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Malignant Testicular Sertoli Cell Tumor

MedGen UID:
235304
Concept ID:
C1334626
Neoplastic Process
Synonyms: Malignant Sertoli Cell Neoplasm of Testis; Malignant Sertoli Cell Neoplasm of the Testis; Malignant Sertoli Cell Tumor of Testis; Malignant Sertoli Cell Tumor of the Testis; Malignant Testicular Sertoli Cell Neoplasm

Definition

A Sertoli cell tumor that arises from the testis and is characterized by nuclear pleomorphism, increased mitotic activity and necrotic changes. Metastases may be present at diagnosis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant Testicular Sertoli Cell Tumor

Professional guidelines

PubMed

Michalová K, Michal M, Hora M, Hes O, Michal M
Cesk Patol 2020 Summer;56(3):153-160. PMID: 33076667
Ye H, Ulbright TM
Arch Pathol Lab Med 2012 Apr;136(4):435-46. doi: 10.5858/arpa.2011-0475-RA. PMID: 22458906
Yan W, Burns KH, Matzuk MM
APMIS 2003 Jan;111(1):174-81; discussion 182-3. doi: 10.1034/j.1600-0463.2003.1110121.x. PMID: 12760377

Recent clinical studies

Etiology

Dupeux M, Maxwell F, Rocher L, Izard V, Guettier C, Ferlicot S
Am J Clin Pathol 2022 Jun 7;157(6):936-941. doi: 10.1093/ajcp/aqab214. PMID: 34935941
Al-Obaidy KI, Idrees MT
Adv Anat Pathol 2021 Jul 1;28(4):258-275. doi: 10.1097/PAP.0000000000000302. PMID: 33871428
Macut D, Ilić D, Mitrović Jovanović A, Bjekić-Macut J
Front Horm Res 2019;53:100-107. Epub 2019 Sep 9 doi: 10.1159/000494906. PMID: 31499493
Schultz KAP, Williams GM, Kamihara J, Stewart DR, Harris AK, Bauer AJ, Turner J, Shah R, Schneider K, Schneider KW, Carr AG, Harney LA, Baldinger S, Frazier AL, Orbach D, Schneider DT, Malkin D, Dehner LP, Messinger YH, Hill DA
Clin Cancer Res 2018 May 15;24(10):2251-2261. Epub 2018 Jan 17 doi: 10.1158/1078-0432.CCR-17-3089. PMID: 29343557Free PMC Article
Mikuz G
Anal Quant Cytopathol Histpathol 2015 Feb;37(1):75-85. PMID: 26072638

Diagnosis

Berney DM, Cree I, Rao V, Moch H, Srigley JR, Tsuzuki T, Amin MB, Comperat EM, Hartmann A, Menon S, Netto GJ, Rubin MA, Turajlic S, Raspollini MR, Tickoo SK
Histopathology 2022 Oct;81(4):459-466. Epub 2022 Jul 1 doi: 10.1111/his.14675. PMID: 35502823Free PMC Article
Al-Obaidy KI, Idrees MT
Adv Anat Pathol 2021 Jul 1;28(4):258-275. doi: 10.1097/PAP.0000000000000302. PMID: 33871428
Macut D, Ilić D, Mitrović Jovanović A, Bjekić-Macut J
Front Horm Res 2019;53:100-107. Epub 2019 Sep 9 doi: 10.1159/000494906. PMID: 31499493
Schultz KAP, Williams GM, Kamihara J, Stewart DR, Harris AK, Bauer AJ, Turner J, Shah R, Schneider K, Schneider KW, Carr AG, Harney LA, Baldinger S, Frazier AL, Orbach D, Schneider DT, Malkin D, Dehner LP, Messinger YH, Hill DA
Clin Cancer Res 2018 May 15;24(10):2251-2261. Epub 2018 Jan 17 doi: 10.1158/1078-0432.CCR-17-3089. PMID: 29343557Free PMC Article
Peckham MJ, McElwain TJ
Clin Endocrinol Metab 1975 Nov;4(3):665-92. doi: 10.1016/s0300-595x(75)80052-1. PMID: 58746

Therapy

Kağızmanlı GA, Besci Ö, Acinikli KY, Şeker G, Yaşar E, Öztürk Y, Demir K, Böber E, Abacı A
J Pediatr Endocrinol Metab 2022 Dec 16;35(12):1565-1570. Epub 2022 Oct 3 doi: 10.1515/jpem-2022-0368. PMID: 36181314
Lakis NS, Lombardo KA, Mangray S, Netto GJ, Salles D, Matoso A
Appl Immunohistochem Mol Morphol 2019 Mar;27(3):203-209. doi: 10.1097/PAI.0000000000000567. PMID: 29084059
Gourgari E, Saloustros E, Stratakis CA
Curr Opin Pediatr 2012 Aug;24(4):518-22. doi: 10.1097/MOP.0b013e328355a279. PMID: 22732638Free PMC Article
Schrader M, Muller M, Straub B, Miller K
Asian J Androl 2002 Mar;4(1):9-15. PMID: 11907623
Peckham MJ, McElwain TJ
Clin Endocrinol Metab 1975 Nov;4(3):665-92. doi: 10.1016/s0300-595x(75)80052-1. PMID: 58746

Prognosis

Siegmund SE, Sholl LM, Tsai HK, Yang Y, Vasudevaraja V, Tran I, Snuderl M, Fletcher CDM, Cornejo KM, Idrees MT, Al-Obaidy KI, Collins K, Gordetsky JB, Wobker SE, Hirsch MS, Trpkov K, Yilmaz A, Anderson WJ, Quiroga-Garza G, Magi-Galluzzi C, Canete-Portillo S, Acosta AM
Mod Pathol 2022 Dec;35(12):1944-1954. Epub 2022 Sep 30 doi: 10.1038/s41379-022-01155-y. PMID: 36180576
Berney DM, Cree I, Rao V, Moch H, Srigley JR, Tsuzuki T, Amin MB, Comperat EM, Hartmann A, Menon S, Netto GJ, Rubin MA, Turajlic S, Raspollini MR, Tickoo SK
Histopathology 2022 Oct;81(4):459-466. Epub 2022 Jul 1 doi: 10.1111/his.14675. PMID: 35502823Free PMC Article
Al-Obaidy KI, Idrees MT, Abdulfatah E, Kunju LP, Wu A, Ulbright TM
Am J Surg Pathol 2022 May 1;46(5):688-700. doi: 10.1097/PAS.0000000000001849. PMID: 34913878
Mesa H, Gilles S, Datta MW, Murugan P, Larson W, Dachel S, Manivel JC
Hum Pathol 2017 Mar;61:181-189. Epub 2016 Dec 8 doi: 10.1016/j.humpath.2016.11.004. PMID: 27939779
Schultz KA, Harris AK, Schneider DT, Young RH, Brown J, Gershenson DM, Dehner LP, Hill DA, Messinger YH, Frazier AL
J Oncol Pract 2016 Oct;12(10):940-946. doi: 10.1200/JOP.2016.016261. PMID: 27858560Free PMC Article

Clinical prediction guides

Kaushik A, Bhartiya D
Stem Cell Res Ther 2022 Jun 8;13(1):243. doi: 10.1186/s13287-022-02784-5. PMID: 35676718Free PMC Article
Anderson WJ, Gordetsky JB, Idrees MT, Al-Obaidy KI, Kao CS, Cornejo KM, Wobker SE, Cheville JC, Vargas SO, Fletcher CDM, Hirsch MS, Acosta AM
Histopathology 2022 Mar;80(4):677-685. Epub 2022 Jan 5 doi: 10.1111/his.14599. PMID: 34780072
Mesa H, Gilles S, Datta MW, Murugan P, Larson W, Dachel S, Manivel JC
Hum Pathol 2017 Mar;61:181-189. Epub 2016 Dec 8 doi: 10.1016/j.humpath.2016.11.004. PMID: 27939779
Schultz KA, Harris AK, Schneider DT, Young RH, Brown J, Gershenson DM, Dehner LP, Hill DA, Messinger YH, Frazier AL
J Oncol Pract 2016 Oct;12(10):940-946. doi: 10.1200/JOP.2016.016261. PMID: 27858560Free PMC Article
Ye H, Ulbright TM
Arch Pathol Lab Med 2012 Apr;136(4):435-46. doi: 10.5858/arpa.2011-0475-RA. PMID: 22458906

Recent systematic reviews

Grogg J, Schneider K, Bode PK, Kranzbühler B, Eberli D, Sulser T, Lorch A, Beyer J, Hermanns T, Fankhauser CD
Oncologist 2020 Jul;25(7):585-590. Epub 2020 Feb 11 doi: 10.1634/theoncologist.2019-0692. PMID: 32043680Free PMC Article

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