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Ovarian Fibrosarcoma

MedGen UID:
235417
•Concept ID:
C1335161
•
Neoplastic Process
Synonyms: Fibrosarcoma of Ovary; Fibrosarcoma of the Ovary

Definition

A usually aggressive malignant neoplasm arising from the ovary. It is characterized by the presence of spindle-shaped fibroblasts and collagenous stroma formation in a herringbone growth pattern. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOvarian Fibrosarcoma

Professional guidelines

PubMed

DICER1-associated Tumors in the Female Genital Tract: Molecular Basis, Clinicopathologic Features, and Differential Diagnosis.
Han LM, Weiel JJ, Longacre TA, Folkins AK
Adv Anat Pathol 2022 Sep 1;29(5):297-308. Epub 2022 Jul 1 doi: 10.1097/PAP.0000000000000351. PMID: 35778792

Recent clinical studies

Etiology

DICER1-associated Tumors in the Female Genital Tract: Molecular Basis, Clinicopathologic Features, and Differential Diagnosis.
Han LM, Weiel JJ, Longacre TA, Folkins AK
Adv Anat Pathol 2022 Sep 1;29(5):297-308. Epub 2022 Jul 1 doi: 10.1097/PAP.0000000000000351. PMID: 35778792
Clinicopathologic characteristics and prognostic factors of ovarian fibrosarcoma: the results of a multi-center retrospective study.
Huang L, Liao LM, Wang HY, Zheng M
BMC Cancer 2010 Oct 27;10:585. doi: 10.1186/1471-2407-10-585. PMID: 20979607Free PMC Article
Primary ovarian fibrosarcoma: a case report and review of the literature.
Gultekin M, Dursun P, Ozyuncu O, Usubutun A, Yuce K, Ayhan A
Int J Gynecol Cancer 2005 Nov-Dec;15(6):1142-7. doi: 10.1111/j.1525-1438.2005.00327.x. PMID: 16343198

Diagnosis

DICER1-associated Tumors in the Female Genital Tract: Molecular Basis, Clinicopathologic Features, and Differential Diagnosis.
Han LM, Weiel JJ, Longacre TA, Folkins AK
Adv Anat Pathol 2022 Sep 1;29(5):297-308. Epub 2022 Jul 1 doi: 10.1097/PAP.0000000000000351. PMID: 35778792
Ovarian fibrosarcoma: A single-institution experience and a review of the literature.
Sun TT, Cheng NH, Cao DY, Peng P
J Ovarian Res 2020 Dec 8;13(1):142. doi: 10.1186/s13048-020-00749-x. PMID: 33292402Free PMC Article
Nuclear Atypia Is a Necessary Factor for Diagnosis of Primary Ovarian Fibrosarcoma: A Case Report and Literature Review.
Zhang Z, Yao A, Xin Q, Shi Y, Zhang A
Gynecol Obstet Invest 2020;85(5):437-445. Epub 2020 Oct 2 doi: 10.1159/000510875. PMID: 33011729
Primary ovarian fibrosarcoma: a case report and review of the literature.
Ozdemır O, Sarı ME, Sen E, Ilgın BU, Gurescı S, Atalay CR
J Exp Ther Oncol 2016 Jul;11(3):225-235. PMID: 28471131
Ovarian fibrosarcoma: case report and latest trends in diagnostic and therapeutic management.
Grauso F, Messalli EM, Salzillo ME, Di Martino L, Falcone F, Orabona P, Caiola A, Balbi G
Eur J Gynaecol Oncol 2015;36(6):742-5. PMID: 26775365

Therapy

Ovarian dysgerminoma associated with fibrosarcoma: a case report.
Alvarado-Cabrero I, Valencia-Cedillo R, Mohs-Alfaro M, De Anda-González J
Int J Gynecol Pathol 2011 Sep;30(5):466-9. doi: 10.1097/PGP.0b013e318217139e. PMID: 21804387
Primary ovarian fibrosarcoma with long-term survival: a report of two cases.
Choi WJ, Ha MT, Shin JK, Lee JH
J Obstet Gynaecol Res 2006 Oct;32(5):524-8. doi: 10.1111/j.1447-0756.2006.00448.x. PMID: 16984523
Primary ovarian fibrosarcoma: a case report and review of the literature.
Gultekin M, Dursun P, Ozyuncu O, Usubutun A, Yuce K, Ayhan A
Int J Gynecol Cancer 2005 Nov-Dec;15(6):1142-7. doi: 10.1111/j.1525-1438.2005.00327.x. PMID: 16343198
Ovarian fibrosarcoma with long-term survival: a case report.
Huang YC, Hsu KF, Chou CY, Dai YC, Tzeng CC
Int J Gynecol Cancer 2001 Jul-Aug;11(4):331-3. doi: 10.1046/j.1525-1438.2001.011004331.x. PMID: 11520377

Prognosis

Ovarian fibrosarcoma: A single-institution experience and a review of the literature.
Sun TT, Cheng NH, Cao DY, Peng P
J Ovarian Res 2020 Dec 8;13(1):142. doi: 10.1186/s13048-020-00749-x. PMID: 33292402Free PMC Article
Nuclear Atypia Is a Necessary Factor for Diagnosis of Primary Ovarian Fibrosarcoma: A Case Report and Literature Review.
Zhang Z, Yao A, Xin Q, Shi Y, Zhang A
Gynecol Obstet Invest 2020;85(5):437-445. Epub 2020 Oct 2 doi: 10.1159/000510875. PMID: 33011729
Primary Ovarian Fibrosarcoma-An Unusual Tumor in an Adolescent: Case Report and Review of the Pediatric Literature.
Kurtmen BT, Dokumcu Z, Divarci E, Serin G, Ergun O, Ozok G, Celik A
J Pediatr Adolesc Gynecol 2017 Dec;30(6):655-658. Epub 2017 May 11 doi: 10.1016/j.jpag.2017.05.003. PMID: 28502829
Ovarian fibrosarcoma: case report and latest trends in diagnostic and therapeutic management.
Grauso F, Messalli EM, Salzillo ME, Di Martino L, Falcone F, Orabona P, Caiola A, Balbi G
Eur J Gynaecol Oncol 2015;36(6):742-5. PMID: 26775365
Clinicopathologic characteristics and prognostic factors of ovarian fibrosarcoma: the results of a multi-center retrospective study.
Huang L, Liao LM, Wang HY, Zheng M
BMC Cancer 2010 Oct 27;10:585. doi: 10.1186/1471-2407-10-585. PMID: 20979607Free PMC Article

Clinical prediction guides

Ovarian fibrosarcoma: A single-institution experience and a review of the literature.
Sun TT, Cheng NH, Cao DY, Peng P
J Ovarian Res 2020 Dec 8;13(1):142. doi: 10.1186/s13048-020-00749-x. PMID: 33292402Free PMC Article
Primary Ovarian Fibrosarcoma-An Unusual Tumor in an Adolescent: Case Report and Review of the Pediatric Literature.
Kurtmen BT, Dokumcu Z, Divarci E, Serin G, Ergun O, Ozok G, Celik A
J Pediatr Adolesc Gynecol 2017 Dec;30(6):655-658. Epub 2017 May 11 doi: 10.1016/j.jpag.2017.05.003. PMID: 28502829
Clinicopathologic characteristics and prognostic factors of ovarian fibrosarcoma: the results of a multi-center retrospective study.
Huang L, Liao LM, Wang HY, Zheng M
BMC Cancer 2010 Oct 27;10:585. doi: 10.1186/1471-2407-10-585. PMID: 20979607Free PMC Article
Color Doppler ultrasound in ovarian fibrosarcoma.
Kaya H, Sezik M, Ozkaya O, Desdicioglu R, Kapucuoglu N
Gynecol Oncol 2004 Jul;94(1):229-31. doi: 10.1016/j.ygyno.2004.04.010. PMID: 15262149
Nevoid basal-cell carcinoma syndrome.
Gorlin RJ
Medicine (Baltimore) 1987 Mar;66(2):98-113. doi: 10.1097/00005792-198703000-00002. PMID: 3547011

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