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Cervical clear cell adenocarcinoma

MedGen UID:
234113
•Concept ID:
C1332912
•
Neoplastic Process
Synonyms: Cervical Clear Cell Adenocarcinoma; cervical clear cell adenocarcinoma; Cervical Clear Cell Carcinoma; cervical clear cell carcinoma; Cervix Clear Cell Adenocarcinoma; cervix clear cell adenocarcinoma; Cervix Clear Cell Carcinoma; cervix clear cell carcinoma; Cervix Uteri Clear Cell Adenocarcinoma; cervix uteri clear cell adenocarcinoma; Cervix Uteri Clear Cell Carcinoma; cervix uteri clear cell carcinoma; Clear Cell Adenocarcinoma of Cervix; clear cell adenocarcinoma of cervix; Clear Cell Adenocarcinoma of Cervix Uteri; clear cell adenocarcinoma of cervix uteri; Clear Cell Adenocarcinoma of the Cervix; clear cell adenocarcinoma of the cervix; Clear Cell Adenocarcinoma of the Cervix Uteri; clear cell adenocarcinoma of the cervix uteri; Clear Cell Adenocarcinoma of the Uterine Cervix; clear cell adenocarcinoma of the uterine cervix; Clear Cell Adenocarcinoma of Uterine Cervix; clear cell adenocarcinoma of uterine cervix; Clear Cell Carcinoma of Cervix; Clear cell carcinoma of cervix; clear cell carcinoma of cervix; Clear Cell Carcinoma of Cervix Uteri; clear cell carcinoma of cervix uteri; Clear Cell Carcinoma of the Cervix; clear cell carcinoma of the cervix; Clear Cell Carcinoma of the Cervix Uteri; clear cell carcinoma of the cervix uteri; Clear Cell Carcinoma of the Uterine Cervix; clear cell carcinoma of the uterine cervix; Clear Cell Carcinoma of Uterine Cervix; clear cell carcinoma of uterine cervix; HPV- Independent Cervical Adenocarcinoma, Clear Cell Type; HPV- Independent Cervical Adenocarcinoma, Clear Cell-Type; Human Papillomavirus-Independent Cervical Adenocarcinoma, Clear Cell Type; Human Papillomavirus-Independent Cervical Adenocarcinoma, Clear Cell-Type; Uterine Cervix Clear Cell Adenocarcinoma; uterine cervix clear cell adenocarcinoma; Uterine Cervix Clear Cell Carcinoma; uterine cervix clear cell carcinoma
 
HPO: HP:0031522
Monarch Initiative: MONDO:0006135

Definition

A type of adenocarcinoma originating in the cervix and characterized by large cells with moderate to abundant clear cytoplasm. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCervical clear cell adenocarcinoma

Professional guidelines

PubMed

Uncommon Cervical Lesions: A Review and Discussion of the Differential Diagnosis.
Griesinger LM, Szczepanski JM, McMullen ER, Skala SL
Arch Pathol Lab Med 2021 Jul 1;145(7):891-902. doi: 10.5858/arpa.2020-0327-RA. PMID: 33091926
International Endocervical Adenocarcinoma Criteria and Classification (IECC): A New Pathogenetic Classification for Invasive Adenocarcinomas of the Endocervix.
Stolnicu S, Barsan I, Hoang L, Patel P, Terinte C, Pesci A, Aviel-Ronen S, Kiyokawa T, Alvarado-Cabrero I, Pike MC, Oliva E, Park KJ, Soslow RA
Am J Surg Pathol 2018 Feb;42(2):214-226. doi: 10.1097/PAS.0000000000000986. PMID: 29135516Free PMC Article
The Role of Molecular Testing in the Differential Diagnosis of Salivary Gland Carcinomas.
Skálová A, Stenman G, Simpson RHW, Hellquist H, Slouka D, Svoboda T, Bishop JA, Hunt JL, Nibu KI, Rinaldo A, Vander Poorten V, Devaney KO, Steiner P, Ferlito A
Am J Surg Pathol 2018 Feb;42(2):e11-e27. doi: 10.1097/PAS.0000000000000980. PMID: 29076877

Recent clinical studies

Etiology

Clinical Features and Prognostic Factors of Cervical Clear Cell Adenocarcinoma: A Retrospective Analysis of 74 Cases from a Tertiary Hospital.
Liu Y, Shi X, Yang J, Zhou H, Peng P, Cao D
Technol Cancer Res Treat 2023 Jan-Dec;22:15330338221149297. doi: 10.1177/15330338221149297. PMID: 36718531Free PMC Article
Incidence rates and risks of diethylstilbestrol-related clear-cell adenocarcinoma of the vagina and cervix: Update after 40-year follow-up.
Huo D, Anderson D, Palmer JR, Herbst AL
Gynecol Oncol 2017 Sep;146(3):566-571. Epub 2017 Jul 6 doi: 10.1016/j.ygyno.2017.06.028. PMID: 28689666
Cervical clear cell adenocarcinoma infected with human papillomavirus type 18 in an adolescent.
Guo Y, Song L, Liu H
J Pediatr Adolesc Gynecol 2014 Feb;27(1):e1-3. Epub 2013 Jul 10 doi: 10.1016/j.jpag.2013.04.007. PMID: 23849091
Pelvic exenteration in clear cell adenocarcinoma of the vagina and cervix.
Senekjian EK, Frey K, Herbst AL
Gynecol Oncol 1989 Sep;34(3):413-6. doi: 10.1016/0090-8258(89)90183-2. PMID: 2767532
Diethylstilboestrol and diethylstilboestrol dipropionate.
IARC Monogr Eval Carcinog Risk Chem Hum 1979 Dec;21:173-231. PMID: 397181

Diagnosis

Clinical Features and Prognostic Factors of Cervical Clear Cell Adenocarcinoma: A Retrospective Analysis of 74 Cases from a Tertiary Hospital.
Liu Y, Shi X, Yang J, Zhou H, Peng P, Cao D
Technol Cancer Res Treat 2023 Jan-Dec;22:15330338221149297. doi: 10.1177/15330338221149297. PMID: 36718531Free PMC Article
Incidence rates and risks of diethylstilbestrol-related clear-cell adenocarcinoma of the vagina and cervix: Update after 40-year follow-up.
Huo D, Anderson D, Palmer JR, Herbst AL
Gynecol Oncol 2017 Sep;146(3):566-571. Epub 2017 Jul 6 doi: 10.1016/j.ygyno.2017.06.028. PMID: 28689666
Cervical clear cell adenocarcinoma infected with human papillomavirus type 18 in an adolescent.
Guo Y, Song L, Liu H
J Pediatr Adolesc Gynecol 2014 Feb;27(1):e1-3. Epub 2013 Jul 10 doi: 10.1016/j.jpag.2013.04.007. PMID: 23849091
Clear cell adenocarcinoma of the vagina and cervix. A report of the Central Netherlands Registry with emphasis on early detection and prognosis.
Hanselaar AG, Van Leusen ND, De Wilde PC, Vooijs GP
Cancer 1991 Apr 1;67(7):1971-8. doi: 10.1002/1097-0142(19910401)67:7<1971::aid-cncr2820670725>3.0.co;2-x. PMID: 2004313
Pathology of the vagina.
Wilkinson EJ
Curr Opin Obstet Gynecol 1991 Aug;3(4):553-60. PMID: 1678972

Therapy

Incidence rates and risks of diethylstilbestrol-related clear-cell adenocarcinoma of the vagina and cervix: Update after 40-year follow-up.
Huo D, Anderson D, Palmer JR, Herbst AL
Gynecol Oncol 2017 Sep;146(3):566-571. Epub 2017 Jul 6 doi: 10.1016/j.ygyno.2017.06.028. PMID: 28689666
Cervical clear cell adenocarcinoma infected with human papillomavirus type 18 in an adolescent.
Guo Y, Song L, Liu H
J Pediatr Adolesc Gynecol 2014 Feb;27(1):e1-3. Epub 2013 Jul 10 doi: 10.1016/j.jpag.2013.04.007. PMID: 23849091
High-risk human papillomavirus seems not involved in DES-related and of limited importance in nonDES related clear-cell carcinoma of the cervix.
Kocken M, Baalbergen A, Snijders PJ, Bulten J, Quint WG, Smedts F, Meijer CJ, Helmerhorst TJ
Gynecol Oncol 2011 Aug;122(2):297-302. Epub 2011 May 26 doi: 10.1016/j.ygyno.2011.05.002. PMID: 21620450
Clear cell adenocarcinoma of the vagina and cervix. A report of the Central Netherlands Registry with emphasis on early detection and prognosis.
Hanselaar AG, Van Leusen ND, De Wilde PC, Vooijs GP
Cancer 1991 Apr 1;67(7):1971-8. doi: 10.1002/1097-0142(19910401)67:7<1971::aid-cncr2820670725>3.0.co;2-x. PMID: 2004313
Diethylstilboestrol and diethylstilboestrol dipropionate.
IARC Monogr Eval Carcinog Risk Chem Hum 1979 Dec;21:173-231. PMID: 397181

Prognosis

Clinical Features and Prognostic Factors of Cervical Clear Cell Adenocarcinoma: A Retrospective Analysis of 74 Cases from a Tertiary Hospital.
Liu Y, Shi X, Yang J, Zhou H, Peng P, Cao D
Technol Cancer Res Treat 2023 Jan-Dec;22:15330338221149297. doi: 10.1177/15330338221149297. PMID: 36718531Free PMC Article
Incidence rates and risks of diethylstilbestrol-related clear-cell adenocarcinoma of the vagina and cervix: Update after 40-year follow-up.
Huo D, Anderson D, Palmer JR, Herbst AL
Gynecol Oncol 2017 Sep;146(3):566-571. Epub 2017 Jul 6 doi: 10.1016/j.ygyno.2017.06.028. PMID: 28689666
Clear cell adenocarcinoma of the vagina and cervix. A report of the Central Netherlands Registry with emphasis on early detection and prognosis.
Hanselaar AG, Van Leusen ND, De Wilde PC, Vooijs GP
Cancer 1991 Apr 1;67(7):1971-8. doi: 10.1002/1097-0142(19910401)67:7<1971::aid-cncr2820670725>3.0.co;2-x. PMID: 2004313

Clinical prediction guides

Clinical Features and Prognostic Factors of Cervical Clear Cell Adenocarcinoma: A Retrospective Analysis of 74 Cases from a Tertiary Hospital.
Liu Y, Shi X, Yang J, Zhou H, Peng P, Cao D
Technol Cancer Res Treat 2023 Jan-Dec;22:15330338221149297. doi: 10.1177/15330338221149297. PMID: 36718531Free PMC Article

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