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Intratubular Non-Seminoma

MedGen UID:
233470
•Concept ID:
C1336096
•
Neoplastic Process

Definition

Intratubular germ cell neoplasia characterized by the filling of the seminiferous tubules by non-seminomatous malignant germ cells. The non-seminomatous malignant germ cells are usually of embryonal carcinoma type. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIntratubular Non-Seminoma

Recent clinical studies

Etiology

Bilateral testicular germ cell tumors in patients treated for clinical stage I non-seminoma within two risk-adapted SWENOTECA protocols.
Tandstad T, Solberg A, Håkansson U, Stahl O, Haugnes HS, Oldenburg J, Dahl O, Kjellman A, Angelsen A, Cohn-Cedermark G; SWENOTECA
Acta Oncol 2015 Apr;54(4):493-9. Epub 2014 Sep 5 doi: 10.3109/0284186X.2014.953256. PMID: 25192551

Diagnosis

Bilateral testicular germ cell tumors in patients treated for clinical stage I non-seminoma within two risk-adapted SWENOTECA protocols.
Tandstad T, Solberg A, Håkansson U, Stahl O, Haugnes HS, Oldenburg J, Dahl O, Kjellman A, Angelsen A, Cohn-Cedermark G; SWENOTECA
Acta Oncol 2015 Apr;54(4):493-9. Epub 2014 Sep 5 doi: 10.3109/0284186X.2014.953256. PMID: 25192551
Involvement of E-cadherin and beta-catenin in germ cell tumours and in normal male fetal germ cell development.
Honecker F, Kersemaekers AM, Molier M, Van Weeren PC, Stoop H, De Krijger RR, Wolffenbuttel KP, Oosterhuis W, Bokemeyer C, Looijenga LH
J Pathol 2004 Oct;204(2):167-74. doi: 10.1002/path.1614. PMID: 15378486

Therapy

Bilateral testicular germ cell tumors in patients treated for clinical stage I non-seminoma within two risk-adapted SWENOTECA protocols.
Tandstad T, Solberg A, Håkansson U, Stahl O, Haugnes HS, Oldenburg J, Dahl O, Kjellman A, Angelsen A, Cohn-Cedermark G; SWENOTECA
Acta Oncol 2015 Apr;54(4):493-9. Epub 2014 Sep 5 doi: 10.3109/0284186X.2014.953256. PMID: 25192551

Prognosis

Bilateral testicular germ cell tumors in patients treated for clinical stage I non-seminoma within two risk-adapted SWENOTECA protocols.
Tandstad T, Solberg A, Håkansson U, Stahl O, Haugnes HS, Oldenburg J, Dahl O, Kjellman A, Angelsen A, Cohn-Cedermark G; SWENOTECA
Acta Oncol 2015 Apr;54(4):493-9. Epub 2014 Sep 5 doi: 10.3109/0284186X.2014.953256. PMID: 25192551
Involvement of E-cadherin and beta-catenin in germ cell tumours and in normal male fetal germ cell development.
Honecker F, Kersemaekers AM, Molier M, Van Weeren PC, Stoop H, De Krijger RR, Wolffenbuttel KP, Oosterhuis W, Bokemeyer C, Looijenga LH
J Pathol 2004 Oct;204(2):167-74. doi: 10.1002/path.1614. PMID: 15378486
Microinvasive germ cell tumour (MGCT) adjacent to testicular germ cell tumours.
von Eyben FE, Jacobsen GK, Rorth M, Von Der Maase H
Histopathology 2004 Jun;44(6):547-54. doi: 10.1111/j.1365-2559.2004.01889.x. PMID: 15186269

Clinical prediction guides

Involvement of E-cadherin and beta-catenin in germ cell tumours and in normal male fetal germ cell development.
Honecker F, Kersemaekers AM, Molier M, Van Weeren PC, Stoop H, De Krijger RR, Wolffenbuttel KP, Oosterhuis W, Bokemeyer C, Looijenga LH
J Pathol 2004 Oct;204(2):167-74. doi: 10.1002/path.1614. PMID: 15378486
Microinvasive germ cell tumour (MGCT) adjacent to testicular germ cell tumours.
von Eyben FE, Jacobsen GK, Rorth M, Von Der Maase H
Histopathology 2004 Jun;44(6):547-54. doi: 10.1111/j.1365-2559.2004.01889.x. PMID: 15186269

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