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Sarcomatoid penile squamous cell carcinoma

MedGen UID:
235580
•Concept ID:
C1335923
•
Neoplastic Process
Synonyms: Penile Sarcomatoid Carcinoma; Penile Spindle Cell Carcinoma; Sarcomatoid Carcinoma of the Penis; sarcomatoid carcinoma of the penis; Sarcomatoid Penile Carcinoma; sarcomatoid penile carcinoma; Sarcomatoid Penile Squamous Cell Carcinoma; sarcomatoid penile squamous cell carcinoma; Sarcomatous Carcinoma of the Penis; sarcomatous carcinoma of the penis; Spindle Cell Carcinoma of the Penis; spindle cell carcinoma of the penis; Squamous Cell Carcinoma of Penis, Sarcomatoid Type; squamous cell carcinoma of penis, sarcomatoid type; Squamous Cell Carcinoma of the Penis, Sarcomatoid Type; squamous cell carcinoma of the penis, sarcomatoid type
 
Monarch Initiative: MONDO:0004410

Definition

A squamous cell carcinoma that arises from the penis and is characterized by the presence of malignant spindle-shaped cells. [from NCI]

Professional guidelines

PubMed

HPV- and non-HPV-related subtypes of penile squamous cell carcinoma (SCC): Morphological features and differential diagnosis according to the new WHO classification (2015).
Sanchez DF, Cañete S, Fernández-Nestosa MJ, Lezcano C, Rodríguez I, Barreto J, Alvarado-Cabrero I, Cubilla AL
Semin Diagn Pathol 2015 May;32(3):198-221. Epub 2014 Dec 30 doi: 10.1053/j.semdp.2014.12.018. PMID: 25701382

Recent clinical studies

Etiology

Tumor lesions of penis and scrotum according to WHO classification 2022.
Michalová K, Beniač P, Kacerovská D
Cesk Patol 2022 Fall;67(4):192-197. PMID: 36513504
Sarcomatoid Squamous Cell Carcinoma of the Penis - a Report of Two Cases.
Bachurska SY, Antonov PA, Staykov DG, Dechev IY
Folia Med (Plovdiv) 2017 Jun 1;59(2):232-237. doi: 10.1515/folmed-2017-0002. PMID: 28704194
HPV- and non-HPV-related subtypes of penile squamous cell carcinoma (SCC): Morphological features and differential diagnosis according to the new WHO classification (2015).
Sanchez DF, Cañete S, Fernández-Nestosa MJ, Lezcano C, Rodríguez I, Barreto J, Alvarado-Cabrero I, Cubilla AL
Semin Diagn Pathol 2015 May;32(3):198-221. Epub 2014 Dec 30 doi: 10.1053/j.semdp.2014.12.018. PMID: 25701382
Developments in the pathology of penile squamous cell carcinomas.
Chaux A, Velazquez EF, Algaba F, Ayala G, Cubilla AL
Urology 2010 Aug;76(2 Suppl 1):S7-S14. doi: 10.1016/j.urology.2010.02.038. PMID: 20691888
Penile squamous cell carcinoma clinicopathological features, nodal metastasis and outcome in 333 cases.
Guimarães GC, Cunha IW, Soares FA, Lopes A, Torres J, Chaux A, Velazquez EF, Ayala G, Cubilla AL
J Urol 2009 Aug;182(2):528-34; discussion 534. Epub 2009 Jun 13 doi: 10.1016/j.juro.2009.04.028. PMID: 19524964

Diagnosis

A challenging diagnosis of penile sarcomatoid squamous cell carcinoma.
Zhang S, Khosravi H, Cardis M, Jedrych J, Ho J, Bunimovich Y
Dermatol Online J 2019 Oct 15;25(10) PMID: 31735007
Sarcomatoid Squamous Cell Carcinoma of the Penis - a Report of Two Cases.
Bachurska SY, Antonov PA, Staykov DG, Dechev IY
Folia Med (Plovdiv) 2017 Jun 1;59(2):232-237. doi: 10.1515/folmed-2017-0002. PMID: 28704194
Diagnostic problems in precancerous lesions and invasive carcinomas of the penis.
Chaux A, Cubilla AL
Semin Diagn Pathol 2012 May;29(2):72-82. doi: 10.1053/j.semdp.2011.08.002. PMID: 22641956
Penile squamous cell carcinoma clinicopathological features, nodal metastasis and outcome in 333 cases.
Guimarães GC, Cunha IW, Soares FA, Lopes A, Torres J, Chaux A, Velazquez EF, Ayala G, Cubilla AL
J Urol 2009 Aug;182(2):528-34; discussion 534. Epub 2009 Jun 13 doi: 10.1016/j.juro.2009.04.028. PMID: 19524964
Penile squamous cell carcinoma: anatomic, pathologic and viral studies in Paraguay (1993-2007).
Velazquez EF, Cubilla AL
Anal Quant Cytol Histol 2007 Aug;29(4):185-98. PMID: 17879626

Prognosis

A challenging diagnosis of penile sarcomatoid squamous cell carcinoma.
Zhang S, Khosravi H, Cardis M, Jedrych J, Ho J, Bunimovich Y
Dermatol Online J 2019 Oct 15;25(10) PMID: 31735007
Sarcomatoid Squamous Cell Carcinoma of the Penis - a Report of Two Cases.
Bachurska SY, Antonov PA, Staykov DG, Dechev IY
Folia Med (Plovdiv) 2017 Jun 1;59(2):232-237. doi: 10.1515/folmed-2017-0002. PMID: 28704194
Diagnostic problems in precancerous lesions and invasive carcinomas of the penis.
Chaux A, Cubilla AL
Semin Diagn Pathol 2012 May;29(2):72-82. doi: 10.1053/j.semdp.2011.08.002. PMID: 22641956
Penile squamous cell carcinoma clinicopathological features, nodal metastasis and outcome in 333 cases.
Guimarães GC, Cunha IW, Soares FA, Lopes A, Torres J, Chaux A, Velazquez EF, Ayala G, Cubilla AL
J Urol 2009 Aug;182(2):528-34; discussion 534. Epub 2009 Jun 13 doi: 10.1016/j.juro.2009.04.028. PMID: 19524964
Penile squamous cell carcinoma: anatomic, pathologic and viral studies in Paraguay (1993-2007).
Velazquez EF, Cubilla AL
Anal Quant Cytol Histol 2007 Aug;29(4):185-98. PMID: 17879626

Clinical prediction guides

Pathological factors, behavior, and histological prognostic risk groups in subtypes of penile squamous cell carcinomas (SCC).
Sanchez DF, Soares F, Alvarado-Cabrero I, Cañete S, Fernández-Nestosa MJ, Rodríguez IM, Barreto J, Cubilla AL
Semin Diagn Pathol 2015 May;32(3):222-31. Epub 2014 Dec 27 doi: 10.1053/j.semdp.2014.12.017. PMID: 25677263
Advances in the pathology of penile carcinomas.
Chaux A, Cubilla AL
Hum Pathol 2012 Jun;43(6):771-89. doi: 10.1016/j.humpath.2012.01.014. PMID: 22595011
CD10 immunoreactivity in sarcomatoid carcinomas: comparison with true sarcomas.
Vennapusa B, Fischer EG, Wick MR, Cerilli LA
Appl Immunohistochem Mol Morphol 2011 Oct;19(5):408-12. doi: 10.1097/PAI.0b013e3182111be5. PMID: 21908981
Penile squamous cell carcinoma clinicopathological features, nodal metastasis and outcome in 333 cases.
Guimarães GC, Cunha IW, Soares FA, Lopes A, Torres J, Chaux A, Velazquez EF, Ayala G, Cubilla AL
J Urol 2009 Aug;182(2):528-34; discussion 534. Epub 2009 Jun 13 doi: 10.1016/j.juro.2009.04.028. PMID: 19524964
Comparison of morphologic features and outcome of resected recurrent and nonrecurrent squamous cell carcinoma of the penis: a study of 81 cases.
Chaux A, Reuter V, Lezcano C, Velazquez EF, Torres J, Cubilla AL
Am J Surg Pathol 2009 Sep;33(9):1299-306. doi: 10.1097/PAS.0b013e3181a418ae. PMID: 19471153

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