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Microglandular adenosis of breast

MedGen UID:
233705
•Concept ID:
C1334753
•
Disease or Syndrome
Synonyms: Breast Microglandular Adenosis; breast microglandular adenosis; Microglandular Adenosis of Breast; microglandular adenosis of breast; Microglandular Adenosis of the Breast; microglandular adenosis of the breast
 
Monarch Initiative: MONDO:0004534

Definition

A rare variant of breast adenosis characterized by the proliferation of small round glands in a collagenous stroma. The epithelial cells are cuboidal and there are no myopepithelial cells present. There is no evidence of atypia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMicroglandular adenosis of breast

Professional guidelines

PubMed

Management of Cystic Conditions.
Ortman H, Abdo J, Tillman R, Seydel A
Surg Clin North Am 2022 Dec;102(6):1089-1102. doi: 10.1016/j.suc.2022.07.004. PMID: 36335927
Cystic breast lesions: sonographic findings and clinical management.
Rinaldi P, Ierardi C, Costantini M, Magno S, Giuliani M, Belli P, Bonomo L
J Ultrasound Med 2010 Nov;29(11):1617-26. doi: 10.7863/jum.2010.29.11.1617. PMID: 20966473
Management of breast pain and nodularity.
Maddox PR, Mansel RE
World J Surg 1989 Nov-Dec;13(6):699-705. doi: 10.1007/BF01658417. PMID: 2696222

Recent clinical studies

Etiology

Fibrocystic Breast Changes.
Faguy K
Radiol Technol 2022 Jan;93(3):303M-315M. PMID: 35017277
Breast pathology in adolescence.
de Vasconcelos Gaspar A, Melo L, Geraldes F, Belo J, Águas F
Breast Dis 2021;40(4):269-274. doi: 10.3233/BD-201043. PMID: 34120893
Polycystic Ovary Syndrome and Fibrocystic Breast Disease: An Updated Review.
Kunicki M, Smolarczyk R
Horm Metab Res 2021 Apr;53(4):219-224. Epub 2021 Mar 8 doi: 10.1055/a-1392-0938. PMID: 33684949
Aluminium and the human breast.
Darbre PD
Morphologie 2016 Jun;100(329):65-74. Epub 2016 Mar 17 doi: 10.1016/j.morpho.2016.02.001. PMID: 26997127
Breast sonography.
Bassett LW, Kimme-Smith C
AJR Am J Roentgenol 1991 Mar;156(3):449-55. doi: 10.2214/ajr.156.3.1899737. PMID: 1899737

Diagnosis

Fibrocystic Change.
Bennett DL, Buckley A, Lee MV
Radiol Clin North Am 2024 Jul;62(4):581-592. Epub 2024 Mar 7 doi: 10.1016/j.rcl.2023.12.008. PMID: 38777535
Fibrocystic Breast Changes.
Faguy K
Radiol Technol 2022 Jan;93(3):303M-315M. PMID: 35017277
Apocrine lesions of the breast.
Quinn CM, D'Arcy C, Wells C
Virchows Arch 2022 Jan;480(1):177-189. Epub 2021 Sep 18 doi: 10.1007/s00428-021-03185-4. PMID: 34537861Free PMC Article
Microglandular Adenosis and Associated Invasive Carcinoma.
Kravtsov O, Jorns JM
Arch Pathol Lab Med 2020 Jan;144(1):42-46. Epub 2019 May 22 doi: 10.5858/arpa.2019-0049-RA. PMID: 31116044
Microglandular adenosis of the breast: a deceptive and still mysterious benign lesion.
Foschini MP, Eusebi V
Hum Pathol 2018 Dec;82:1-9. Epub 2018 Jun 24 doi: 10.1016/j.humpath.2018.06.025. PMID: 29949742

Therapy

Tamoxifen in Mastalgia: A Meta-Analysis.
Sinha MK, Barman A, Sahu S, Jha AK, Asharaf AA
J Obstet Gynaecol Can 2022 Oct;44(10):1084-1094. Epub 2022 Jun 22 doi: 10.1016/j.jogc.2022.06.006. PMID: 35752405
Aluminium and the human breast.
Darbre PD
Morphologie 2016 Jun;100(329):65-74. Epub 2016 Mar 17 doi: 10.1016/j.morpho.2016.02.001. PMID: 26997127
The female breast and diabetes.
Gouveri E, Papanas N, Maltezos E
Breast 2011 Jun;20(3):205-11. Epub 2011 Mar 16 doi: 10.1016/j.breast.2011.02.019. PMID: 21414785
The health consequences of caffeine.
Curatolo PW, Robertson D
Ann Intern Med 1983 May;98(5 Pt 1):641-53. doi: 10.7326/0003-4819-98-5-641. PMID: 6342491
Danazol.
Madanes AE, Farber M
Ann Intern Med 1982 May;96(5):625-30. doi: 10.7326/0003-4819-96-5-625. PMID: 7041729

Prognosis

Ultrasound characteristics of sclerosing adenosis mimicking breast carcinoma.
Liu W, Li W, Li Z, Shi L, Zhao P, Guo Z, Tian J, Wang Z
Breast Cancer Res Treat 2020 May;181(1):127-134. Epub 2020 Mar 29 doi: 10.1007/s10549-020-05609-2. PMID: 32227257
Microglandular adenosis of the breast: a deceptive and still mysterious benign lesion.
Foschini MP, Eusebi V
Hum Pathol 2018 Dec;82:1-9. Epub 2018 Jun 24 doi: 10.1016/j.humpath.2018.06.025. PMID: 29949742
Sclerosing adenosis and risk of breast cancer.
Visscher DW, Nassar A, Degnim AC, Frost MH, Vierkant RA, Frank RD, Tarabishy Y, Radisky DC, Hartmann LC
Breast Cancer Res Treat 2014 Feb;144(1):205-12. Epub 2014 Feb 8 doi: 10.1007/s10549-014-2862-5. PMID: 24510013Free PMC Article
The female breast and diabetes.
Gouveri E, Papanas N, Maltezos E
Breast 2011 Jun;20(3):205-11. Epub 2011 Mar 16 doi: 10.1016/j.breast.2011.02.019. PMID: 21414785
Fibrocystic changes.
Fiorica JV
Obstet Gynecol Clin North Am 1994 Sep;21(3):445-52. PMID: 7816405

Clinical prediction guides

Breast pathology in adolescence.
de Vasconcelos Gaspar A, Melo L, Geraldes F, Belo J, Águas F
Breast Dis 2021;40(4):269-274. doi: 10.3233/BD-201043. PMID: 34120893
Clinical and sonographic features of nipple lesions.
Cai S, Wang H, Zhu Q, Li J, Sun Q, Jiang Y
Medicine (Baltimore) 2020 Apr;99(15):e19728. doi: 10.1097/MD.0000000000019728. PMID: 32282731Free PMC Article
Microglandular adenosis of the breast: a deceptive and still mysterious benign lesion.
Foschini MP, Eusebi V
Hum Pathol 2018 Dec;82:1-9. Epub 2018 Jun 24 doi: 10.1016/j.humpath.2018.06.025. PMID: 29949742
Microglandular adenosis: a prime suspect in triple-negative breast cancer development.
Tsang JY, Tse GM
J Pathol 2016 Jun;239(2):129-32. doi: 10.1002/path.4726. PMID: 27061094
Breast thermography.
Nyirjesy I
Clin Obstet Gynecol 1982 Jun;25(2):401-8. doi: 10.1097/00003081-198206000-00023. PMID: 7105516

Recent systematic reviews

Adenosquamous proliferation in radial sclerosing lesions: Histologic spectrum and key features in systematic review of 247 lesions.
Bachert SE, Cornea V, Bocklage T
Breast 2023 Oct;71:99-105. Epub 2023 Aug 7 doi: 10.1016/j.breast.2023.08.002. PMID: 37566996Free PMC Article
P53 Expression in benign Breast Disease Development: A Systematic Review.
Costa RSS, Silva IFD
Asian Pac J Cancer Prev 2020 Sep 1;21(9):2485-2491. doi: 10.31557/APJCP.2020.21.9.2485. PMID: 32986343Free PMC Article
Diagnostic performance of breast tumor tissue selection in diffusion weighted imaging: A systematic review and meta-analysis.
Wielema M, Dorrius MD, Pijnappel RM, De Bock GH, Baltzer PAT, Oudkerk M, Sijens PE
PLoS One 2020;15(5):e0232856. Epub 2020 May 6 doi: 10.1371/journal.pone.0232856. PMID: 32374781Free PMC Article

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