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Diffuse Follicular Lymphoma

MedGen UID:
234201
•Concept ID:
C1333290
•
Neoplastic Process
Synonyms: Diffuse follicle center lymphoma; Diffuse Follicle Centre Lymphoma; Follicle Centre Lymphoma Diffuse
SNOMED CT: Diffuse follicle center lymphoma (449220000)

Definition

A lymphoma with the morphologic and immunophenotypic features of a follicular lymphoma that shows entirely a diffuse pattern. It is usually seen in small biopsy specimens and most probably represents a diffuse area of a follicular lymphoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDiffuse Follicular Lymphoma

Professional guidelines

PubMed

Review of lymphoma in the duodenum: An update of diagnosis and management.
Iwamuro M, Tanaka T, Okada H
World J Gastroenterol 2023 Mar 28;29(12):1852-1862. doi: 10.3748/wjg.v29.i12.1852. PMID: 37032723Free PMC Article
CAR therapy for hematological cancers: can success seen in the treatment of B-cell acute lymphoblastic leukemia be applied to other hematological malignancies?
Pegram HJ, Smith EL, Rafiq S, Brentjens RJ
Immunotherapy 2015;7(5):545-61. doi: 10.2217/imt.15.6. PMID: 26065479Free PMC Article
Relapse in common lymphoma subtypes: salvage treatment options for follicular lymphoma, diffuse large cell lymphoma and Hodgkin disease.
Seyfarth B, Josting A, Dreyling M, Schmitz N
Br J Haematol 2006 Apr;133(1):3-18. doi: 10.1111/j.1365-2141.2006.05975.x. PMID: 16512824

Recent clinical studies

Diagnosis

Characterization of a variant of t(14;18) negative nodal diffuse follicular lymphoma with CD23 expression, 1p36/TNFRSF14 abnormalities, and STAT6 mutations.
Siddiqi IN, Friedman J, Barry-Holson KQ, Ma C, Thodima V, Kang I, Padmanabhan R, Dias LM, Kelly KR, Brynes RK, Kamalakaran S, Houldsworth J
Mod Pathol 2016 Jun;29(6):570-81. Epub 2016 Mar 11 doi: 10.1038/modpathol.2016.51. PMID: 26965583

Therapy

Phase I trial of recombinant macrophage colony-stimulating factor and recombinant gamma-interferon: toxicity, monocytosis, and clinical effects.
Weiner LM, Li W, Holmes M, Catalano RB, Dovnarsky M, Padavic K, Alpaugh RK
Cancer Res 1994 Aug 1;54(15):4084-90. PMID: 8033141

Prognosis

Phase I trial of recombinant macrophage colony-stimulating factor and recombinant gamma-interferon: toxicity, monocytosis, and clinical effects.
Weiner LM, Li W, Holmes M, Catalano RB, Dovnarsky M, Padavic K, Alpaugh RK
Cancer Res 1994 Aug 1;54(15):4084-90. PMID: 8033141

Clinical prediction guides

Characterization of a variant of t(14;18) negative nodal diffuse follicular lymphoma with CD23 expression, 1p36/TNFRSF14 abnormalities, and STAT6 mutations.
Siddiqi IN, Friedman J, Barry-Holson KQ, Ma C, Thodima V, Kang I, Padmanabhan R, Dias LM, Kelly KR, Brynes RK, Kamalakaran S, Houldsworth J
Mod Pathol 2016 Jun;29(6):570-81. Epub 2016 Mar 11 doi: 10.1038/modpathol.2016.51. PMID: 26965583
Phase I trial of recombinant macrophage colony-stimulating factor and recombinant gamma-interferon: toxicity, monocytosis, and clinical effects.
Weiner LM, Li W, Holmes M, Catalano RB, Dovnarsky M, Padavic K, Alpaugh RK
Cancer Res 1994 Aug 1;54(15):4084-90. PMID: 8033141

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