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Non-invasive bladder urothelial carcinoma

MedGen UID:
233466
•Concept ID:
C1336089
•
Neoplastic Process
Synonyms: Non-Invasive Bladder Urothelial Carcinoma; non-invasive bladder urothelial carcinoma; stage 0 bladder urothelial cancer; Stage 0 Bladder Urothelial Carcinoma; stage 0 bladder urothelial carcinoma; stage 0 bladder urothelial carcinoma aJCC v6; Stage 0 Bladder Urothelial Carcinoma AJCC v6 and v7; stage 0 bladder urothelial carcinoma aJCC v6 and v7; Stage 0 Bladder Urothelial Carcinoma AJCC v7; stage 0 bladder urothelial carcinoma aJCC v7; Stage 0 Transitional Cell Carcinoma of Bladder; stage 0 transitional cell carcinoma of bladder; Stage 0 Transitional Cell Carcinoma of the Bladder; stage 0 transitional cell carcinoma of the bladder; Stage 0 Transitional Cell Carcinoma of the Urinary Bladder; stage 0 transitional cell carcinoma of the urinary bladder; Stage 0 Transitional Cell Carcinoma of Urinary Bladder; stage 0 transitional cell carcinoma of urinary bladder; Stage 0 Urinary Bladder Transitional Cell Carcinoma; stage 0 urinary bladder transitional cell carcinoma
 
Monarch Initiative: MONDO:0003930

Definition

Stage 0 includes: 0a (Ta, N0, M0); 0is (Tis, N0, M0). Ta: Noninvasive papillary carcinoma. Tis: Carcinoma in situ: ""flat tumor"". N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.) [from NCI]

Professional guidelines

PubMed

Bladder Cancer Diagnosis and Follow-Up: The Current Status and Possible Role of Extracellular Vesicles.
Oeyen E, Hoekx L, De Wachter S, Baldewijns M, Ameye F, Mertens I
Int J Mol Sci 2019 Feb 14;20(4) doi: 10.3390/ijms20040821. PMID: 30769831Free PMC Article
Urethral recurrence after cystectomy: current preventative measures, diagnosis and management.
Chan Y, Fisher P, Tilki D, Evans CP
BJU Int 2016 Apr;117(4):563-9. Epub 2015 Dec 12 doi: 10.1111/bju.13370. PMID: 26556525
Stage pT1 bladder carcinoma: diagnostic criteria, pitfalls and prognostic significance.
Lopez-Beltran A, Cheng L
Pathology 2003 Dec;35(6):484-91. doi: 10.1080/00313020310001619127. PMID: 14660098

Recent clinical studies

Etiology

Plasma proteomic profiling discovers molecular features associated with upper tract urothelial carcinoma.
Qu Y, Yao Z, Xu N, Shi G, Su J, Ye S, Chang K, Li K, Wang Y, Tan S, Pei X, Chen Y, Qin Z, Feng J, Lv J, Zhu J, Ma F, Tang S, Xu W, Tian X, Anwaier A, Tian S, Xu W, Wu X, Zhu S, Zhu Y, Cao D, Sun M, Gan H, Zhao J, Zhang H, Ye D, Ding C
Cell Rep Med 2023 Sep 19;4(9):101166. Epub 2023 Aug 25 doi: 10.1016/j.xcrm.2023.101166. PMID: 37633276Free PMC Article
Heterogenous NECTIN4 expression in urothelial high-risk non-muscle-invasive bladder cancer.
Garczyk S, Degener S, Bischoff F, Schnitzler T, Salz A, Golz R, Buchner A, Schulz GB, Schneider U, Gaisa NT, Knüchel R
Virchows Arch 2022 Jul;481(1):83-92. Epub 2022 Apr 28 doi: 10.1007/s00428-022-03328-1. PMID: 35484425Free PMC Article
Validation of grading of non-invasive urothelial carcinoma by digital pathology for routine diagnosis.
Colling R, Colling H, Browning L, Verrill C
BMC Cancer 2021 Sep 6;21(1):995. doi: 10.1186/s12885-021-08698-4. PMID: 34488682Free PMC Article
Non-Muscle Invasive Bladder Cancer with Variant Histology: Biological Features and Clinical Implications.
Sanguedolce F, Calò B, Mancini V, Zanelli M, Palicelli A, Zizzo M, Ascani S, Carrieri G, Cormio L
Oncology 2021;99(6):345-358. Epub 2021 Mar 18 doi: 10.1159/000514759. PMID: 33735905
Precursor lesions of the urinary bladder.
McKenney JK
Histopathology 2019 Jan;74(1):68-76. doi: 10.1111/his.13762. PMID: 30565304

Diagnosis

Plasma proteomic profiling discovers molecular features associated with upper tract urothelial carcinoma.
Qu Y, Yao Z, Xu N, Shi G, Su J, Ye S, Chang K, Li K, Wang Y, Tan S, Pei X, Chen Y, Qin Z, Feng J, Lv J, Zhu J, Ma F, Tang S, Xu W, Tian X, Anwaier A, Tian S, Xu W, Wu X, Zhu S, Zhu Y, Cao D, Sun M, Gan H, Zhao J, Zhang H, Ye D, Ding C
Cell Rep Med 2023 Sep 19;4(9):101166. Epub 2023 Aug 25 doi: 10.1016/j.xcrm.2023.101166. PMID: 37633276Free PMC Article
Circulating and urinary tumour DNA in urothelial carcinoma - upper tract, lower tract and metastatic disease.
Rose KM, Huelster HL, Meeks JJ, Faltas BM, Sonpavde GP, Lerner SP, Ross JS, Spiess PE, Grass GD, Jain RK, Kamat AM, Vosoughi A, Wang L, Wang X, Li R
Nat Rev Urol 2023 Jul;20(7):406-419. Epub 2023 Mar 28 doi: 10.1038/s41585-023-00725-2. PMID: 36977797
News in the classification of WHO 2022 bladder tumors.
Raspollini MR, Comperat EM, Lopez-Beltran A, Montironi R, Cimadamore A, Tsuzuki T, Netto GJ
Pathologica 2022 Feb;115(1):32-40. Epub 2023 Jan 25 doi: 10.32074/1591-951X-838. PMID: 36704871Free PMC Article
Advances in bladder cancer biology and therapy.
Tran L, Xiao JF, Agarwal N, Duex JE, Theodorescu D
Nat Rev Cancer 2021 Feb;21(2):104-121. Epub 2020 Dec 2 doi: 10.1038/s41568-020-00313-1. PMID: 33268841Free PMC Article
The occult urothelial cancer.
Ragonese M, Racioppi M, D'Agostino D, Di Gianfrancesco L, Lenci N, Bientinesi R, Palermo G, Sacco E, Pinto F, Bassi PF
Urologia 2016 May 24;83(2):55-60. Epub 2016 Mar 14 doi: 10.5301/uro.5000131. PMID: 26481721

Therapy

5-year outcomes after stereotactic ablative body radiotherapy for primary renal cell carcinoma: an individual patient data meta-analysis from IROCK (the International Radiosurgery Consortium of the Kidney).
Siva S, Ali M, Correa RJM, Muacevic A, Ponsky L, Ellis RJ, Lo SS, Onishi H, Swaminath A, McLaughlin M, Morgan SC, Cury FL, Teh BS, Mahadevan A, Kaplan ID, Chu W, Grubb W, Hannan R, Staehler M, Warner A, Louie AV
Lancet Oncol 2022 Dec;23(12):1508-1516. Epub 2022 Nov 16 doi: 10.1016/S1470-2045(22)00656-8. PMID: 36400098
Advances in bladder cancer biology and therapy.
Tran L, Xiao JF, Agarwal N, Duex JE, Theodorescu D
Nat Rev Cancer 2021 Feb;21(2):104-121. Epub 2020 Dec 2 doi: 10.1038/s41568-020-00313-1. PMID: 33268841Free PMC Article
Toward clinical understanding of aristolochic acid upper-tract urothelial carcinoma.
Boot A, Jiang N, Rozen SG
Theranostics 2020;10(12):5578-5580. Epub 2020 Apr 21 doi: 10.7150/thno.46489. PMID: 32373232Free PMC Article
Can urinary biomarkers replace cystoscopy?
Maas M, Bedke J, Stenzl A, Todenhöfer T
World J Urol 2019 Sep;37(9):1741-1749. Epub 2018 Oct 3 doi: 10.1007/s00345-018-2505-2. PMID: 30283995
Bladder cancer.
Ozen H
Curr Opin Oncol 1999 May;11(3):207-12. doi: 10.1097/00001622-199905000-00013. PMID: 10328596

Prognosis

Plasma proteomic profiling discovers molecular features associated with upper tract urothelial carcinoma.
Qu Y, Yao Z, Xu N, Shi G, Su J, Ye S, Chang K, Li K, Wang Y, Tan S, Pei X, Chen Y, Qin Z, Feng J, Lv J, Zhu J, Ma F, Tang S, Xu W, Tian X, Anwaier A, Tian S, Xu W, Wu X, Zhu S, Zhu Y, Cao D, Sun M, Gan H, Zhao J, Zhang H, Ye D, Ding C
Cell Rep Med 2023 Sep 19;4(9):101166. Epub 2023 Aug 25 doi: 10.1016/j.xcrm.2023.101166. PMID: 37633276Free PMC Article
Circulating and urinary tumour DNA in urothelial carcinoma - upper tract, lower tract and metastatic disease.
Rose KM, Huelster HL, Meeks JJ, Faltas BM, Sonpavde GP, Lerner SP, Ross JS, Spiess PE, Grass GD, Jain RK, Kamat AM, Vosoughi A, Wang L, Wang X, Li R
Nat Rev Urol 2023 Jul;20(7):406-419. Epub 2023 Mar 28 doi: 10.1038/s41585-023-00725-2. PMID: 36977797
Non-Muscle Invasive Bladder Cancer with Variant Histology: Biological Features and Clinical Implications.
Sanguedolce F, Calò B, Mancini V, Zanelli M, Palicelli A, Zizzo M, Ascani S, Carrieri G, Cormio L
Oncology 2021;99(6):345-358. Epub 2021 Mar 18 doi: 10.1159/000514759. PMID: 33735905
Advances in bladder cancer biology and therapy.
Tran L, Xiao JF, Agarwal N, Duex JE, Theodorescu D
Nat Rev Cancer 2021 Feb;21(2):104-121. Epub 2020 Dec 2 doi: 10.1038/s41568-020-00313-1. PMID: 33268841Free PMC Article
Bladder cancer.
Ozen H
Curr Opin Oncol 1999 May;11(3):207-12. doi: 10.1097/00001622-199905000-00013. PMID: 10328596

Clinical prediction guides

Plasma proteomic profiling discovers molecular features associated with upper tract urothelial carcinoma.
Qu Y, Yao Z, Xu N, Shi G, Su J, Ye S, Chang K, Li K, Wang Y, Tan S, Pei X, Chen Y, Qin Z, Feng J, Lv J, Zhu J, Ma F, Tang S, Xu W, Tian X, Anwaier A, Tian S, Xu W, Wu X, Zhu S, Zhu Y, Cao D, Sun M, Gan H, Zhao J, Zhang H, Ye D, Ding C
Cell Rep Med 2023 Sep 19;4(9):101166. Epub 2023 Aug 25 doi: 10.1016/j.xcrm.2023.101166. PMID: 37633276Free PMC Article
Circulating and urinary tumour DNA in urothelial carcinoma - upper tract, lower tract and metastatic disease.
Rose KM, Huelster HL, Meeks JJ, Faltas BM, Sonpavde GP, Lerner SP, Ross JS, Spiess PE, Grass GD, Jain RK, Kamat AM, Vosoughi A, Wang L, Wang X, Li R
Nat Rev Urol 2023 Jul;20(7):406-419. Epub 2023 Mar 28 doi: 10.1038/s41585-023-00725-2. PMID: 36977797
Non-Muscle Invasive Bladder Cancer with Variant Histology: Biological Features and Clinical Implications.
Sanguedolce F, Calò B, Mancini V, Zanelli M, Palicelli A, Zizzo M, Ascani S, Carrieri G, Cormio L
Oncology 2021;99(6):345-358. Epub 2021 Mar 18 doi: 10.1159/000514759. PMID: 33735905
Advances in bladder cancer biology and therapy.
Tran L, Xiao JF, Agarwal N, Duex JE, Theodorescu D
Nat Rev Cancer 2021 Feb;21(2):104-121. Epub 2020 Dec 2 doi: 10.1038/s41568-020-00313-1. PMID: 33268841Free PMC Article
Bladder cancer.
Ozen H
Curr Opin Oncol 1999 May;11(3):207-12. doi: 10.1097/00001622-199905000-00013. PMID: 10328596

Recent systematic reviews

Urinary MicroRNAs as Biomarkers of Urological Cancers: A Systematic Review.
Aveta A, Cilio S, Contieri R, Spena G, Napolitano L, Manfredi C, Franco A, Crocerossa F, Cerrato C, Ferro M, Del Giudice F, Verze P, Lasorsa F, Salonia A, Nair R, Walz J, Lucarelli G, Pandolfo SD
Int J Mol Sci 2023 Jun 29;24(13) doi: 10.3390/ijms241310846. PMID: 37446024Free PMC Article
Diagnostic and prognostic roles of CK20 in the pathology of urothelial lesions. A systematic review.
Sanguedolce F, Russo D, Calò B, Cindolo L, Carrieri G, Cormio L
Pathol Res Pract 2019 Jun;215(6):152413. Epub 2019 Apr 6 doi: 10.1016/j.prp.2019.04.005. PMID: 30987832

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