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Childhood Chronic Myelogenous Leukemia, BCR-ABL1 Positive

MedGen UID:
233004
•Concept ID:
C1327920
•
Neoplastic Process
Synonyms: Childhood Chronic Myelogenous Leukemia; Childhood Chronic Myelogenous Leukemia, BCR::ABL1 Positive; Childhood Chronic Myeloid Leukemia; Childhood CML

Definition

A chronic myelogenous leukemia occurring during childhood. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChildhood Chronic Myelogenous Leukemia, BCR-ABL1 Positive

Professional guidelines

PubMed

Current childhood chronic myeloid leukemia management under tyrosine kinase inhibitor treatment.
Karadaş N, Göktepe ŞŞÖ, Baş İ, Ece D, Özdemir HH, Balkan C, Kavaklı K, Aydinok Y, Karapinar DY
Int J Hematol 2023 Mar;117(3):446-455. Epub 2022 Nov 19 doi: 10.1007/s12185-022-03497-4. PMID: 36401784
Optimal management for pediatric chronic myeloid leukemia.
Tanizawa A
Pediatr Int 2016 Mar;58(3):171-179. doi: 10.1111/ped.12876. PMID: 26646444
Management of chronic myeloid leukemia in childhood.
Suttorp M, Eckardt L, Tauer JT, Millot F
Curr Hematol Malig Rep 2012 Jun;7(2):116-24. doi: 10.1007/s11899-012-0113-6. PMID: 22395816

Recent clinical studies

Etiology

Chronic Myeloid Leukemia in Children and Adolescents.
Gotesman M, Raheel S, Panosyan EH
Adv Pediatr 2023 Aug;70(1):145-155. Epub 2023 May 12 doi: 10.1016/j.yapd.2023.04.002. PMID: 37422292
Current childhood chronic myeloid leukemia management under tyrosine kinase inhibitor treatment.
Karadaş N, Göktepe ŞŞÖ, Baş İ, Ece D, Özdemir HH, Balkan C, Kavaklı K, Aydinok Y, Karapinar DY
Int J Hematol 2023 Mar;117(3):446-455. Epub 2022 Nov 19 doi: 10.1007/s12185-022-03497-4. PMID: 36401784
Minimal residual disease in BCR::ABL1-positive acute lymphoblastic leukemia: different significance in typical ALL and in CML-like disease.
Zuna J, Hovorkova L, Krotka J, Koehrmann A, Bardini M, Winkowska L, Fronkova E, Alten J, Koehler R, Eckert C, Brizzolara L, Trkova M, Stuchly J, Zimmermann M, De Lorenzo P, Valsecchi MG, Conter V, Stary J, Schrappe M, Biondi A, Trka J, Zaliova M, Cazzaniga G, Cario G
Leukemia 2022 Dec;36(12):2793-2801. Epub 2022 Aug 6 doi: 10.1038/s41375-022-01668-0. PMID: 35933523
Distribution and frequency of tyrosine kinase inhibitor-associated long-term complications in children with chronic myeloid leukemia.
Dong EE, Bruno MA, Kim JJ, Bernhardt MB, Brown AL, Gramatges MM
Pediatr Blood Cancer 2022 Sep;69(9):e29786. Epub 2022 May 20 doi: 10.1002/pbc.29786. PMID: 35593027
Ponatinib in childhood Philadelphia chromosome-positive leukaemias: an international registry of childhood chronic myeloid leukaemia study.
Millot F, Suttorp M, Versluys AB, Kalwak K, Nelken B, Ducassou S, Bertrand Y, Baruchel A
Eur J Cancer 2020 Sep;136:107-112. Epub 2020 Jul 12 doi: 10.1016/j.ejca.2020.05.020. PMID: 32668374

Diagnosis

Chronic Myeloid Leukemia in Children and Adolescents.
Gotesman M, Raheel S, Panosyan EH
Adv Pediatr 2023 Aug;70(1):145-155. Epub 2023 May 12 doi: 10.1016/j.yapd.2023.04.002. PMID: 37422292
Minimal residual disease in BCR::ABL1-positive acute lymphoblastic leukemia: different significance in typical ALL and in CML-like disease.
Zuna J, Hovorkova L, Krotka J, Koehrmann A, Bardini M, Winkowska L, Fronkova E, Alten J, Koehler R, Eckert C, Brizzolara L, Trkova M, Stuchly J, Zimmermann M, De Lorenzo P, Valsecchi MG, Conter V, Stary J, Schrappe M, Biondi A, Trka J, Zaliova M, Cazzaniga G, Cario G
Leukemia 2022 Dec;36(12):2793-2801. Epub 2022 Aug 6 doi: 10.1038/s41375-022-01668-0. PMID: 35933523
Chronic Myelogenous Leukemia in Childhood.
Smith SM, Hijiya N, Sakamoto KM
Curr Oncol Rep 2021 Mar 14;23(4):40. doi: 10.1007/s11912-021-01025-x. PMID: 33718985
Progress and Prospects in Pediatric Leukemia.
Madhusoodhan PP, Carroll WL, Bhatla T
Curr Probl Pediatr Adolesc Health Care 2016 Jul;46(7):229-241. Epub 2016 Jun 6 doi: 10.1016/j.cppeds.2016.04.003. PMID: 27283082
Genes and childhood leukemia.
Kęsy J, Januszkiewicz-Lewandowska D
Postepy Hig Med Dosw (Online) 2015 Mar 5;69:302-8. doi: 10.5604/17322693.1142719. PMID: 25748621

Therapy

Chronic Myeloid Leukemia in Children and Adolescents.
Gotesman M, Raheel S, Panosyan EH
Adv Pediatr 2023 Aug;70(1):145-155. Epub 2023 May 12 doi: 10.1016/j.yapd.2023.04.002. PMID: 37422292
Chronic Myelogenous Leukemia in Childhood.
Smith SM, Hijiya N, Sakamoto KM
Curr Oncol Rep 2021 Mar 14;23(4):40. doi: 10.1007/s11912-021-01025-x. PMID: 33718985
Progress and Prospects in Pediatric Leukemia.
Madhusoodhan PP, Carroll WL, Bhatla T
Curr Probl Pediatr Adolesc Health Care 2016 Jul;46(7):229-241. Epub 2016 Jun 6 doi: 10.1016/j.cppeds.2016.04.003. PMID: 27283082
Management of chronic myeloid leukemia in childhood.
Suttorp M, Eckardt L, Tauer JT, Millot F
Curr Hematol Malig Rep 2012 Jun;7(2):116-24. doi: 10.1007/s11899-012-0113-6. PMID: 22395816
Juvenile chronic myelogenous leukemia.
Freedman MH, Estrov Z, Chan HS
Am J Pediatr Hematol Oncol 1988 Fall;10(3):261-7. doi: 10.1097/00043426-198823000-00016. PMID: 3052147

Prognosis

Minimal residual disease in BCR::ABL1-positive acute lymphoblastic leukemia: different significance in typical ALL and in CML-like disease.
Zuna J, Hovorkova L, Krotka J, Koehrmann A, Bardini M, Winkowska L, Fronkova E, Alten J, Koehler R, Eckert C, Brizzolara L, Trkova M, Stuchly J, Zimmermann M, De Lorenzo P, Valsecchi MG, Conter V, Stary J, Schrappe M, Biondi A, Trka J, Zaliova M, Cazzaniga G, Cario G
Leukemia 2022 Dec;36(12):2793-2801. Epub 2022 Aug 6 doi: 10.1038/s41375-022-01668-0. PMID: 35933523
Progress and Prospects in Pediatric Leukemia.
Madhusoodhan PP, Carroll WL, Bhatla T
Curr Probl Pediatr Adolesc Health Care 2016 Jul;46(7):229-241. Epub 2016 Jun 6 doi: 10.1016/j.cppeds.2016.04.003. PMID: 27283082
Genes and childhood leukemia.
Kęsy J, Januszkiewicz-Lewandowska D
Postepy Hig Med Dosw (Online) 2015 Mar 5;69:302-8. doi: 10.5604/17322693.1142719. PMID: 25748621
Childhood myeloproliferative disorders.
Cotter FE
Baillieres Clin Haematol 1998 Dec;11(4):875-98. doi: 10.1016/s0950-3536(98)80044-9. PMID: 10640222
Acute leukemia in children.
Gaynon PS
Curr Opin Hematol 1995 Jul;2(4):240-6. doi: 10.1097/00062752-199502040-00002. PMID: 9372003

Clinical prediction guides

Minimal residual disease in BCR::ABL1-positive acute lymphoblastic leukemia: different significance in typical ALL and in CML-like disease.
Zuna J, Hovorkova L, Krotka J, Koehrmann A, Bardini M, Winkowska L, Fronkova E, Alten J, Koehler R, Eckert C, Brizzolara L, Trkova M, Stuchly J, Zimmermann M, De Lorenzo P, Valsecchi MG, Conter V, Stary J, Schrappe M, Biondi A, Trka J, Zaliova M, Cazzaniga G, Cario G
Leukemia 2022 Dec;36(12):2793-2801. Epub 2022 Aug 6 doi: 10.1038/s41375-022-01668-0. PMID: 35933523
Ponatinib in childhood Philadelphia chromosome-positive leukaemias: an international registry of childhood chronic myeloid leukaemia study.
Millot F, Suttorp M, Versluys AB, Kalwak K, Nelken B, Ducassou S, Bertrand Y, Baruchel A
Eur J Cancer 2020 Sep;136:107-112. Epub 2020 Jul 12 doi: 10.1016/j.ejca.2020.05.020. PMID: 32668374
Emerging translational science discoveries, clonal approaches, and treatment trends in chronic myeloproliferative neoplasms.
Mughal TI, Pemmaraju N, Radich JP, Deininger MW, Kucine N, Kiladjian JJ, Bose P, Gotlib J, Valent P, Chen CC, Barbui T, Rampal R, Verstovsek S, Koschmieder S, Saglio G, Van Etten RA
Hematol Oncol 2019 Aug;37(3):240-252. Epub 2019 Jun 20 doi: 10.1002/hon.2622. PMID: 31013548
Monitoring of childhood ALL using BCR-ABL1 genomic breakpoints identifies a subgroup with CML-like biology.
Hovorkova L, Zaliova M, Venn NC, Bleckmann K, Trkova M, Potuckova E, Vaskova M, Linhartova J, Machova Polakova K, Fronkova E, Muskovic W, Giles JE, Shaw PJ, Cario G, Sutton R, Stary J, Trka J, Zuna J
Blood 2017 May 18;129(20):2771-2781. Epub 2017 Mar 22 doi: 10.1182/blood-2016-11-749978. PMID: 28331056
Acute leukemia in children.
Gaynon PS
Curr Opin Hematol 1995 Jul;2(4):240-6. doi: 10.1097/00062752-199502040-00002. PMID: 9372003

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