Anal Paget disease

MedGen UID:: 233981
•Concept ID:: C1332274
•: Neoplastic Process

Synonyms:	Anal Paget Disease; anal Paget disease; Anal Paget's Disease; anal Paget's disease; anus mammary Paget's disease; anus Paget disease; Paget Disease of the Anus; Paget disease of the anus; Paget's Disease of Anus; Paget's disease of anus; Paget's Disease of the Anus; Paget's disease of the anus

Monarch Initiative:	MONDO:0002651

Definition

A slowly spreading, erythematous eczematoid plaque in the anal region. Histologically, the basal part or whole thickness of the squamous epithelium is infiltrated by large cells with abundant pale cytoplasm and large nuclei. Half of the cases are associated with an internal malignancy, most often a colorectal adenocarcinoma. The other half of the cases, have a high local recurrence rate and they may become invasive (WHO). [from NCI]

Professional guidelines

PubMed

Spectrum of Changes in Anogenital Mammary-like Glands in Primary Extramammary (Anogenital) Paget Disease and Their Possible Role in the Pathogenesis of the Disease.

Konstantinova AM, Spagnolo DV, Stewart CJR, Kacerovska D, Shelekhova KV, Plaza JA, Suster S, Bouda J, Kyrpychova L, Michal M, Belousova IE, Kerl K, Kazakov DV
Am J Surg Pathol 2017 Aug;41(8):1053-1058. doi: 10.1097/PAS.0000000000000857. PMID: 28614205

Extra-mammary Paget's disease of the perianal region: a review of the literature emphasizing the operative management technique.

Kyriazanos ID, Stamos NP, Miliadis L, Noussis G, Stoidis CN
Surg Oncol 2011 Jun;20(2):e61-71. doi: 10.1016/j.suronc.2010.09.005. PMID: 20884199

Management of less common tumors of the colon, rectum, and anus.

Cuffy M, Abir F, Longo WE
Clin Colorectal Cancer 2006 Jan;5(5):327-37. doi: 10.3816/CCC.2006.n.002. PMID: 16512991

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