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Signet ring cell gastric adenocarcinoma

MedGen UID:
234782
•Concept ID:
C1335965
•
Neoplastic Process
Synonyms: Gastric Signet Ring Cell Adenocarcinoma; gastric signet ring cell adenocarcinoma; gastric signet Ring cell adenocarcinoma; Gastric Signet-Ring Cell Adenocarcinoma; Signet Ring Cell Adenocarcinoma of Stomach; signet Ring cell adenocarcinoma of stomach; Signet Ring Cell Adenocarcinoma of the Stomach; signet Ring cell adenocarcinoma of the stomach; signet ring cell carcinoma of the stomach; Signet Ring Cell Gastric Adenocarcinoma; signet ring cell gastric adenocarcinoma; Signet Ring Cell Stomach Adenocarcinoma; signet Ring cell stomach adenocarcinoma
 
Monarch Initiative: MONDO:0006409

Definition

A poorly cohesive gastric adenocarcinoma characterized by malignant cells containing intracytoplasmic mucin. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSignet ring cell gastric adenocarcinoma

Professional guidelines

PubMed

Should Signet Ring Cell Histology Alter the Treatment Approach for Clinical Stage I Gastric Cancer?
Turgeon MK, Gamboa AC, Rupji M, Lee RM, Switchenko JM, El-Rayes BF, Russell MC, Cardona K, Kooby DA, Staley CA, Maithel SK, Shah MM
Ann Surg Oncol 2021 Jan;28(1):97-105. Epub 2020 Jun 10 doi: 10.1245/s10434-020-08714-0. PMID: 32524459Free PMC Article

Recent clinical studies

Etiology

Association Between Hereditary Lobular Breast Cancer Due to CDH1 Variants and Gastric Cancer Risk.
Gamble LA, Rossi A, Fasaye GA, Kesserwan C, Hernandez JM, Blakely AM, Davis JL
JAMA Surg 2022 Jan 1;157(1):18-22. doi: 10.1001/jamasurg.2021.5118. PMID: 34643667Free PMC Article
Should Signet Ring Cell Histology Alter the Treatment Approach for Clinical Stage I Gastric Cancer?
Turgeon MK, Gamboa AC, Rupji M, Lee RM, Switchenko JM, El-Rayes BF, Russell MC, Cardona K, Kooby DA, Staley CA, Maithel SK, Shah MM
Ann Surg Oncol 2021 Jan;28(1):97-105. Epub 2020 Jun 10 doi: 10.1245/s10434-020-08714-0. PMID: 32524459Free PMC Article
Acquired deficiency in C1-inhibitor associated with signet ring cell gastric adenocarcinoma: a probable connection of antitumor-associated antibodies, hemolytic anemia, and complement turnover.
Wasserfallen JB, Spaeth P, Guillou L, Pécoud AR
J Allergy Clin Immunol 1995 Jan;95(1 Pt 1):124-31. doi: 10.1016/s0091-6749(95)70160-5. PMID: 7822653

Diagnosis

A Rare Case of Synchronous Intraductal Papillary Mucinous Neoplasm-Associated Pancreatic Adenocarcinoma and Signet Ring Cell Gastric Adenocarcinoma.
Shupp B, Liaquat H, Rollins S, Stoll L, Singh G, Quiros RM, Matin A
Am J Case Rep 2022 Aug 8;23:e935242. doi: 10.12659/AJCR.935242. PMID: 35939415Free PMC Article
An Immaculate Deception: Persistently Elevated Serum β-Hcg in Metastatic Signet Ring Cell Gastric Adenocarcinoma.
Hryniewicki AT, LaFree A
J Emerg Med 2022 Apr;62(4):475-479. Epub 2022 Feb 27 doi: 10.1016/j.jemermed.2022.01.010. PMID: 35236614
Association Between Hereditary Lobular Breast Cancer Due to CDH1 Variants and Gastric Cancer Risk.
Gamble LA, Rossi A, Fasaye GA, Kesserwan C, Hernandez JM, Blakely AM, Davis JL
JAMA Surg 2022 Jan 1;157(1):18-22. doi: 10.1001/jamasurg.2021.5118. PMID: 34643667Free PMC Article
Dural Metastasis without Subdural Hematoma or Subdural Fluid Collection in a Patient with Signet Ring Cell Gastric Adenocarcinoma.
Cioni E, Marchiani C, Gagliano M, Bandini G, Palagano N, Ciuti G, Moggi Pignone A
Am J Case Rep 2020 Oct 3;21:e925599. doi: 10.12659/AJCR.925599. PMID: 33010147Free PMC Article
Chylous ascites due to signet ring cell gastric adenocarcinoma.
de Mello RA, Gregório T, Cardoso T
Niger J Clin Pract 2012 Oct-Dec;15(4):487-90. doi: 10.4103/1119-3077.104536. PMID: 23238204

Prognosis

Dural Metastasis without Subdural Hematoma or Subdural Fluid Collection in a Patient with Signet Ring Cell Gastric Adenocarcinoma.
Cioni E, Marchiani C, Gagliano M, Bandini G, Palagano N, Ciuti G, Moggi Pignone A
Am J Case Rep 2020 Oct 3;21:e925599. doi: 10.12659/AJCR.925599. PMID: 33010147Free PMC Article
Diffuse Signet-Ring Cell Gastric Adenocarcinoma "Linitis Plastica" and Pernicious Anemia: a Rare Association.
Majumder S, Habibi H, Gazi G, Dasanu CA
J Gastrointest Cancer 2012 Sep;43 Suppl 1:S283-5. doi: 10.1007/s12029-012-9408-z. PMID: 22760711
A rare case of signet ring cell gastric adenocarcinoma.
Dickey A, Hrom J
J Miss State Med Assoc 2007 Sep;48(9):271-5. PMID: 19292116
Acquired deficiency in C1-inhibitor associated with signet ring cell gastric adenocarcinoma: a probable connection of antitumor-associated antibodies, hemolytic anemia, and complement turnover.
Wasserfallen JB, Spaeth P, Guillou L, Pécoud AR
J Allergy Clin Immunol 1995 Jan;95(1 Pt 1):124-31. doi: 10.1016/s0091-6749(95)70160-5. PMID: 7822653
Polyvinylpyrrolidone storage disease: a source of error in the diagnosis of signet ring cell gastric adenocarcinoma.
Hewan-Lowe K, Hammers Y, Lyons JM, Wilcox CM
Ultrastruct Pathol 1994 Jan-Apr;18(1-2):271-8. doi: 10.3109/01913129409016300. PMID: 8191638

Clinical prediction guides

Hereditary diffuse gastric cancer due to a previously undescribed CDH1 splice site mutation.
Matsukuma KE, Mullins FM, Dietz L, Zehnder JL, Ford JM, Chun NM, Schrijver I
Hum Pathol 2010 Aug;41(8):1200-3. doi: 10.1016/j.humpath.2010.01.022. PMID: 20624523
Acquired deficiency in C1-inhibitor associated with signet ring cell gastric adenocarcinoma: a probable connection of antitumor-associated antibodies, hemolytic anemia, and complement turnover.
Wasserfallen JB, Spaeth P, Guillou L, Pécoud AR
J Allergy Clin Immunol 1995 Jan;95(1 Pt 1):124-31. doi: 10.1016/s0091-6749(95)70160-5. PMID: 7822653
Polyvinylpyrrolidone storage disease: a source of error in the diagnosis of signet ring cell gastric adenocarcinoma.
Hewan-Lowe K, Hammers Y, Lyons JM, Wilcox CM
Ultrastruct Pathol 1994 Jan-Apr;18(1-2):271-8. doi: 10.3109/01913129409016300. PMID: 8191638

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