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Diffuse Blastoid B-Cell Lymphoma

MedGen UID:
234040
•Concept ID:
C1332568
•
Neoplastic Process
Synonym: Blastoid Follicular Lymphoma

Definition

A distinct subtype of high-grade follicular center cell lymphoma, representing a diffuse transformation of conventional follicular lymphoma. Although this type of lymphoma strongly expresses BCL-2, it does not carry the characteristic t(14;18)(q32;q21) chromosomal translocation found in follicular lymphomas. Instead, extra copies of chromosome 18 are often detected. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDiffuse Blastoid B-Cell Lymphoma

Recent clinical studies

Etiology

The Clinicopathologic Features and Molecular Signatures of Blastoid High-Grade B Cell Lymphoma, Not Otherwise Specified.
Qiu L, Lin P, Khanlari M, Xu J, Cohen EN, Garces S, Miranda RN, Wang W, Fang H, Bueso-Ramos CE, Medeiros LJ, Li S
Mod Pathol 2023 Dec;36(12):100349. Epub 2023 Oct 10 doi: 10.1016/j.modpat.2023.100349. PMID: 37820764
Brexucabtagene Autoleucel for Relapsed or Refractory Mantle Cell Lymphoma in Standard-of-Care Practice: Results From the US Lymphoma CAR T Consortium.
Wang Y, Jain P, Locke FL, Maurer MJ, Frank MJ, Munoz JL, Dahiya S, Beitinjaneh AM, Jacobs MT, Mcguirk JP, Vose JM, Goy A, Andreadis C, Hill BT, Dorritie KA, Oluwole OO, Deol A, Paludo J, Shah B, Wang T, Banerjee R, Miklos DB, Rapoport AP, Lekakis L, Ghobadi A, Neelapu SS, Lin Y, Wang ML, Jain MD
J Clin Oncol 2023 May 10;41(14):2594-2606. Epub 2023 Feb 8 doi: 10.1200/JCO.22.01797. PMID: 36753699Free PMC Article
Blastoid high-grade B-cell lymphoma initially presenting in bone marrow: a diagnostic challenge.
Khanlari M, Medeiros LJ, Lin P, Xu J, You MJ, Tang G, Yin CC, Wang W, Qiu L, Miranda RN, Bueso-Ramos CE, Li S
Mod Pathol 2022 Mar;35(3):419-426. Epub 2021 Oct 4 doi: 10.1038/s41379-021-00909-4. PMID: 34608246
Aggressive B-cell lymphomas: how many categories do we need?
Said JW
Mod Pathol 2013 Jan;26 Suppl 1(0 1):S42-56. Epub 2012 Nov 16 doi: 10.1038/modpathol.2012.178. PMID: 23154748Free PMC Article
Lymphoblastic lymphoma.
Cortelazzo S, Ponzoni M, Ferreri AJ, Hoelzer D
Crit Rev Oncol Hematol 2011 Sep;79(3):330-43. Epub 2011 Jan 26 doi: 10.1016/j.critrevonc.2010.12.003. PMID: 21273093

Diagnosis

SOX11+ Large B-Cell Neoplasms: Cyclin D1-Negative Blastoid/Pleomorphic Mantle Cell Lymphoma or Large B-Cell Lymphoma?
Li S, Tang G, Jain P, Lin P, Xu J, Miranda RN, Cheng J, Yin CC, You MJ, Wang ML, Medeiros LJ
Mod Pathol 2024 Feb;37(2):100405. Epub 2023 Dec 15 doi: 10.1016/j.modpat.2023.100405. PMID: 38104893
Blastoid high-grade B-cell lymphoma initially presenting in bone marrow: a diagnostic challenge.
Khanlari M, Medeiros LJ, Lin P, Xu J, You MJ, Tang G, Yin CC, Wang W, Qiu L, Miranda RN, Bueso-Ramos CE, Li S
Mod Pathol 2022 Mar;35(3):419-426. Epub 2021 Oct 4 doi: 10.1038/s41379-021-00909-4. PMID: 34608246
Defining and treating high-grade B-cell lymphoma, NOS.
Olszewski AJ, Kurt H, Evens AM
Blood 2022 Sep 1;140(9):943-954. doi: 10.1182/blood.2020008374. PMID: 34525177
CD5-negative blastoid variant mantle cell lymphoma: a diagnostic dilemma.
Yamamoto N, Maeshima AM, Taniguchi H, Makita S, Fukuhara S, Munakata W, Suzuki T, Maruyama D, Izutsu K
Hum Pathol 2021 May;111:84-91. Epub 2021 Mar 13 doi: 10.1016/j.humpath.2021.03.005. PMID: 33727166
Lymphoblastic lymphoma.
Cortelazzo S, Ponzoni M, Ferreri AJ, Hoelzer D
Crit Rev Oncol Hematol 2011 Sep;79(3):330-43. Epub 2011 Jan 26 doi: 10.1016/j.critrevonc.2010.12.003. PMID: 21273093

Therapy

Brexucabtagene Autoleucel for Relapsed or Refractory Mantle Cell Lymphoma in Standard-of-Care Practice: Results From the US Lymphoma CAR T Consortium.
Wang Y, Jain P, Locke FL, Maurer MJ, Frank MJ, Munoz JL, Dahiya S, Beitinjaneh AM, Jacobs MT, Mcguirk JP, Vose JM, Goy A, Andreadis C, Hill BT, Dorritie KA, Oluwole OO, Deol A, Paludo J, Shah B, Wang T, Banerjee R, Miklos DB, Rapoport AP, Lekakis L, Ghobadi A, Neelapu SS, Lin Y, Wang ML, Jain MD
J Clin Oncol 2023 May 10;41(14):2594-2606. Epub 2023 Feb 8 doi: 10.1200/JCO.22.01797. PMID: 36753699Free PMC Article
CD5(-) diffuse large B-cell lymphoma with peculiar cyclin D1+ phenotype. Pathologic and molecular characterization of a single case.
Lucioni M, Novara F, Riboni R, Fiandrino G, Nicola M, Kindl S, Boveri E, Jemos V, Arcaini L, Zuffardi O, Paulli M
Hum Pathol 2011 Aug;42(8):1204-8. Epub 2011 Feb 21 doi: 10.1016/j.humpath.2010.11.015. PMID: 21334716
Lymphoblastic lymphoma.
Cortelazzo S, Ponzoni M, Ferreri AJ, Hoelzer D
Crit Rev Oncol Hematol 2011 Sep;79(3):330-43. Epub 2011 Jan 26 doi: 10.1016/j.critrevonc.2010.12.003. PMID: 21273093
Plasmablastic lymphoma of the oral cavity in immunocompetent patients: report of two cases.
Rao DD, Aggarwal N, Anehosur V, Doddihal H, Shiraganvi M, Gopalkrishnan K
Int J Oral Maxillofac Surg 2010 Oct;39(10):1036-9. doi: 10.1016/j.ijom.2010.04.040. PMID: 20537863
Mantle-cell lymphoma: classification and therapeutic implications.
Fisher RI
Ann Oncol 1996;7 Suppl 6:S35-9. doi: 10.1093/annonc/7.suppl_6.s35. PMID: 9010577

Prognosis

Brexucabtagene Autoleucel for Relapsed or Refractory Mantle Cell Lymphoma in Standard-of-Care Practice: Results From the US Lymphoma CAR T Consortium.
Wang Y, Jain P, Locke FL, Maurer MJ, Frank MJ, Munoz JL, Dahiya S, Beitinjaneh AM, Jacobs MT, Mcguirk JP, Vose JM, Goy A, Andreadis C, Hill BT, Dorritie KA, Oluwole OO, Deol A, Paludo J, Shah B, Wang T, Banerjee R, Miklos DB, Rapoport AP, Lekakis L, Ghobadi A, Neelapu SS, Lin Y, Wang ML, Jain MD
J Clin Oncol 2023 May 10;41(14):2594-2606. Epub 2023 Feb 8 doi: 10.1200/JCO.22.01797. PMID: 36753699Free PMC Article
Blastoid high-grade B-cell lymphoma initially presenting in bone marrow: a diagnostic challenge.
Khanlari M, Medeiros LJ, Lin P, Xu J, You MJ, Tang G, Yin CC, Wang W, Qiu L, Miranda RN, Bueso-Ramos CE, Li S
Mod Pathol 2022 Mar;35(3):419-426. Epub 2021 Oct 4 doi: 10.1038/s41379-021-00909-4. PMID: 34608246
Defining and treating high-grade B-cell lymphoma, NOS.
Olszewski AJ, Kurt H, Evens AM
Blood 2022 Sep 1;140(9):943-954. doi: 10.1182/blood.2020008374. PMID: 34525177
Lymphoblastic lymphoma.
Cortelazzo S, Ponzoni M, Ferreri AJ, Hoelzer D
Crit Rev Oncol Hematol 2011 Sep;79(3):330-43. Epub 2011 Jan 26 doi: 10.1016/j.critrevonc.2010.12.003. PMID: 21273093
Mantle-cell lymphoma: classification and therapeutic implications.
Fisher RI
Ann Oncol 1996;7 Suppl 6:S35-9. doi: 10.1093/annonc/7.suppl_6.s35. PMID: 9010577

Clinical prediction guides

SOX11+ Large B-Cell Neoplasms: Cyclin D1-Negative Blastoid/Pleomorphic Mantle Cell Lymphoma or Large B-Cell Lymphoma?
Li S, Tang G, Jain P, Lin P, Xu J, Miranda RN, Cheng J, Yin CC, You MJ, Wang ML, Medeiros LJ
Mod Pathol 2024 Feb;37(2):100405. Epub 2023 Dec 15 doi: 10.1016/j.modpat.2023.100405. PMID: 38104893
Complex genetic and histopathological study of 15 patient-derived xenografts of aggressive lymphomas.
Jakša R, Karolová J, Svatoň M, Kazantsev D, Grajciarová M, Pokorná E, Tonar Z, Klánová M, Winkowska L, Maláriková D, Vočková P, Forsterová K, Renešová N, Dolníková A, Nožičková K, Dundr P, Froňková E, Trněný M, Klener P
Lab Invest 2022 Sep;102(9):957-965. Epub 2022 Apr 29 doi: 10.1038/s41374-022-00784-w. PMID: 35488033Free PMC Article
Blastoid high-grade B-cell lymphoma initially presenting in bone marrow: a diagnostic challenge.
Khanlari M, Medeiros LJ, Lin P, Xu J, You MJ, Tang G, Yin CC, Wang W, Qiu L, Miranda RN, Bueso-Ramos CE, Li S
Mod Pathol 2022 Mar;35(3):419-426. Epub 2021 Oct 4 doi: 10.1038/s41379-021-00909-4. PMID: 34608246
CD5-negative blastoid variant mantle cell lymphoma: a diagnostic dilemma.
Yamamoto N, Maeshima AM, Taniguchi H, Makita S, Fukuhara S, Munakata W, Suzuki T, Maruyama D, Izutsu K
Hum Pathol 2021 May;111:84-91. Epub 2021 Mar 13 doi: 10.1016/j.humpath.2021.03.005. PMID: 33727166
Mantle cell lymphomas with concomitant MYC and CCND1 breakpoints are recurrently TdT positive and frequently show high-grade pathological and genetic features.
Aukema SM, Croci GA, Bens S, Oehl-Huber K, Wagener R, Ott G, Rosenwald A, Kluin PM, van den Berg E, Bosga-Bouwer AG, Hoogendoorn M, Hoster E, Bittmann I, Nagel I, Murga Penas EM, Kreuz M, Bausinger J, Belder W, Oschlies I, Dyer MJS, Jayne S, Siebert R, Klapper W
Virchows Arch 2021 Jul;479(1):133-145. Epub 2021 Feb 2 doi: 10.1007/s00428-021-03022-8. PMID: 33528622

Recent systematic reviews

Complexities in the diagnosis of large B-cell lymphomas, classic Hodgkin lymphomas and overlapping peripheral T-cell lymphomas simplified: An evidence-based guide.
Wen KW, Fakhri B, Menke J, Ruiz-Cordero R, Gill RM, Ohgami RS
Ann Diagn Pathol 2020 Jun;46:151534. Epub 2020 May 15 doi: 10.1016/j.anndiagpath.2020.151534. PMID: 32473554

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