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Low Grade Paranasal Sinus Sarcoma

MedGen UID:
235263
•Concept ID:
C1334426
•
Neoplastic Process
Synonyms: Low Grade Accessory Sinus Sarcoma; Low Grade Sarcoma of Accessory Sinus; Low Grade Sarcoma of Paranasal Sinus; Low Grade Sarcoma of the Accessory Sinus; Low Grade Sarcoma of the Paranasal Sinus

Definition

A malignant soft tissue neoplasm that arises from the paranasal sinus. It is characterized by the presence of low-grade histologic features. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLow Grade Paranasal Sinus Sarcoma

Professional guidelines

PubMed

Challenging differential diagnoses in small biopsies from the sinonasal tract.
Israel AK, Cracolici V, Griffith CC
Semin Diagn Pathol 2023 Sep;40(5):321-332. Epub 2023 Apr 14 doi: 10.1053/j.semdp.2023.04.011. PMID: 37085435
Soft Tissue Special Issue: Biphenotypic Sinonasal Sarcoma: A Review with Emphasis on Differential Diagnosis.
Gross J, Fritchie K
Head Neck Pathol 2020 Mar;14(1):33-42. Epub 2020 Jan 16 doi: 10.1007/s12105-019-01092-4. PMID: 31950469Free PMC Article
Biphenotypic sinonasal sarcoma: A series of six cases with evaluation of role of β-catenin immunohistochemistry in differential diagnosis.
Kakkar A, Rajeshwari M, Sakthivel P, Sharma MC, Sharma SC
Ann Diagn Pathol 2018 Apr;33:6-10. Epub 2017 Nov 8 doi: 10.1016/j.anndiagpath.2017.11.005. PMID: 29566950

Recent clinical studies

Etiology

Risk Factors for Recurrence and the Role of Radiotherapy in Low-grade Myofibroblastic Sarcoma: A Systematic Review.
Mamikunian G, Ziegler A, Block A, Thorpe E
Am J Clin Oncol 2023 Sep 1;46(9):420-425. Epub 2023 Jun 26 doi: 10.1097/COC.0000000000001025. PMID: 37358303
Challenging differential diagnoses in small biopsies from the sinonasal tract.
Israel AK, Cracolici V, Griffith CC
Semin Diagn Pathol 2023 Sep;40(5):321-332. Epub 2023 Apr 14 doi: 10.1053/j.semdp.2023.04.011. PMID: 37085435
Biphenotypic sinonasal sarcoma: European multicentre case-series and systematic literature review.
Turri-Zanoni M, Dalfino G, Lechner M, Dallan I, Battaglia P, Facco C, Franzi F, Gravante G, Ferrari M, Terzakis D, Jay A, Forster MD, Ambrosoli AL, Bignami M, Georgalas C, Herman P, Nicolai P, Lund VJ, Castelnuovo P
Acta Otorhinolaryngol Ital 2022 Dec;42(6):545-553. doi: 10.14639/0392-100X-N2087. PMID: 36654521Free PMC Article
A Rare Pathology: Low-Grade Fibromyxoid Sarcoma of the Maxilla.
Spalthoff S, Bredt M, Gellrich NC, Jehn P
J Oral Maxillofac Surg 2016 Jan;74(1):219.e1-10. Epub 2015 Sep 25 doi: 10.1016/j.joms.2015.09.018. PMID: 26455471
Sarcomas of the head and neck.
Potter BO, Sturgis EM
Surg Oncol Clin N Am 2003 Apr;12(2):379-417. doi: 10.1016/s1055-3207(03)00005-x. PMID: 12916461

Diagnosis

Challenging differential diagnoses in small biopsies from the sinonasal tract.
Israel AK, Cracolici V, Griffith CC
Semin Diagn Pathol 2023 Sep;40(5):321-332. Epub 2023 Apr 14 doi: 10.1053/j.semdp.2023.04.011. PMID: 37085435
High-grade transformation of low-grade biphenotypic sinonasal sarcoma: Radiological, morphophenotypic variation and confirmatory molecular analysis.
Bell D, Phan J, DeMonte F, Hanna EY
Ann Diagn Pathol 2022 Apr;57:151889. Epub 2022 Jan 10 doi: 10.1016/j.anndiagpath.2021.151889. PMID: 35030392
Biphenotypic Sinonasal Sarcoma: A Review and Update.
Carter CS, East EG, McHugh JB
Arch Pathol Lab Med 2018 Oct;142(10):1196-1201. doi: 10.5858/arpa.2018-0207-RA. PMID: 30281368
Low-Grade Sinonasal Sarcoma With Neural and Myogenic Features: A Recently Discovered Entity With Unique Features and Diagnostic Challenge.
Triki M, Ayadi L
Arch Pathol Lab Med 2017 May;141(5):718-721. doi: 10.5858/arpa.2016-0133-RS. PMID: 28447903
Hematolymphoid lesions of the sinonasal tract.
Crane GM, Duffield AS
Semin Diagn Pathol 2016 Mar;33(2):71-80. Epub 2015 Sep 9 doi: 10.1053/j.semdp.2015.09.008. PMID: 26472692Free PMC Article

Therapy

Particle beam radiation therapy for sinonasal malignancies: Single institutional experience at the Shanghai Proton and Heavy Ion Center.
Hu W, Hu J, Huang Q, Gao J, Yang J, Qiu X, Kong L, Lu JJ
Cancer Med 2020 Nov;9(21):7914-7924. Epub 2020 Sep 25 doi: 10.1002/cam4.3393. PMID: 32977357Free PMC Article
Treatment planning and verification of proton therapy using spot scanning: initial experiences.
Lomax AJ, Böhringer T, Bolsi A, Coray D, Emert F, Goitein G, Jermann M, Lin S, Pedroni E, Rutz H, Stadelmann O, Timmermann B, Verwey J, Weber DC
Med Phys 2004 Nov;31(11):3150-7. doi: 10.1118/1.1779371. PMID: 15587667
Sarcomas of the head and neck.
Potter BO, Sturgis EM
Surg Oncol Clin N Am 2003 Apr;12(2):379-417. doi: 10.1016/s1055-3207(03)00005-x. PMID: 12916461
Fast neutron radiotherapy for advanced malignant tumors of the paranasal sinuses.
Schwarz R, Hübener KH
Strahlenther Onkol 1990 Jan;166(1):99-101. PMID: 2154053
Status report of fast neutron therapy in the Department of Radiotherapy at the University Hospital Hamburg-Eppendorf.
Schwarz R, Krüll A, Schmidt R, Hübener KH
Strahlenther Onkol 1990 Jan;166(1):72-5. PMID: 2154051

Prognosis

Particle beam radiation therapy for sinonasal malignancies: Single institutional experience at the Shanghai Proton and Heavy Ion Center.
Hu W, Hu J, Huang Q, Gao J, Yang J, Qiu X, Kong L, Lu JJ
Cancer Med 2020 Nov;9(21):7914-7924. Epub 2020 Sep 25 doi: 10.1002/cam4.3393. PMID: 32977357Free PMC Article
Hematolymphoid lesions of the sinonasal tract.
Crane GM, Duffield AS
Semin Diagn Pathol 2016 Mar;33(2):71-80. Epub 2015 Sep 9 doi: 10.1053/j.semdp.2015.09.008. PMID: 26472692Free PMC Article
A Rare Pathology: Low-Grade Fibromyxoid Sarcoma of the Maxilla.
Spalthoff S, Bredt M, Gellrich NC, Jehn P
J Oral Maxillofac Surg 2016 Jan;74(1):219.e1-10. Epub 2015 Sep 25 doi: 10.1016/j.joms.2015.09.018. PMID: 26455471
Sarcomas of the head and neck.
Potter BO, Sturgis EM
Surg Oncol Clin N Am 2003 Apr;12(2):379-417. doi: 10.1016/s1055-3207(03)00005-x. PMID: 12916461
Sinonasal fibrosarcomas, malignant schwannomas, and "Triton" tumors. A clinicopathologic study of 67 cases.
Heffner DK, Gnepp DR
Cancer 1992 Sep 1;70(5):1089-101. doi: 10.1002/1097-0142(19920901)70:5<1089::aid-cncr2820700513>3.0.co;2-j. PMID: 1515984

Clinical prediction guides

Biphenotypic Sinonasal Sarcoma: A Case Report and Review of Literature.
Kominsky E, Boyke AE, Madani D, Kamat A, Schiff BA, Agarwal V
Ear Nose Throat J 2023 Jun;102(6):385-390. Epub 2021 Apr 5 doi: 10.1177/0145561321999196. PMID: 33813901
Biphenotypic sinonasal sarcoma: European multicentre case-series and systematic literature review.
Turri-Zanoni M, Dalfino G, Lechner M, Dallan I, Battaglia P, Facco C, Franzi F, Gravante G, Ferrari M, Terzakis D, Jay A, Forster MD, Ambrosoli AL, Bignami M, Georgalas C, Herman P, Nicolai P, Lund VJ, Castelnuovo P
Acta Otorhinolaryngol Ital 2022 Dec;42(6):545-553. doi: 10.14639/0392-100X-N2087. PMID: 36654521Free PMC Article
Clinicopathological analysis of low-grade papillary Schneiderian carcinoma: report of five new cases and review of the literature.
Zhai C, Wang H, Li S, Wang D
Histopathology 2021 Sep;79(3):370-380. Epub 2021 Apr 14 doi: 10.1111/his.14347. PMID: 33539575
Sinonasal synovial sarcoma: evaluation of the role of radiological and clinicopathological features in diagnosis.
Lin N, Liu X, Zhang F, Pan Y, Qi M, Sha Y
Clin Radiol 2021 Jan;76(1):78.e1-78.e8. Epub 2020 Sep 28 doi: 10.1016/j.crad.2020.08.007. PMID: 32896427
Sarcomas of the head and neck.
Potter BO, Sturgis EM
Surg Oncol Clin N Am 2003 Apr;12(2):379-417. doi: 10.1016/s1055-3207(03)00005-x. PMID: 12916461

Recent systematic reviews

Risk Factors for Recurrence and the Role of Radiotherapy in Low-grade Myofibroblastic Sarcoma: A Systematic Review.
Mamikunian G, Ziegler A, Block A, Thorpe E
Am J Clin Oncol 2023 Sep 1;46(9):420-425. Epub 2023 Jun 26 doi: 10.1097/COC.0000000000001025. PMID: 37358303
Biphenotypic sinonasal sarcoma: European multicentre case-series and systematic literature review.
Turri-Zanoni M, Dalfino G, Lechner M, Dallan I, Battaglia P, Facco C, Franzi F, Gravante G, Ferrari M, Terzakis D, Jay A, Forster MD, Ambrosoli AL, Bignami M, Georgalas C, Herman P, Nicolai P, Lund VJ, Castelnuovo P
Acta Otorhinolaryngol Ital 2022 Dec;42(6):545-553. doi: 10.14639/0392-100X-N2087. PMID: 36654521Free PMC Article

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