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Malignant Submandibular Gland Mixed Tumor

MedGen UID:
233160
•Concept ID:
C1334622
•
Neoplastic Process
Synonyms: Malignant Mixed Neoplasm of Submandibular Gland; Malignant Mixed Neoplasm of the Submandibular Gland; Malignant Mixed Tumor of Submandibular Gland; Malignant Mixed Tumor of the Submandibular Gland; Malignant Submandibular Gland Mixed Neoplasm

Definition

A malignant tumor arising from the submandibular gland. It includes carcinoma ex pleomorphic adenoma, a malignant epithelial tumor arising from a pre-existing pleomorphic adenoma and carcinosarcoma which is characterized by a mixture of malignant epithelial and sarcomatous elements. [from NCI]

Professional guidelines

PubMed

Pediatric primary salivary gland tumors.
Jesberg P, Monzon A, Gitomer SA, Herrmann BW
Am J Otolaryngol 2023 Sep-Oct;44(5):103948. Epub 2023 Jun 8 doi: 10.1016/j.amjoto.2023.103948. PMID: 37352681
Management of malignant submandibular gland tumors: A 30-year experience from a single center.
Luksic I, Mamic M, Suton P
Oral Surg Oral Med Oral Pathol Oral Radiol 2022 Sep;134(3):302-309. Epub 2022 Feb 4 doi: 10.1016/j.oooo.2022.01.023. PMID: 35428601
Clinical Utility of Qualitative Elastography Using Acoustic Radiation Force Impulse for Differentiating Benign from Malignant Salivary Gland Tumors.
Matsuda E, Fukuhara T, Donishi R, Taira K, Koyama S, Morisaki T, Fujiwara K, Takeuchi H
Ultrasound Med Biol 2021 Feb;47(2):279-287. Epub 2020 Nov 12 doi: 10.1016/j.ultrasmedbio.2020.10.007. PMID: 33189412

Recent clinical studies

Etiology

Pediatric primary salivary gland tumors.
Jesberg P, Monzon A, Gitomer SA, Herrmann BW
Am J Otolaryngol 2023 Sep-Oct;44(5):103948. Epub 2023 Jun 8 doi: 10.1016/j.amjoto.2023.103948. PMID: 37352681
Functional gland-preserving surgery for submandibular gland pleomorphic adenoma.
Roh JL
J Cancer Res Clin Oncol 2022 Oct;148(10):2623-2629. Epub 2021 Oct 27 doi: 10.1007/s00432-021-03844-8. PMID: 34705103
Histopathological comparison of pleomorphic adenomas of the parotid and submandibular gland.
Mantsopoulos K, Sievert M, Iro AK, Müller SK, Koch M, Schapher M, Agaimy A, Iro H
Oral Dis 2022 May;28(4):1131-1136. Epub 2021 Apr 5 doi: 10.1111/odi.13858. PMID: 33772981
The recurrent pleomorphic adenoma conundrum.
Bradley PJ
Curr Opin Otolaryngol Head Neck Surg 2018 Apr;26(2):134-141. doi: 10.1097/MOO.0000000000000435. PMID: 29278551
Imaging of salivary gland tumours.
Lee YY, Wong KT, King AD, Ahuja AT
Eur J Radiol 2008 Jun;66(3):419-36. Epub 2008 Mar 11 doi: 10.1016/j.ejrad.2008.01.027. PMID: 18337041

Diagnosis

Controversies in Oral and Maxillofacial Oncology.
Ettinger KS, Yetzer JG
Oral Maxillofac Surg Clin North Am 2017 Nov;29(4):487-501. doi: 10.1016/j.coms.2017.07.004. PMID: 28987229
Submandibular triangle masses.
Dalgic A, Karakoc O, Karahatay S, Hidir Y, Gamsizkan M, Birkent H, Gerek M
J Craniofac Surg 2013;24(5):e529-31. doi: 10.1097/SCS.0b013e3182a238f9. PMID: 24036836Free PMC Article
Imaging of salivary gland tumours.
Lee YY, Wong KT, King AD, Ahuja AT
Eur J Radiol 2008 Jun;66(3):419-36. Epub 2008 Mar 11 doi: 10.1016/j.ejrad.2008.01.027. PMID: 18337041
Salivary glands.
Silvers AR, Som PM
Radiol Clin North Am 1998 Sep;36(5):941-66, vi. doi: 10.1016/s0033-8389(05)70070-1. PMID: 9747195
Salivary glands.
Saunders JR Jr, Hirata RM, Jaques DA
Surg Clin North Am 1986 Feb;66(1):59-81. doi: 10.1016/s0039-6109(16)43829-6. PMID: 3003940

Therapy

Patterns of Care and Outcomes of Carcinosarcoma of the Major Salivary Glands.
Talwar A, Patel E, Tam M, Zhou F, Hu K, Persky M, Vaezi A, Jacobson A, Givi B
Otolaryngol Head Neck Surg 2023 Apr;168(4):775-781. Epub 2023 Jan 29 doi: 10.1177/01945998221120646. PMID: 35998038
Hsp27 and Hsp60 in human submandibular salivary gland: Quantitative patterns in healthy and cancerous tissues with potential implications for differential diagnosis and carcinogenesis.
Basset CA, Rappa F, Lentini VL, Barone R, Pitruzzella A, Unti E, Cappello F, Conway de Macario E, Macario AJL, Leone A
Acta Histochem 2021 Sep;123(6):151771. Epub 2021 Aug 19 doi: 10.1016/j.acthis.2021.151771. PMID: 34419757
Robot-assisted versus endoscopic submandibular gland resection via retroauricular approach: a prospective nonrandomized study.
Lee HS, Kim D, Lee SY, Byeon HK, Kim WS, Hong HJ, Koh YW, Choi EC
Br J Oral Maxillofac Surg 2014 Feb;52(2):179-84. Epub 2013 Dec 17 doi: 10.1016/j.bjoms.2013.11.002. PMID: 24360715
Endoscope assisted submandibular sialadenectomy: the face-lift approach.
Kim HS, Chung SM, Pae SY, Park HS
Eur Arch Otorhinolaryngol 2011 Apr;268(4):619-22. Epub 2010 Oct 5 doi: 10.1007/s00405-010-1392-y. PMID: 20922402
First insights into the molecular basis of pleomorphic adenomas of the salivary glands.
Voz ML, Van de Ven WJ, Kas K
Adv Dent Res 2000 Dec;14:81-3. doi: 10.1177/08959374000140011301. PMID: 11842929

Prognosis

Is the neutrophil-to-lymphocyte ratio a marker for differentiating between benign and malignant submandibular gland masses?
Bora A
Rev Assoc Med Bras (1992) 2023;69(11):e20230738. Epub 2023 Oct 27 doi: 10.1590/1806-9282.20230738. PMID: 37909621Free PMC Article
The recurrent pleomorphic adenoma conundrum.
Bradley PJ
Curr Opin Otolaryngol Head Neck Surg 2018 Apr;26(2):134-141. doi: 10.1097/MOO.0000000000000435. PMID: 29278551
Preoperative evaluation and surgical planning of submandibular gland tumors.
Atula T, Panigrahi J, Tarkkanen J, Mäkitie A, Aro K
Head Neck 2017 Jun;39(6):1071-1077. Epub 2017 Mar 28 doi: 10.1002/hed.24691. PMID: 28370782
Pediatric trans-oral submandibular gland excision: A safe and effective technique.
Hughes CA, Brown J
Int J Pediatr Otorhinolaryngol 2017 Feb;93:13-16. Epub 2016 Dec 1 doi: 10.1016/j.ijporl.2016.11.026. PMID: 28109484
Malignant mixed tumors arising in salivary glands. I. Carcinomas arising in benign mixed tumors: a clinicopathologic study.
LiVolsi VA, Perzin KH
Cancer 1977 May;39(5):2209-30. doi: 10.1002/1097-0142(197705)39:5<2209::aid-cncr2820390540>3.0.co;2-8. PMID: 192443

Clinical prediction guides

Is the neutrophil-to-lymphocyte ratio a marker for differentiating between benign and malignant submandibular gland masses?
Bora A
Rev Assoc Med Bras (1992) 2023;69(11):e20230738. Epub 2023 Oct 27 doi: 10.1590/1806-9282.20230738. PMID: 37909621Free PMC Article
Pediatric primary salivary gland tumors.
Jesberg P, Monzon A, Gitomer SA, Herrmann BW
Am J Otolaryngol 2023 Sep-Oct;44(5):103948. Epub 2023 Jun 8 doi: 10.1016/j.amjoto.2023.103948. PMID: 37352681
Histopathological comparison of pleomorphic adenomas of the parotid and submandibular gland.
Mantsopoulos K, Sievert M, Iro AK, Müller SK, Koch M, Schapher M, Agaimy A, Iro H
Oral Dis 2022 May;28(4):1131-1136. Epub 2021 Apr 5 doi: 10.1111/odi.13858. PMID: 33772981
Submandibular gland pleomorphic adenoma: Histopathological capsular characteristics and correlation with the surgical outcome.
Mantsopoulos K, Goncalves M, Koch M, Iro H, Agaimy A
Ann Diagn Pathol 2018 Jun;34:166-169. Epub 2018 Apr 18 doi: 10.1016/j.anndiagpath.2018.04.002. PMID: 29689463
Modified submandibular sialoadenectomy.
Hussain A, Murray DP
Ear Nose Throat J 2004 Nov;83(11):768, 770-1. PMID: 15628634

Recent systematic reviews

Intraductal carcinomas of the salivary glands: systematic review and classification of 93 published cases.
Palicelli A
APMIS 2020 Mar;128(3):191-200. Epub 2020 Jan 3 doi: 10.1111/apm.13009. PMID: 31697865

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