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Mixed testicular germ cell cancer

MedGen UID:
237005
•Concept ID:
C1336720
•
Neoplastic Process
Synonyms: Mixed Germ Cell Neoplasm of Testis; mixed germ cell neoplasm of testis; Mixed Germ Cell Neoplasm of the Testis; mixed germ cell neoplasm of the testis; mixed germ cell tumor; Mixed Germ Cell Tumor of Testis; mixed germ cell tumor of testis; Mixed Germ Cell Tumor of the Testis; mixed germ cell tumor of the testis; mixed germ cell tumour; mixed germ cell tumour of testis; mixed germ cell tumour of the testis; mixed testicular germ cell cancer; mixed testicular germ cell tumor; mixed testicular germ cell tumour; Testicular Germ Cell Tumor (Mixed); testicular germ cell tumor (mixed); testicular germ cell tumour (mixed); Testicular Mixed Germ Cell Neoplasm; testicular mixed germ cell neoplasm; Testicular Mixed Germ Cell Tumor; testicular mixed germ cell tumor; testicular mixed germ cell tumour; testis mixed germ cell tumor; testis mixed germ cell tumour
 
Monarch Initiative: MONDO:0003120

Definition

A malignant germ cell tumor that arises from the testis and is characterized by the presence of more than one histologic component. Representative examples include mixed choriocarcinoma and embryonal carcinoma, mixed embryonal carcinoma and seminoma, and mixed yolk sac tumor and teratoma. [from NCI]

Professional guidelines

PubMed

Testicular Germ Cell Tumors: Classification, Pathologic Features, Imaging Findings, and Management.
Katabathina VS, Vargas-Zapata D, Monge RA, Nazarullah A, Ganeshan D, Tammisetti V, Prasad SR
Radiographics 2021 Oct;41(6):1698-1716. doi: 10.1148/rg.2021210024. PMID: 34597218
Surgical Management of Cervical Non-seminomatous Germ Cell Tumor Metastases.
Nwosu OI, Jones AJ, Alwani M, Einhorn LH, Moore MG, Mantravadi AV
Laryngoscope 2021 Jul;131(7):1528-1534. Epub 2021 Jan 9 doi: 10.1002/lary.29364. PMID: 33421136
Critical review of the management of primary central nervous nongerminomatous germ cell tumors.
Abu Arja MH, Bouffet E, Finlay JL, AbdelBaki MS
Pediatr Blood Cancer 2019 Jun;66(6):e27658. Epub 2019 Feb 15 doi: 10.1002/pbc.27658. PMID: 30767415

Recent clinical studies

Etiology

Testicular Germ Cell Tumors: Classification, Pathologic Features, Imaging Findings, and Management.
Katabathina VS, Vargas-Zapata D, Monge RA, Nazarullah A, Ganeshan D, Tammisetti V, Prasad SR
Radiographics 2021 Oct;41(6):1698-1716. doi: 10.1148/rg.2021210024. PMID: 34597218
Testicular Tumors: A Contemporary Update on Morphologic, Immunohistochemical and Molecular Features.
Al-Obaidy KI, Idrees MT
Adv Anat Pathol 2021 Jul 1;28(4):258-275. doi: 10.1097/PAP.0000000000000302. PMID: 33871428
Ovarian germ cell tumour classification: views from the testis.
Berney DM, Stoneham S, Arora R, Shamash J, Lockley M
Histopathology 2020 Jan;76(1):25-36. doi: 10.1111/his.14016. PMID: 31846529
Association Between Marijuana Use and Risk of Cancer: A Systematic Review and Meta-analysis.
Ghasemiesfe M, Barrow B, Leonard S, Keyhani S, Korenstein D
JAMA Netw Open 2019 Nov 1;2(11):e1916318. doi: 10.1001/jamanetworkopen.2019.16318. PMID: 31774524Free PMC Article
Current urologic care for testicular germ cell tumors in pediatric and adolescent patients.
Grantham EC, Caldwell BT, Cost NG
Urol Oncol 2016 Feb;34(2):65-75. Epub 2015 Jul 15 doi: 10.1016/j.urolonc.2015.06.008. PMID: 26187598

Diagnosis

Metastatic germ cell tumour in effusion cytology.
Saini T, Kundu R, Rastogi P, Rohilla M, Gupta P, Gupta N, Srinivasan R, Dey P
Cytopathology 2022 Jul;33(4):493-498. Epub 2022 Apr 9 doi: 10.1111/cyt.13122. PMID: 35347771
Testicular Germ Cell Tumors: Classification, Pathologic Features, Imaging Findings, and Management.
Katabathina VS, Vargas-Zapata D, Monge RA, Nazarullah A, Ganeshan D, Tammisetti V, Prasad SR
Radiographics 2021 Oct;41(6):1698-1716. doi: 10.1148/rg.2021210024. PMID: 34597218
Testicular Tumors: A Contemporary Update on Morphologic, Immunohistochemical and Molecular Features.
Al-Obaidy KI, Idrees MT
Adv Anat Pathol 2021 Jul 1;28(4):258-275. doi: 10.1097/PAP.0000000000000302. PMID: 33871428
Current knowledge of risk factors for testicular germ cell tumors.
Fukawa T, Kanayama HO
Int J Urol 2018 Apr;25(4):337-344. Epub 2018 Jan 17 doi: 10.1111/iju.13519. PMID: 29345008
Perspectives on testicular germ cell neoplasms.
Cheng L, Lyu B, Roth LM
Hum Pathol 2017 Jan;59:10-25. Epub 2016 Aug 26 doi: 10.1016/j.humpath.2016.08.002. PMID: 27569298

Therapy

Testicular Mixed Germ Cell Tumor Presenting with Upper Gastrointestinal Bleeding: A Case Report.
Trpchevska EN, Todorovska B, Todorovska MB, Trajkovska M, Nikolova D, Dzambaz D, Deriban G, Licoska-Josifovikj F
Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2023 Jul 1;44(2):47-52. Epub 2023 Jul 15 doi: 10.2478/prilozi-2023-0024. PMID: 37453124
177Lu-PSMA Therapy for Metastatic Testicular Mixed Germ Cell Tumor.
Has Simsek D, Civan C, Ekenel M, Kuyumcu S, Sanli Y
Clin Nucl Med 2021 May 1;46(5):415-418. doi: 10.1097/RLU.0000000000003563. PMID: 33630811
Association Between Marijuana Use and Risk of Cancer: A Systematic Review and Meta-analysis.
Ghasemiesfe M, Barrow B, Leonard S, Keyhani S, Korenstein D
JAMA Netw Open 2019 Nov 1;2(11):e1916318. doi: 10.1001/jamanetworkopen.2019.16318. PMID: 31774524Free PMC Article
Current knowledge of risk factors for testicular germ cell tumors.
Fukawa T, Kanayama HO
Int J Urol 2018 Apr;25(4):337-344. Epub 2018 Jan 17 doi: 10.1111/iju.13519. PMID: 29345008
A giant testicular mixed germ cell tumour.
Reekhaye A, Harris A, Nagarajan S, Chadwick D
Ann R Coll Surg Engl 2016 Nov;98(8):e171-e172. Epub 2016 Aug 4 doi: 10.1308/rcsann.2016.0219. PMID: 27490988Free PMC Article

Prognosis

Testicular Germ Cell Tumors: Classification, Pathologic Features, Imaging Findings, and Management.
Katabathina VS, Vargas-Zapata D, Monge RA, Nazarullah A, Ganeshan D, Tammisetti V, Prasad SR
Radiographics 2021 Oct;41(6):1698-1716. doi: 10.1148/rg.2021210024. PMID: 34597218
Diagnostic performance of microRNAs in testicular germ cell tumors: a systematic review and meta-analysis.
Zhao XY, Gao YL, Li DF, Liu HC, Zhu RF, Zhu CT
Aging (Albany NY) 2021 Aug 3;13(15):19657-19677. doi: 10.18632/aging.203376. PMID: 34343969Free PMC Article
Current knowledge of risk factors for testicular germ cell tumors.
Fukawa T, Kanayama HO
Int J Urol 2018 Apr;25(4):337-344. Epub 2018 Jan 17 doi: 10.1111/iju.13519. PMID: 29345008
Perspectives on testicular germ cell neoplasms.
Cheng L, Lyu B, Roth LM
Hum Pathol 2017 Jan;59:10-25. Epub 2016 Aug 26 doi: 10.1016/j.humpath.2016.08.002. PMID: 27569298
Germ-cell tumors of the mediastinum.
Weidner N
Semin Diagn Pathol 1999 Feb;16(1):42-50. PMID: 10355653

Clinical prediction guides

Comprehensive characteristics of pathological subtypes in testicular germ cell tumor: Gene expression, mutation and alternative splicing.
Yao X, Zhou H, Duan C, Wu X, Li B, Liu H, Zhang Y
Front Immunol 2022;13:1096494. Epub 2023 Jan 13 doi: 10.3389/fimmu.2022.1096494. PMID: 36713456Free PMC Article
SOX2 and PRAME in the "reprogramming" of seminoma cells.
Orsatti A, Sirolli M, Ambrosi F, Franceschini T, Giunchi F, Franchini E, Grillini M, Massari F, Mollica V, Bianchi FM, Colecchia M, Fiorentino M, Ricci C
Pathol Res Pract 2022 Sep;237:154044. Epub 2022 Jul 28 doi: 10.1016/j.prp.2022.154044. PMID: 35930824
Diagnostic performance of microRNAs in testicular germ cell tumors: a systematic review and meta-analysis.
Zhao XY, Gao YL, Li DF, Liu HC, Zhu RF, Zhu CT
Aging (Albany NY) 2021 Aug 3;13(15):19657-19677. doi: 10.18632/aging.203376. PMID: 34343969Free PMC Article
N-cadherin expression in primary and metastatic testicular germ cell tumors.
Aytac Vuruskan B, Ozturk Nazlioglu H, Vuruskan H
J BUON 2018 Jul-Aug;23(4):1125-1129. PMID: 30358221
Perspectives on testicular germ cell neoplasms.
Cheng L, Lyu B, Roth LM
Hum Pathol 2017 Jan;59:10-25. Epub 2016 Aug 26 doi: 10.1016/j.humpath.2016.08.002. PMID: 27569298

Recent systematic reviews

Identifying the unmet supportive care needs of individuals affected by testicular cancer: a systematic review.
Doyle R, Craft P, Turner M, Paterson C
J Cancer Surviv 2024 Apr;18(2):263-287. Epub 2022 Jul 4 doi: 10.1007/s11764-022-01219-7. PMID: 35781623Free PMC Article
Diagnostic performance of microRNAs in testicular germ cell tumors: a systematic review and meta-analysis.
Zhao XY, Gao YL, Li DF, Liu HC, Zhu RF, Zhu CT
Aging (Albany NY) 2021 Aug 3;13(15):19657-19677. doi: 10.18632/aging.203376. PMID: 34343969Free PMC Article
Association Between Marijuana Use and Risk of Cancer: A Systematic Review and Meta-analysis.
Ghasemiesfe M, Barrow B, Leonard S, Keyhani S, Korenstein D
JAMA Netw Open 2019 Nov 1;2(11):e1916318. doi: 10.1001/jamanetworkopen.2019.16318. PMID: 31774524Free PMC Article
Association between KITLG Gene Polymorphisms and Testicular Germ Cell Tumors: A Systematic Review and Meta-analysis.
Qin JX, Cai ZL, Yang YF, Xing JC, Zhuang X
Curr Med Sci 2019 Oct;39(5):702-706. Epub 2019 Oct 14 doi: 10.1007/s11596-019-2095-2. PMID: 31612386
Management of stage I non-seminomatous testicular cancer: a systematic review and meta-analysis.
Hotte SJ, Mayhew LA, Jewett M, Chin J, Winquist E; Genitourinary Cancer Disease Site Group of the Cancer Care Ontario Program in Evidence-based Care
Clin Oncol (R Coll Radiol) 2010 Feb;22(1):17-26. Epub 2009 Oct 17 doi: 10.1016/j.clon.2009.09.005. PMID: 19836934

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