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Pediatric CNS choriocarcinoma

MedGen UID:
234603
•Concept ID:
C1377604
•
Neoplastic Process
Synonyms: Central nervous system choriocarcinoma; Childhood Central Nervous System Choriocarcinoma; childhood central nervous system choriocarcinoma; childhood choriocarcinoma of the central nervous system; Childhood CNS Choriocarcinoma; childhood CNS choriocarcinoma; Choriocarcinoma of Childhood Central Nervous System; choriocarcinoma of childhood central nervous system; Choriocarcinoma of Childhood CNS; choriocarcinoma of childhood CNS; choriocarcinoma of paediatric central nervous system; choriocarcinoma of paediatric CNS; Choriocarcinoma of Pediatric Central Nervous System; choriocarcinoma of pediatric central nervous system; Choriocarcinoma of Pediatric CNS; choriocarcinoma of pediatric CNS; choriocarcinoma of the central nervous system of childhood; Choriocarcinoma of the Childhood Central Nervous System; choriocarcinoma of the childhood central nervous system; Choriocarcinoma of the Childhood CNS; choriocarcinoma of the childhood CNS; choriocarcinoma of the paediatric central nervous system; choriocarcinoma of the paediatric CNS; Choriocarcinoma of the Pediatric Central Nervous System; choriocarcinoma of the pediatric central nervous system; Choriocarcinoma of the Pediatric CNS; choriocarcinoma of the pediatric CNS; paediatric central nervous system choriocarcinoma; paediatric choriocarcinoma of the central nervous system; Pediatric Central Nervous System Choriocarcinoma; pediatric central nervous system choriocarcinoma; pediatric choriocarcinoma of the central nervous system; Pediatric CNS Choriocarcinoma; pediatric CNS choriocarcinoma
 
Monarch Initiative: MONDO:0003953

Definition

A choriocarcinoma that arises from the central nervous system and occurs during childhood. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPediatric CNS choriocarcinoma

Professional guidelines

PubMed

Impact of tumor markers on diagnosis, treatment and prognosis in CNS germ cell tumors: correlations with clinical practice and histopathology.
Takami H, Graffeo CS, Perry A, Giannini C, Nakazato Y, Saito N, Matsutani M, Nishikawa R, Daniels DJ, Ichimura K
Brain Tumor Pathol 2023 Apr;40(2):124-132. Epub 2023 Mar 30 doi: 10.1007/s10014-023-00460-x. PMID: 36995447Free PMC Article
Outcomes of intracranial non-germinomatous germ cell tumors: a retrospective Asian multinational study on treatment strategies and prognostic factors.
Hong KT, Han JW, Fuji H, Byun HK, Koh KN, Wong RX, Lee HL, Yoon HI, Lee JH, Phi JH, Kim SK, Kim DS, Lyu CJ, Choi JY, Kang HJ, Chen YW, Lee YY, Im HJ, Ra YS, Do Ahn S, Low SYY, Looi WS, Park HJ, Suh YG, Suh CO, Wang KC, Tan EEK, Wong TT, Kim JY
J Neurooncol 2022 Oct;160(1):41-53. Epub 2022 Aug 31 doi: 10.1007/s11060-022-04100-w. PMID: 36045266

Recent clinical studies

Etiology

Outcomes of intracranial non-germinomatous germ cell tumors: a retrospective Asian multinational study on treatment strategies and prognostic factors.
Hong KT, Han JW, Fuji H, Byun HK, Koh KN, Wong RX, Lee HL, Yoon HI, Lee JH, Phi JH, Kim SK, Kim DS, Lyu CJ, Choi JY, Kang HJ, Chen YW, Lee YY, Im HJ, Ra YS, Do Ahn S, Low SYY, Looi WS, Park HJ, Suh YG, Suh CO, Wang KC, Tan EEK, Wong TT, Kim JY
J Neurooncol 2022 Oct;160(1):41-53. Epub 2022 Aug 31 doi: 10.1007/s11060-022-04100-w. PMID: 36045266
A rare manifestation of choriocarcinoma syndrome in a child with primary intracranial germ cell tumor and extracranial metastases: A case report and review of the literature.
Keenan C, Ramirez N, Elijovich L, Klimo P Jr, Bag AK, Acharya S, Upadhyaya SA
Pediatr Blood Cancer 2021 Jun;68(6):e29000. Epub 2021 Apr 5 doi: 10.1002/pbc.29000. PMID: 33818876Free PMC Article
Pediatric central nervous system tumors: a single-center experience from 1989 to 2009.
Pinho RS, Andreoni S, Silva NS, Cappellano AM, Masruha MR, Cavalheiro S, Vilanova LC
J Pediatr Hematol Oncol 2011 Dec;33(8):605-9. doi: 10.1097/MPH.0b013e31822031d9. PMID: 22031123
Gonadotrophin-independent puberty in a boy with a beta-HCG-secreting brain tumour.
Marx M, Beck JD, Grabenbauer GG, Fahlbusch R, Dörr HG
Horm Res 2000;54(1):44-8. doi: 10.1159/000063436. PMID: 11182635

Diagnosis

Impact of tumor markers on diagnosis, treatment and prognosis in CNS germ cell tumors: correlations with clinical practice and histopathology.
Takami H, Graffeo CS, Perry A, Giannini C, Nakazato Y, Saito N, Matsutani M, Nishikawa R, Daniels DJ, Ichimura K
Brain Tumor Pathol 2023 Apr;40(2):124-132. Epub 2023 Mar 30 doi: 10.1007/s10014-023-00460-x. PMID: 36995447Free PMC Article
PD-L1 and PD-1 expression in pediatric central nervous system germ cell tumors.
Woods JK, Lidov HG, Ligon KL, Santagata S, Chi SN, Yeo KK, Alexandrescu S
Mod Pathol 2022 Dec;35(12):1770-1774. Epub 2022 Sep 3 doi: 10.1038/s41379-022-01142-3. PMID: 36057740
Outcomes of intracranial non-germinomatous germ cell tumors: a retrospective Asian multinational study on treatment strategies and prognostic factors.
Hong KT, Han JW, Fuji H, Byun HK, Koh KN, Wong RX, Lee HL, Yoon HI, Lee JH, Phi JH, Kim SK, Kim DS, Lyu CJ, Choi JY, Kang HJ, Chen YW, Lee YY, Im HJ, Ra YS, Do Ahn S, Low SYY, Looi WS, Park HJ, Suh YG, Suh CO, Wang KC, Tan EEK, Wong TT, Kim JY
J Neurooncol 2022 Oct;160(1):41-53. Epub 2022 Aug 31 doi: 10.1007/s11060-022-04100-w. PMID: 36045266
Pediatric central nervous system tumors: a single-center experience from 1989 to 2009.
Pinho RS, Andreoni S, Silva NS, Cappellano AM, Masruha MR, Cavalheiro S, Vilanova LC
J Pediatr Hematol Oncol 2011 Dec;33(8):605-9. doi: 10.1097/MPH.0b013e31822031d9. PMID: 22031123
Gonadotrophin-independent puberty in a boy with a beta-HCG-secreting brain tumour.
Marx M, Beck JD, Grabenbauer GG, Fahlbusch R, Dörr HG
Horm Res 2000;54(1):44-8. doi: 10.1159/000063436. PMID: 11182635

Therapy

Carotid cavernous fistula in CNS choriocarcinoma.
Lawton CT, Deveikis J, Rumboldt Z, Tuite G, Cavalier M
Pediatr Blood Cancer 2008 Apr;50(4):893-5. doi: 10.1002/pbc.21178. PMID: 17366524
Gonadotrophin-independent puberty in a boy with a beta-HCG-secreting brain tumour.
Marx M, Beck JD, Grabenbauer GG, Fahlbusch R, Dörr HG
Horm Res 2000;54(1):44-8. doi: 10.1159/000063436. PMID: 11182635

Prognosis

Impact of tumor markers on diagnosis, treatment and prognosis in CNS germ cell tumors: correlations with clinical practice and histopathology.
Takami H, Graffeo CS, Perry A, Giannini C, Nakazato Y, Saito N, Matsutani M, Nishikawa R, Daniels DJ, Ichimura K
Brain Tumor Pathol 2023 Apr;40(2):124-132. Epub 2023 Mar 30 doi: 10.1007/s10014-023-00460-x. PMID: 36995447Free PMC Article
PD-L1 and PD-1 expression in pediatric central nervous system germ cell tumors.
Woods JK, Lidov HG, Ligon KL, Santagata S, Chi SN, Yeo KK, Alexandrescu S
Mod Pathol 2022 Dec;35(12):1770-1774. Epub 2022 Sep 3 doi: 10.1038/s41379-022-01142-3. PMID: 36057740
Outcomes of intracranial non-germinomatous germ cell tumors: a retrospective Asian multinational study on treatment strategies and prognostic factors.
Hong KT, Han JW, Fuji H, Byun HK, Koh KN, Wong RX, Lee HL, Yoon HI, Lee JH, Phi JH, Kim SK, Kim DS, Lyu CJ, Choi JY, Kang HJ, Chen YW, Lee YY, Im HJ, Ra YS, Do Ahn S, Low SYY, Looi WS, Park HJ, Suh YG, Suh CO, Wang KC, Tan EEK, Wong TT, Kim JY
J Neurooncol 2022 Oct;160(1):41-53. Epub 2022 Aug 31 doi: 10.1007/s11060-022-04100-w. PMID: 36045266
12p gain is predominantly observed in non-germinomatous germ cell tumors and identifies an unfavorable subgroup of central nervous system germ cell tumors.
Satomi K, Takami H, Fukushima S, Yamashita S, Matsushita Y, Nakazato Y, Suzuki T, Tanaka S, Mukasa A, Saito N, Kanamori M, Kumabe T, Tominaga T, Kobayashi K, Nagane M, Iuchi T, Yoshimoto K, Tamura K, Maehara T, Sakai K, Sugiyama K, Yokogami K, Takeshima H, Nonaka M, Asai A, Ushijima T, Matsutani M, Nishikawa R, Ichimura K
Neuro Oncol 2022 May 4;24(5):834-846. doi: 10.1093/neuonc/noab246. PMID: 34698864Free PMC Article
Pediatric central nervous system tumors: a single-center experience from 1989 to 2009.
Pinho RS, Andreoni S, Silva NS, Cappellano AM, Masruha MR, Cavalheiro S, Vilanova LC
J Pediatr Hematol Oncol 2011 Dec;33(8):605-9. doi: 10.1097/MPH.0b013e31822031d9. PMID: 22031123

Clinical prediction guides

12p gain is predominantly observed in non-germinomatous germ cell tumors and identifies an unfavorable subgroup of central nervous system germ cell tumors.
Satomi K, Takami H, Fukushima S, Yamashita S, Matsushita Y, Nakazato Y, Suzuki T, Tanaka S, Mukasa A, Saito N, Kanamori M, Kumabe T, Tominaga T, Kobayashi K, Nagane M, Iuchi T, Yoshimoto K, Tamura K, Maehara T, Sakai K, Sugiyama K, Yokogami K, Takeshima H, Nonaka M, Asai A, Ushijima T, Matsutani M, Nishikawa R, Ichimura K
Neuro Oncol 2022 May 4;24(5):834-846. doi: 10.1093/neuonc/noab246. PMID: 34698864Free PMC Article
Gonadotrophin-independent puberty in a boy with a beta-HCG-secreting brain tumour.
Marx M, Beck JD, Grabenbauer GG, Fahlbusch R, Dörr HG
Horm Res 2000;54(1):44-8. doi: 10.1159/000063436. PMID: 11182635

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