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Metastatic Carcinoid Tumor

MedGen UID:
233180
•Concept ID:
C1334715
•
Neoplastic Process
Synonym: Metastatic carcinoid tumor
SNOMED CT: Metastatic carcinoid tumor (705176003); Metastatic carcinoid tumor (1269232001)

Definition

A carcinoid tumor that has extended beyond its original site of growth to other anatomic sites. [from NCI]

Professional guidelines

PubMed

Results of liver transplantation in the treatment of metastatic neuroendocrine tumors. A 31-case French multicentric report.
Le Treut YP, Delpero JR, Dousset B, Cherqui D, Segol P, Mantion G, Hannoun L, Benhamou G, Launois B, Boillot O, Domergue J, Bismuth H
Ann Surg 1997 Apr;225(4):355-64. doi: 10.1097/00000658-199704000-00003. PMID: 9114793Free PMC Article
Evaluation of combined cyclophosphamide and methotrexate therapy in the treatment of metastatic carcinoid tumor and the malignant carcinoid syndrome.
Moertel CG, O'Connell MJ, Reitemeier RJ, Rubin J
Cancer Treat Rep 1984 Apr;68(4):665-7. PMID: 6201271
Treatment of metastatic carcinoid tumor with dactinomycin or dacarbazine.
van Hazel GA, Rubin J, Moertel CG
Cancer Treat Rep 1983 Jun;67(6):583-5. PMID: 6861165

Recent clinical studies

Etiology

Sclerosing Mesenteritis: A Concise Clinical Review for Clinicians.
Saha B, Tome J, Wang XJ
Mayo Clin Proc 2024 May;99(5):812-820. doi: 10.1016/j.mayocp.2024.01.019. PMID: 38702129
Pre-operative endovascular occlusion for unresectable metastatic carcinoid tumor: technique and initial results.
Voutsinas N, Patel RS, Bishay VL, Ranade M, Nowakowski FS, Kim E, Fischman AM, Divino CM, Marin ML, Lookstein RA
Abdom Radiol (NY) 2020 Aug;45(8):2554-2560. doi: 10.1007/s00261-020-02534-2. PMID: 32318762
Metastatic carcinoid tumor: changing patterns of care over two decades.
Townsend A, Price T, Yeend S, Pittman K, Patterson K, Luke C
J Clin Gastroenterol 2010 Mar;44(3):195-9. doi: 10.1097/MCG.0b013e3181a9f10a. PMID: 19609217
Metastatic carcinoid tumor to the ovary: a clinicopathologic analysis of seventeen cases.
Strosberg J, Nasir A, Cragun J, Gardner N, Kvols L
Gynecol Oncol 2007 Jul;106(1):65-8. Epub 2007 May 1 doi: 10.1016/j.ygyno.2007.02.034. PMID: 17475313
Metastatic carcinoid tumor to the heart: echocardiographic-pathologic study of 11 patients.
Pandya UH, Pellikka PA, Enriquez-Sarano M, Edwards WD, Schaff HV, Connolly HM
J Am Coll Cardiol 2002 Oct 2;40(7):1328-32. doi: 10.1016/s0735-1097(02)02109-5. PMID: 12383582

Diagnosis

Sclerosing Mesenteritis: A Concise Clinical Review for Clinicians.
Saha B, Tome J, Wang XJ
Mayo Clin Proc 2024 May;99(5):812-820. doi: 10.1016/j.mayocp.2024.01.019. PMID: 38702129
Molecular biology of carcinoid heart disease: Seeking therapeutic targets in the era of targeted therapy.
Khan SA, Devkota D, Chaudhary RK, Luitel A, Parajuli SB, Bista M, Rayamajhi A
Medicine (Baltimore) 2023 Nov 24;102(47):e36043. doi: 10.1097/MD.0000000000036043. PMID: 38013349Free PMC Article
Multiomic sequencing of paired primary and metastatic small bowel carcinoids.
Postel MD, Darabi S, Howe JR, Liang WS, Craig DW, Demeure MJ
F1000Res 2023;12:417. Epub 2023 Oct 4 doi: 10.12688/f1000research.130251.2. PMID: 37954063Free PMC Article
A Case of Primary Insular Ovarian Carcinoid Tumor with Hyperandrogenism and Carcinoid Heart Disease.
Mansour S, Anaka MR, Al-Agha R
Am J Case Rep 2022 Oct 1;23:e937403. doi: 10.12659/AJCR.937403. PMID: 36181247Free PMC Article
Carcinoid tumors of the urinary tract and prostate.
Murali R, Kneale K, Lalak N, Delprado W
Arch Pathol Lab Med 2006 Nov;130(11):1693-706. doi: 10.5858/2006-130-1693-CTOTUT. PMID: 17076534

Therapy

Sclerosing Mesenteritis: A Concise Clinical Review for Clinicians.
Saha B, Tome J, Wang XJ
Mayo Clin Proc 2024 May;99(5):812-820. doi: 10.1016/j.mayocp.2024.01.019. PMID: 38702129
Metastatic carcinoid tumor--atypical presentation.
Pleşa A, Sarca E, Maxim R
Rev Med Chir Soc Med Nat Iasi 2014 Oct-Dec;118(4):1018-23. PMID: 25581963
Metastatic carcinoid tumor: changing patterns of care over two decades.
Townsend A, Price T, Yeend S, Pittman K, Patterson K, Luke C
J Clin Gastroenterol 2010 Mar;44(3):195-9. doi: 10.1097/MCG.0b013e3181a9f10a. PMID: 19609217
Therapy of metastatic carcinoid tumor and the malignant carcinoid syndrome with recombinant leukocyte A interferon.
Moertel CG, Rubin J, Kvols LK
J Clin Oncol 1989 Jul;7(7):865-8. doi: 10.1200/JCO.1989.7.7.865. PMID: 2738623
Combination chemotherapy trials in metastatic carcinoid tumor and the malignant carcinoid syndrome.
Moertel CG, Hanley JA
Cancer Clin Trials 1979 Winter;2(4):327-34. PMID: 93982

Prognosis

Sclerosing Mesenteritis: A Concise Clinical Review for Clinicians.
Saha B, Tome J, Wang XJ
Mayo Clin Proc 2024 May;99(5):812-820. doi: 10.1016/j.mayocp.2024.01.019. PMID: 38702129
Multiomic sequencing of paired primary and metastatic small bowel carcinoids.
Postel MD, Darabi S, Howe JR, Liang WS, Craig DW, Demeure MJ
F1000Res 2023;12:417. Epub 2023 Oct 4 doi: 10.12688/f1000research.130251.2. PMID: 37954063Free PMC Article
Ki67 Proliferative Index in Carcinoid Tumors Involving Ovary.
Zhang X, Jones A, Jenkins SM, Huang Y
Endocr Pathol 2018 Mar;29(1):43-48. doi: 10.1007/s12022-017-9510-7. PMID: 29349725
Metastatic carcinoid tumor: changing patterns of care over two decades.
Townsend A, Price T, Yeend S, Pittman K, Patterson K, Luke C
J Clin Gastroenterol 2010 Mar;44(3):195-9. doi: 10.1097/MCG.0b013e3181a9f10a. PMID: 19609217
Metastatic carcinoid tumor to the orbit and brain.
Nida TY, Hall WA, Glantz MJ, Clark HB
Neurosurgery 1992 Nov;31(5):949-52; discussion 952. doi: 10.1227/00006123-199211000-00020. PMID: 1436423

Clinical prediction guides

Multiomic sequencing of paired primary and metastatic small bowel carcinoids.
Postel MD, Darabi S, Howe JR, Liang WS, Craig DW, Demeure MJ
F1000Res 2023;12:417. Epub 2023 Oct 4 doi: 10.12688/f1000research.130251.2. PMID: 37954063Free PMC Article
LONG-TERM OBSERVATION OF MULTIFOCAL METASTATIC INTRAOCULAR CARCINOID WITH ACQUIRED IRIS HETEROCHROMIA.
Wolkow N, Jakobiec FA, Gragoudas ES
Retin Cases Brief Rep 2020 Summer;14(3):265-267. doi: 10.1097/ICB.0000000000000690. PMID: 29251664
Ki67 Proliferative Index in Carcinoid Tumors Involving Ovary.
Zhang X, Jones A, Jenkins SM, Huang Y
Endocr Pathol 2018 Mar;29(1):43-48. doi: 10.1007/s12022-017-9510-7. PMID: 29349725
Is the treatment of metastatic carcinoid tumor with interferon not as successful as suggested?
Välimäki M, Järvinen H, Salmela P, Sane T, Sjöblom SM, Pelkonen R
Cancer 1991 Feb 1;67(3):547-9. doi: 10.1002/1097-0142(19910201)67:3<547::aid-cncr2820670302>3.0.co;2-j. PMID: 1702352
Combination chemotherapy trials in metastatic carcinoid tumor and the malignant carcinoid syndrome.
Moertel CG, Hanley JA
Cancer Clin Trials 1979 Winter;2(4):327-34. PMID: 93982

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