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Human Papillomavirus-Related Anal Squamous Cell Carcinoma

MedGen UID:
232295
•Concept ID:
C1334049
•
Neoplastic Process
Synonyms: HPV-Related Anal Squamous Cell Carcinoma; Human Papilloma Virus Related Anal Squamous Cell Carcinoma; Human Papilloma Virus-Related Anal Squamous Cell Carcinoma

Definition

An anal squamous cell carcinoma related to infection with sexually transmittable human papillomavirus. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHuman Papillomavirus-Related Anal Squamous Cell Carcinoma

Professional guidelines

PubMed

Treatment efficacy for human papillomavirus-related anal squamous cell dysplasia in an under-represented population: human immunodeficiency-negative, non-men having sex with men, and non-transplant population.
Messick CA
Colorectal Dis 2020 Jan;22(1):29-35. Epub 2019 Aug 7 doi: 10.1111/codi.14786. PMID: 31344295
The human papillomavirus vaccine as a treatment for human papillomavirus-related dysplastic and neoplastic conditions: A literature review.
Pham CT, Juhasz M, Sung CT, Mesinkovska NA
J Am Acad Dermatol 2020 Jan;82(1):202-212. Epub 2019 May 11 doi: 10.1016/j.jaad.2019.04.067. PMID: 31085272

Recent clinical studies

Etiology

New Insights into the Role of Human Papillomavirus in Anal Cancer and Anal Wart Development.
Albuquerque A, Medeiros R
Acta Cytol 2019;63(2):118-123. Epub 2019 Mar 12 doi: 10.1159/000491815. PMID: 30861525
Molecular biology of anal squamous cell carcinoma: implications for future research and clinical intervention.
Bernardi MP, Ngan SY, Michael M, Lynch AC, Heriot AG, Ramsay RG, Phillips WA
Lancet Oncol 2015 Dec;16(16):e611-21. doi: 10.1016/S1470-2045(15)00292-2. PMID: 26678214
Human papillomavirus-related squamous cell carcinoma of the anal canal with papillary features.
Leon ME, Shamekh R, Coppola D
World J Gastroenterol 2015 Feb 21;21(7):2210-3. doi: 10.3748/wjg.v21.i7.2210. PMID: 25717259Free PMC Article
Human papillomavirus-related genital disease in the immunocompromised host: Part I.
Gormley RH, Kovarik CL
J Am Acad Dermatol 2012 Jun;66(6):867.e1-14; quiz 881-2. doi: 10.1016/j.jaad.2010.12.050. PMID: 22583720
Spectrum of human papillomavirus-related dysplasia and carcinoma of the anus in HIV-infected patients.
Panther LA, Schlecht HP, Dezube BJ
AIDS Read 2005 Feb;15(2):79-82, 85-6, 88, 91. PMID: 15712398

Diagnosis

An Unusual Case of Human Papillomavirus-Related Anorectal Adenocarcinoma With Progression to Perianal Paget's Disease.
Katerji R, Liao X, Huber A, Zhang D
Int J Surg Pathol 2021 Sep;29(6):672-676. Epub 2020 Dec 24 doi: 10.1177/1066896920982367. PMID: 33356675
Molecular biology of anal squamous cell carcinoma: implications for future research and clinical intervention.
Bernardi MP, Ngan SY, Michael M, Lynch AC, Heriot AG, Ramsay RG, Phillips WA
Lancet Oncol 2015 Dec;16(16):e611-21. doi: 10.1016/S1470-2045(15)00292-2. PMID: 26678214
Human papillomavirus-related genital disease in the immunocompromised host: Part I.
Gormley RH, Kovarik CL
J Am Acad Dermatol 2012 Jun;66(6):867.e1-14; quiz 881-2. doi: 10.1016/j.jaad.2010.12.050. PMID: 22583720
Screening HIV-infected individuals for anal cancer precursor lesions: a systematic review.
Chiao EY, Giordano TP, Palefsky JM, Tyring S, El Serag H
Clin Infect Dis 2006 Jul 15;43(2):223-33. Epub 2006 Jun 7 doi: 10.1086/505219. PMID: 16779751
Spectrum of human papillomavirus-related dysplasia and carcinoma of the anus in HIV-infected patients.
Panther LA, Schlecht HP, Dezube BJ
AIDS Read 2005 Feb;15(2):79-82, 85-6, 88, 91. PMID: 15712398

Therapy

The human papillomavirus vaccine as a treatment for human papillomavirus-related dysplastic and neoplastic conditions: A literature review.
Pham CT, Juhasz M, Sung CT, Mesinkovska NA
J Am Acad Dermatol 2020 Jan;82(1):202-212. Epub 2019 May 11 doi: 10.1016/j.jaad.2019.04.067. PMID: 31085272
Clearance of human papillomavirus related anal condylomas after oral and endorectal multistrain probiotic supplementation in an HIV positive male: A case report.
Ceccarelli G, Cavallari EN, Savinelli S, Bianchi L, Pierangeli A, Vullo F, Ciardi A, D'ettorre G
Medicine (Baltimore) 2018 Apr;97(16):e0329. doi: 10.1097/MD.0000000000010329. PMID: 29668581Free PMC Article
Risk of Second Malignancies in Solid Organ Transplant Recipients Who Develop Keratinocyte Cancers.
Zamoiski RD, Yanik E, Gibson TM, Cahoon EK, Madeleine MM, Lynch CF, Gustafson S, Goodman MT, Skeans M, Israni AK, Engels EA, Morton LM
Cancer Res 2017 Aug 1;77(15):4196-4203. Epub 2017 Jun 14 doi: 10.1158/0008-5472.CAN-16-3291. PMID: 28615224Free PMC Article
Molecular biology of anal squamous cell carcinoma: implications for future research and clinical intervention.
Bernardi MP, Ngan SY, Michael M, Lynch AC, Heriot AG, Ramsay RG, Phillips WA
Lancet Oncol 2015 Dec;16(16):e611-21. doi: 10.1016/S1470-2045(15)00292-2. PMID: 26678214
High reproducibility of histological diagnosis of human papillomavirus-related intraepithelial lesions of the anal canal.
Roberts JM, Jin F, Thurloe JK, Biro C, Poynten IM, Tabrizi SN, Fairley CK, Templeton DJ, Carr AD, Garland SM, Hillman RJ, Cornall AM, Grulich AE, Farnsworth A
Pathology 2015 Jun;47(4):308-13. doi: 10.1097/PAT.0000000000000246. PMID: 25938361

Prognosis

Condyloma Acuminatum of Urinary Bladder: Relation to Squamous Cell Carcinoma.
Samarska IV, Epstein JI
Am J Surg Pathol 2019 Nov;43(11):1547-1553. doi: 10.1097/PAS.0000000000001339. PMID: 31368913
New Insights into the Role of Human Papillomavirus in Anal Cancer and Anal Wart Development.
Albuquerque A, Medeiros R
Acta Cytol 2019;63(2):118-123. Epub 2019 Mar 12 doi: 10.1159/000491815. PMID: 30861525
Elevated risk of human papillomavirus-related second cancers in survivors of anal canal cancer.
Nelson RA, Lai LL
Cancer 2017 Oct 15;123(20):4013-4021. Epub 2017 Jun 13 doi: 10.1002/cncr.30828. PMID: 28608917
Molecular biology of anal squamous cell carcinoma: implications for future research and clinical intervention.
Bernardi MP, Ngan SY, Michael M, Lynch AC, Heriot AG, Ramsay RG, Phillips WA
Lancet Oncol 2015 Dec;16(16):e611-21. doi: 10.1016/S1470-2045(15)00292-2. PMID: 26678214
Spectrum of human papillomavirus-related dysplasia and carcinoma of the anus in HIV-infected patients.
Panther LA, Schlecht HP, Dezube BJ
AIDS Read 2005 Feb;15(2):79-82, 85-6, 88, 91. PMID: 15712398

Clinical prediction guides

A Pilot Study of a Screening Program for Human Papillomavirus-Related Squamous Intraepithelial Lesion and Malignancy in Gynecologic Oncology Patients.
Watson CH, Spinosa D, Hayes T, Scott A, Jackson L, Thacker JK, Sherman KL, Moss HA, Havrilesky LJ, McNally JL
J Low Genit Tract Dis 2023 Apr 1;27(2):120-124. Epub 2023 Feb 3 doi: 10.1097/LGT.0000000000000723. PMID: 36745862
Elevated risk of human papillomavirus-related second cancers in survivors of anal canal cancer.
Nelson RA, Lai LL
Cancer 2017 Oct 15;123(20):4013-4021. Epub 2017 Jun 13 doi: 10.1002/cncr.30828. PMID: 28608917
Molecular biology of anal squamous cell carcinoma: implications for future research and clinical intervention.
Bernardi MP, Ngan SY, Michael M, Lynch AC, Heriot AG, Ramsay RG, Phillips WA
Lancet Oncol 2015 Dec;16(16):e611-21. doi: 10.1016/S1470-2045(15)00292-2. PMID: 26678214
High reproducibility of histological diagnosis of human papillomavirus-related intraepithelial lesions of the anal canal.
Roberts JM, Jin F, Thurloe JK, Biro C, Poynten IM, Tabrizi SN, Fairley CK, Templeton DJ, Carr AD, Garland SM, Hillman RJ, Cornall AM, Grulich AE, Farnsworth A
Pathology 2015 Jun;47(4):308-13. doi: 10.1097/PAT.0000000000000246. PMID: 25938361

Recent systematic reviews

The human papillomavirus vaccine as a treatment for human papillomavirus-related dysplastic and neoplastic conditions: A literature review.
Pham CT, Juhasz M, Sung CT, Mesinkovska NA
J Am Acad Dermatol 2020 Jan;82(1):202-212. Epub 2019 May 11 doi: 10.1016/j.jaad.2019.04.067. PMID: 31085272
Screening HIV-infected individuals for anal cancer precursor lesions: a systematic review.
Chiao EY, Giordano TP, Palefsky JM, Tyring S, El Serag H
Clin Infect Dis 2006 Jul 15;43(2):223-33. Epub 2006 Jun 7 doi: 10.1086/505219. PMID: 16779751

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