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Recurrent Childhood Brain Stem Astrocytoma

MedGen UID:
233909
•Concept ID:
C1335695
•
Neoplastic Process
Synonym: Recurrent Childhood Brainstem Astrocytoma

Definition

The reemergence of brain stem astrocytoma in childhood after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Childhood Brain Stem Astrocytoma

Professional guidelines

PubMed

The Epigenetic Evolution of Glioma Is Determined by the IDH1 Mutation Status and Treatment Regimen.
Malta TM, Sabedot TS, Morosini NS, Datta I, Garofano L, Vallentgoed W, Varn FS, Aldape K, D'Angelo F, Bakas S, Barnholtz-Sloan JS, Gan HK, Hasanain M, Hau AC, Johnson KC, Cazacu S, deCarvalho AC, Khasraw M, Kocakavuk E, Kouwenhoven MCM, Migliozzi S, Niclou SP, Niers JM, Ormond DR, Paek SH, Reifenberger G, Sillevis Smitt PA, Smits M, Stead LF, van den Bent MJ, Van Meir EG, Walenkamp A, Weiss T, Weller M, Westerman BA, Ylstra B, Wesseling P, Lasorella A, French PJ, Poisson LM; Consortium The GLASS, Verhaak RGW, Iavarone A, Noushmehr H
Cancer Res 2024 Mar 4;84(5):741-756. doi: 10.1158/0008-5472.CAN-23-2093. PMID: 38117484Free PMC Article
Exophytic glioma of the medulla: presentation, management and outcome.
Ghodsi M, Mortazavi A, Shahjouei S, Hanaei S, Esmaeili A, Nejat F, El Khashab M
Pediatr Neurosurg 2013;49(4):195-201. Epub 2014 May 22 doi: 10.1159/000362621. PMID: 24861884
The impact of extent of resection in the management of malignant gliomas of childhood.
Finlay JL, Wisoff JH
Childs Nerv Syst 1999 Nov;15(11-12):786-8. doi: 10.1007/s003810050471. PMID: 10603023

Recent clinical studies

Etiology

Selumetinib in paediatric patients with BRAF-aberrant or neurofibromatosis type 1-associated recurrent, refractory, or progressive low-grade glioma: a multicentre, phase 2 trial.
Fangusaro J, Onar-Thomas A, Young Poussaint T, Wu S, Ligon AH, Lindeman N, Banerjee A, Packer RJ, Kilburn LB, Goldman S, Pollack IF, Qaddoumi I, Jakacki RI, Fisher PG, Dhall G, Baxter P, Kreissman SG, Stewart CF, Jones DTW, Pfister SM, Vezina G, Stern JS, Panigrahy A, Patay Z, Tamrazi B, Jones JY, Haque SS, Enterline DS, Cha S, Fisher MJ, Doyle LA, Smith M, Dunkel IJ, Fouladi M
Lancet Oncol 2019 Jul;20(7):1011-1022. Epub 2019 May 28 doi: 10.1016/S1470-2045(19)30277-3. PMID: 31151904Free PMC Article
Surveillance imaging strategies following surgery and/or radiotherapy for childhood cerebellar low-grade astrocytoma.
Saunders DE, Phipps KP, Wade AM, Hayward RD
J Neurosurg 2005 Mar;102(2 Suppl):172-8. doi: 10.3171/jns.2005.102.2.0172. PMID: 16156227
Paclitaxel for the treatment of progressive or recurrent childhood brain tumors: a pediatric oncology phase II study.
Hurwitz CA, Strauss LC, Kepner J, Kretschmar C, Harris MB, Friedman H, Kun L, Kadota R
J Pediatr Hematol Oncol 2001 Jun-Jul;23(5):277-81. doi: 10.1097/00043426-200106000-00008. PMID: 11464982
Neurofibromatosis and childhood tumors.
Blatt J, Jaffe R, Deutsch M, Adkins JC
Cancer 1986 Mar 15;57(6):1225-9. doi: 10.1002/1097-0142(19860315)57:6<1225::aid-cncr2820570627>3.0.co;2-p. PMID: 3080222
Pediatric brain stem tumors: patterns of treatment failure and their implications for radiotherapy.
Halperin EC
Int J Radiat Oncol Biol Phys 1985 Jul;11(7):1293-8. doi: 10.1016/0360-3016(85)90244-5. PMID: 2989230

Diagnosis

Selumetinib in paediatric patients with BRAF-aberrant or neurofibromatosis type 1-associated recurrent, refractory, or progressive low-grade glioma: a multicentre, phase 2 trial.
Fangusaro J, Onar-Thomas A, Young Poussaint T, Wu S, Ligon AH, Lindeman N, Banerjee A, Packer RJ, Kilburn LB, Goldman S, Pollack IF, Qaddoumi I, Jakacki RI, Fisher PG, Dhall G, Baxter P, Kreissman SG, Stewart CF, Jones DTW, Pfister SM, Vezina G, Stern JS, Panigrahy A, Patay Z, Tamrazi B, Jones JY, Haque SS, Enterline DS, Cha S, Fisher MJ, Doyle LA, Smith M, Dunkel IJ, Fouladi M
Lancet Oncol 2019 Jul;20(7):1011-1022. Epub 2019 May 28 doi: 10.1016/S1470-2045(19)30277-3. PMID: 31151904Free PMC Article
Brainstem astrocytoma as a neuro-Behçet's disease mimic.
Manasson J, Howard J, Nowatzky J
BMJ Case Rep 2018 Dec 7;11(1) doi: 10.1136/bcr-2018-226945. PMID: 30567204Free PMC Article
Surveillance imaging strategies following surgery and/or radiotherapy for childhood cerebellar low-grade astrocytoma.
Saunders DE, Phipps KP, Wade AM, Hayward RD
J Neurosurg 2005 Mar;102(2 Suppl):172-8. doi: 10.3171/jns.2005.102.2.0172. PMID: 16156227
The impact of extent of resection in the management of malignant gliomas of childhood.
Finlay JL, Wisoff JH
Childs Nerv Syst 1999 Nov;15(11-12):786-8. doi: 10.1007/s003810050471. PMID: 10603023
Pediatric brain stem tumors: patterns of treatment failure and their implications for radiotherapy.
Halperin EC
Int J Radiat Oncol Biol Phys 1985 Jul;11(7):1293-8. doi: 10.1016/0360-3016(85)90244-5. PMID: 2989230

Therapy

Selumetinib in paediatric patients with BRAF-aberrant or neurofibromatosis type 1-associated recurrent, refractory, or progressive low-grade glioma: a multicentre, phase 2 trial.
Fangusaro J, Onar-Thomas A, Young Poussaint T, Wu S, Ligon AH, Lindeman N, Banerjee A, Packer RJ, Kilburn LB, Goldman S, Pollack IF, Qaddoumi I, Jakacki RI, Fisher PG, Dhall G, Baxter P, Kreissman SG, Stewart CF, Jones DTW, Pfister SM, Vezina G, Stern JS, Panigrahy A, Patay Z, Tamrazi B, Jones JY, Haque SS, Enterline DS, Cha S, Fisher MJ, Doyle LA, Smith M, Dunkel IJ, Fouladi M
Lancet Oncol 2019 Jul;20(7):1011-1022. Epub 2019 May 28 doi: 10.1016/S1470-2045(19)30277-3. PMID: 31151904Free PMC Article
Paclitaxel for the treatment of progressive or recurrent childhood brain tumors: a pediatric oncology phase II study.
Hurwitz CA, Strauss LC, Kepner J, Kretschmar C, Harris MB, Friedman H, Kun L, Kadota R
J Pediatr Hematol Oncol 2001 Jun-Jul;23(5):277-81. doi: 10.1097/00043426-200106000-00008. PMID: 11464982
The impact of extent of resection in the management of malignant gliomas of childhood.
Finlay JL, Wisoff JH
Childs Nerv Syst 1999 Nov;15(11-12):786-8. doi: 10.1007/s003810050471. PMID: 10603023
Is there a role for high-dose chemotherapy with stem cell rescue for brain stem tumors of childhood?
Dunkel IJ, O'Malley B, Finlay JL
Pediatr Neurosurg 1996;24(5):263-6. doi: 10.1159/000121049. PMID: 8933570
High-dose multi-agent chemotherapy followed by bone marrow 'rescue' for malignant astrocytomas of childhood and adolescence.
Finlay JL, August C, Packer R, Zimmerman R, Sutton L, Freid A, Rorke L, Bayever E, Kamani N, Kramer E
J Neurooncol 1990 Dec;9(3):239-48. doi: 10.1007/BF02341155. PMID: 1964962

Prognosis

Selumetinib in paediatric patients with BRAF-aberrant or neurofibromatosis type 1-associated recurrent, refractory, or progressive low-grade glioma: a multicentre, phase 2 trial.
Fangusaro J, Onar-Thomas A, Young Poussaint T, Wu S, Ligon AH, Lindeman N, Banerjee A, Packer RJ, Kilburn LB, Goldman S, Pollack IF, Qaddoumi I, Jakacki RI, Fisher PG, Dhall G, Baxter P, Kreissman SG, Stewart CF, Jones DTW, Pfister SM, Vezina G, Stern JS, Panigrahy A, Patay Z, Tamrazi B, Jones JY, Haque SS, Enterline DS, Cha S, Fisher MJ, Doyle LA, Smith M, Dunkel IJ, Fouladi M
Lancet Oncol 2019 Jul;20(7):1011-1022. Epub 2019 May 28 doi: 10.1016/S1470-2045(19)30277-3. PMID: 31151904Free PMC Article
Brainstem astrocytoma as a neuro-Behçet's disease mimic.
Manasson J, Howard J, Nowatzky J
BMJ Case Rep 2018 Dec 7;11(1) doi: 10.1136/bcr-2018-226945. PMID: 30567204Free PMC Article
Paclitaxel for the treatment of progressive or recurrent childhood brain tumors: a pediatric oncology phase II study.
Hurwitz CA, Strauss LC, Kepner J, Kretschmar C, Harris MB, Friedman H, Kun L, Kadota R
J Pediatr Hematol Oncol 2001 Jun-Jul;23(5):277-81. doi: 10.1097/00043426-200106000-00008. PMID: 11464982
Neurofibromatosis and childhood tumors.
Blatt J, Jaffe R, Deutsch M, Adkins JC
Cancer 1986 Mar 15;57(6):1225-9. doi: 10.1002/1097-0142(19860315)57:6<1225::aid-cncr2820570627>3.0.co;2-p. PMID: 3080222
Pediatric brain stem tumors: patterns of treatment failure and their implications for radiotherapy.
Halperin EC
Int J Radiat Oncol Biol Phys 1985 Jul;11(7):1293-8. doi: 10.1016/0360-3016(85)90244-5. PMID: 2989230

Clinical prediction guides

Actinomycin D downregulates Sox2 and improves survival in preclinical models of recurrent glioblastoma.
Taylor JT, Ellison S, Pandele A, Wood S, Nathan E, Forte G, Parker H, Zindy E, Elvin M, Dickson A, Williams KJ, Karabatsou K, McCabe M, McBain C, Bigger BW
Neuro Oncol 2020 Sep 29;22(9):1289-1301. doi: 10.1093/neuonc/noaa051. PMID: 32227096Free PMC Article
Selumetinib in paediatric patients with BRAF-aberrant or neurofibromatosis type 1-associated recurrent, refractory, or progressive low-grade glioma: a multicentre, phase 2 trial.
Fangusaro J, Onar-Thomas A, Young Poussaint T, Wu S, Ligon AH, Lindeman N, Banerjee A, Packer RJ, Kilburn LB, Goldman S, Pollack IF, Qaddoumi I, Jakacki RI, Fisher PG, Dhall G, Baxter P, Kreissman SG, Stewart CF, Jones DTW, Pfister SM, Vezina G, Stern JS, Panigrahy A, Patay Z, Tamrazi B, Jones JY, Haque SS, Enterline DS, Cha S, Fisher MJ, Doyle LA, Smith M, Dunkel IJ, Fouladi M
Lancet Oncol 2019 Jul;20(7):1011-1022. Epub 2019 May 28 doi: 10.1016/S1470-2045(19)30277-3. PMID: 31151904Free PMC Article
The impact of extent of resection in the management of malignant gliomas of childhood.
Finlay JL, Wisoff JH
Childs Nerv Syst 1999 Nov;15(11-12):786-8. doi: 10.1007/s003810050471. PMID: 10603023
High-dose multi-agent chemotherapy followed by bone marrow 'rescue' for malignant astrocytomas of childhood and adolescence.
Finlay JL, August C, Packer R, Zimmerman R, Sutton L, Freid A, Rorke L, Bayever E, Kamani N, Kramer E
J Neurooncol 1990 Dec;9(3):239-48. doi: 10.1007/BF02341155. PMID: 1964962
Pediatric brain stem tumors: patterns of treatment failure and their implications for radiotherapy.
Halperin EC
Int J Radiat Oncol Biol Phys 1985 Jul;11(7):1293-8. doi: 10.1016/0360-3016(85)90244-5. PMID: 2989230

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