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Metastatic Bone Ewing Sarcoma

MedGen UID:
233698
•Concept ID:
C1334713
•
Neoplastic Process
Synonyms: Metastatic Bone Ewing's Sarcoma; Metastatic Ewing's Sarcoma of Bone; Metastatic Ewing's Sarcoma of the Bone; Metastatic Osseous Ewing's Sarcoma; Metastatic Skeletal Ewing's Sarcoma

Definition

An Ewing sarcoma of the bone which has spread from its original site of growth to another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Bone Ewing Sarcoma

Professional guidelines

PubMed

Treatment outcomes of extraskeletal Ewing sarcoma.
Houdek MT, Heidenreich MJ, Ahmed SK, Allen-Rhoades W, Siontis BL, Robinson SI, Petersen IA, Rose PS
J Surg Oncol 2023 Jul;128(1):105-110. Epub 2023 Mar 31 doi: 10.1002/jso.27250. PMID: 36999583
Ewing Sarcoma: Current Management and Future Approaches Through Collaboration.
Gaspar N, Hawkins DS, Dirksen U, Lewis IJ, Ferrari S, Le Deley MC, Kovar H, Grimer R, Whelan J, Claude L, Delattre O, Paulussen M, Picci P, Sundby Hall K, van den Berg H, Ladenstein R, Michon J, Hjorth L, Judson I, Luksch R, Bernstein ML, Marec-Bérard P, Brennan B, Craft AW, Womer RB, Juergens H, Oberlin O
J Clin Oncol 2015 Sep 20;33(27):3036-46. Epub 2015 Aug 24 doi: 10.1200/JCO.2014.59.5256. PMID: 26304893
Diagnosis and treatment of Ewing sarcoma of the bone: a review article.
Ozaki T
J Orthop Sci 2015 Mar;20(2):250-63. Epub 2015 Feb 19 doi: 10.1007/s00776-014-0687-z. PMID: 25691401Free PMC Article

Recent clinical studies

Etiology

Small round cell sarcomas.
Cidre-Aranaz F, Watson S, Amatruda JF, Nakamura T, Delattre O, de Alava E, Dirksen U, Grünewald TGP
Nat Rev Dis Primers 2022 Oct 6;8(1):66. doi: 10.1038/s41572-022-00393-3. PMID: 36202860
Ewing sarcoma.
Eaton BR, Claude L, Indelicato DJ, Vatner R, Yeh B, Schwarz R, Laack N
Pediatr Blood Cancer 2021 May;68 Suppl 2:e28355. doi: 10.1002/pbc.28355. PMID: 33818887
International randomised controlled trial for the treatment of newly diagnosed EWING sarcoma family of tumours - EURO EWING 2012 Protocol.
Anderton J, Moroz V, Marec-Bérard P, Gaspar N, Laurence V, Martín-Broto J, Sastre A, Gelderblom H, Owens C, Kaiser S, Fernández-Pinto M, Fenwick N, Evans A, Strauss S, Whelan J, Wheatley K, Brennan B
Trials 2020 Jan 17;21(1):96. doi: 10.1186/s13063-019-4026-8. PMID: 31952545Free PMC Article
Ewing sarcoma.
Grünewald TGP, Cidre-Aranaz F, Surdez D, Tomazou EM, de Álava E, Kovar H, Sorensen PH, Delattre O, Dirksen U
Nat Rev Dis Primers 2018 Jul 5;4(1):5. doi: 10.1038/s41572-018-0003-x. PMID: 29977059
Ewing's sarcoma.
Balamuth NJ, Womer RB
Lancet Oncol 2010 Feb;11(2):184-92. doi: 10.1016/S1470-2045(09)70286-4. PMID: 20152770

Diagnosis

Ewing Sarcoma Drug Therapy: Current Standard of Care and Emerging Agents.
Setty BA, Gikandi A, DuBois SG
Paediatr Drugs 2023 Jul;25(4):389-397. Epub 2023 Apr 4 doi: 10.1007/s40272-023-00568-9. PMID: 37014523
Comparison of two chemotherapy regimens in patients with newly diagnosed Ewing sarcoma (EE2012): an open-label, randomised, phase 3 trial.
Brennan B, Kirton L, Marec-Bérard P, Gaspar N, Laurence V, Martín-Broto J, Sastre A, Gelderblom H, Owens C, Fenwick N, Strauss S, Moroz V, Whelan J, Wheatley K
Lancet 2022 Oct 29;400(10362):1513-1521. doi: 10.1016/S0140-6736(22)01790-1. PMID: 36522207
Ewing sarcoma.
Grünewald TGP, Cidre-Aranaz F, Surdez D, Tomazou EM, de Álava E, Kovar H, Sorensen PH, Delattre O, Dirksen U
Nat Rev Dis Primers 2018 Jul 5;4(1):5. doi: 10.1038/s41572-018-0003-x. PMID: 29977059
Diagnosis and treatment of Ewing sarcoma of the bone: a review article.
Ozaki T
J Orthop Sci 2015 Mar;20(2):250-63. Epub 2015 Feb 19 doi: 10.1007/s00776-014-0687-z. PMID: 25691401Free PMC Article
Ewing's sarcoma.
Balamuth NJ, Womer RB
Lancet Oncol 2010 Feb;11(2):184-92. doi: 10.1016/S1470-2045(09)70286-4. PMID: 20152770

Therapy

Comparison of two chemotherapy regimens in patients with newly diagnosed Ewing sarcoma (EE2012): an open-label, randomised, phase 3 trial.
Brennan B, Kirton L, Marec-Bérard P, Gaspar N, Laurence V, Martín-Broto J, Sastre A, Gelderblom H, Owens C, Fenwick N, Strauss S, Moroz V, Whelan J, Wheatley K
Lancet 2022 Oct 29;400(10362):1513-1521. doi: 10.1016/S0140-6736(22)01790-1. PMID: 36522207
International randomised controlled trial for the treatment of newly diagnosed EWING sarcoma family of tumours - EURO EWING 2012 Protocol.
Anderton J, Moroz V, Marec-Bérard P, Gaspar N, Laurence V, Martín-Broto J, Sastre A, Gelderblom H, Owens C, Kaiser S, Fernández-Pinto M, Fenwick N, Evans A, Strauss S, Whelan J, Wheatley K, Brennan B
Trials 2020 Jan 17;21(1):96. doi: 10.1186/s13063-019-4026-8. PMID: 31952545Free PMC Article
Pembrolizumab in advanced soft-tissue sarcoma and bone sarcoma (SARC028): a multicentre, two-cohort, single-arm, open-label, phase 2 trial.
Tawbi HA, Burgess M, Bolejack V, Van Tine BA, Schuetze SM, Hu J, D'Angelo S, Attia S, Riedel RF, Priebat DA, Movva S, Davis LE, Okuno SH, Reed DR, Crowley J, Butterfield LH, Salazar R, Rodriguez-Canales J, Lazar AJ, Wistuba II, Baker LH, Maki RG, Reinke D, Patel S
Lancet Oncol 2017 Nov;18(11):1493-1501. Epub 2017 Oct 4 doi: 10.1016/S1470-2045(17)30624-1. PMID: 28988646Free PMC Article
Ewing's sarcoma.
Balamuth NJ, Womer RB
Lancet Oncol 2010 Feb;11(2):184-92. doi: 10.1016/S1470-2045(09)70286-4. PMID: 20152770
Addition of ifosfamide and etoposide to standard chemotherapy for Ewing's sarcoma and primitive neuroectodermal tumor of bone.
Grier HE, Krailo MD, Tarbell NJ, Link MP, Fryer CJ, Pritchard DJ, Gebhardt MC, Dickman PS, Perlman EJ, Meyers PA, Donaldson SS, Moore S, Rausen AR, Vietti TJ, Miser JS
N Engl J Med 2003 Feb 20;348(8):694-701. doi: 10.1056/NEJMoa020890. PMID: 12594313

Prognosis

Ewing Sarcoma and Osteosarcoma Have Distinct Immune Signatures and Intercellular Communication Networks.
Cillo AR, Mukherjee E, Bailey NG, Onkar S, Daley J, Salgado C, Li X, Liu D, Ranganathan S, Burgess M, Sembrat J, Weiss K, Watters R, Bruno TC, Vignali DAA, Bailey KM
Clin Cancer Res 2022 Nov 14;28(22):4968-4982. doi: 10.1158/1078-0432.CCR-22-1471. PMID: 36074145Free PMC Article
Ewing sarcoma.
Eaton BR, Claude L, Indelicato DJ, Vatner R, Yeh B, Schwarz R, Laack N
Pediatr Blood Cancer 2021 May;68 Suppl 2:e28355. doi: 10.1002/pbc.28355. PMID: 33818887
Ewing's sarcoma.
Karosas AO
Am J Health Syst Pharm 2010 Oct 1;67(19):1599-605. doi: 10.2146/ajhp090526. PMID: 20852160
Primary bone lymphoma.
Bhagavathi S, Fu K
Arch Pathol Lab Med 2009 Nov;133(11):1868-71. doi: 10.5858/133.11.1868. PMID: 19886726
Addition of ifosfamide and etoposide to standard chemotherapy for Ewing's sarcoma and primitive neuroectodermal tumor of bone.
Grier HE, Krailo MD, Tarbell NJ, Link MP, Fryer CJ, Pritchard DJ, Gebhardt MC, Dickman PS, Perlman EJ, Meyers PA, Donaldson SS, Moore S, Rausen AR, Vietti TJ, Miser JS
N Engl J Med 2003 Feb 20;348(8):694-701. doi: 10.1056/NEJMoa020890. PMID: 12594313

Clinical prediction guides

STAG2 loss rewires oncogenic and developmental programs to promote metastasis in Ewing sarcoma.
Adane B, Alexe G, Seong BKA, Lu D, Hwang EE, Hnisz D, Lareau CA, Ross L, Lin S, Dela Cruz FS, Richardson M, Weintraub AS, Wang S, Iniguez AB, Dharia NV, Conway AS, Robichaud AL, Tanenbaum B, Krill-Burger JM, Vazquez F, Schenone M, Berman JN, Kung AL, Carr SA, Aryee MJ, Young RA, Crompton BD, Stegmaier K
Cancer Cell 2021 Jun 14;39(6):827-844.e10. doi: 10.1016/j.ccell.2021.05.007. PMID: 34129824Free PMC Article
Heparanase: A Potential Therapeutic Target in Sarcomas.
Cassinelli G, Lanzi C
Adv Exp Med Biol 2020;1221:405-431. doi: 10.1007/978-3-030-34521-1_15. PMID: 32274719
BCOR-CCNB3 Fusion Positive Sarcomas: A Clinicopathologic and Molecular Analysis of 36 Cases With Comparison to Morphologic Spectrum and Clinical Behavior of Other Round Cell Sarcomas.
Kao YC, Owosho AA, Sung YS, Zhang L, Fujisawa Y, Lee JC, Wexler L, Argani P, Swanson D, Dickson BC, Fletcher CDM, Antonescu CR
Am J Surg Pathol 2018 May;42(5):604-615. doi: 10.1097/PAS.0000000000000965. PMID: 29300189Free PMC Article
Bone Marrow Involvement in Metastatic Pediatric Ewing Sarcoma.
Khan SJ, Ishaq I, Saeed H, Fayyaz MB, Baqari SAS, Wali RM
J Coll Physicians Surg Pak 2017 Aug;27(8):502-504. PMID: 28903844
Ewing sarcoma: The clinical relevance of the insulin-like growth factor 1 and the poly-ADP-ribose-polymerase pathway.
van Maldegem AM, Bovée JV, Peterse EF, Hogendoorn PC, Gelderblom H
Eur J Cancer 2016 Jan;53:171-80. Epub 2016 Jan 5 doi: 10.1016/j.ejca.2015.09.009. PMID: 26765686

Recent systematic reviews

High-dose chemotherapy followed by autologous haematopoietic cell transplantation for children, adolescents, and young adults with primary metastatic Ewing sarcoma.
Haveman LM, van Ewijk R, van Dalen EC, Breunis WB, Kremer LC, van den Berg H, Dirksen U, Merks JH
Cochrane Database Syst Rev 2021 Sep 2;9(9):CD011405. doi: 10.1002/14651858.CD011405.pub2. PMID: 34472082Free PMC Article
Role of bone marrow biopsy for staging new patients with Ewing sarcoma: A systematic review.
Campbell KM, Shulman DS, Grier HE, DuBois SG
Pediatr Blood Cancer 2021 Feb;68(2):e28807. Epub 2020 Nov 21 doi: 10.1002/pbc.28807. PMID: 33219750
Colonic Ewing Sarcoma/PNET associated with liver metastases: A systematic review and case report.
Parcesepe P, Giordano G, Zanella C, Giuliani J, Greco F, Bonetti A, Pancione M, Manfrin E, Molinari E, Latiano TP, D'Andrea MR, Fassan M, Olivieri N, Remo A
Pathol Res Pract 2019 Feb;215(2):387-391. Epub 2018 Nov 29 doi: 10.1016/j.prp.2018.11.021. PMID: 30553605
Whole Lung Irradiation in Patients with Osteosarcoma and Ewing Sarcoma.
Ronchi L, Buwenge M, Cortesi A, Ammendolia I, Frakulli R, Abate ME, Arcelli A, Donati CM, Macchia G, Morganti AG, Cammelli S
Anticancer Res 2018 Sep;38(9):4977-4985. doi: 10.21873/anticanres.12816. PMID: 30194141
A Review of Ewing Sarcoma Treatment: Is it Still a Subject of Debate?
Kridis WB, Toumi N, Chaari H, Khanfir A, Ayadi K, Keskes H, Boudawara T, Daoud J, Frikha M
Rev Recent Clin Trials 2017;12(1):19-23. doi: 10.2174/1574887112666170120100147. PMID: 28117008

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