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Adult central nervous system embryonal carcinoma

MedGen UID:
234580
•Concept ID:
C1370503
•
Neoplastic Process
Synonyms: Adult Central Nervous System Embryonal Carcinoma; adult central nervous system embryonal carcinoma; Adult CNS Embryonal Carcinoma; adult CNS embryonal carcinoma; adult embryonal carcinoma of the central nervous system; Central nervous system embryonal carcinoma; Embryonal Carcinoma of Adult Central Nervous System; embryonal carcinoma of adult central nervous system; Embryonal Carcinoma of Adult CNS; embryonal carcinoma of adult CNS; Embryonal Carcinoma of the Adult Central Nervous System; embryonal carcinoma of the adult central nervous system; Embryonal Carcinoma of the Adult CNS; embryonal carcinoma of the adult CNS; embryonal carcinoma of the central nervous system of adults
 
Monarch Initiative: MONDO:0004155

Definition

A embryonal carcinoma of the central nervous system that occurs in an adult. [from MONDO]

Professional guidelines

PubMed

Central nervous system germ cell tumors: classification, clinical features, and treatment with a historical overview.
Fujimaki T
J Child Neurol 2009 Nov;24(11):1439-45. doi: 10.1177/0883073809342127. PMID: 19841431
Germ cell tumours of the central nervous system: treatment consideration based on 111 cases and their long-term clinical outcomes.
Sawamura Y, Ikeda J, Shirato H, Tada M, Abe H
Eur J Cancer 1998 Jan;34(1):104-10. doi: 10.1016/s0959-8049(97)10045-4. PMID: 9624246
Management of extragonadal germ-cell tumors and the significance of bilateral testicular biopsies.
Daugaard G, Rørth M, von der Maase H, Skakkebaek NE
Ann Oncol 1992 Apr;3(4):283-9. doi: 10.1093/oxfordjournals.annonc.a058180. PMID: 1327076

Recent clinical studies

Etiology

Diseases Predisposing to Adrenocortical Malignancy (Li-Fraumeni Syndrome, Beckwith-Wiedemann Syndrome, and Carney Complex).
Jouinot A, Bertherat J
Exp Suppl 2019;111:149-169. doi: 10.1007/978-3-030-25905-1_9. PMID: 31588532
Clinicopathological and immunohistochemical features of primary central nervous system germ cell tumors: a 24-years experience.
Gao Y, Jiang J, Liu Q
Int J Clin Exp Pathol 2014;7(10):6965-72. Epub 2014 Sep 15 PMID: 25400782Free PMC Article
Epidemiology of glial and non-glial brain tumours in Europe.
Crocetti E, Trama A, Stiller C, Caldarella A, Soffietti R, Jaal J, Weber DC, Ricardi U, Slowinski J, Brandes A; RARECARE working group
Eur J Cancer 2012 Jul;48(10):1532-42. Epub 2012 Jan 7 doi: 10.1016/j.ejca.2011.12.013. PMID: 22227039
Molecular diagnostics in embryonal brain tumors.
Eberhart CG
Brain Pathol 2011 Jan;21(1):96-104. doi: 10.1111/j.1750-3639.2010.00455.x. PMID: 21129063Free PMC Article
International patterns of cancer incidence in adolescents.
Stiller CA
Cancer Treat Rev 2007 Nov;33(7):631-45. Epub 2007 Feb 27 doi: 10.1016/j.ctrv.2007.01.001. PMID: 17329031

Diagnosis

Diseases Predisposing to Adrenocortical Malignancy (Li-Fraumeni Syndrome, Beckwith-Wiedemann Syndrome, and Carney Complex).
Jouinot A, Bertherat J
Exp Suppl 2019;111:149-169. doi: 10.1007/978-3-030-25905-1_9. PMID: 31588532
INSM1 Expression Is Frequent in Primary Central Nervous System Neoplasms but Not in the Adult Brain Parenchyma.
Ames HM, Rooper LM, Laterra JJ, Eberhart CG, Rodriguez FJ
J Neuropathol Exp Neurol 2018 May 1;77(5):374-382. doi: 10.1093/jnen/nly014. PMID: 29490065Free PMC Article
Clinicopathological and immunohistochemical features of primary central nervous system germ cell tumors: a 24-years experience.
Gao Y, Jiang J, Liu Q
Int J Clin Exp Pathol 2014;7(10):6965-72. Epub 2014 Sep 15 PMID: 25400782Free PMC Article
Molecular diagnostics in embryonal brain tumors.
Eberhart CG
Brain Pathol 2011 Jan;21(1):96-104. doi: 10.1111/j.1750-3639.2010.00455.x. PMID: 21129063Free PMC Article
Central nervous system germ cell tumors: classification, clinical features, and treatment with a historical overview.
Fujimaki T
J Child Neurol 2009 Nov;24(11):1439-45. doi: 10.1177/0883073809342127. PMID: 19841431

Therapy

Synchronous versus metachronous brain metastasis from testicular germ cell tumors (TGCT): an analysis from the Spanish Germ Cell Cancer Group data base.
Girones R, Aparicio J, Roure P, Germa-Lluch JR, García Del Muro X, Vazquez-Estevez S, Saenz A, Sastre J, Arranz Arija J, Gallardo E, Gonzalez-Billalabeitia E, Sanchez-Hernandez A, Terrasa J, Hernandez A, Santander C, Cillan E, Sagastibelza N, Almenar-Cubells D, Lopez Brea M, Maroto JP; Spanish Germ Cell Cancer Group (SGCCG)
Clin Transl Oncol 2014 Nov;16(11):959-65. Epub 2014 Apr 10 doi: 10.1007/s12094-014-1179-5. PMID: 24719184
Isolated central nervous system relapse of non-seminomatous germ cell tumour of the testis. A case report and review of the literature.
Cohn DA, Stuart-Harris R
Oncology 2001;61(3):184-8. doi: 10.1159/000055372. PMID: 11574772
Germ cell tumours of the central nervous system: treatment consideration based on 111 cases and their long-term clinical outcomes.
Sawamura Y, Ikeda J, Shirato H, Tada M, Abe H
Eur J Cancer 1998 Jan;34(1):104-10. doi: 10.1016/s0959-8049(97)10045-4. PMID: 9624246
Radiation therapy for primary intracranial germ-cell tumors.
Wolden SL, Wara WM, Larson DA, Prados MD, Edwards MS, Sneed PK
Int J Radiat Oncol Biol Phys 1995 Jul 15;32(4):943-9. doi: 10.1016/0360-3016(95)00067-9. PMID: 7607968
Chemotherapy trials in recurrent primary intracranial germ cell tumors.
Allen JC, Bosl G, Walker R
J Neurooncol 1985;3(2):147-52. doi: 10.1007/BF02228891. PMID: 3897472

Prognosis

12p gain is predominantly observed in non-germinomatous germ cell tumors and identifies an unfavorable subgroup of central nervous system germ cell tumors.
Satomi K, Takami H, Fukushima S, Yamashita S, Matsushita Y, Nakazato Y, Suzuki T, Tanaka S, Mukasa A, Saito N, Kanamori M, Kumabe T, Tominaga T, Kobayashi K, Nagane M, Iuchi T, Yoshimoto K, Tamura K, Maehara T, Sakai K, Sugiyama K, Yokogami K, Takeshima H, Nonaka M, Asai A, Ushijima T, Matsutani M, Nishikawa R, Ichimura K
Neuro Oncol 2022 May 4;24(5):834-846. doi: 10.1093/neuonc/noab246. PMID: 34698864Free PMC Article
INSM1 Expression Is Frequent in Primary Central Nervous System Neoplasms but Not in the Adult Brain Parenchyma.
Ames HM, Rooper LM, Laterra JJ, Eberhart CG, Rodriguez FJ
J Neuropathol Exp Neurol 2018 May 1;77(5):374-382. doi: 10.1093/jnen/nly014. PMID: 29490065Free PMC Article
Clinicopathological and immunohistochemical features of primary central nervous system germ cell tumors: a 24-years experience.
Gao Y, Jiang J, Liu Q
Int J Clin Exp Pathol 2014;7(10):6965-72. Epub 2014 Sep 15 PMID: 25400782Free PMC Article
Nestin expression in central nervous system germ cell tumors.
Sakurada K, Saino M, Mouri W, Sato A, Kitanaka C, Kayama T
Neurosurg Rev 2008 Apr;31(2):173-6; discussion 176-7. Epub 2007 Dec 19 doi: 10.1007/s10143-007-0115-3. PMID: 18092184
The MYCN oncogene as a specific and selective drug target for peripheral and central nervous system tumors.
Pession A, Tonelli R
Curr Cancer Drug Targets 2005 Jun;5(4):273-83. doi: 10.2174/1568009054064606. PMID: 15975048

Clinical prediction guides

Co-fractionation-mass spectrometry to characterize native mitochondrial protein assemblies in mammalian neurons and brain.
Zilocchi M, Rahmatbakhsh M, Moutaoufik MT, Broderick K, Gagarinova A, Jessulat M, Phanse S, Aoki H, Aly KA, Babu M
Nat Protoc 2023 Dec;18(12):3918-3973. Epub 2023 Nov 20 doi: 10.1038/s41596-023-00901-z. PMID: 37985878
12p gain is predominantly observed in non-germinomatous germ cell tumors and identifies an unfavorable subgroup of central nervous system germ cell tumors.
Satomi K, Takami H, Fukushima S, Yamashita S, Matsushita Y, Nakazato Y, Suzuki T, Tanaka S, Mukasa A, Saito N, Kanamori M, Kumabe T, Tominaga T, Kobayashi K, Nagane M, Iuchi T, Yoshimoto K, Tamura K, Maehara T, Sakai K, Sugiyama K, Yokogami K, Takeshima H, Nonaka M, Asai A, Ushijima T, Matsutani M, Nishikawa R, Ichimura K
Neuro Oncol 2022 May 4;24(5):834-846. doi: 10.1093/neuonc/noab246. PMID: 34698864Free PMC Article
Trends in Cancer Mortality Among Adolescents and Young Adults in Brazil.
Balmant NV, de Souza Reis R, de Oliveira Santos M, Pinto Oliveira J, de Camargo B
J Adolesc Young Adult Oncol 2017 Jun;6(2):341-347. Epub 2017 Jan 4 doi: 10.1089/jayao.2016.0042. PMID: 28051344
Clinicopathological and immunohistochemical features of primary central nervous system germ cell tumors: a 24-years experience.
Gao Y, Jiang J, Liu Q
Int J Clin Exp Pathol 2014;7(10):6965-72. Epub 2014 Sep 15 PMID: 25400782Free PMC Article
Nestin expression in central nervous system germ cell tumors.
Sakurada K, Saino M, Mouri W, Sato A, Kitanaka C, Kayama T
Neurosurg Rev 2008 Apr;31(2):173-6; discussion 176-7. Epub 2007 Dec 19 doi: 10.1007/s10143-007-0115-3. PMID: 18092184

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