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Breast Complex Fibroadenoma

MedGen UID:
234170
•Concept ID:
C1333137
•
Neoplastic Process
Synonyms: Complex Breast Fibroadenoma; Complex Fibroadenoma; Complex Fibroadenoma of Breast; Complex Fibroadenoma of the Breast

Definition

A breast fibroadenoma that displays fibrocystic changes including apocrine metaplasia, sclerosing adenosis, and cyst formation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBreast Complex Fibroadenoma

Professional guidelines

PubMed

Fibroepithelial lesions revisited: implications for diagnosis and management.
Tan PH
Mod Pathol 2021 Jan;34(Suppl 1):15-37. Epub 2020 May 27 doi: 10.1038/s41379-020-0583-3. PMID: 32461622
Breast Lesions in Children and Adolescents: Diagnosis and Management.
Lee EJ, Chang YW, Oh JH, Hwang J, Hong SS, Kim HJ
Korean J Radiol 2018 Sep-Oct;19(5):978-991. Epub 2018 Aug 6 doi: 10.3348/kjr.2018.19.5.978. PMID: 30174488Free PMC Article
Diagnosis and management of benign, atypical, and indeterminate breast lesions detected on core needle biopsy.
Neal L, Sandhu NP, Hieken TJ, Glazebrook KN, Mac Bride MB, Dilaveri CA, Wahner-Roedler DL, Ghosh K, Visscher DW
Mayo Clin Proc 2014 Apr;89(4):536-47. doi: 10.1016/j.mayocp.2014.02.004. PMID: 24684875

Recent clinical studies

Etiology

Fibroepithelial lesions revisited: implications for diagnosis and management.
Tan PH
Mod Pathol 2021 Jan;34(Suppl 1):15-37. Epub 2020 May 27 doi: 10.1038/s41379-020-0583-3. PMID: 32461622
Benign Disorders of the Breast in Pregnancy and Lactation.
Taib NA, Rahmat K
Adv Exp Med Biol 2020;1252:43-51. doi: 10.1007/978-3-030-41596-9_6. PMID: 32816261
Benign Breast Disease in Women.
Stachs A, Stubert J, Reimer T, Hartmann S
Dtsch Arztebl Int 2019 Aug 9;116(33-34):565-574. doi: 10.3238/arztebl.2019.0565. PMID: 31554551Free PMC Article
Genetics and genomics of breast fibroadenomas.
Loke BN, Md Nasir ND, Thike AA, Lee JYH, Lee CS, Teh BT, Tan PH
J Clin Pathol 2018 May;71(5):381-387. Epub 2017 Dec 16 doi: 10.1136/jclinpath-2017-204838. PMID: 29248888
Phyllodes tumours of the breast: a consensus review.
Tan BY, Acs G, Apple SK, Badve S, Bleiweiss IJ, Brogi E, Calvo JP, Dabbs DJ, Ellis IO, Eusebi V, Farshid G, Fox SB, Ichihara S, Lakhani SR, Rakha EA, Reis-Filho JS, Richardson AL, Sahin A, Schmitt FC, Schnitt SJ, Siziopikou KP, Soares FA, Tse GM, Vincent-Salomon A, Tan PH
Histopathology 2016 Jan;68(1):5-21. doi: 10.1111/his.12876. PMID: 26768026Free PMC Article

Diagnosis

Fibroepithelial tumours of the breast-a review.
Lerwill MF, Lee AHS, Tan PH
Virchows Arch 2022 Jan;480(1):45-63. Epub 2021 Sep 10 doi: 10.1007/s00428-021-03175-6. PMID: 34505197
Fibroadenomas: a multidisciplinary review of the variants.
Basara Akin I, Balci P
Clin Imaging 2021 Mar;71:83-100. Epub 2020 Nov 6 doi: 10.1016/j.clinimag.2020.10.058. PMID: 33186871
Benign Breast Disease in Women.
Stachs A, Stubert J, Reimer T, Hartmann S
Dtsch Arztebl Int 2019 Aug 9;116(33-34):565-574. doi: 10.3238/arztebl.2019.0565. PMID: 31554551Free PMC Article
Genetics and genomics of breast fibroadenomas.
Loke BN, Md Nasir ND, Thike AA, Lee JYH, Lee CS, Teh BT, Tan PH
J Clin Pathol 2018 May;71(5):381-387. Epub 2017 Dec 16 doi: 10.1136/jclinpath-2017-204838. PMID: 29248888
Phyllodes tumours of the breast: a consensus review.
Tan BY, Acs G, Apple SK, Badve S, Bleiweiss IJ, Brogi E, Calvo JP, Dabbs DJ, Ellis IO, Eusebi V, Farshid G, Fox SB, Ichihara S, Lakhani SR, Rakha EA, Reis-Filho JS, Richardson AL, Sahin A, Schmitt FC, Schnitt SJ, Siziopikou KP, Soares FA, Tse GM, Vincent-Salomon A, Tan PH
Histopathology 2016 Jan;68(1):5-21. doi: 10.1111/his.12876. PMID: 26768026Free PMC Article

Therapy

BCDnet: Parallel heterogeneous eight-class classification model of breast pathology.
He Q, Cheng G, Ju H
PLoS One 2021;16(7):e0253764. Epub 2021 Jul 12 doi: 10.1371/journal.pone.0253764. PMID: 34252112Free PMC Article
Role of the contrast-enhanced spectral mammography for the diagnosis of breast metastases from extramammary neoplasms.
La Forgia D, Catino A, Dentamaro R, Galetta D, Gatta G, Losurdo L, Massafra R, Scattone A, Tangaro S, Fanizzi A
J BUON 2019 Jul-Aug;24(4):1360-1366. PMID: 31646778
Genomics of uterine leiomyomas: insights from high-throughput sequencing.
Mehine M, Mäkinen N, Heinonen HR, Aaltonen LA, Vahteristo P
Fertil Steril 2014 Sep;102(3):621-9. Epub 2014 Aug 5 doi: 10.1016/j.fertnstert.2014.06.050. PMID: 25106763
Breast cancer, passive and active cigarette smoking and N-acetyltransferase 2 genotype.
Delfino RJ, Smith C, West JG, Lin HJ, White E, Liao SY, Gim JS, Ma HL, Butler J, Anton-Culver H
Pharmacogenetics 2000 Jul;10(5):461-9. doi: 10.1097/00008571-200007000-00009. PMID: 10898115
Copper, zinc and superoxide dismutase in precancerous, benign diseases and gastric, colorectal and breast cancer.
Magálová T, Bella V, Brtková A, Beno I, Kudlácková M, Volkovová K
Neoplasma 1999;46(2):100-4. PMID: 10466433

Prognosis

Awareness and Knowledge of Breast Cancer and Breast Examination amongst Undergraduate Students. Mixed Method Approach.
Makinde OY, Wuraola FO, Aderounmu AA, Ugalahi TO, Olasehinde O, Adisa AO
West Afr J Med 2023 Aug 28;40(8):857-862. PMID: 37639531
Fibroepithelial tumours of the breast-a review.
Lerwill MF, Lee AHS, Tan PH
Virchows Arch 2022 Jan;480(1):45-63. Epub 2021 Sep 10 doi: 10.1007/s00428-021-03175-6. PMID: 34505197
Fibroepithelial lesions revisited: implications for diagnosis and management.
Tan PH
Mod Pathol 2021 Jan;34(Suppl 1):15-37. Epub 2020 May 27 doi: 10.1038/s41379-020-0583-3. PMID: 32461622
Genetics and genomics of breast fibroadenomas.
Loke BN, Md Nasir ND, Thike AA, Lee JYH, Lee CS, Teh BT, Tan PH
J Clin Pathol 2018 May;71(5):381-387. Epub 2017 Dec 16 doi: 10.1136/jclinpath-2017-204838. PMID: 29248888
Phyllodes tumours of the breast: a consensus review.
Tan BY, Acs G, Apple SK, Badve S, Bleiweiss IJ, Brogi E, Calvo JP, Dabbs DJ, Ellis IO, Eusebi V, Farshid G, Fox SB, Ichihara S, Lakhani SR, Rakha EA, Reis-Filho JS, Richardson AL, Sahin A, Schmitt FC, Schnitt SJ, Siziopikou KP, Soares FA, Tse GM, Vincent-Salomon A, Tan PH
Histopathology 2016 Jan;68(1):5-21. doi: 10.1111/his.12876. PMID: 26768026Free PMC Article

Clinical prediction guides

Complex Fibroadenoma Mimicking Breast Cancer on 68Ga-FAPI-04 and 18F-FDG PET/CT.
Alçin G, Tatar G, Menengiç Koç MS, Arslan E, Ergül N, Çermik TF
Clin Nucl Med 2023 Mar 1;48(3):e121-e123. Epub 2022 Nov 11 doi: 10.1097/RLU.0000000000004495. PMID: 36723896
Genetics and genomics of breast fibroadenomas.
Loke BN, Md Nasir ND, Thike AA, Lee JYH, Lee CS, Teh BT, Tan PH
J Clin Pathol 2018 May;71(5):381-387. Epub 2017 Dec 16 doi: 10.1136/jclinpath-2017-204838. PMID: 29248888
Phyllodes tumours of the breast: a consensus review.
Tan BY, Acs G, Apple SK, Badve S, Bleiweiss IJ, Brogi E, Calvo JP, Dabbs DJ, Ellis IO, Eusebi V, Farshid G, Fox SB, Ichihara S, Lakhani SR, Rakha EA, Reis-Filho JS, Richardson AL, Sahin A, Schmitt FC, Schnitt SJ, Siziopikou KP, Soares FA, Tse GM, Vincent-Salomon A, Tan PH
Histopathology 2016 Jan;68(1):5-21. doi: 10.1111/his.12876. PMID: 26768026Free PMC Article
Complex fibroadenoma and breast cancer risk: a Mayo Clinic Benign Breast Disease Cohort Study.
Nassar A, Visscher DW, Degnim AC, Frank RD, Vierkant RA, Frost M, Radisky DC, Vachon CM, Kraft RA, Hartmann LC, Ghosh K
Breast Cancer Res Treat 2015 Sep;153(2):397-405. Epub 2015 Aug 12 doi: 10.1007/s10549-015-3535-8. PMID: 26264469Free PMC Article
Activin, inhibin and the human breast.
Reis FM, Luisi S, Carneiro MM, Cobellis L, Federico M, Camargos AF, Petraglia F
Mol Cell Endocrinol 2004 Oct 15;225(1-2):77-82. doi: 10.1016/j.mce.2004.02.016. PMID: 15451571

Recent systematic reviews

Systematic review of fibroadenoma as a risk factor for breast cancer.
El-Wakeel H, Umpleby HC
Breast 2003 Oct;12(5):302-7. doi: 10.1016/s0960-9776(03)00123-1. PMID: 14659144

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