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Childhood pilocytic astrocytoma

MedGen UID:
232355
•Concept ID:
C1332995
•
Neoplastic Process
Synonyms: Childhood Pilocytic Astrocytoma; childhood pilocytic astrocytoma; paediatric pilocytic astrocytoma; Pediatric Pilocytic Astrocytoma; pediatric pilocytic astrocytoma; Pilocytic Astrocytoma of Childhood; pilocytic astrocytoma of childhood
 
Monarch Initiative: MONDO:0004000

Definition

A pilocytic astrocytoma that occurs during childhood. [from NCI]

Professional guidelines

PubMed

Clinical Features, Treatment and Outcome of Childhood Glial Tumors.
Kara B, Ertan K, Karabagli P, Karabagli H, Yavas G, Caglayan AO, Koksal Y
Turk Neurosurg 2022;32(1):135-142. doi: 10.5137/1019-5149.JTN.34801-21.2. PMID: 34751424
Diagnosis and Treatment of Pediatric Brain Tumors.
Hodžić M, Ercegović Z, Korkut D, Moranjkić M, Brkić H, Jakupović S
Acta Med Acad 2020;49 Suppl 1:37-44. doi: 10.5644/ama2006-124.305. PMID: 33543629
Childhood brain tumors: current management, biological insights, and future directions.
Pollack IF, Agnihotri S, Broniscer A
J Neurosurg Pediatr 2019 Mar 1;23(3):261-273. doi: 10.3171/2018.10.PEDS18377. PMID: 30835699Free PMC Article

Recent clinical studies

Diagnosis

Diagnostic challenges of primary thalamic gliomas-identification of a minimally enhancing neuroradiological subtype with aggressive neuropathology and poor clinical outcome.
Kurian KM, Zhang Y, Haynes HR, Macaskill NA, Bradley M
Clin Neuroradiol 2014 Sep;24(3):231-8. Epub 2013 May 25 doi: 10.1007/s00062-013-0225-y. PMID: 23708758
Successful treatment of childhood pilocytic astrocytomas metastatic to the leptomeninges with high-dose cyclophosphamide.
McCowage G, Tien R, McLendon R, Felsberg G, Fuchs H, Graham ML, Kurtzberg J, Moghrabi A, Ferrell L, Kerby T, Duncan-Brown M, Stewart E, Robertson PL, Colvin OM, Golembe B, Bigner DD, Friedman HS
Med Pediatr Oncol 1996 Jul;27(1):32-9. doi: 10.1002/(SICI)1096-911X(199607)27:1<32::AID-MPO7>3.0.CO;2-V. PMID: 8614389

Therapy

Differences in vasculature between pilocytic and anaplastic astrocytomas of childhood.
Gesundheit B, Klement G, Senger C, Kerbel R, Kieran M, Baruchel S, Becker L
Med Pediatr Oncol 2003 Dec;41(6):516-26. doi: 10.1002/mpo.10308. PMID: 14595708
Successful treatment of childhood pilocytic astrocytomas metastatic to the leptomeninges with high-dose cyclophosphamide.
McCowage G, Tien R, McLendon R, Felsberg G, Fuchs H, Graham ML, Kurtzberg J, Moghrabi A, Ferrell L, Kerby T, Duncan-Brown M, Stewart E, Robertson PL, Colvin OM, Golembe B, Bigner DD, Friedman HS
Med Pediatr Oncol 1996 Jul;27(1):32-9. doi: 10.1002/(SICI)1096-911X(199607)27:1<32::AID-MPO7>3.0.CO;2-V. PMID: 8614389

Prognosis

Midbrain Gliofibroma Presenting in Adulthood following "Cure" of a Childhood Intraventricular Pilocytic Astrocytoma.
Ahmad MU, Barborie A, Pizer B, Husband D, Mallucci C, Jenkinson MD
Pediatr Neurosurg 2017;52(3):151-154. Epub 2017 Mar 1 doi: 10.1159/000455920. PMID: 28245445
Diagnostic challenges of primary thalamic gliomas-identification of a minimally enhancing neuroradiological subtype with aggressive neuropathology and poor clinical outcome.
Kurian KM, Zhang Y, Haynes HR, Macaskill NA, Bradley M
Clin Neuroradiol 2014 Sep;24(3):231-8. Epub 2013 May 25 doi: 10.1007/s00062-013-0225-y. PMID: 23708758
Differences in vasculature between pilocytic and anaplastic astrocytomas of childhood.
Gesundheit B, Klement G, Senger C, Kerbel R, Kieran M, Baruchel S, Becker L
Med Pediatr Oncol 2003 Dec;41(6):516-26. doi: 10.1002/mpo.10308. PMID: 14595708

Clinical prediction guides

mRNA and miRNA Expression Analyses of the MYC/E2F/miR-17-92 Network in the Most Common Pediatric Brain Tumors.
Gruszka R, Zakrzewski K, Liberski PP, Zakrzewska M
Int J Mol Sci 2021 Jan 7;22(2) doi: 10.3390/ijms22020543. PMID: 33430425Free PMC Article
Diagnostic challenges of primary thalamic gliomas-identification of a minimally enhancing neuroradiological subtype with aggressive neuropathology and poor clinical outcome.
Kurian KM, Zhang Y, Haynes HR, Macaskill NA, Bradley M
Clin Neuroradiol 2014 Sep;24(3):231-8. Epub 2013 May 25 doi: 10.1007/s00062-013-0225-y. PMID: 23708758
Differences in vasculature between pilocytic and anaplastic astrocytomas of childhood.
Gesundheit B, Klement G, Senger C, Kerbel R, Kieran M, Baruchel S, Becker L
Med Pediatr Oncol 2003 Dec;41(6):516-26. doi: 10.1002/mpo.10308. PMID: 14595708

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