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Salivary Gland Myoepithelial Carcinoma

MedGen UID:
235575
•Concept ID:
C1335904
•
Neoplastic Process

Definition

A locally aggressive carcinoma that arises from the salivary glands, predominantly the parotid gland. It is characterized by the presence of a malignant cellular infiltrate exhibiting myoepithelial differentiation. Patients usually present with a painless mass. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSalivary Gland Myoepithelial Carcinoma

Professional guidelines

PubMed

Oncocytoid Salivary Tumors: Differential Diagnosis and Utility of Newly Described Immunohistochemistry.
Katabi N
Head Neck Pathol 2024 Mar 19;18(1):20. doi: 10.1007/s12105-024-01622-9. PMID: 38502259Free PMC Article
Current diagnosis and treatment of salivary gland-type tumors of the lung.
Horio Y, Kuroda H, Masago K, Matsushita H, Sasaki E, Fujiwara Y
Jpn J Clin Oncol 2024 Mar 9;54(3):229-247. doi: 10.1093/jjco/hyad160. PMID: 38018262
Selinexor for the treatment of recurrent or metastatic salivary gland tumors: Results from the GEMS-001 clinical trial.
Hernando-Calvo A, Malone E, Day D, Prawira A, Weinreb I, Yang SYC, Wong H, Rodriguez A, Jennings S, Eliason A, Wang L, Spreafico A, Siu LL, Hansen AR
Cancer Med 2023 Oct;12(20):20299-20310. Epub 2023 Oct 11 doi: 10.1002/cam4.6589. PMID: 37818869Free PMC Article

Recent clinical studies

Etiology

Clinicopathological features and prognostic factors of salivary gland myoepithelial carcinoma: institutional experience of 42 cases.
Wu Y, Xu W, Lu H, Liu L, Liu S, Yang W
Int J Oral Maxillofac Surg 2024 Apr;53(4):268-274. Epub 2023 Aug 15 doi: 10.1016/j.ijom.2023.07.009. PMID: 37591716
Clinicopathological and survival profile of patients with salivary gland myoepithelial carcinoma: A systematic review.
Lavareze L, Scarini JF, de Lima-Souza RA, Kimura TC, Gondak RO, Egal ESA, Altemani A, Mariano FV
J Oral Pathol Med 2023 Feb;52(2):101-108. Epub 2023 Jan 9 doi: 10.1111/jop.13395. PMID: 36504414
Risk Factors and Prognosis for Myoepithelial Carcinoma of the Major Salivary Glands.
Su YX, Roberts DB, Hanna EY, El-Naggar A, Saylam G, Frank SJ, Weber RS, Kupferman ME
Ann Surg Oncol 2015 Oct;22(11):3701-7. Epub 2015 Jan 31 doi: 10.1245/s10434-015-4389-3. PMID: 25636455

Diagnosis

Clinicopathological features and prognostic factors of salivary gland myoepithelial carcinoma: institutional experience of 42 cases.
Wu Y, Xu W, Lu H, Liu L, Liu S, Yang W
Int J Oral Maxillofac Surg 2024 Apr;53(4):268-274. Epub 2023 Aug 15 doi: 10.1016/j.ijom.2023.07.009. PMID: 37591716
Cytopathology of salivary gland myoepithelial carcinoma: A study of 13 cases and review of the literature.
Argyris PP, Wakely PE Jr
J Am Soc Cytopathol 2023 Nov-Dec;12(6):461-468. Epub 2023 May 11 doi: 10.1016/j.jasc.2023.05.001. PMID: 37270329
Clinicopathological and survival profile of patients with salivary gland myoepithelial carcinoma: A systematic review.
Lavareze L, Scarini JF, de Lima-Souza RA, Kimura TC, Gondak RO, Egal ESA, Altemani A, Mariano FV
J Oral Pathol Med 2023 Feb;52(2):101-108. Epub 2023 Jan 9 doi: 10.1111/jop.13395. PMID: 36504414
Salivary gland myoepithelial carcinoma.
Vilar-González S, Bradley K, Rico-Pérez J, Vogiatzis P, Golka D, Nigam A, Sivaramalingam M, Kazmi S
Clin Transl Oncol 2015 Nov;17(11):847-55. Epub 2015 Jul 2 doi: 10.1007/s12094-015-1329-4. PMID: 26133522

Therapy

Risk Factors and Prognosis for Myoepithelial Carcinoma of the Major Salivary Glands.
Su YX, Roberts DB, Hanna EY, El-Naggar A, Saylam G, Frank SJ, Weber RS, Kupferman ME
Ann Surg Oncol 2015 Oct;22(11):3701-7. Epub 2015 Jan 31 doi: 10.1245/s10434-015-4389-3. PMID: 25636455

Prognosis

Clinicopathological features and prognostic factors of salivary gland myoepithelial carcinoma: institutional experience of 42 cases.
Wu Y, Xu W, Lu H, Liu L, Liu S, Yang W
Int J Oral Maxillofac Surg 2024 Apr;53(4):268-274. Epub 2023 Aug 15 doi: 10.1016/j.ijom.2023.07.009. PMID: 37591716
Clinicopathological and survival profile of patients with salivary gland myoepithelial carcinoma: A systematic review.
Lavareze L, Scarini JF, de Lima-Souza RA, Kimura TC, Gondak RO, Egal ESA, Altemani A, Mariano FV
J Oral Pathol Med 2023 Feb;52(2):101-108. Epub 2023 Jan 9 doi: 10.1111/jop.13395. PMID: 36504414
Risk Factors and Prognosis for Myoepithelial Carcinoma of the Major Salivary Glands.
Su YX, Roberts DB, Hanna EY, El-Naggar A, Saylam G, Frank SJ, Weber RS, Kupferman ME
Ann Surg Oncol 2015 Oct;22(11):3701-7. Epub 2015 Jan 31 doi: 10.1245/s10434-015-4389-3. PMID: 25636455

Clinical prediction guides

Clinicopathological features and prognostic factors of salivary gland myoepithelial carcinoma: institutional experience of 42 cases.
Wu Y, Xu W, Lu H, Liu L, Liu S, Yang W
Int J Oral Maxillofac Surg 2024 Apr;53(4):268-274. Epub 2023 Aug 15 doi: 10.1016/j.ijom.2023.07.009. PMID: 37591716
Risk Factors and Prognosis for Myoepithelial Carcinoma of the Major Salivary Glands.
Su YX, Roberts DB, Hanna EY, El-Naggar A, Saylam G, Frank SJ, Weber RS, Kupferman ME
Ann Surg Oncol 2015 Oct;22(11):3701-7. Epub 2015 Jan 31 doi: 10.1245/s10434-015-4389-3. PMID: 25636455

Recent systematic reviews

Clinicopathological and survival profile of patients with salivary gland myoepithelial carcinoma: A systematic review.
Lavareze L, Scarini JF, de Lima-Souza RA, Kimura TC, Gondak RO, Egal ESA, Altemani A, Mariano FV
J Oral Pathol Med 2023 Feb;52(2):101-108. Epub 2023 Jan 9 doi: 10.1111/jop.13395. PMID: 36504414

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