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T-Cell Proliferation of Uncertain Malignant Potential

MedGen UID:
234377
•Concept ID:
C1336550
•
Neoplastic Process

Definition

A T-cell lymphoproliferative disorder with uncertain malignant potential. A representative example is lymphomatoid papulosis. [from NCI]

Recent clinical studies

Etiology

Knock down of APE1 suppressed gastric cancer metastasis via improving immune disorders caused by myeloid-derived suppressor cells.
Zhang B, Tang Q, Shi W, Bao Z, Gao S, Pan C
Cell Cycle 2024 Mar;23(5):602-612. Epub 2024 May 8 doi: 10.1080/15384101.2024.2351629. PMID: 38717991
Identify and validate circadian regulators as potential prognostic markers and immune infiltrates in head and neck squamous cell carcinoma.
Jin Y, Wang Z, Huang S, Liu C, Wu X, Wang H
Sci Rep 2023 Nov 15;13(1):19939. doi: 10.1038/s41598-023-46560-8. PMID: 37968308Free PMC Article
First case of very late-onset FHL2 in Spain with two variants in the PRF1 gene.
Sienes Bailo P, Goñi Ros N, Menéndez Jándula B, Álvarez Alegret R, González Gómez E, González Tarancón R, Izquierdo Álvarez S
Ann Clin Biochem 2023 Sep;60(5):356-364. Epub 2023 Jun 26 doi: 10.1177/00045632231186076. PMID: 37365821

Diagnosis

First case of very late-onset FHL2 in Spain with two variants in the PRF1 gene.
Sienes Bailo P, Goñi Ros N, Menéndez Jándula B, Álvarez Alegret R, González Gómez E, González Tarancón R, Izquierdo Álvarez S
Ann Clin Biochem 2023 Sep;60(5):356-364. Epub 2023 Jun 26 doi: 10.1177/00045632231186076. PMID: 37365821
Tumoral presentation of primary central nervous system lymphomatoid granulomatosis.
González-Darder JM, Vera-Román JM, Pesudo-Martínez JV, Cerdá-Nicolás M, Ochoa E
Acta Neurochir (Wien) 2011 Oct;153(10):1963-70. Epub 2011 Jul 27 doi: 10.1007/s00701-011-1088-0. PMID: 21792698

Prognosis

Identify and validate circadian regulators as potential prognostic markers and immune infiltrates in head and neck squamous cell carcinoma.
Jin Y, Wang Z, Huang S, Liu C, Wu X, Wang H
Sci Rep 2023 Nov 15;13(1):19939. doi: 10.1038/s41598-023-46560-8. PMID: 37968308Free PMC Article
Stromal interleukin-33 promotes regulatory T cell-mediated immunosuppression in head and neck squamous cell carcinoma and correlates with poor prognosis.
Wen YH, Lin HQ, Li H, Zhao Y, Lui VWY, Chen L, Wu XM, Sun W, Wen WP
Cancer Immunol Immunother 2019 Feb;68(2):221-232. Epub 2018 Oct 25 doi: 10.1007/s00262-018-2265-2. PMID: 30357458Free PMC Article
Glucocorticoid resistance in T-lineage acute lymphoblastic leukaemia is associated with a proliferative metabolism.
Beesley AH, Firth MJ, Ford J, Weller RE, Freitas JR, Perera KU, Kees UR
Br J Cancer 2009 Jun 16;100(12):1926-36. Epub 2009 May 12 doi: 10.1038/sj.bjc.6605072. PMID: 19436302Free PMC Article
The MTCP-1/c6.1B gene encodes for a cytoplasmic 8 kD protein overexpressed in T cell leukemia bearing a t(X;14) translocation.
Soulier J, Madani A, Cacheux V, Rosenzwajg M, Sigaux F, Stern MH
Oncogene 1994 Dec;9(12):3565-70. PMID: 7970717

Clinical prediction guides

Identify and validate circadian regulators as potential prognostic markers and immune infiltrates in head and neck squamous cell carcinoma.
Jin Y, Wang Z, Huang S, Liu C, Wu X, Wang H
Sci Rep 2023 Nov 15;13(1):19939. doi: 10.1038/s41598-023-46560-8. PMID: 37968308Free PMC Article
Glucocorticoid resistance in T-lineage acute lymphoblastic leukaemia is associated with a proliferative metabolism.
Beesley AH, Firth MJ, Ford J, Weller RE, Freitas JR, Perera KU, Kees UR
Br J Cancer 2009 Jun 16;100(12):1926-36. Epub 2009 May 12 doi: 10.1038/sj.bjc.6605072. PMID: 19436302Free PMC Article
The MTCP-1/c6.1B gene encodes for a cytoplasmic 8 kD protein overexpressed in T cell leukemia bearing a t(X;14) translocation.
Soulier J, Madani A, Cacheux V, Rosenzwajg M, Sigaux F, Stern MH
Oncogene 1994 Dec;9(12):3565-70. PMID: 7970717

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