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Vaginal squamous papilloma

MedGen UID:
234983
•Concept ID:
C1336943
•
Neoplastic Process
Synonyms: Squamous Papilloma of the Vagina; squamous papilloma of the vagina; Squamous Papilloma of Vagina; squamous papilloma of vagina; vagina squamous papilloma; Vaginal Squamous Cell Papilloma; Vaginal Squamous Papilloma; vaginal squamous papilloma
 
Monarch Initiative: MONDO:0001779

Definition

A benign papillary neoplasm that arises from the vagina and is characterized by the presence of a fibrovascular stalk lined by normal squamous epithelium. There is no evidence of atypia or relation to human papillomavirus. [from NCI]

Professional guidelines

PubMed

Innovations in the Management of Vaginal Cancer.
Kulkarni A, Dogra N, Zigras T
Curr Oncol 2022 Apr 27;29(5):3082-3092. doi: 10.3390/curroncol29050250. PMID: 35621640Free PMC Article
Evaluation and management of vaginoplasty complications.
Amies Oelschlager AM, Kirby A, Breech L
Curr Opin Obstet Gynecol 2017 Oct;29(5):316-321. doi: 10.1097/GCO.0000000000000391. PMID: 28696998
Cervical cancer: screening, diagnosis and staging.
Tsikouras P, Zervoudis S, Manav B, Tomara E, Iatrakis G, Romanidis C, Bothou A, Galazios G
J BUON 2016 Mar-Apr;21(2):320-5. PMID: 27273940

Recent clinical studies

Etiology

Evaluation and management of vaginoplasty complications.
Amies Oelschlager AM, Kirby A, Breech L
Curr Opin Obstet Gynecol 2017 Oct;29(5):316-321. doi: 10.1097/GCO.0000000000000391. PMID: 28696998
Microbiological diagnosis of human papilloma virus infection.
Mateos-Lindemann ML, Pérez-Castro S, Rodríguez-Iglesias M, Pérez-Gracia MT
Enferm Infecc Microbiol Clin 2017 Nov;35(9):593-602. Epub 2016 Jun 25 doi: 10.1016/j.eimc.2016.05.008. PMID: 27353835
Cervical cancer: screening, diagnosis and staging.
Tsikouras P, Zervoudis S, Manav B, Tomara E, Iatrakis G, Romanidis C, Bothou A, Galazios G
J BUON 2016 Mar-Apr;21(2):320-5. PMID: 27273940
EMT-Inducing Molecular Factors in Gynecological Cancers.
Campo L, Zhang C, Breuer EK
Biomed Res Int 2015;2015:420891. Epub 2015 Aug 19 doi: 10.1155/2015/420891. PMID: 26356073Free PMC Article
Human papilloma virions in the laboratory.
Dunne EF, Markowitz LE, Taylor LD, Unger ER, Wheeler CM
J Clin Virol 2014 Oct;61(2):196-8. Epub 2014 Jun 23 doi: 10.1016/j.jcv.2014.06.014. PMID: 25088765Free PMC Article

Diagnosis

Interactions between microbiota and cervical epithelial, immune, and mucus barrier.
Dong M, Dong Y, Bai J, Li H, Ma X, Li B, Wang C, Li H, Qi W, Wang Y, Fan A, Han C, Xue F
Front Cell Infect Microbiol 2023;13:1124591. Epub 2023 Feb 24 doi: 10.3389/fcimb.2023.1124591. PMID: 36909729Free PMC Article
Pediatric Gynecologic Cancers.
Pommert L, Bradley W
Curr Oncol Rep 2017 Jul;19(7):44. doi: 10.1007/s11912-017-0604-7. PMID: 28501984
Cervical cancer: screening, diagnosis and staging.
Tsikouras P, Zervoudis S, Manav B, Tomara E, Iatrakis G, Romanidis C, Bothou A, Galazios G
J BUON 2016 Mar-Apr;21(2):320-5. PMID: 27273940
Sexually Transmitted Infections.
Smith L, Angarone MP
Urol Clin North Am 2015 Nov;42(4):507-18. doi: 10.1016/j.ucl.2015.06.004. PMID: 26475947
Mammary and extramammary Paget's disease.
Lopes Filho LL, Lopes IM, Lopes LR, Enokihara MM, Michalany AO, Matsunaga N
An Bras Dermatol 2015 Mar-Apr;90(2):225-31. doi: 10.1590/abd1806-4841.20153189. PMID: 25830993Free PMC Article

Therapy

The role of probiotics in vaginal health.
Mei Z, Li D
Front Cell Infect Microbiol 2022;12:963868. Epub 2022 Jul 28 doi: 10.3389/fcimb.2022.963868. PMID: 35967876Free PMC Article
Targeting HPV in gynaecological cancers - Current status, ongoing challenges and future directions.
Crusz SM, El-Shakankery K, Miller RE
Womens Health (Lond) 2020 Jan-Dec;16:1745506520961709. doi: 10.1177/1745506520961709. PMID: 33296284Free PMC Article
Evaluation and management of vaginoplasty complications.
Amies Oelschlager AM, Kirby A, Breech L
Curr Opin Obstet Gynecol 2017 Oct;29(5):316-321. doi: 10.1097/GCO.0000000000000391. PMID: 28696998
Sexually Transmitted Infections.
Smith L, Angarone MP
Urol Clin North Am 2015 Nov;42(4):507-18. doi: 10.1016/j.ucl.2015.06.004. PMID: 26475947
Human papilloma virions in the laboratory.
Dunne EF, Markowitz LE, Taylor LD, Unger ER, Wheeler CM
J Clin Virol 2014 Oct;61(2):196-8. Epub 2014 Jun 23 doi: 10.1016/j.jcv.2014.06.014. PMID: 25088765Free PMC Article

Prognosis

Interactions between microbiota and cervical epithelial, immune, and mucus barrier.
Dong M, Dong Y, Bai J, Li H, Ma X, Li B, Wang C, Li H, Qi W, Wang Y, Fan A, Han C, Xue F
Front Cell Infect Microbiol 2023;13:1124591. Epub 2023 Feb 24 doi: 10.3389/fcimb.2023.1124591. PMID: 36909729Free PMC Article
Cervical, vaginal and vulvar cancer incidence and survival trends in Denmark, Finland, Norway and Sweden with implications to treatment.
Hemminki K, Kanerva A, Försti A, Hemminki A
BMC Cancer 2022 Apr 26;22(1):456. doi: 10.1186/s12885-022-09582-5. PMID: 35473606Free PMC Article
Gynecological radiotherapy in people living with human immunodeficiency virus: a semi-systematic literature review.
Fenlon JB, Rositch AF, Dickey BL, Kimani S, Suneja G
Int J Gynecol Cancer 2022 Mar;32(3):429-435. doi: 10.1136/ijgc-2021-002533. PMID: 35256433
Cervical cancer: screening, diagnosis and staging.
Tsikouras P, Zervoudis S, Manav B, Tomara E, Iatrakis G, Romanidis C, Bothou A, Galazios G
J BUON 2016 Mar-Apr;21(2):320-5. PMID: 27273940
Mammary and extramammary Paget's disease.
Lopes Filho LL, Lopes IM, Lopes LR, Enokihara MM, Michalany AO, Matsunaga N
An Bras Dermatol 2015 Mar-Apr;90(2):225-31. doi: 10.1590/abd1806-4841.20153189. PMID: 25830993Free PMC Article

Clinical prediction guides

Interactions between microbiota and cervical epithelial, immune, and mucus barrier.
Dong M, Dong Y, Bai J, Li H, Ma X, Li B, Wang C, Li H, Qi W, Wang Y, Fan A, Han C, Xue F
Front Cell Infect Microbiol 2023;13:1124591. Epub 2023 Feb 24 doi: 10.3389/fcimb.2023.1124591. PMID: 36909729Free PMC Article
Vaginal Lactobacilli and Vaginal Dysbiosis-Associated Bacteria Differently Affect Cervical Epithelial and Immune Homeostasis and Anti-Viral Defenses.
Nicolò S, Tanturli M, Mattiuz G, Antonelli A, Baccani I, Bonaiuto C, Baldi S, Nannini G, Menicatti M, Bartolucci G, Rossolini GM, Amedei A, Torcia MG
Int J Mol Sci 2021 Jun 17;22(12) doi: 10.3390/ijms22126487. PMID: 34204294Free PMC Article
Cervical cytology reproducibility and associated clinical and demographic factors.
Hwang H, Follen M, Guillaud M, Scheurer M, MacAulay C, MacAulay C, Staerkel GA, van Niekerk D, Yamal JM
Diagn Cytopathol 2020 Jan;48(1):35-42. Epub 2019 Oct 22 doi: 10.1002/dc.24325. PMID: 31639288Free PMC Article
Vaginal dysbiosis and the risk of human papillomavirus and cervical cancer: systematic review and meta-analysis.
Brusselaers N, Shrestha S, van de Wijgert J, Verstraelen H
Am J Obstet Gynecol 2019 Jul;221(1):9-18.e8. Epub 2018 Dec 12 doi: 10.1016/j.ajog.2018.12.011. PMID: 30550767
Cervical cancer: screening, diagnosis and staging.
Tsikouras P, Zervoudis S, Manav B, Tomara E, Iatrakis G, Romanidis C, Bothou A, Galazios G
J BUON 2016 Mar-Apr;21(2):320-5. PMID: 27273940

Recent systematic reviews

The significance of nonsurgical therapies for cervical infection of high-risk human papilloma virus: A systematic review and meta-analysis.
Zhuang Y, Yang H
J Obstet Gynaecol Res 2023 Sep;49(9):2213-2231. Epub 2023 Jun 26 doi: 10.1111/jog.15726. PMID: 37365015
Gynecological radiotherapy in people living with human immunodeficiency virus: a semi-systematic literature review.
Fenlon JB, Rositch AF, Dickey BL, Kimani S, Suneja G
Int J Gynecol Cancer 2022 Mar;32(3):429-435. doi: 10.1136/ijgc-2021-002533. PMID: 35256433
Diagnostic accuracy of novel folate receptor-mediated staining solution detection (FRD) for CIN2+: A systematic review and meta analysis.
Li YX, Luo HX, Wang W, Wang Z, Zhao WH, Hao M
Medicine (Baltimore) 2021 May 21;100(20):e26004. doi: 10.1097/MD.0000000000026004. PMID: 34011097Free PMC Article
Vaginal dysbiosis and the risk of human papillomavirus and cervical cancer: systematic review and meta-analysis.
Brusselaers N, Shrestha S, van de Wijgert J, Verstraelen H
Am J Obstet Gynecol 2019 Jul;221(1):9-18.e8. Epub 2018 Dec 12 doi: 10.1016/j.ajog.2018.12.011. PMID: 30550767
Interventions for encouraging sexual lifestyles and behaviours intended to prevent cervical cancer.
Shepherd J, Weston R, Peersman G, Napuli IZ
Cochrane Database Syst Rev 2000;(2):CD001035. doi: 10.1002/14651858.CD001035. PMID: 10796735

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