CJ, Berkhof J, Castle PE, Hesselink AT, Franco EL, Ronco G, Arbyn M, Bosch FX, Cuzick J, Dillner J, Heideman DA, Snijders PJ
Int J Cancer 2009 Feb 1;124(3):516-20. doi: 10.1002/ijc.24010. PMID: 18973271Free PMC Article

Therapy

Hendriks N, Koeneman MM, van de Sande AJM, Penders CGJ, Piek JMJ, Kooreman LFS, van Kuijk SMJ, Hoosemans L, Sep SJS, de Vos Van Steenwijk PJ, van Beekhuizen HJ, Slangen BFM, Nijman HW, Kruitwagen RFPM, Kruse AJ
J Immunother 2022 Apr 1;45(3):180-186. doi: 10.1097/CJI.0000000000000414. PMID: 35180719Free PMC Article
Jentschke M, Kampers J, Becker J, Sibbertsen P, Hillemanns P
Vaccine 2020 Sep 22;38(41):6402-6409. Epub 2020 Aug 4 doi: 10.1016/j.vaccine.2020.07.055. PMID: 32762871
Ogilvie GS, van Niekerk D, Krajden M, Smith LW, Cook D, Gondara L, Ceballos K, Quinlan D, Lee M, Martin RE, Gentile L, Peacock S, Stuart GCE, Franco EL, Coldman AJ
JAMA 2018 Jul 3;320(1):43-52. doi: 10.1001/jama.2018.7464. PMID: 29971397Free PMC Article
Arbyn M, Redman CWE, Verdoodt F, Kyrgiou M, Tzafetas M, Ghaem-Maghami S, Petry KU, Leeson S, Bergeron C, Nieminen P, Gondry J, Reich O, Moss EL
Lancet Oncol 2017 Dec;18(12):1665-1679. Epub 2017 Nov 7 doi: 10.1016/S1470-2045(17)30700-3. PMID: 29126708
FUTURE II Study Group
N Engl J Med 2007 May 10;356(19):1915-27. doi: 10.1056/NEJMoa061741. PMID: 17494925

Prognosis

Causin RL, da Silva LS, Evangelista AF, Leal LF, Souza KCB, Pessôa-Pereira D, Matsushita GM, Reis RM, Fregnani JHTG, Marques MMC
Biomed Res Int 2021;2021:6650966. Epub 2021 Apr 13 doi: 10.1155/2021/6650966. PMID: 33954190Free PMC Article
Ogilvie GS, van Niekerk D, Krajden M, Smith LW, Cook D, Gondara L, Ceballos K, Quinlan D, Lee M, Martin RE, Gentile L, Peacock S, Stuart GCE, Franco EL, Coldman AJ
JAMA 2018 Jul 3;320(1):43-52. doi: 10.1001/jama.2018.7464. PMID: 29971397Free PMC Article
Arbyn M, Redman CWE, Verdoodt F, Kyrgiou M, Tzafetas M, Ghaem-Maghami S, Petry KU, Leeson S, Bergeron C, Nieminen P, Gondry J, Reich O, Moss EL
Lancet Oncol 2017 Dec;18(12):1665-1679. Epub 2017 Nov 7 doi: 10.1016/S1470-2045(17)30700-3. PMID: 29126708
Koeneman MM, Kruitwagen RF, Nijman HW, Slangen BF, Van Gorp T, Kruse AJ
Expert Rev Mol Diagn 2015 Apr;15(4):527-46. Epub 2015 Feb 21 doi: 10.1586/14737159.2015.1012068. PMID: 25703310
FUTURE II Study Group
N Engl J Med 2007 May 10;356(19):1915-27. doi: 10.1056/NEJMoa061741. PMID: 17494925

Clinical prediction guides

Liu Y, Wang S, Liu J, Su M, Diao X, Liang X, Zhang J, Wang Q, Zhan Y
J Transl Med 2023 Nov 16;21(1):816. doi: 10.1186/s12967-023-04676-5. PMID: 37974192Free PMC Article
Hendriks N, Koeneman MM, van de Sande AJM, Penders CGJ, Piek JMJ, Kooreman LFS, van Kuijk SMJ, Hoosemans L, Sep SJS, de Vos Van Steenwijk PJ, van Beekhuizen HJ, Slangen BFM, Nijman HW, Kruitwagen RFPM, Kruse AJ
J Immunother 2022 Apr 1;45(3):180-186. doi: 10.1097/CJI.0000000000000414. PMID: 35180719Free PMC Article
Sykes PH, Simcock BJ, Innes CR, Harker D, Williman JA, Whitehead M, van der Griend RA, Lawton BA, Hibma M, Fitzgerald P, Dudley NM, Petrich S, Eva L, Bergzoll C, Kathuria J, McPherson G, Tristram A, Faherty J, Hardie D, Robertson A, Robertson V, Pather S, Wrede CD, Gastrell F, Fentiman G, John M, White E, Parker C, Sadler L
Am J Obstet Gynecol 2022 Feb;226(2):222.e1-222.e13. Epub 2021 Sep 14 doi: 10.1016/j.ajog.2021.09.009. PMID: 34534506
Causin RL, da Silva LS, Evangelista AF, Leal LF, Souza KCB, Pessôa-Pereira D, Matsushita GM, Reis RM, Fregnani JHTG, Marques MMC
Biomed Res Int 2021;2021:6650966. Epub 2021 Apr 13 doi: 10.1155/2021/6650966. PMID: 33954190Free PMC Article
Arbyn M, Redman CWE, Verdoodt F, Kyrgiou M, Tzafetas M, Ghaem-Maghami S, Petry KU, Leeson S, Bergeron C, Nieminen P, Gondry J, Reich O, Moss EL
Lancet Oncol 2017 Dec;18(12):1665-1679. Epub 2017 Nov 7 doi: 10.1016/S1470-2045(17)30700-3. PMID: 29126708

Recent systematic reviews

van de Sande AJM, Kengsakul M, Koeneman MM, Jozwiak M, Gerestein CG, Kruse AJ, van Esch EMG, de Vos van Steenwijk PJ, Muntinga CLP, Bramer WM, van Doorn HC, van Kemenade FJ, van Beekhuizen HJ
Int J Gynaecol Obstet 2024 Jan;164(1):66-74. Epub 2023 Jun 23 doi: 10.1002/ijgo.14953. PMID: 37350560
Jentschke M, Kampers J, Becker J, Sibbertsen P, Hillemanns P
Vaccine 2020 Sep 22;38(41):6402-6409. Epub 2020 Aug 4 doi: 10.1016/j.vaccine.2020.07.055. PMID: 32762871
Atemnkeng N, Aji AD, de Sanjose S, Mayaud P, Kelly H
Clin Infect Dis 2020 Dec 17;71(10):e540-e548. doi: 10.1093/cid/ciaa238. PMID: 32162657
Arbyn M, Redman CWE, Verdoodt F, Kyrgiou M, Tzafetas M, Ghaem-Maghami S, Petry KU, Leeson S, Bergeron C, Nieminen P, Gondry J, Reich O, Moss EL
Lancet Oncol 2017 Dec;18(12):1665-1679. Epub 2017 Nov 7 doi: 10.1016/S1470-2045(17)30700-3. PMID: 29126708
Koshiol J, Lindsay L, Pimenta JM, Poole C, Jenkins D, Smith JS
Am J Epidemiol 2008 Jul 15;168(2):123-37. Epub 2008 May 15 doi: 10.1093/aje/kwn036. PMID: 18483125Free PMC Article

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