U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Mixed germ cell tumor of central nervous system

MedGen UID:
233713
Concept ID:
C1334785
Neoplastic Process
Synonyms: Central Nervous System Mixed Germ Cell Tumor; central nervous system mixed germ cell tumor; central nervous system mixed germ cell tumour; CNS Mixed Germ Cell Tumor; CNS mixed germ cell tumor; CNS mixed germ cell tumour; Mixed germ cell neoplasm of central nervous system; Mixed Germ Cell Neoplasm of the Central Nervous System; mixed germ cell neoplasm of the central nervous system; mixed germ cell tumor of central nervous system; Mixed Germ Cell Tumor of CNS; Mixed germ cell tumor of CNS; mixed germ cell tumor of CNS; Mixed Germ Cell Tumor of the Central Nervous System; mixed germ cell tumor of the central nervous system; Mixed Germ Cell Tumor of the CNS; mixed germ cell tumor of the CNS; mixed germ cell tumour of CNS; mixed germ cell tumour of the central nervous system; mixed germ cell tumour of the CNS
SNOMED CT: Mixed germ cell neoplasm of central nervous system (866050001)
 
Monarch Initiative: MONDO:0016742
Orphanet: ORPHA252021

Definition

A malignant germ cell tumor of the central nervous system characterized by the presence of at least two types of germ cell neoplasia. [from NCI]

Term Hierarchy

Professional guidelines

PubMed

Sait SF, Giantini-Larsen AM, Tringale KR, Souweidane MM, Karajannis MA
Curr Neurol Neurosci Rep 2023 Apr;23(4):185-199. Epub 2023 Mar 7 doi: 10.1007/s11910-023-01257-3. PMID: 36881254Free PMC Article
Abu Arja MH, Bouffet E, Finlay JL, AbdelBaki MS
Pediatr Blood Cancer 2019 Jun;66(6):e27658. Epub 2019 Feb 15 doi: 10.1002/pbc.27658. PMID: 30767415
Walker DG, Kaye AH
Australas Radiol 2001 Nov;45(4):472-82. doi: 10.1046/j.1440-1673.2001.00959.x. PMID: 11903181

Recent clinical studies

Etiology

Wu PB, Filley AC, Miller ML, Bruce JN
Adv Exp Med Biol 2023;1405:31-71. doi: 10.1007/978-3-031-23705-8_2. PMID: 37452934
Vladoiu MC, El-Hamamy I, Donovan LK, Farooq H, Holgado BL, Sundaravadanam Y, Ramaswamy V, Hendrikse LD, Kumar S, Mack SC, Lee JJY, Fong V, Juraschka K, Przelicki D, Michealraj A, Skowron P, Luu B, Suzuki H, Morrissy AS, Cavalli FMG, Garzia L, Daniels C, Wu X, Qazi MA, Singh SK, Chan JA, Marra MA, Malkin D, Dirks P, Heisler L, Pugh T, Ng K, Notta F, Thompson EM, Kleinman CL, Joyner AL, Jabado N, Stein L, Taylor MD
Nature 2019 Aug;572(7767):67-73. Epub 2019 May 1 doi: 10.1038/s41586-019-1158-7. PMID: 31043743Free PMC Article
Filbin MG, Sturm D
Semin Neurol 2018 Feb;38(1):121-130. Epub 2018 Mar 16 doi: 10.1055/s-0038-1635106. PMID: 29548059
Perry A, Wesseling P
Handb Clin Neurol 2016;134:71-95. doi: 10.1016/B978-0-12-802997-8.00005-0. PMID: 26948349
Yu X, Liu R, Wang Y, Wang H, Zhao H, Wu Z
Clin Neurol Neurosurg 2012 Feb;114(2):112-9. Epub 2011 Oct 21 doi: 10.1016/j.clineuro.2011.09.010. PMID: 22018920

Diagnosis

Wu PB, Filley AC, Miller ML, Bruce JN
Adv Exp Med Biol 2023;1405:31-71. doi: 10.1007/978-3-031-23705-8_2. PMID: 37452934
Viaene AN, Santi M, Hawkins C
Pediatr Dev Pathol 2022 Jan-Feb;25(1):46-58. Epub 2021 Apr 19 doi: 10.1177/10935266211009101. PMID: 33872106
Slegers RJ, Blumcke I
Acta Neuropathol Commun 2020 Mar 9;8(1):27. doi: 10.1186/s40478-020-00904-x. PMID: 32151273Free PMC Article
Filbin MG, Sturm D
Semin Neurol 2018 Feb;38(1):121-130. Epub 2018 Mar 16 doi: 10.1055/s-0038-1635106. PMID: 29548059
Perry A, Wesseling P
Handb Clin Neurol 2016;134:71-95. doi: 10.1016/B978-0-12-802997-8.00005-0. PMID: 26948349

Therapy

Sait SF, Giantini-Larsen AM, Tringale KR, Souweidane MM, Karajannis MA
Curr Neurol Neurosci Rep 2023 Apr;23(4):185-199. Epub 2023 Mar 7 doi: 10.1007/s11910-023-01257-3. PMID: 36881254Free PMC Article
Abu Arja MH, Stanek JR, Finlay JL, AbdelBaki MS
Childs Nerv Syst 2018 Nov;34(11):2179-2186. Epub 2018 Aug 3 doi: 10.1007/s00381-018-3940-5. PMID: 30076436
Bidros DS, Vogelbaum MA
Neurotherapeutics 2009 Jul;6(3):539-46. doi: 10.1016/j.nurt.2009.04.004. PMID: 19560743Free PMC Article
van den Bent MJ, Afra D, de Witte O, Ben Hassel M, Schraub S, Hoang-Xuan K, Malmström PO, Collette L, Piérart M, Mirimanoff R, Karim AB; EORTC Radiotherapy and Brain Tumor Groups and the UK Medical Research Council
Lancet 2005 Sep 17-23;366(9490):985-90. doi: 10.1016/S0140-6736(05)67070-5. PMID: 16168780
Burton EC, Prados MD
Curr Treat Options Oncol 2000 Dec;1(5):459-68. doi: 10.1007/s11864-000-0073-2. PMID: 12057153

Prognosis

Wu PB, Filley AC, Miller ML, Bruce JN
Adv Exp Med Biol 2023;1405:31-71. doi: 10.1007/978-3-031-23705-8_2. PMID: 37452934
Viaene AN, Santi M, Hawkins C
Pediatr Dev Pathol 2022 Jan-Feb;25(1):46-58. Epub 2021 Apr 19 doi: 10.1177/10935266211009101. PMID: 33872106
Vladoiu MC, El-Hamamy I, Donovan LK, Farooq H, Holgado BL, Sundaravadanam Y, Ramaswamy V, Hendrikse LD, Kumar S, Mack SC, Lee JJY, Fong V, Juraschka K, Przelicki D, Michealraj A, Skowron P, Luu B, Suzuki H, Morrissy AS, Cavalli FMG, Garzia L, Daniels C, Wu X, Qazi MA, Singh SK, Chan JA, Marra MA, Malkin D, Dirks P, Heisler L, Pugh T, Ng K, Notta F, Thompson EM, Kleinman CL, Joyner AL, Jabado N, Stein L, Taylor MD
Nature 2019 Aug;572(7767):67-73. Epub 2019 May 1 doi: 10.1038/s41586-019-1158-7. PMID: 31043743Free PMC Article
Filbin MG, Sturm D
Semin Neurol 2018 Feb;38(1):121-130. Epub 2018 Mar 16 doi: 10.1055/s-0038-1635106. PMID: 29548059
Perry A, Wesseling P
Handb Clin Neurol 2016;134:71-95. doi: 10.1016/B978-0-12-802997-8.00005-0. PMID: 26948349

Clinical prediction guides

Lubieniecki F, Vazquez V, Lamas GS, Camarero S, Nuñez FJ, Baroni L, Schüller U, Alderete D
Childs Nerv Syst 2023 Feb;39(2):379-386. Epub 2022 Dec 19 doi: 10.1007/s00381-022-05741-y. PMID: 36534132
Kweh BTS, Rosenfeld JV, Hunn M, Tee JW
J Neurosurg 2022 Mar 1;136(3):736-748. Epub 2021 Aug 20 doi: 10.3171/2021.2.JNS204052. PMID: 34416731
Lampros MG, Vlachos N, Voulgaris S, Alexiou GA
Childs Nerv Syst 2021 Aug;37(8):2465-2474. Epub 2021 Jun 17 doi: 10.1007/s00381-021-05257-x. PMID: 34137942
Wang KY, Vankov ER, Lin DDM
J Neurosurg Pediatr 2018 Feb;21(2):153-163. Epub 2017 Dec 1 doi: 10.3171/2017.7.PEDS17133. PMID: 29192869
Yu X, Liu R, Wang Y, Wang H, Zhao H, Wu Z
Clin Neurol Neurosurg 2012 Feb;114(2):112-9. Epub 2011 Oct 21 doi: 10.1016/j.clineuro.2011.09.010. PMID: 22018920

Recent systematic reviews

Kweh BTS, Rosenfeld JV, Hunn M, Tee JW
J Neurosurg 2022 Mar 1;136(3):736-748. Epub 2021 Aug 20 doi: 10.3171/2021.2.JNS204052. PMID: 34416731
Wang S, Sun MZ, Abecassis IJ, Weil AG, Ibrahim GM, Fallah A, Ene C, Leary SES, Cole BL, Lockwood CM, Olson JM, Geyer JR, Ellenbogen RG, Ojemann JG, Wang AC
J Neurooncol 2021 Nov;155(2):155-163. Epub 2021 Oct 6 doi: 10.1007/s11060-021-03860-1. PMID: 34613581Free PMC Article
Lampros MG, Vlachos N, Voulgaris S, Alexiou GA
Childs Nerv Syst 2021 Aug;37(8):2465-2474. Epub 2021 Jun 17 doi: 10.1007/s00381-021-05257-x. PMID: 34137942
Kreis C, Doessegger E, Lupatsch JE, Spycher BD
Eur J Epidemiol 2019 Jan;34(1):9-21. Epub 2018 Nov 16 doi: 10.1007/s10654-018-0456-y. PMID: 30446850Free PMC Article
Graffeo CS, Perry A, Copeland WR 3rd, Giannini C, Neff BA, Driscoll CL, Link MJ
World Neurosurg 2017 Feb;98:632-643. Epub 2016 Nov 12 doi: 10.1016/j.wneu.2016.11.002. PMID: 27836701

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...