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Lung mixed small cell and squamous cell carcinoma

MedGen UID:
235331
•Concept ID:
C1334788
•
Neoplastic Process
Synonyms: Combined Lung Small Cell and Squamous Cell Carcinoma; Combined Small Cell and Squamous Cell Lung Carcinoma; combined small cell and squamous cell lung carcinoma; lung mixed small cell and squamous cell carcinoma; Mixed Small Cell and Squamous Cell Carcinoma of Lung; mixed small cell and squamous cell carcinoma of lung; Mixed Small Cell and Squamous Cell Carcinoma of the Lung; mixed small cell and squamous cell carcinoma of the lung; small cell and large cell carcinoma of the lung; Small Cell and Squamous Cell Carcinoma of Lung; small cell and squamous cell carcinoma of lung; Small Cell and Squamous Cell Carcinoma of the Lung; small cell and squamous cell carcinoma of the lung; Small Cell and Squamous Cell Lung Carcinoma; small cell and squamous cell lung carcinoma
 
Monarch Initiative: MONDO:0004100

Definition

A lung carcinoma characterized by a combination of small cell carcinoma and squamous cell carcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLung mixed small cell and squamous cell carcinoma

Professional guidelines

PubMed

Association between time-to-treatment and outcomes in non-small cell lung cancer: a systematic review.
Hall H, Tocock A, Burdett S, Fisher D, Ricketts WM, Robson J, Round T, Gorolay S, MacArthur E, Chung D, Janes SM, Peake MD, Navani N
Thorax 2022 Aug;77(8):762-768. Epub 2021 Aug 17 doi: 10.1136/thoraxjnl-2021-216865. PMID: 34404753Free PMC Article
Highly accurate DNA-based detection and treatment results of MET exon 14 skipping mutations in lung cancer.
Pruis MA, Geurts-Giele WRR, von der TJH, Meijssen IC, Dinjens WNM, Aerts JGJV, Dingemans AMC, Lolkema MP, Paats MS, Dubbink HJ
Lung Cancer 2020 Feb;140:46-54. Epub 2019 Nov 18 doi: 10.1016/j.lungcan.2019.11.010. PMID: 31862577
Exploring the Benefit/Risk Associated with Antiangiogenic Agents for the Treatment of Non-Small Cell Lung Cancer Patients.
Kurzrock R, Stewart DJ
Clin Cancer Res 2017 Mar 1;23(5):1137-1148. Epub 2016 Dec 9 doi: 10.1158/1078-0432.CCR-16-1968. PMID: 27940520

Recent clinical studies

Etiology

Association between time-to-treatment and outcomes in non-small cell lung cancer: a systematic review.
Hall H, Tocock A, Burdett S, Fisher D, Ricketts WM, Robson J, Round T, Gorolay S, MacArthur E, Chung D, Janes SM, Peake MD, Navani N
Thorax 2022 Aug;77(8):762-768. Epub 2021 Aug 17 doi: 10.1136/thoraxjnl-2021-216865. PMID: 34404753Free PMC Article
Chaperone-Mediated Autophagy Markers LAMP2A and HSPA8 in Advanced Non-Small Cell Lung Cancer after Neoadjuvant Therapy.
Losmanova T, Zens P, Scherz A, Schmid RA, Tschan MP, Berezowska S
Cells 2021 Oct 13;10(10) doi: 10.3390/cells10102731. PMID: 34685711Free PMC Article
EGFR mutation exists in squamous cell lung carcinoma.
Cheung AH, Tong JH, Chung LY, Chau SL, Ng CS, Wan IYP, To KF
Pathology 2020 Apr;52(3):323-328. Epub 2020 Feb 27 doi: 10.1016/j.pathol.2019.12.003. PMID: 32113673
Tisotumab vedotin in patients with advanced or metastatic solid tumours (InnovaTV 201): a first-in-human, multicentre, phase 1-2 trial.
de Bono JS, Concin N, Hong DS, Thistlethwaite FC, Machiels JP, Arkenau HT, Plummer R, Jones RH, Nielsen D, Windfeld K, Ghatta S, Slomovitz BM, Spicer JF, Yachnin J, Ang JE, Mau-Sørensen PM, Forster MD, Collins D, Dean E, Rangwala RA, Lassen U
Lancet Oncol 2019 Mar;20(3):383-393. Epub 2019 Feb 8 doi: 10.1016/S1470-2045(18)30859-3. PMID: 30745090
What's new in lung tumor heterogeneity?
Müller KM, Fisseler-Eckhoff A
Pathol Res Pract 1988 Dec;184(1):108-15. doi: 10.1016/S0344-0338(88)80201-2. PMID: 2852798

Diagnosis

Diagnosis of lung cancer by flexible fiberoptic bronchoscopy: a descriptive study.
Biciuşcă V, Popescu IAS, Traşcă DM, Olteanu M, Stan IS, Durand P, Camen GC, Bălteanu MA, Cazacu IM, Demetrian AD, Streba CT, Călăraşu C, Cioboată R
Rom J Morphol Embryol 2022 Apr-Jun;63(2):369-381. doi: 10.47162/RJME.63.2.08. PMID: 36374142Free PMC Article
Association between time-to-treatment and outcomes in non-small cell lung cancer: a systematic review.
Hall H, Tocock A, Burdett S, Fisher D, Ricketts WM, Robson J, Round T, Gorolay S, MacArthur E, Chung D, Janes SM, Peake MD, Navani N
Thorax 2022 Aug;77(8):762-768. Epub 2021 Aug 17 doi: 10.1136/thoraxjnl-2021-216865. PMID: 34404753Free PMC Article
EGFR mutation exists in squamous cell lung carcinoma.
Cheung AH, Tong JH, Chung LY, Chau SL, Ng CS, Wan IYP, To KF
Pathology 2020 Apr;52(3):323-328. Epub 2020 Feb 27 doi: 10.1016/j.pathol.2019.12.003. PMID: 32113673
International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma.
Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, Garg K, Austin JH, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, Sanchez-Cespedes M, Sculier JP, Takahashi T, Tsuboi M, Vansteenkiste J, Wistuba I, Yang PC, Aberle D, Brambilla C, Flieder D, Franklin W, Gazdar A, Gould M, Hasleton P, Henderson D, Johnson B, Johnson D, Kerr K, Kuriyama K, Lee JS, Miller VA, Petersen I, Roggli V, Rosell R, Saijo N, Thunnissen E, Tsao M, Yankelewitz D
J Thorac Oncol 2011 Feb;6(2):244-85. doi: 10.1097/JTO.0b013e318206a221. PMID: 21252716Free PMC Article
Primary small cell carcinoma of esophagus: report of 9 cases and review of literature.
Wu Z, Ma JY, Yang JJ, Zhao YF, Zhang SF
World J Gastroenterol 2004 Dec 15;10(24):3680-2. doi: 10.3748/wjg.v10.i24.3680. PMID: 15534932Free PMC Article

Therapy

Long-term comparative efficacy and safety of nivolumab plus ipilimumab relative to other first-line therapies for advanced non-small-cell lung cancer: A systematic literature review and network meta-analysis.
O'Byrne K, Popoff E, Badin F, Lee A, Yuan Y, Lozano-Ortega G, Eccles LJ, Varol N, Waser N, Penrod JR, Goring S
Lung Cancer 2023 Mar;177:11-20. Epub 2023 Jan 11 doi: 10.1016/j.lungcan.2023.01.006. PMID: 36669321
Association between time-to-treatment and outcomes in non-small cell lung cancer: a systematic review.
Hall H, Tocock A, Burdett S, Fisher D, Ricketts WM, Robson J, Round T, Gorolay S, MacArthur E, Chung D, Janes SM, Peake MD, Navani N
Thorax 2022 Aug;77(8):762-768. Epub 2021 Aug 17 doi: 10.1136/thoraxjnl-2021-216865. PMID: 34404753Free PMC Article
Phase I Study of 2- or 3-Week Dosing of Telisotuzumab Vedotin, an Antibody-Drug Conjugate Targeting c-Met, Monotherapy in Patients with Advanced Non-Small Cell Lung Carcinoma.
Camidge DR, Morgensztern D, Heist RS, Barve M, Vokes E, Goldman JW, Hong DS, Bauer TM, Strickler JH, Angevin E, Motwani M, Parikh A, Sun Z, Bach BA, Wu J, Komarnitsky PB, Kelly K
Clin Cancer Res 2021 Nov 1;27(21):5781-5792. Epub 2021 Aug 23 doi: 10.1158/1078-0432.CCR-21-0765. PMID: 34426443Free PMC Article
Tisotumab vedotin in patients with advanced or metastatic solid tumours (InnovaTV 201): a first-in-human, multicentre, phase 1-2 trial.
de Bono JS, Concin N, Hong DS, Thistlethwaite FC, Machiels JP, Arkenau HT, Plummer R, Jones RH, Nielsen D, Windfeld K, Ghatta S, Slomovitz BM, Spicer JF, Yachnin J, Ang JE, Mau-Sørensen PM, Forster MD, Collins D, Dean E, Rangwala RA, Lassen U
Lancet Oncol 2019 Mar;20(3):383-393. Epub 2019 Feb 8 doi: 10.1016/S1470-2045(18)30859-3. PMID: 30745090
Exploring the Benefit/Risk Associated with Antiangiogenic Agents for the Treatment of Non-Small Cell Lung Cancer Patients.
Kurzrock R, Stewart DJ
Clin Cancer Res 2017 Mar 1;23(5):1137-1148. Epub 2016 Dec 9 doi: 10.1158/1078-0432.CCR-16-1968. PMID: 27940520

Prognosis

Molecular profiling of human non-small cell lung cancer by single-cell RNA-seq.
Li Q, Wang R, Yang Z, Li W, Yang J, Wang Z, Bai H, Cui Y, Tian Y, Wu Z, Guo Y, Xu J, Wen L, He J, Tang F, Wang J
Genome Med 2022 Aug 13;14(1):87. doi: 10.1186/s13073-022-01089-9. PMID: 35962452Free PMC Article
Association between time-to-treatment and outcomes in non-small cell lung cancer: a systematic review.
Hall H, Tocock A, Burdett S, Fisher D, Ricketts WM, Robson J, Round T, Gorolay S, MacArthur E, Chung D, Janes SM, Peake MD, Navani N
Thorax 2022 Aug;77(8):762-768. Epub 2021 Aug 17 doi: 10.1136/thoraxjnl-2021-216865. PMID: 34404753Free PMC Article
Comprehensive molecular characterization of lung tumors implicates AKT and MYC signaling in adenocarcinoma to squamous cell transdifferentiation.
Quintanal-Villalonga A, Taniguchi H, Zhan YA, Hasan MM, Chavan SS, Meng F, Uddin F, Allaj V, Manoj P, Shah NS, Chan JM, Ciampricotti M, Chow A, Offin M, Ray-Kirton J, Egger JD, Bhanot UK, Linkov I, Asher M, Roehrl MH, Ventura K, Qiu J, de Stanchina E, Chang JC, Rekhtman N, Houck-Loomis B, Koche RP, Yu HA, Sen T, Rudin CM
J Hematol Oncol 2021 Oct 16;14(1):170. doi: 10.1186/s13045-021-01186-z. PMID: 34656143Free PMC Article
Distribution and prognostic significance of gluconeogenesis and glycolysis in lung cancer.
Smolle E, Leko P, Stacher-Priehse E, Brcic L, El-Heliebi A, Hofmann L, Quehenberger F, Hrzenjak A, Popper HH, Olschewski H, Leithner K
Mol Oncol 2020 Nov;14(11):2853-2867. Epub 2020 Sep 1 doi: 10.1002/1878-0261.12780. PMID: 32777161Free PMC Article
International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma.
Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, Garg K, Austin JH, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, Sanchez-Cespedes M, Sculier JP, Takahashi T, Tsuboi M, Vansteenkiste J, Wistuba I, Yang PC, Aberle D, Brambilla C, Flieder D, Franklin W, Gazdar A, Gould M, Hasleton P, Henderson D, Johnson B, Johnson D, Kerr K, Kuriyama K, Lee JS, Miller VA, Petersen I, Roggli V, Rosell R, Saijo N, Thunnissen E, Tsao M, Yankelewitz D
J Thorac Oncol 2011 Feb;6(2):244-85. doi: 10.1097/JTO.0b013e318206a221. PMID: 21252716Free PMC Article

Clinical prediction guides

Association between time-to-treatment and outcomes in non-small cell lung cancer: a systematic review.
Hall H, Tocock A, Burdett S, Fisher D, Ricketts WM, Robson J, Round T, Gorolay S, MacArthur E, Chung D, Janes SM, Peake MD, Navani N
Thorax 2022 Aug;77(8):762-768. Epub 2021 Aug 17 doi: 10.1136/thoraxjnl-2021-216865. PMID: 34404753Free PMC Article
Comprehensive molecular characterization of lung tumors implicates AKT and MYC signaling in adenocarcinoma to squamous cell transdifferentiation.
Quintanal-Villalonga A, Taniguchi H, Zhan YA, Hasan MM, Chavan SS, Meng F, Uddin F, Allaj V, Manoj P, Shah NS, Chan JM, Ciampricotti M, Chow A, Offin M, Ray-Kirton J, Egger JD, Bhanot UK, Linkov I, Asher M, Roehrl MH, Ventura K, Qiu J, de Stanchina E, Chang JC, Rekhtman N, Houck-Loomis B, Koche RP, Yu HA, Sen T, Rudin CM
J Hematol Oncol 2021 Oct 16;14(1):170. doi: 10.1186/s13045-021-01186-z. PMID: 34656143Free PMC Article
Phase I Study of 2- or 3-Week Dosing of Telisotuzumab Vedotin, an Antibody-Drug Conjugate Targeting c-Met, Monotherapy in Patients with Advanced Non-Small Cell Lung Carcinoma.
Camidge DR, Morgensztern D, Heist RS, Barve M, Vokes E, Goldman JW, Hong DS, Bauer TM, Strickler JH, Angevin E, Motwani M, Parikh A, Sun Z, Bach BA, Wu J, Komarnitsky PB, Kelly K
Clin Cancer Res 2021 Nov 1;27(21):5781-5792. Epub 2021 Aug 23 doi: 10.1158/1078-0432.CCR-21-0765. PMID: 34426443Free PMC Article
EGFR mutation exists in squamous cell lung carcinoma.
Cheung AH, Tong JH, Chung LY, Chau SL, Ng CS, Wan IYP, To KF
Pathology 2020 Apr;52(3):323-328. Epub 2020 Feb 27 doi: 10.1016/j.pathol.2019.12.003. PMID: 32113673
International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma.
Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, Garg K, Austin JH, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, Sanchez-Cespedes M, Sculier JP, Takahashi T, Tsuboi M, Vansteenkiste J, Wistuba I, Yang PC, Aberle D, Brambilla C, Flieder D, Franklin W, Gazdar A, Gould M, Hasleton P, Henderson D, Johnson B, Johnson D, Kerr K, Kuriyama K, Lee JS, Miller VA, Petersen I, Roggli V, Rosell R, Saijo N, Thunnissen E, Tsao M, Yankelewitz D
J Thorac Oncol 2011 Feb;6(2):244-85. doi: 10.1097/JTO.0b013e318206a221. PMID: 21252716Free PMC Article

Recent systematic reviews

Long-term comparative efficacy and safety of nivolumab plus ipilimumab relative to other first-line therapies for advanced non-small-cell lung cancer: A systematic literature review and network meta-analysis.
O'Byrne K, Popoff E, Badin F, Lee A, Yuan Y, Lozano-Ortega G, Eccles LJ, Varol N, Waser N, Penrod JR, Goring S
Lung Cancer 2023 Mar;177:11-20. Epub 2023 Jan 11 doi: 10.1016/j.lungcan.2023.01.006. PMID: 36669321
Association between time-to-treatment and outcomes in non-small cell lung cancer: a systematic review.
Hall H, Tocock A, Burdett S, Fisher D, Ricketts WM, Robson J, Round T, Gorolay S, MacArthur E, Chung D, Janes SM, Peake MD, Navani N
Thorax 2022 Aug;77(8):762-768. Epub 2021 Aug 17 doi: 10.1136/thoraxjnl-2021-216865. PMID: 34404753Free PMC Article
Diagnostic Accuracy of Fine-Needle Aspiration Cytology for Discrimination of Squamous Cell Carcinoma from Adenocarcinoma in Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis.
Layfield LJ, Pearson L, Walker BS, White SK, Schmidt RL
Acta Cytol 2018;62(5-6):318-326. Epub 2018 Oct 31 doi: 10.1159/000493942. PMID: 30380531
First-line treatment of advanced epidermal growth factor receptor (EGFR) mutation positive non-squamous non-small cell lung cancer.
Greenhalgh J, Dwan K, Boland A, Bates V, Vecchio F, Dundar Y, Jain P, Green JA
Cochrane Database Syst Rev 2016 May 25;(5):CD010383. doi: 10.1002/14651858.CD010383.pub2. PMID: 27223332
International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma.
Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, Garg K, Austin JH, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, Sanchez-Cespedes M, Sculier JP, Takahashi T, Tsuboi M, Vansteenkiste J, Wistuba I, Yang PC, Aberle D, Brambilla C, Flieder D, Franklin W, Gazdar A, Gould M, Hasleton P, Henderson D, Johnson B, Johnson D, Kerr K, Kuriyama K, Lee JS, Miller VA, Petersen I, Roggli V, Rosell R, Saijo N, Thunnissen E, Tsao M, Yankelewitz D
J Thorac Oncol 2011 Feb;6(2):244-85. doi: 10.1097/JTO.0b013e318206a221. PMID: 21252716Free PMC Article

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