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Encapsulated thymoma

MedGen UID:
232452
•Concept ID:
C1333383
•
Neoplastic Process
Synonyms: Encapsulated Thymoma; encapsulated thymoma
 
Monarch Initiative: MONDO:0002587

Definition

A thymoma that is confined within the capsule and may display benign or malignant morphologic characteristics. [from NCI]

Professional guidelines

PubMed

Results of surgical treatment for thymoma based on 66 patients.
Fujimura S, Kondo T, Handa M, Shiraishi Y, Tamahashi N, Nakada T
J Thorac Cardiovasc Surg 1987 May;93(5):708-14. PMID: 3573783

Recent clinical studies

Etiology

The role of a pseudocapsula in thymic epithelial tumors: outcome and correlation with established prognostic parameters. Results of a 20-year single centre retrospective analysis.
Dango S, Passlick B, Thiemann U, Kayser G, Stremmel C
J Cardiothorac Surg 2009 Jul 15;4:33. doi: 10.1186/1749-8090-4-33. PMID: 19604398Free PMC Article
Flow cytometric analysis of lymphoid cells in thymic epithelial neoplasms.
Nakajima J, Takamoto S, Oka T, Tanaka M, Takeuchi E, Murakawa T
Eur J Cardiothorac Surg 2000 Sep;18(3):287-92. doi: 10.1016/s1010-7940(00)00523-6. PMID: 10973537
Results from surgical treatment for thymoma. 43 years of experience.
Murakawa T, Nakajima J, Kohno T, Tanaka M, Matsumoto J, Takeuchi E, Takamoto S
Jpn J Thorac Cardiovasc Surg 2000 Feb;48(2):89-95. doi: 10.1007/BF03218097. PMID: 10769987
Primary thymic epithelial neoplasms showing combined features of thymoma and thymic carcinoma. A clinicopathologic study of 22 cases.
Suster S, Moran CA
Am J Surg Pathol 1996 Dec;20(12):1469-80. doi: 10.1097/00000478-199612000-00006. PMID: 8944040
Results of surgical treatment for thymoma based on 66 patients.
Fujimura S, Kondo T, Handa M, Shiraishi Y, Tamahashi N, Nakada T
J Thorac Cardiovasc Surg 1987 May;93(5):708-14. PMID: 3573783

Diagnosis

Cystic and Encapsulated Atypical Thymoma (World Health Organization Type B3).
Lindholm KE, Moran CA
Am J Clin Pathol 2019 Sep 9;152(4):512-516. doi: 10.1093/ajcp/aqz064. PMID: 31184706
Pulmonary metastasis 12 years after resection of thymoma with microscopic capsule invasion.
Nomori H, Watanabe K, Ohtsuka T, Naruke T, Suemasu K, Orikasa H, Yamazaki K
Jpn J Clin Oncol 2004 Oct;34(10):630-3. doi: 10.1093/jjco/hyh105. PMID: 15591463
Multiple thymoma with myotonic dystrophy.
Hirai T, Yamanaka A, Fujimoto T, Takahashi A, Takayama Y, Yamanaka K
Jpn J Thorac Cardiovasc Surg 2001 Jul;49(7):457-60. doi: 10.1007/BF02913913. PMID: 11517583
Flow cytometric analysis of lymphoid cells in thymic epithelial neoplasms.
Nakajima J, Takamoto S, Oka T, Tanaka M, Takeuchi E, Murakawa T
Eur J Cardiothorac Surg 2000 Sep;18(3):287-92. doi: 10.1016/s1010-7940(00)00523-6. PMID: 10973537
Morphological imaging of thymic disorders.
Camera L, Brunetti A, Romano M, Larobina M, Marano I, Salvatore M
Ann Med 1999 Oct;31 Suppl 2:57-62. PMID: 10574157

Therapy

Pleural "drop metastases" 21 years after resection of a thymoma.
Chiang CC, Parsons AM, Kriegshauser JS, Paripati HR, Zarka MA, Leis AA
Muscle Nerve 2017 Jul;56(1):171-175. Epub 2017 Jan 4 doi: 10.1002/mus.25479. PMID: 27862032
Seeding of stage I thymoma into the chest wall 12 years after needle biopsy.
Kattach H, Hasan S, Clelland C, Pillai R
Ann Thorac Surg 2005 Jan;79(1):323-4. doi: 10.1016/j.athoracsur.2003.08.004. PMID: 15620969
Pulmonary metastasis 12 years after resection of thymoma with microscopic capsule invasion.
Nomori H, Watanabe K, Ohtsuka T, Naruke T, Suemasu K, Orikasa H, Yamazaki K
Jpn J Clin Oncol 2004 Oct;34(10):630-3. doi: 10.1093/jjco/hyh105. PMID: 15591463
Clinical-pathologic conference: cutaneous paraneoplastic pemphigus associated with benign encapsulated thymoma.
Hartz RS, Daroca PJ
J Thorac Cardiovasc Surg 2003 Feb;125(2):400-6. doi: 10.1067/mtc.2003.60. PMID: 12579111
Pure red cell aplasia following irradiation of an asymptomatic thymoma.
Shibata K, Masaoka A, Mizuno T, Ichimura H
Jpn J Surg 1982;12(6):419-23. doi: 10.1007/BF02469831. PMID: 7166912

Prognosis

Pleural "drop metastases" 21 years after resection of a thymoma.
Chiang CC, Parsons AM, Kriegshauser JS, Paripati HR, Zarka MA, Leis AA
Muscle Nerve 2017 Jul;56(1):171-175. Epub 2017 Jan 4 doi: 10.1002/mus.25479. PMID: 27862032
Diffuse panbronchiolitis complicated with thymoma: a report of 2 cases with literature review.
Xie G, Li L, Liu H, Xu K, Zhu Y
Chin Med J (Engl) 2003 Nov;116(11):1723-7. PMID: 14642145
Systemic lupus erythematosus and thymoma--a double-edged sword.
Zandman-Goddard G, Lorber M, Shoenfeld Y
Int Arch Allergy Immunol 1995 Sep;108(1):99-102. doi: 10.1159/000237125. PMID: 7647592
Thymoma: radiologic-pathologic correlation.
Rosado-de-Christenson ML, Galobardes J, Moran CA
Radiographics 1992 Jan;12(1):151-68. doi: 10.1148/radiographics.12.1.1734461. PMID: 1734461
Thymomas and thymic carcinomas.
Walker AN, Mills SE, Fechner RE
Semin Diagn Pathol 1990 Nov;7(4):250-65. PMID: 2284513

Clinical prediction guides

The role of a pseudocapsula in thymic epithelial tumors: outcome and correlation with established prognostic parameters. Results of a 20-year single centre retrospective analysis.
Dango S, Passlick B, Thiemann U, Kayser G, Stremmel C
J Cardiothorac Surg 2009 Jul 15;4:33. doi: 10.1186/1749-8090-4-33. PMID: 19604398Free PMC Article
Results from surgical treatment for thymoma. 43 years of experience.
Murakawa T, Nakajima J, Kohno T, Tanaka M, Matsumoto J, Takeuchi E, Takamoto S
Jpn J Thorac Cardiovasc Surg 2000 Feb;48(2):89-95. doi: 10.1007/BF03218097. PMID: 10769987
Primary thymic epithelial neoplasms showing combined features of thymoma and thymic carcinoma. A clinicopathologic study of 22 cases.
Suster S, Moran CA
Am J Surg Pathol 1996 Dec;20(12):1469-80. doi: 10.1097/00000478-199612000-00006. PMID: 8944040

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