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Non-seminomatous lesion

MedGen UID:
233785
•Concept ID:
C1335059
•
Neoplastic Process
Synonyms: Non-Seminomatous Lesion; non-seminomatous lesion; Nonseminoma; Nonseminomatous Lesion
 
Monarch Initiative: MONDO:0006323

Definition

A group of testicular cancers that begin in the germ cells (cells that give rise to sperm). Nonseminomas are identified by the type of cell in which they begin and include embryonal carcinoma, teratoma, choriocarcinoma, and yolk sac carcinoma. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNon-seminomatous lesion

Professional guidelines

PubMed

Primary and Postchemotherapy Retroperitoneal Lymphadenectomy for Testicular Cancer.
Heidenreich A, Paffenholz P, Nestler T, Pfister D
Oncol Res Treat 2018;41(6):370-378. Epub 2018 May 17 doi: 10.1159/000489508. PMID: 29772568
Diagnosing testicular lumps in primary care.
Stonier T, Simson N, Challacombe B
Practitioner 2017 Apr;261(1803):13-7. PMID: 29020728
The role of magnetic resonance imaging and computed tomography in the treatment evaluation of retroperitoneal lymph-node metastases of non-seminomatous testicular tumors.
Hogeboom WR, Hoekstra HJ, Mooyaart EL, Sleijfer DT, Freling NJ, Willemse PH, Schraffordt Koops H
Eur J Radiol 1991 Jul-Aug;13(1):31-6. doi: 10.1016/0720-048x(91)90052-w. PMID: 1716204

Recent clinical studies

Etiology

When to ask for an MRI of the scrotum.
Tsili AC, Argyropoulou MI, Dolciami M, Ercolani G, Catalano C, Manganaro L
Andrology 2021 Sep;9(5):1395-1409. Epub 2021 Jun 11 doi: 10.1111/andr.13032. PMID: 33964115Free PMC Article
The potential role of MR based radiomic biomarkers in the characterization of focal testicular lesions.
Feliciani G, Mellini L, Carnevale A, Sarnelli A, Menghi E, Piccinini F, Scarpi E, Loi E, Galeotti R, Giganti M, Parenti GC
Sci Rep 2021 Feb 10;11(1):3456. doi: 10.1038/s41598-021-83023-4. PMID: 33568713Free PMC Article
Primary and Postchemotherapy Retroperitoneal Lymphadenectomy for Testicular Cancer.
Heidenreich A, Paffenholz P, Nestler T, Pfister D
Oncol Res Treat 2018;41(6):370-378. Epub 2018 May 17 doi: 10.1159/000489508. PMID: 29772568
Diagnosing testicular lumps in primary care.
Stonier T, Simson N, Challacombe B
Practitioner 2017 Apr;261(1803):13-7. PMID: 29020728
Human testicular (non)seminomatous germ cell tumours: the clinical implications of recent pathobiological insights.
Looijenga LH
J Pathol 2009 Jun;218(2):146-62. doi: 10.1002/path.2522. PMID: 19253916

Diagnosis

Imaging Techniques to Differentiate Benign Testicular Masses from Germ Cell Tumors.
Saidian A, Bagrodia A
Curr Urol Rep 2023 Sep;24(9):451-454. Epub 2023 Jun 27 doi: 10.1007/s11934-023-01172-7. PMID: 37368095Free PMC Article
When to ask for an MRI of the scrotum.
Tsili AC, Argyropoulou MI, Dolciami M, Ercolani G, Catalano C, Manganaro L
Andrology 2021 Sep;9(5):1395-1409. Epub 2021 Jun 11 doi: 10.1111/andr.13032. PMID: 33964115Free PMC Article
The potential role of MR based radiomic biomarkers in the characterization of focal testicular lesions.
Feliciani G, Mellini L, Carnevale A, Sarnelli A, Menghi E, Piccinini F, Scarpi E, Loi E, Galeotti R, Giganti M, Parenti GC
Sci Rep 2021 Feb 10;11(1):3456. doi: 10.1038/s41598-021-83023-4. PMID: 33568713Free PMC Article
Human testicular (non)seminomatous germ cell tumours: the clinical implications of recent pathobiological insights.
Looijenga LH
J Pathol 2009 Jun;218(2):146-62. doi: 10.1002/path.2522. PMID: 19253916
OCT4: biological functions and clinical applications as a marker of germ cell neoplasia.
Cheng L, Sung MT, Cossu-Rocca P, Jones TD, MacLennan GT, De Jong J, Lopez-Beltran A, Montironi R, Looijenga LH
J Pathol 2007 Jan;211(1):1-9. doi: 10.1002/path.2105. PMID: 17117392

Therapy

Primary and Postchemotherapy Retroperitoneal Lymphadenectomy for Testicular Cancer.
Heidenreich A, Paffenholz P, Nestler T, Pfister D
Oncol Res Treat 2018;41(6):370-378. Epub 2018 May 17 doi: 10.1159/000489508. PMID: 29772568
Collaborating with our adult colleagues: A case series of robotic surgery for suspicious and cancerous lesions in children and young adults performed in a free-standing children's hospital.
Varda BK, Cho P, Wagner AA, Lee RS
J Pediatr Urol 2018 Apr;14(2):182.e1-182.e8. Epub 2018 Mar 2 doi: 10.1016/j.jpurol.2018.01.003. PMID: 29503221Free PMC Article
Histopathological assessment of residual retroperitoneal mass removed in patients after chemotherapy for non-seminomatous germ cell tumours of the testis.
Jaszczyński J, Wilk W, Kruczak A, Wohadlo Ł, Faron P, Łuczyńska E, Chłosta P, Stelmach A, Jakubowicz J
Pol J Pathol 2015 Dec;66(4):420-5. doi: 10.5114/pjp.2015.57257. PMID: 27003776
The growing teratoma syndrome.
Jeffery GM, Theaker JM, Lee AH, Blaquiere RM, Smart CJ, Mead GM
Br J Urol 1991 Feb;67(2):195-202. doi: 10.1111/j.1464-410x.1991.tb15109.x. PMID: 2004236
The role of magnetic resonance imaging and computed tomography in the treatment evaluation of retroperitoneal lymph-node metastases of non-seminomatous testicular tumors.
Hogeboom WR, Hoekstra HJ, Mooyaart EL, Sleijfer DT, Freling NJ, Willemse PH, Schraffordt Koops H
Eur J Radiol 1991 Jul-Aug;13(1):31-6. doi: 10.1016/0720-048x(91)90052-w. PMID: 1716204

Prognosis

The potential role of MR based radiomic biomarkers in the characterization of focal testicular lesions.
Feliciani G, Mellini L, Carnevale A, Sarnelli A, Menghi E, Piccinini F, Scarpi E, Loi E, Galeotti R, Giganti M, Parenti GC
Sci Rep 2021 Feb 10;11(1):3456. doi: 10.1038/s41598-021-83023-4. PMID: 33568713Free PMC Article
Primary and Postchemotherapy Retroperitoneal Lymphadenectomy for Testicular Cancer.
Heidenreich A, Paffenholz P, Nestler T, Pfister D
Oncol Res Treat 2018;41(6):370-378. Epub 2018 May 17 doi: 10.1159/000489508. PMID: 29772568
Diagnosing testicular lumps in primary care.
Stonier T, Simson N, Challacombe B
Practitioner 2017 Apr;261(1803):13-7. PMID: 29020728
Human testicular (non)seminomatous germ cell tumours: the clinical implications of recent pathobiological insights.
Looijenga LH
J Pathol 2009 Jun;218(2):146-62. doi: 10.1002/path.2522. PMID: 19253916
OCT4: biological functions and clinical applications as a marker of germ cell neoplasia.
Cheng L, Sung MT, Cossu-Rocca P, Jones TD, MacLennan GT, De Jong J, Lopez-Beltran A, Montironi R, Looijenga LH
J Pathol 2007 Jan;211(1):1-9. doi: 10.1002/path.2105. PMID: 17117392

Clinical prediction guides

The potential role of MR based radiomic biomarkers in the characterization of focal testicular lesions.
Feliciani G, Mellini L, Carnevale A, Sarnelli A, Menghi E, Piccinini F, Scarpi E, Loi E, Galeotti R, Giganti M, Parenti GC
Sci Rep 2021 Feb 10;11(1):3456. doi: 10.1038/s41598-021-83023-4. PMID: 33568713Free PMC Article
Radiomics allows for detection of benign and malignant histopathology in patients with metastatic testicular germ cell tumors prior to post-chemotherapy retroperitoneal lymph node dissection.
Baessler B, Nestler T, Pinto Dos Santos D, Paffenholz P, Zeuch V, Pfister D, Maintz D, Heidenreich A
Eur Radiol 2020 Apr;30(4):2334-2345. Epub 2019 Dec 11 doi: 10.1007/s00330-019-06495-z. PMID: 31828413
Incidentally detected testicular lesions <10 mm in diameter: can orchidectomy be avoided?
Scandura G, Verrill C, Protheroe A, Joseph J, Ansell W, Sahdev A, Shamash J, Berney DM
BJU Int 2018 Apr;121(4):575-582. Epub 2017 Nov 12 doi: 10.1111/bju.14056. PMID: 29032579
Differential expression of Mediator complex subunit MED15 in testicular germ cell tumors.
Klümper N, Syring I, Offermann A, Adler D, Vogel W, Müller SC, Ellinger J, Strauß A, Radzun HJ, Ströbel P, Brägelmann J, Perner S, Bremmer F
Diagn Pathol 2015 Sep 17;10:165. doi: 10.1186/s13000-015-0398-6. PMID: 26377566Free PMC Article
Human testicular (non)seminomatous germ cell tumours: the clinical implications of recent pathobiological insights.
Looijenga LH
J Pathol 2009 Jun;218(2):146-62. doi: 10.1002/path.2522. PMID: 19253916

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