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Thymic carcinoid tumor

MedGen UID:
234428
•Concept ID:
C1336746
•
Neoplastic Process
Synonyms: Carcinoid Tumor of the Thymus; Carcinoid Tumor of Thymus; Malignant carcinoid tumor of thymus; Thymic Carcinoid; Thymic Carcinoid Tumor; Thymus Carcinoid; Thymus Carcinoid Tumor
SNOMED CT: Malignant carcinoid tumor of thymus (726652005)
 
HPO: HP:0034954

Definition

A primary thymic neuroendocrine tumor. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVThymic carcinoid tumor

Professional guidelines

PubMed

Lung and thymic carcinoids: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up(☆).
Baudin E, Caplin M, Garcia-Carbonero R, Fazio N, Ferolla P, Filosso PL, Frilling A, de Herder WW, Hörsch D, Knigge U, Korse CM, Lim E, Lombard-Bohas C, Pavel M, Scoazec JY, Sundin A, Berruti A; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2021 Apr;32(4):439-451. Epub 2021 Jan 19 doi: 10.1016/j.annonc.2021.01.003. PMID: 33482246
About thymic carcinomas: challenges in diagnosis and management.
Mlika M, Boudaya S, Braham E, Chermiti F, Sayi A, Marghli A, El Mezni F
Asian Cardiovasc Thorac Ann 2016 May;24(4):350-4. Epub 2016 Mar 21 doi: 10.1177/0218492316640129. PMID: 27002097
Diagnosis and treatment of multiple endocrine neoplasia type 1 (MEN1).
Gaztambide S, Vazquez F, Castaño L
Minerva Endocrinol 2013 Mar;38(1):17-28. PMID: 23435440

Recent clinical studies

Etiology

Recurrent thymic carcinoid tumor in the pleural cavity. 2 cases of long-term survivors.
Tsuchida M, Yamato Y, Hashimoto T, Saito M, Hayashi J
Jpn J Thorac Cardiovasc Surg 2001 Nov;49(11):666-8. doi: 10.1007/BF02912476. PMID: 11757339
Double transmanubrial approach and sternotomy for resection of a giant thymic carcinoid tumor.
Spaggiari L, Pastorino U
Ann Thorac Surg 2001 Aug;72(2):629-31. doi: 10.1016/s0003-4975(01)02710-2. PMID: 11515922
Strontium-89 (89Sr) analgesia for rare thymic carcinoid tumor with bony metastases.
Vishne TH, Ron IG
Am J Clin Oncol 1998 Dec;21(6):602-4. doi: 10.1097/00000421-199812000-00014. PMID: 9856663
Spontaneous vulvar necrotizing fasciitis in Cushing's syndrome.
Cunningham DS, Cutler GB Jr
South Med J 1994 Aug;87(8):837-8. doi: 10.1097/00007611-199408000-00018. PMID: 8052898

Diagnosis

Atypical thymic carcinoid tumor with ectopic ACTH syndrome in a 33-year-old male patient: A rare case report and literature review.
Li LY, Zhao HY, Tong HC, Li YC, Xu HT, Ma S, Yang LH, Zhang WL, Wildes T, Wang E
Medicine (Baltimore) 2023 Jun 2;102(22):e33847. doi: 10.1097/MD.0000000000033847. PMID: 37266641Free PMC Article
MEN4, the MEN1 Mimicker: A Case Series of three Phenotypically Heterogenous Patients With Unique CDKN1B Mutations.
Seabrook A, Wijewardene A, De Sousa S, Wong T, Sheriff N, Gill AJ, Iyer R, Field M, Luxford C, Clifton-Bligh R, McCormack A, Tucker K
J Clin Endocrinol Metab 2022 Jul 14;107(8):2339-2349. doi: 10.1210/clinem/dgac162. PMID: 35323929Free PMC Article
Coexisting Thymic and Pulmonary Carcinoid Tumors Associated with Multiple Endocrine Neoplasia Type1.
Motoishi M, Horimoto K, Hayashi K, Sawai S, Moriyoshi K
Ann Thorac Cardiovasc Surg 2018 Jun 20;24(3):147-150. Epub 2017 Oct 26 doi: 10.5761/atcs.cr.17-00042. PMID: 29070772Free PMC Article
Thymic carcinoid tumor.
Tamura M, Ohta Y, Oda M, Watanabe G
Jpn J Thorac Cardiovasc Surg 2003 Jan;51(1):29-31. doi: 10.1007/s11748-003-0063-y. PMID: 12645153
Thymic carcinoid tumor--a report of 7 cases.
Zhang Z, Ren H, Yu H, Li Z, Liu H, Lu Z
Chin Med Sci J 1993 Mar;8(1):48-51. PMID: 8274723

Therapy

An Overlooked Manifestation of Hypercortisolism: Cerebral Cortical Atrophy and Challenges in Identifying the Etiology of Hypercortisolism - A Report of 2 Pediatric Cases.
Eviz E, Yesiltepe Mutlu G, Arduc Akcay A, Erbey F, Guran T, Hatun S
Horm Res Paediatr 2024;97(2):172-179. Epub 2023 Mar 27 doi: 10.1159/000530391. PMID: 36972563
Ectopic ACTH-syndrome due to a thymic carcinoid tumor.
Van Schaeybroeck S, Van Imschoot S, Cochez P
Acta Clin Belg 2002 Jan-Feb;57(1):23-5. doi: 10.1179/acb.2002.006. PMID: 12017752
Paraneoplastic Cushing's syndrome associated to locally advanced thymic carcinoid tumor.
Andrés R, Mayordomo JI, Ramón y Cajal S, Tres A
Tumori 2002 Jan-Feb;88(1):65-7. PMID: 12004854
Strontium-89 (89Sr) analgesia for rare thymic carcinoid tumor with bony metastases.
Vishne TH, Ron IG
Am J Clin Oncol 1998 Dec;21(6):602-4. doi: 10.1097/00000421-199812000-00014. PMID: 9856663

Prognosis

Atypical thymic carcinoid tumor with ectopic ACTH syndrome in a 33-year-old male patient: A rare case report and literature review.
Li LY, Zhao HY, Tong HC, Li YC, Xu HT, Ma S, Yang LH, Zhang WL, Wildes T, Wang E
Medicine (Baltimore) 2023 Jun 2;102(22):e33847. doi: 10.1097/MD.0000000000033847. PMID: 37266641Free PMC Article
Single-incision port robot-assisted surgery for thymic carcinoid tumor resection.
Shidei H, Mitsuboshi S, Yamamoto T, Kanzaki M
J Cardiothorac Surg 2022 May 3;17(1):90. doi: 10.1186/s13019-022-01847-1. PMID: 35505364Free PMC Article
Atypical thymic carcinoid and malignant somatostatinoma in type I multiple endocrine neoplasia syndrome: case report.
Lin FC, Lin CM, Hsieh CC, Li WY, Wang LS
Am J Clin Oncol 2003 Jun;26(3):270-2. doi: 10.1097/01.COC.0000020584.56294.72. PMID: 12796599
Thymic neuroendocrine carcinoma (carcinoid): a clinicopathologic study of fourteen cases.
de Montpréville VT, Macchiarini P, Dulmet E
J Thorac Cardiovasc Surg 1996 Jan;111(1):134-41. doi: 10.1016/S0022-5223(96)70409-9. PMID: 8551758
Thymic carcinoid tumor--a report of 7 cases.
Zhang Z, Ren H, Yu H, Li Z, Liu H, Lu Z
Chin Med Sci J 1993 Mar;8(1):48-51. PMID: 8274723

Clinical prediction guides

A rare case of multiple endocrine neoplasia type 1 initially presenting as an asymptomatic, huge mediastinal mass: case report.
Jun JE, Hwang YC, Ahn KJ, Chung HY, Jeong IK
BMC Endocr Disord 2021 Feb 25;21(1):31. doi: 10.1186/s12902-021-00695-9. PMID: 33632163Free PMC Article
Normal and neoplastic cells of brown adipose tissue express the adhesion molecule CD31.
Rosso R, Lucioni M
Arch Pathol Lab Med 2006 Apr;130(4):480-2. doi: 10.5858/2006-130-480-NANCOB. PMID: 16594742
Carcinoid tumor of the thymus with divergent sarcomatoid differentiation: report of a case with histogenetic consideration.
Kuo TT
Hum Pathol 1994 Mar;25(3):319-23. doi: 10.1016/0046-8177(94)90205-4. PMID: 7908657
Ultrastructural studies of a thymic carcinoid tumor.
Kaneko H, Ishikawa S, Sumida T, Sekiya M, Toshima M, Kobayashi H, Naka Y
Acta Pathol Jpn 1980 Jul;30(4):651-8. doi: 10.1111/j.1440-1827.1980.tb01360.x. PMID: 7191192
Chemical characterization of ectopic ACTH purified from a malignant thymic carcinoid tumor.
Lowry PJ, Rees LH, Tomlin S, Gillies G, Landon J
J Clin Endocrinol Metab 1976 Oct;43(4):831-5. doi: 10.1210/jcem-43-4-831. PMID: 185233

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