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Bronchial Intraepithelial Neoplasia

MedGen UID:
234816
•Concept ID:
C1336084
•
Neoplastic Process
Synonym: Lung Squamous Dysplasia

Definition

A term referring to neoplastic changes in the bronchial epithelium manifested as dysplasia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBronchial Intraepithelial Neoplasia

Professional guidelines

PubMed

Diagnosis and treatment of bronchial intraepithelial neoplasia and early lung cancer of the central airways: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines.
Wisnivesky JP, Yung RC, Mathur PN, Zulueta JJ
Chest 2013 May;143(5 Suppl):e263S-e277S. doi: 10.1378/chest.12-2358. PMID: 23649442
Bronchial intraepithelial neoplasia/early central airways lung cancer: ACCP evidence-based clinical practice guidelines (2nd edition).
Kennedy TC, McWilliams A, Edell E, Sutedja T, Downie G, Yung R, Gazdar A, Mathur PN; American College of Chest Physicians
Chest 2007 Sep;132(3 Suppl):221S-233S. doi: 10.1378/chest.07-1377. PMID: 17873170

Recent clinical studies

Etiology

LncRNA PKMYT1AR promotes cancer stem cell maintenance in non-small cell lung cancer via activating Wnt signaling pathway.
He Y, Jiang X, Duan L, Xiong Q, Yuan Y, Liu P, Jiang L, Shen Q, Zhao S, Yang C, Chen Y
Mol Cancer 2021 Dec 2;20(1):156. doi: 10.1186/s12943-021-01469-6. PMID: 34856993Free PMC Article
Lung cancer chemoprevention.
Keith RL
Proc Am Thorac Soc 2012 May;9(2):52-6. doi: 10.1513/pats.201107-038MS. PMID: 22550242Free PMC Article
Early diagnosis of lung cancer.
Yasufuku K
Clin Chest Med 2010 Mar;31(1):39-47, Table of Contents. doi: 10.1016/j.ccm.2009.08.004. PMID: 20172431
Pulmonary preneoplasia--sequential molecular carcinogenetic events.
Lantuéjoul S, Salameire D, Salon C, Brambilla E
Histopathology 2009 Jan;54(1):43-54. doi: 10.1111/j.1365-2559.2008.03182.x. PMID: 19187179
Pulmonary preinvasive neoplasia.
Kerr KM
J Clin Pathol 2001 Apr;54(4):257-71. doi: 10.1136/jcp.54.4.257. PMID: 11304841Free PMC Article

Diagnosis

Circular RNA circSATB2 promotes progression of non-small cell lung cancer cells.
Zhang N, Nan A, Chen L, Li X, Jia Y, Qiu M, Dai X, Zhou H, Zhu J, Zhang H, Jiang Y
Mol Cancer 2020 Jun 3;19(1):101. doi: 10.1186/s12943-020-01221-6. PMID: 32493389Free PMC Article
Early lung cancer: methods for detection.
Nakajima T, Yasufuku K
Clin Chest Med 2013 Sep;34(3):373-83. Epub 2013 Jun 19 doi: 10.1016/j.ccm.2013.04.005. PMID: 23993810
Frontiers in bronchoscopic imaging.
Ohtani K, Lee AM, Lam S
Respirology 2012 Feb;17(2):261-9. doi: 10.1111/j.1440-1843.2011.02108.x. PMID: 22126413
Bronchoscopy simulation: a brief review.
Davoudi M, Colt HG
Adv Health Sci Educ Theory Pract 2009 May;14(2):287-96. Epub 2008 Jan 24 doi: 10.1007/s10459-007-9095-x. PMID: 18214705
Endobronchial laser therapy.
Turner JF Jr, Wang KP
Clin Chest Med 1999 Mar;20(1):107-22. doi: 10.1016/s0272-5231(05)70130-1. PMID: 10205721

Therapy

Lung cancer chemoprevention.
Keith RL
Proc Am Thorac Soc 2012 May;9(2):52-6. doi: 10.1513/pats.201107-038MS. PMID: 22550242Free PMC Article
Chemoprevention of lung cancer.
Keith RL
Proc Am Thorac Soc 2009 Apr 15;6(2):187-93. doi: 10.1513/pats.200807-067LC. PMID: 19349487Free PMC Article
Detection and localization of intraepithelial neoplasia and invasive carcinoma using fluorescence-reflectance bronchoscopy: an international, multicenter clinical trial.
Edell E, Lam S, Pass H, Miller YE, Sutedja T, Kennedy T, Loewen G, Keith RL, Gazdar A
J Thorac Oncol 2009 Jan;4(1):49-54. doi: 10.1097/JTO.0b013e3181914506. PMID: 19096306Free PMC Article
Fluorescent bronchoscopy.
Gilbert S, Luketich JD, Christie NA
Thorac Surg Clin 2004 Feb;14(1):71-7, viii. doi: 10.1016/S1547-4127(04)00041-6. PMID: 15382310
Post-pneumonectomy oesophageal fistula.
Evans JP
Thorax 1972 Nov;27(6):674-7. doi: 10.1136/thx.27.6.674. PMID: 4119141Free PMC Article

Prognosis

LncRNA PKMYT1AR promotes cancer stem cell maintenance in non-small cell lung cancer via activating Wnt signaling pathway.
He Y, Jiang X, Duan L, Xiong Q, Yuan Y, Liu P, Jiang L, Shen Q, Zhao S, Yang C, Chen Y
Mol Cancer 2021 Dec 2;20(1):156. doi: 10.1186/s12943-021-01469-6. PMID: 34856993Free PMC Article
Linc8087 predicts favorable prognosis and inhibits cell migration and invasion in NSCLC.
Qi Q, Chen C, Liu C, Zhang B, Ma Y, Zhang H, Huang W, Wang C
Pathol Res Pract 2021 Sep;225:153569. Epub 2021 Jul 30 doi: 10.1016/j.prp.2021.153569. PMID: 34391179
Circular RNA circSATB2 promotes progression of non-small cell lung cancer cells.
Zhang N, Nan A, Chen L, Li X, Jia Y, Qiu M, Dai X, Zhou H, Zhu J, Zhang H, Jiang Y
Mol Cancer 2020 Jun 3;19(1):101. doi: 10.1186/s12943-020-01221-6. PMID: 32493389Free PMC Article
Residual disease at the bronchial stump after curative resection for lung cancer.
Wind J, Smit EJ, Senan S, Eerenberg JP
Eur J Cardiothorac Surg 2007 Jul;32(1):29-34. Epub 2007 Apr 27 doi: 10.1016/j.ejcts.2007.04.003. PMID: 17466532
Future diagnostic procedures.
Lam S, Becker HD
Chest Surg Clin N Am 1996 May;6(2):363-80. PMID: 8724284

Clinical prediction guides

Linc8087 predicts favorable prognosis and inhibits cell migration and invasion in NSCLC.
Qi Q, Chen C, Liu C, Zhang B, Ma Y, Zhang H, Huang W, Wang C
Pathol Res Pract 2021 Sep;225:153569. Epub 2021 Jul 30 doi: 10.1016/j.prp.2021.153569. PMID: 34391179
Clinical and Pathological Characteristics of KEAP1- and NFE2L2-Mutated Non-Small Cell Lung Carcinoma (NSCLC).
Frank R, Scheffler M, Merkelbach-Bruse S, Ihle MA, Kron A, Rauer M, Ueckeroth F, König K, Michels S, Fischer R, Eisert A, Fassunke J, Heydt C, Serke M, Ko YD, Gerigk U, Geist T, Kaminsky B, Heukamp LC, Clement-Ziza M, Büttner R, Wolf J
Clin Cancer Res 2018 Jul 1;24(13):3087-3096. Epub 2018 Apr 3 doi: 10.1158/1078-0432.CCR-17-3416. PMID: 29615460
Detection and localization of intraepithelial neoplasia and invasive carcinoma using fluorescence-reflectance bronchoscopy: an international, multicenter clinical trial.
Edell E, Lam S, Pass H, Miller YE, Sutedja T, Kennedy T, Loewen G, Keith RL, Gazdar A
J Thorac Oncol 2009 Jan;4(1):49-54. doi: 10.1097/JTO.0b013e3181914506. PMID: 19096306Free PMC Article
Immunohistochemical markers of cancerogenesis in the lung.
Pankiewicz W, Minarowski L, Niklińska W, Naumnik W, Nikliński J, Chyczewski L
Folia Histochem Cytobiol 2007;45(2):65-74. PMID: 17597018
Fluorescent bronchoscopy.
Gilbert S, Luketich JD, Christie NA
Thorac Surg Clin 2004 Feb;14(1):71-7, viii. doi: 10.1016/S1547-4127(04)00041-6. PMID: 15382310

Supplemental Content

Table of contents

    Practice guidelines

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      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

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