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Rectal Undifferentiated Carcinoma

MedGen UID:
234451
•Concept ID:
C1336864
•
Neoplastic Process
Synonyms: Anaplastic Carcinoma of Rectum; Anaplastic Carcinoma of the Rectum; Carcinoma Simplex of the Rectum.; Rectal Anaplastic Carcinoma; Undifferentiated Carcinoma of Rectum; Undifferentiated Carcinoma of the Rectum; Undifferentiated Rectal Carcinoma

Definition

An invasive malignant epithelial tumor that arises from the rectum. There is no morphologic, immunophenotypic, or molecular biological evidence of glandular or squamous differentiation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRectal Undifferentiated Carcinoma

Professional guidelines

PubMed

Squamous rectal carcinoma: a rare malignancy, literature review and management recommendations.
Astaras C, Bornand A, Koessler T
ESMO Open 2021 Aug;6(4):100180. Epub 2021 Jun 7 doi: 10.1016/j.esmoop.2021.100180. PMID: 34111760Free PMC Article
Diagnosis and Management of Gastrointestinal Neuroendocrine Neoplasms.
Gonzalez RS
Surg Pathol Clin 2020 Sep;13(3):377-397. doi: 10.1016/j.path.2020.04.002. PMID: 32773190
Guidelines for the management of iron deficiency anaemia.
Goddard AF, James MW, McIntyre AS, Scott BB; British Society of Gastroenterology
Gut 2011 Oct;60(10):1309-16. Epub 2011 May 11 doi: 10.1136/gut.2010.228874. PMID: 21561874

Recent clinical studies

Etiology

Survival and prognostic factors in patients with rectal squamous cell carcinoma.
Kommalapati A, Tella SH, Yadav S, Goyal G, Hallemeier C, Durgin L, Jin Z, Mahipal A
Eur J Surg Oncol 2020 Jun;46(6):1111-1117. Epub 2020 Mar 4 doi: 10.1016/j.ejso.2020.02.039. PMID: 32201124
Meta-analysis of histopathological outcomes of laparoscopic assisted rectal resection (LARR) vs open rectal resection (ORR) for carcinoma.
Memon MA, Awaiz A, Yunus RM, Memon B, Khan S
Am J Surg 2018 Nov;216(5):1004-1015. Epub 2018 Jun 19 doi: 10.1016/j.amjsurg.2018.06.012. PMID: 29958656
Adoption of Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer.
Cercek A, Roxburgh CSD, Strombom P, Smith JJ, Temple LKF, Nash GM, Guillem JG, Paty PB, Yaeger R, Stadler ZK, Seier K, Gonen M, Segal NH, Reidy DL, Varghese A, Shia J, Vakiani E, Wu AJ, Crane CH, Gollub MJ, Garcia-Aguilar J, Saltz LB, Weiser MR
JAMA Oncol 2018 Jun 14;4(6):e180071. doi: 10.1001/jamaoncol.2018.0071. PMID: 29566109Free PMC Article
Comparison of outcomes between rectal squamous cell carcinoma and adenocarcinoma.
Chiu MS, Verma V, Bennion NR, Bhirud AR, Li J, Charlton ME, Are C, Lin C
Cancer Med 2016 Dec;5(12):3394-3402. Epub 2016 Oct 26 doi: 10.1002/cam4.927. PMID: 27781400Free PMC Article
The current landscape of locally advanced rectal cancer.
Aklilu M, Eng C
Nat Rev Clin Oncol 2011 Aug 9;8(11):649-59. doi: 10.1038/nrclinonc.2011.118. PMID: 21826084

Diagnosis

Survival and prognostic factors in patients with rectal squamous cell carcinoma.
Kommalapati A, Tella SH, Yadav S, Goyal G, Hallemeier C, Durgin L, Jin Z, Mahipal A
Eur J Surg Oncol 2020 Jun;46(6):1111-1117. Epub 2020 Mar 4 doi: 10.1016/j.ejso.2020.02.039. PMID: 32201124
Fistula-associated anal carcinoma in Crohn's disease.
Yamamoto T, Kotze PG, Spinelli A, Panaccione R
Expert Rev Gastroenterol Hepatol 2018 Sep;12(9):917-925. Epub 2018 Jul 24 doi: 10.1080/17474124.2018.1500175. PMID: 29999429
Colorectal cancer in young adults.
Inra JA, Syngal S
Dig Dis Sci 2015 Mar;60(3):722-33. Epub 2014 Dec 6 doi: 10.1007/s10620-014-3464-0. PMID: 25480403
Anal neoplasms.
Garrett K, Kalady MF
Surg Clin North Am 2010 Feb;90(1):147-61, Table of Contents. doi: 10.1016/j.suc.2009.09.008. PMID: 20109639
Cancer cellulitis.
Graham BS, Wong SW
South Med J 1984 Feb;77(2):277-8. doi: 10.1097/00007611-198402000-00044. PMID: 6701607

Therapy

Practice-changing clinical trials in radiation oncology for gastrointestinal malignancies in 2021-2023.
Boustani J, Huguet F, Vendrely V
Cancer Radiother 2023 Dec;27(8):768-777. Epub 2023 Oct 26 doi: 10.1016/j.canrad.2023.08.001. PMID: 38415359
Surgical steps for standard laparoscopic low anterior resection.
Allen SK, Schwab KE, Rockall TA
Minerva Chir 2018 Apr;73(2):227-238. Epub 2018 Feb 21 doi: 10.23736/S0026-4733.18.07572-7. PMID: 29471614
Effect of adding mFOLFOX6 after neoadjuvant chemoradiation in locally advanced rectal cancer: a multicentre, phase 2 trial.
Garcia-Aguilar J, Chow OS, Smith DD, Marcet JE, Cataldo PA, Varma MG, Kumar AS, Oommen S, Coutsoftides T, Hunt SR, Stamos MJ, Ternent CA, Herzig DO, Fichera A, Polite BN, Dietz DW, Patil S, Avila K; Timing of Rectal Cancer Response to Chemoradiation Consortium
Lancet Oncol 2015 Aug;16(8):957-66. Epub 2015 Jul 14 doi: 10.1016/S1470-2045(15)00004-2. PMID: 26187751Free PMC Article
The neoadjuvant treatment of rectal cancer: a review.
Nussbaum N, Altomare I
Curr Oncol Rep 2015 Mar;17(3):434. doi: 10.1007/s11912-014-0434-9. PMID: 25691086
Induction therapy for rectal carcinoma.
Busse PM, Ng A, Recht A
Semin Surg Oncol 1998 Sep;15(2):120-5. doi: 10.1002/(sici)1098-2388(199809)15:2<120::aid-ssu9>3.0.co;2-1. PMID: 9730418

Prognosis

Survival and prognostic factors in patients with rectal squamous cell carcinoma.
Kommalapati A, Tella SH, Yadav S, Goyal G, Hallemeier C, Durgin L, Jin Z, Mahipal A
Eur J Surg Oncol 2020 Jun;46(6):1111-1117. Epub 2020 Mar 4 doi: 10.1016/j.ejso.2020.02.039. PMID: 32201124
Optimal fractionation of preoperative radiotherapy and timing to surgery for rectal cancer (Stockholm III): a multicentre, randomised, non-blinded, phase 3, non-inferiority trial.
Erlandsson J, Holm T, Pettersson D, Berglund Å, Cedermark B, Radu C, Johansson H, Machado M, Hjern F, Hallböök O, Syk I, Glimelius B, Martling A
Lancet Oncol 2017 Mar;18(3):336-346. Epub 2017 Feb 10 doi: 10.1016/S1470-2045(17)30086-4. PMID: 28190762
Anal Dysplasia.
Messick CA, Rodriguez-Bigas MA
Surg Oncol Clin N Am 2017 Jan;26(1):33-43. doi: 10.1016/j.soc.2016.07.005. PMID: 27889035
Colorectal cancer in young adults.
Inra JA, Syngal S
Dig Dis Sci 2015 Mar;60(3):722-33. Epub 2014 Dec 6 doi: 10.1007/s10620-014-3464-0. PMID: 25480403
Adjuvant therapy for colorectal cancer.
Vernava AM 3rd
Cleve Clin J Med 1992 Nov-Dec;59(6):603-7. doi: 10.3949/ccjm.59.6.603. PMID: 1424071

Clinical prediction guides

Rectal Cancer in Adolescent and Young Adult Patients: Pattern of Clinical Presentation and Case-Matched Comparison of Outcomes.
Foppa C, Francesca Bertuzzi A, Cianchi F, Carvello M, Maroli A, Wolthuis AM, Rimassa L, Laghi L, Montorsi M, D'Hoore AJL, Spinelli A
Dis Colon Rectum 2021 Sep 1;64(9):1064-1073. doi: 10.1097/DCR.0000000000002022. PMID: 34397557
Survival and prognostic factors in patients with rectal squamous cell carcinoma.
Kommalapati A, Tella SH, Yadav S, Goyal G, Hallemeier C, Durgin L, Jin Z, Mahipal A
Eur J Surg Oncol 2020 Jun;46(6):1111-1117. Epub 2020 Mar 4 doi: 10.1016/j.ejso.2020.02.039. PMID: 32201124
Pathologic assessment of gastrointestinal tract and pancreatic carcinoma after neoadjuvant therapy.
Pai RK, Pai RK
Mod Pathol 2018 Jan;31(1):4-23. Epub 2017 Aug 4 doi: 10.1038/modpathol.2017.87. PMID: 28776577
Rectal cancer: An evidence-based update for primary care providers.
Gaertner WB, Kwaan MR, Madoff RD, Melton GB
World J Gastroenterol 2015 Jul 7;21(25):7659-71. doi: 10.3748/wjg.v21.i25.7659. PMID: 26167068Free PMC Article
Clinical and histopathological correlations of fecal calprotectin release in colorectal carcinoma.
Lehmann FS, Trapani F, Fueglistaler I, Terracciano LM, von Flüe M, Cathomas G, Zettl A, Benkert P, Oertli D, Beglinger C
World J Gastroenterol 2014 May 7;20(17):4994-9. doi: 10.3748/wjg.v20.i17.4994. PMID: 24803811Free PMC Article

Recent systematic reviews

Health effects of milk consumption: phenome-wide Mendelian randomization study.
Yuan S, Sun J, Lu Y, Xu F, Li D, Jiang F, Wan Z, Li X, Qin LQ, Larsson SC
BMC Med 2022 Nov 23;20(1):455. doi: 10.1186/s12916-022-02658-w. PMID: 36424608Free PMC Article
Effects and duration of exercise-based prehabilitation in surgical therapy of colon and rectal cancer: a systematic review and meta-analysis.
Falz R, Bischoff C, Thieme R, Lässing J, Mehdorn M, Stelzner S, Busse M, Gockel I
J Cancer Res Clin Oncol 2022 Sep;148(9):2187-2213. Epub 2022 Jun 13 doi: 10.1007/s00432-022-04088-w. PMID: 35695931Free PMC Article
Consumption of red meat and processed meat and cancer incidence: a systematic review and meta-analysis of prospective studies.
Farvid MS, Sidahmed E, Spence ND, Mante Angua K, Rosner BA, Barnett JB
Eur J Epidemiol 2021 Sep;36(9):937-951. Epub 2021 Aug 29 doi: 10.1007/s10654-021-00741-9. PMID: 34455534
Incidence and mortality of anastomotic dehiscence requiring reoperation after rectal carcinoma resection.
Cong ZJ, Hu LH, Xing JJ, Bian ZQ, Fu CG, Yu ED, Li ZS, Zhong M
Int Surg 2014 Mar-Apr;99(2):112-9. doi: 10.9738/INTSURG-D-13-00059. PMID: 24670019Free PMC Article
Rectal carcinoids: a systematic review.
McDermott FD, Heeney A, Courtney D, Mohan H, Winter D
Surg Endosc 2014 Jul;28(7):2020-6. Epub 2014 Mar 1 doi: 10.1007/s00464-014-3430-0. PMID: 24584484

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