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Metastatic Benign Neoplasm

MedGen UID:: 235321
•Concept ID:: C1334712
•: Neoplastic Process

Definition

A very rare benign neoplasm that metastasizes inexplicably. This category includes metastasizing pleomorphic adenoma of the salivary gland and uterine corpus metastasizing leiomyoma. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVMetastatic Benign Neoplasm

Phenotypic abnormality
- Neoplasm
  - Neoplasm by Special Category
    - Benign neoplasm
      - Metastatic Benign Neoplasm
        Benign metastasizing leiomyoma
        Metastasizing Pleomorphic Adenoma of the Salivary Gland

Professional guidelines

PubMed

Metastatic colorectal cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up.

Cervantes A, Adam R, Roselló S, Arnold D, Normanno N, Taïeb J, Seligmann J, De Baere T, Osterlund P, Yoshino T, Martinelli E; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2023 Jan;34(1):10-32. Epub 2022 Oct 25 doi: 10.1016/j.annonc.2022.10.003. PMID: 36307056

Diagnosis and treatment of basal cell carcinoma: European consensus-based interdisciplinary guidelines.

Peris K, Fargnoli MC, Garbe C, Kaufmann R, Bastholt L, Seguin NB, Bataille V, Marmol VD, Dummer R, Harwood CA, Hauschild A, Höller C, Haedersdal M, Malvehy J, Middleton MR, Morton CA, Nagore E, Stratigos AJ, Szeimies RM, Tagliaferri L, Trakatelli M, Zalaudek I, Eggermont A, Grob JJ; European Dermatology Forum (EDF), the European Association of Dermato-Oncology (EADO) and the European Organization for Research and Treatment of Cancer (EORTC)
Eur J Cancer 2019 Sep;118:10-34. Epub 2019 Jul 6 doi: 10.1016/j.ejca.2019.06.003. PMID: 31288208

Pheochromocytoma and paraganglioma: an endocrine society clinical practice guideline.

Lenders JW, Duh QY, Eisenhofer G, Gimenez-Roqueplo AP, Grebe SK, Murad MH, Naruse M, Pacak K, Young WF Jr; Endocrine Society
J Clin Endocrinol Metab 2014 Jun;99(6):1915-42. doi: 10.1210/jc.2014-1498. PMID: 24893135

See all (27292)

Recent clinical studies

Etiology

Gene expression profile in metastatic and non-metastatic parathyroid carcinoma.

Condello V, Cetani F, Denaro M, Torregrossa L, Pardi E, Piaggi P, Borsari S, Poma AM, Muscarella LA, Graziano P, Chiofalo MG, Repaci A, Tallini G, Boi F, Materazzi G, Basolo F, Marcocci C
Endocr Relat Cancer 2021 Feb;28(2):111-134. doi: 10.1530/ERC-20-0450. PMID: 33290252

Nivolumab with or without ipilimumab treatment for metastatic sarcoma (Alliance A091401): two open-label, non-comparative, randomised, phase 2 trials.

D'Angelo SP, Mahoney MR, Van Tine BA, Atkins J, Milhem MM, Jahagirdar BN, Antonescu CR, Horvath E, Tap WD, Schwartz GK, Streicher H
Lancet Oncol 2018 Mar;19(3):416-426. Epub 2018 Jan 19 doi: 10.1016/S1470-2045(18)30006-8. PMID: 29370992 Free PMC Article

Melanoma progression.

Elder DE
Pathology 2016 Feb;48(2):147-54. Epub 2016 Jan 16 doi: 10.1016/j.pathol.2015.12.002. PMID: 27020387

Pathological grading for predicting metastasis in phaeochromocytoma and paraganglioma.

Kimura N, Takayanagi R, Takizawa N, Itagaki E, Katabami T, Kakoi N, Rakugi H, Ikeda Y, Tanabe A, Nigawara T, Ito S, Kimura I, Naruse M; Phaeochromocytoma Study Group in Japan
Endocr Relat Cancer 2014 Jun;21(3):405-14. Epub 2014 May 6 doi: 10.1530/ERC-13-0494. PMID: 24521857

Pediatric germ cell tumors.

Rescorla FJ
Semin Pediatr Surg 2012 Feb;21(1):51-60. doi: 10.1053/j.sempedsurg.2011.10.005. PMID: 22248970

See all (145695)

Diagnosis

PRAME Expression in Melanocytic Tumors.

Lezcano C, Jungbluth AA, Nehal KS, Hollmann TJ, Busam KJ
Am J Surg Pathol 2018 Nov;42(11):1456-1465. doi: 10.1097/PAS.0000000000001134. PMID: 30045064 Free PMC Article

Melanoma progression.

Elder DE
Pathology 2016 Feb;48(2):147-54. Epub 2016 Jan 16 doi: 10.1016/j.pathol.2015.12.002. PMID: 27020387

Ameloblastic Carcinoma.

Gunaratne DA, Coleman HG, Lim L, Morgan GJ
Am J Case Rep 2015 Jul 1;16:415-9. doi: 10.12659/AJCR.893918. PMID: 26126621 Free PMC Article

Sebaceous carcinoma: review of the literature.

Kyllo RL, Brady KL, Hurst EA
Dermatol Surg 2015 Jan;41(1):1-15. doi: 10.1097/DSS.0000000000000152. PMID: 25521100

Pathology of the pleura: what the pulmonologists need to know.

Cagle PT, Allen TC
Respirology 2011 Apr;16(3):430-8. doi: 10.1111/j.1440-1843.2011.01957.x. PMID: 21362105

See all (134091)

Therapy

Metastatic uveal melanoma: The final frontier.

Rantala ES, Hernberg MM, Piperno-Neumann S, Grossniklaus HE, Kivelä TT
Prog Retin Eye Res 2022 Sep;90:101041. Epub 2022 Jan 6 doi: 10.1016/j.preteyeres.2022.101041. PMID: 34999237

Treatment Strategies for Oligometastatic Breast Cancer.

Nesbit EG, Donnelly ED, Strauss JB
Curr Treat Options Oncol 2021 Aug 23;22(10):94. doi: 10.1007/s11864-021-00889-2. PMID: 34426881

Checkpoint inhibitor therapy for metastatic triple-negative breast cancer.

Heeke AL, Tan AR
Cancer Metastasis Rev 2021 Jun;40(2):537-547. Epub 2021 Jun 8 doi: 10.1007/s10555-021-09972-4. PMID: 34101053 Free PMC Article

The Emerging Role of Local Therapy in Metastatic Prostate Cancer.

Sundahl N, Tree A, Parker C
Curr Oncol Rep 2020 Jan 20;22(1):2. doi: 10.1007/s11912-020-0868-1. PMID: 31960153

Recent advances in medical therapy for metastatic urothelial cancer.

Yuasa T, Urakami S, Yonese J
Int J Clin Oncol 2018 Aug;23(4):599-607. Epub 2018 Mar 20 doi: 10.1007/s10147-018-1260-0. PMID: 29556919 Free PMC Article

See all (136254)

Prognosis

Metastasis patterns and prognosis of octogenarians with metastatic breast cancer: A large-cohort retrospective study.

Lv Z, Zhang W, Zhang Y, Zhong G, Zhang X, Yang Q, Li Y
PLoS One 2022;17(2):e0263104. Epub 2022 Feb 17 doi: 10.1371/journal.pone.0263104. PMID: 35176034 Free PMC Article

Recurrent and metastatic congenital mesoblastic nephroma: where does the evidence stand?

Jehangir S, Kurian JJ, Selvarajah D, Thomas RJ, Holland AJA
Pediatr Surg Int 2017 Nov;33(11):1183-1188. Epub 2017 Aug 30 doi: 10.1007/s00383-017-4149-5. PMID: 28856451

Incidence and prognosis of patients with brain metastases at diagnosis of systemic malignancy: a population-based study.

Cagney DN, Martin AM, Catalano PJ, Redig AJ, Lin NU, Lee EQ, Wen PY, Dunn IF, Bi WL, Weiss SE, Haas-Kogan DA, Alexander BM, Aizer AA
Neuro Oncol 2017 Oct 19;19(11):1511-1521. doi: 10.1093/neuonc/nox077. PMID: 28444227 Free PMC Article

Phyllodes tumour among participants in screening mammography.

Farshid G, Gill PG
ANZ J Surg 2017 Dec;87(12):E285-E292. Epub 2015 Mar 19 doi: 10.1111/ans.13056. PMID: 25786884

Pathological grading for predicting metastasis in phaeochromocytoma and paraganglioma.

See all (138063)

Clinical prediction guides

Do not break a sweat: avoiding pitfalls in the diagnosis of sweat gland tumors.

Brenn T
Mod Pathol 2020 Jan;33(Suppl 1):25-41. Epub 2019 Sep 26 doi: 10.1038/s41379-019-0377-7. PMID: 31558783

Prognostic and predictive markers in liver limited stage IV colorectal cancer.

Rehman AH, Jones RP, Poston G
Eur J Surg Oncol 2019 Dec;45(12):2251-2256. Epub 2019 Jun 27 doi: 10.1016/j.ejso.2019.06.038. PMID: 31279594

Pulmonary imaging after stereotactic radiotherapy-does RECIST still apply?

Mattonen SA, Ward AD, Palma DA
Br J Radiol 2016 Sep;89(1065):20160113. Epub 2016 Jun 20 doi: 10.1259/bjr.20160113. PMID: 27245137 Free PMC Article

GATA3: a multispecific but potentially useful marker in surgical pathology: a systematic analysis of 2500 epithelial and nonepithelial tumors.

Miettinen M, McCue PA, Sarlomo-Rikala M, Rys J, Czapiewski P, Wazny K, Langfort R, Waloszczyk P, Biernat W, Lasota J, Wang Z
Am J Surg Pathol 2014 Jan;38(1):13-22. doi: 10.1097/PAS.0b013e3182a0218f. PMID: 24145643 Free PMC Article

Clinical score for predicting recurrence after hepatic resection for metastatic colorectal cancer: analysis of 1001 consecutive cases.

Fong Y, Fortner J, Sun RL, Brennan MF, Blumgart LH
Ann Surg 1999 Sep;230(3):309-18; discussion 318-21. doi: 10.1097/00000658-199909000-00004. PMID: 10493478 Free PMC Article

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Recent systematic reviews

ESTRO clinical practice guideline: Stereotactic body radiotherapy for spine metastases.

Guckenberger M, Andratschke N, Belka C, Bellut D, Cuccia F, Dahele M, Guninski RS, Josipovic M, Mancosu P, Minniti G, Niyazi M, Ricardi U, Munck Af Rosenschold P, Sahgal A, Tsang Y, Verbakel W, Alongi F
Radiother Oncol 2024 Jan;190:109966. Epub 2023 Nov 2 doi: 10.1016/j.radonc.2023.109966. PMID: 37925107

Stereotactic radiosurgery versus whole brain radiotherapy in patients with intracranial metastatic disease and small-cell lung cancer: a systematic review and meta-analysis.

Gaebe K, Li AY, Park A, Parmar A, Lok BH, Sahgal A, Chan KKW, Erickson AW, Das S
Lancet Oncol 2022 Jul;23(7):931-939. Epub 2022 May 26 doi: 10.1016/S1470-2045(22)00271-6. PMID: 35644163

Bone metastasis from glioblastoma: a systematic review.

Strong MJ, Koduri S, Allison JA, Pesavento CM, Ogunsola S, Ogunsola O, Yee TJ, Khalsa SSS, Saadeh YS, Joseph JR, Kashlan ON, Park P, Oppenlander ME, Szerlip NJ
J Neurooncol 2022 Jul;158(3):379-392. Epub 2022 May 17 doi: 10.1007/s11060-022-04025-4. PMID: 35578056

Prostate Radiotherapy for Metastatic Hormone-sensitive Prostate Cancer: A STOPCAP Systematic Review and Meta-analysis.

Burdett S, Boevé LM, Ingleby FC, Fisher DJ, Rydzewska LH, Vale CL, van Andel G, Clarke NW, Hulshof MC, James ND, Parker CC, Parmar MK, Sweeney CJ, Sydes MR, Tombal B, Verhagen PC, Tierney JF; STOPCAP M1 Radiotherapy Collaborators
Eur Urol 2019 Jul;76(1):115-124. Epub 2019 Feb 28 doi: 10.1016/j.eururo.2019.02.003. PMID: 30826218 Free PMC Article

Breast surgery for metastatic breast cancer.

Tosello G, Torloni MR, Mota BS, Neeman T, Riera R
Cochrane Database Syst Rev 2018 Mar 15;3(3):CD011276. doi: 10.1002/14651858.CD011276.pub2. PMID: 29542106 Free PMC Article

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National Center for Biotechnology Information