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Hodgkin-Like Post-Transplant Lymphoproliferative Disorder

MedGen UID:
234355
•Concept ID:
C1334036
•
Neoplastic Process
Synonyms: Hodgkin's-Like Post-Transplant Lymphoproliferative Disorder; Hodgkin's-like PTLD; Hodgkin-like PTLD

Definition

A lymphoproliferative disorder with morphologic features resembling Hodgkin lymphoma that develops in a patient following transplantation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHodgkin-Like Post-Transplant Lymphoproliferative Disorder

Recent clinical studies

Etiology

Effect of anti-CD 20 antibody rituximab in patients with post-transplant lymphoproliferative disorder (PTLD).
Oertel SH, Verschuuren E, Reinke P, Zeidler K, Papp-Váry M, Babel N, Trappe RU, Jonas S, Hummel M, Anagnostopoulos I, Dörken B, Riess HB
Am J Transplant 2005 Dec;5(12):2901-6. doi: 10.1111/j.1600-6143.2005.01098.x. PMID: 16303003

Diagnosis

Primary cutaneous Hodgkin-like polymorphic post-transplant lymphoproliferative disorder.
Dunn C, Nguyen HP, Patel V, Barker HS, Diwan AH, Yared M, Elghetany T, Restrepo A, Dao H
J Cutan Pathol 2019 May;46(5):358-362. Epub 2019 Feb 27 doi: 10.1111/cup.13427. PMID: 30672006
Differentiation of EBV-induced post-transplant Hodgkin lymphoma from Hodgkin-like post-transplant lymphoproliferative disease.
Rohr JC, Wagner HJ, Lauten M, Wacker HH, Jüttner E, Hanke C, Pohl M, Niemeyer CM
Pediatr Transplant 2008 Jun;12(4):426-31. doi: 10.1111/j.1399-3046.2007.00816.x. PMID: 18466428
Hodgkin-like posttransplant lymphoproliferative disorder in children: does it differ from posttransplant Hodgkin lymphoma?
Ranganathan S, Webber S, Ahuja S, Jaffe R
Pediatr Dev Pathol 2004 Jul-Aug;7(4):348-60. Epub 2004 Jun 17 doi: 10.1007/s10024-003-9877-y. PMID: 14564542
Allogeneic peripheral blood stem cell transplant for myelodysplasia after chemotherapy for post-transplant lymphoma in a cardiac transplant recipient at 10 years.
Lister J, Simpson JK, deMagalhaes-Silverman MM, Rybka WB, Donnenberg AD, Myers DJ, Ball ED
Bone Marrow Transplant 1997 May;19(9):943-5. doi: 10.1038/sj.bmt.1700758. PMID: 9156271

Therapy

Epstein-Barr virus-associated post-transplant lymphoproliferative disorders after allogeneic peripheral blood stem cell transplantation for Hodgkin-like adult T-cell leukemia/lymphoma.
Yagi T, Ishikawa J, Aono N, Yamashita Y, Kusakabe S, Yoshinami T, Akazawa Y, Sakai D, Yamamoto S, Hamanaka Y, Masaie H, Sugimoto N, Yoshida H, Tomita Y, Imamura F
Int J Hematol 2012 Feb;95(2):214-6. Epub 2011 Dec 16 doi: 10.1007/s12185-011-0979-4. PMID: 22170229
Differentiation of EBV-induced post-transplant Hodgkin lymphoma from Hodgkin-like post-transplant lymphoproliferative disease.
Rohr JC, Wagner HJ, Lauten M, Wacker HH, Jüttner E, Hanke C, Pohl M, Niemeyer CM
Pediatr Transplant 2008 Jun;12(4):426-31. doi: 10.1111/j.1399-3046.2007.00816.x. PMID: 18466428
Effect of anti-CD 20 antibody rituximab in patients with post-transplant lymphoproliferative disorder (PTLD).
Oertel SH, Verschuuren E, Reinke P, Zeidler K, Papp-Váry M, Babel N, Trappe RU, Jonas S, Hummel M, Anagnostopoulos I, Dörken B, Riess HB
Am J Transplant 2005 Dec;5(12):2901-6. doi: 10.1111/j.1600-6143.2005.01098.x. PMID: 16303003
Hodgkin-like posttransplant lymphoproliferative disorder in children: does it differ from posttransplant Hodgkin lymphoma?
Ranganathan S, Webber S, Ahuja S, Jaffe R
Pediatr Dev Pathol 2004 Jul-Aug;7(4):348-60. Epub 2004 Jun 17 doi: 10.1007/s10024-003-9877-y. PMID: 14564542
Allogeneic peripheral blood stem cell transplant for myelodysplasia after chemotherapy for post-transplant lymphoma in a cardiac transplant recipient at 10 years.
Lister J, Simpson JK, deMagalhaes-Silverman MM, Rybka WB, Donnenberg AD, Myers DJ, Ball ED
Bone Marrow Transplant 1997 May;19(9):943-5. doi: 10.1038/sj.bmt.1700758. PMID: 9156271

Prognosis

Differentiation of EBV-induced post-transplant Hodgkin lymphoma from Hodgkin-like post-transplant lymphoproliferative disease.
Rohr JC, Wagner HJ, Lauten M, Wacker HH, Jüttner E, Hanke C, Pohl M, Niemeyer CM
Pediatr Transplant 2008 Jun;12(4):426-31. doi: 10.1111/j.1399-3046.2007.00816.x. PMID: 18466428
Effect of anti-CD 20 antibody rituximab in patients with post-transplant lymphoproliferative disorder (PTLD).
Oertel SH, Verschuuren E, Reinke P, Zeidler K, Papp-Váry M, Babel N, Trappe RU, Jonas S, Hummel M, Anagnostopoulos I, Dörken B, Riess HB
Am J Transplant 2005 Dec;5(12):2901-6. doi: 10.1111/j.1600-6143.2005.01098.x. PMID: 16303003

Clinical prediction guides

Effect of anti-CD 20 antibody rituximab in patients with post-transplant lymphoproliferative disorder (PTLD).
Oertel SH, Verschuuren E, Reinke P, Zeidler K, Papp-Váry M, Babel N, Trappe RU, Jonas S, Hummel M, Anagnostopoulos I, Dörken B, Riess HB
Am J Transplant 2005 Dec;5(12):2901-6. doi: 10.1111/j.1600-6143.2005.01098.x. PMID: 16303003

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