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Anal Canal Intraepithelial Neoplasia

MedGen UID:
233978
•Concept ID:
C1332260
•
Neoplastic Process
Synonyms: Anal Canal Dysplasia; Anal Canal Squamous Dysplasia; Anal Canal Squamous Intraepithelial Neoplasia; Anal Squamous Intraepithelial Neoplasia

Definition

A precancerous neoplastic intraepithelial process involving the anal canal. When it is clinically noticeable, it may appear as an eczematous or papillary lesion, plaques, or papules. Morphologically, it is characterized by loss of epithelial stratification and nuclear polarity, cytologic atypia, and the presence of mitotic figures. It may be classified as low or high grade. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnal Canal Intraepithelial Neoplasia

Professional guidelines

PubMed

Anal intraepithelial neoplasia: a review of terminology, differential diagnoses, and patient management.
Vyas M, Gonzalez RS
Hum Pathol 2023 Feb;132:56-64. Epub 2022 Jul 16 doi: 10.1016/j.humpath.2022.07.005. PMID: 35843339
Diagnosis and screening for anal intraepithelial neoplasia in Belgium: position statement.
Roelandt P, De Looze D, De Schepper H, Ledouble V, Surmont M, Cuming T
Acta Gastroenterol Belg 2022 Oct-Dec;85(4):625-631. doi: 10.51821/85.4.10820. PMID: 36566372
Management of early anal cancer: need for guidelines and standardisation.
Jones MP, Carroll S, Martin J, Hillman R, Grulich A, O'Connell D, Young C, Poynten IM
Int J Colorectal Dis 2017 Dec;32(12):1719-1724. Epub 2017 Oct 15 doi: 10.1007/s00384-017-2913-6. PMID: 29034437

Recent clinical studies

Etiology

Interventions for anal canal intraepithelial neoplasia.
Macaya A, Muñoz-Santos C, Balaguer A, Barberà MJ
Cochrane Database Syst Rev 2012 Dec 12;12(12):CD009244. doi: 10.1002/14651858.CD009244.pub2. PMID: 23235673Free PMC Article
A double-blind, randomized controlled trial of the use of imiquimod cream for the treatment of anal canal high-grade anal intraepithelial neoplasia in HIV-positive MSM on HAART, with long-term follow-up data including the use of open-label imiquimod.
Fox PA, Nathan M, Francis N, Singh N, Weir J, Dixon G, Barton SE, Bower M
AIDS 2010 Sep 24;24(15):2331-5. doi: 10.1097/QAD.0b013e32833d466c. PMID: 20729710

Diagnosis

Intraepithelial neoplasia in the anal canal. The appearance and relation to genital neoplasia.
Fenger C, Nielsen VT
Acta Pathol Microbiol Immunol Scand A 1986 Sep;94(5):343-9. doi: 10.1111/j.1699-0463.1986.tb03003.x. PMID: 3766143

Therapy

Interventions for anal canal intraepithelial neoplasia.
Macaya A, Muñoz-Santos C, Balaguer A, Barberà MJ
Cochrane Database Syst Rev 2012 Dec 12;12(12):CD009244. doi: 10.1002/14651858.CD009244.pub2. PMID: 23235673Free PMC Article
A double-blind, randomized controlled trial of the use of imiquimod cream for the treatment of anal canal high-grade anal intraepithelial neoplasia in HIV-positive MSM on HAART, with long-term follow-up data including the use of open-label imiquimod.
Fox PA, Nathan M, Francis N, Singh N, Weir J, Dixon G, Barton SE, Bower M
AIDS 2010 Sep 24;24(15):2331-5. doi: 10.1097/QAD.0b013e32833d466c. PMID: 20729710

Recent systematic reviews

Interventions for anal canal intraepithelial neoplasia.
Macaya A, Muñoz-Santos C, Balaguer A, Barberà MJ
Cochrane Database Syst Rev 2012 Dec 12;12(12):CD009244. doi: 10.1002/14651858.CD009244.pub2. PMID: 23235673Free PMC Article

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